Clinical Trials at Duke University

As of August 2026, 163 paid clinical trials are recruiting at Duke University, located at 2301 ERWIN ROAD EMERGEENCY MEDICINE RESIDENCY, DURHAM, NC 27710-0001, phone (919) 681-2247 in Durham, North Carolina. Compensation typically covers time, travel, and study visits — most studies also offer study-related medical care at no cost to participants.

Recruiting trial data synced daily from ClinicalTrials.gov. Last sync: August 27, 2026.

Filter results

Filter results

State

City

Facility

Recruitment status

Phase

Study type

Intervention

Condition

Sex

Age

Healthy volunteers only

165 clinical trials at Duke University

·Clear filters·

Get a weekly email when new trials open in Durham, NC.

Ethicon Pelvic Mesh Post Market Clinical Follow-up Registry

for Stress Urinary Incontinence

Sites in Durham +3 more locations

Sponsor: Ethicon, Inc.

Sex: Female·Age: 21+

Code: NCT04829175·Recruiting·Listed Apr 2021

Apply to this trial

Study of SX-682 Plus Enzalutamide in Men With ARPI-Resistant Metastatic Castration Resistant Prostate Cancer

for Metastatic Castration-resistant Prostate Cancer

Sites in Durham +5 more locations

Sponsor: Syntrix Biosystems, Inc.

Sex: Male·Age: 18+

Code: NCT06228053·Phase 2·Recruiting·Listed Jan 2024

Apply to this trial

Efficacy of Atenativ in Patients With Congenital Antithrombin Deficiency Undergoing Surgery or Delivery

for Congenital Antithrombin Deficiency

Sites in Durham +4 more locations

Sponsor: Octapharma

Sex: All·Age: 12 - 80

Code: NCT04918173·Phase 3·Recruiting·Listed Jun 2021

Apply to this trial

A Phase 1, Dose Escalation Trial of RP-A601 in Subjects With PKP2 Variant-Mediated Arrhythmogenic Cardiomyopathy (PKP2-ACM)

for PKP2 Arrhythmogenic Cardiomyopathy (PKP2-ACM)

Sites in Durham +1 more location

Sponsor: Rocket Pharmaceuticals Inc.

Sex: All·Age: 18+

Code: NCT05885412·Phase 1·Recruiting·Listed Jun 2023

Apply to this trial

Enhancing Heart Allograft Function With the OCS Heart System Trial

for Heart Transplant

Sites in Durham +7 more locations

Sponsor: TransMedics

Sex: All·Age: 18+

Code: NCT07145515·Recruiting·Listed Aug 2025

Apply to this trial

PKP2-ACM Natural History Study

for Cardiomyopathies

Sites in Durham +1 more location

Sponsor: Rocket Pharmaceuticals Inc.

Sex: All·Age: 12+

Code: NCT06644742·Recruiting·Listed Oct 2024

Apply to this trial

A Study of Selinexor Monotherapy in Subjects With JAK Inhibitor-naïve Myelofibrosis and Moderate Thrombocytopenia

for Myelofibrosis

Drug: Selinexor

Sites in Durham +6 more locations

Sponsor: Karyopharm Therapeutics Inc

Sex: All·Age: 18+

Code: NCT05980806·Phase 2·Recruiting·Listed Aug 2023

Apply to this trial

X-ray Psoralen Activated Cancer Therapy in Head and Neck, Breast, Sarcoma and Melanoma

for Advanced Solid Tumor Cancer

Sites in Durham, Charlotte +2 more locations

Sponsor: Immunolight, LLC

Sex: All·Age: 18+

Code: NCT04389281·Phase 1·Recruiting·Listed May 2020

Apply to this trial

US National TOP Registry

for Lung Transplant

Sites in Durham +6 more locations

Sponsor: TransMedics

Sex: All·Age: All ages

Code: NCT06513091·Recruiting·Listed Jul 2024

Apply to this trial

CAP-100 for Subjects With Relapsed/Refractory Chronic Lymphocytic Leukemia

for Lymphocytic Leukemia, Chronic

Sites in Durham +1 more location

Sponsor: Catapult Therapeutics

Sex: All·Age: 18+

Code: NCT04704323·Phase 1·Recruiting·Listed Jan 2021

Apply to this trial

Pediatric Post-Approval Registry

for Obstructive Sleep Apnea

Sites in Durham +6 more locations

Sponsor: Inspire Medical Systems, Inc.

Sex: All·Age: 18 - 21

Code: NCT04457154·Recruiting·Listed Jul 2020

Apply to this trial

Registry of Arthrex Hand and Wrist Products

for Ulnar/Radial Collateral Ligament Reconstruction

Sites in Durham +3 more locations

Sponsor: Arthrex, Inc.

Sex: All·Age: 18+·Accepts healthy volunteers

Code: NCT05046600·Recruiting·Listed Sep 2021

Apply to this trial

Evaluation of Eflornithine Plus Temozolomide in Patients With Newly Diagnosed Glioblastoma or Astrocytoma

for Glioblastoma, IDH-wildtype

Sites in Durham +6 more locations

Sponsor: Orbus Therapeutics, Inc.

Sex: All·Age: 18+

Code: NCT05879367·Phase 1·Recruiting·Listed May 2023

Apply to this trial

CORCYM Mitral, Aortic aNd Tricuspid Post-maRket Study in a reAl-world Setting

for Cardiac Valve Disease

Sites in Durham, Greenville +5 more locations

Sponsor: Corcym S.r.l

Sex: All·Age: All ages

Code: NCT05002543·Recruiting·Listed Aug 2021

Apply to this trial

Modulation of SERCA2a of Intra-myocytic Calcium Trafficking in Heart Failure With Preserved Ejection Fraction

for Heart Failure, Diastolic

Sites in Durham +1 more location

Sponsor: Sardocor Corp.

Sex: All·Age: 50+

Code: NCT06061549·Phase 1·Recruiting·Listed Sep 2023

Apply to this trial

Stress and Menstrual Health

for Menstrual Dysfunction

1 location in Durham

Sponsor: Duke University

Sex: Female·Age: 18 - 45·Accepts healthy volunteers

Code: NCT07566260·Recruiting·Listed May 2026

Apply to this trial

Continued Pressure for Alveolar Protection (CPAP Trial)

for Bronchopulmonary Dysplasia (BPD)

Sites in Durham +14 more locations

Sponsor: NICHD Neonatal Research Network

Sex: All·Age: Up to 31 Weeks

Code: NCT07417111·Recruiting·Listed Feb 2026

Apply to this trial

SickleFit Exercise and Nutrition Study

for Sickle Cell Disease

1 location in Durham

Sponsor: Duke University

Sex: All·Age: 35+

Code: NCT07442851·Recruiting·Listed Mar 2026

Apply to this trial

Target Validation and Efficacy of Metformin in Patients With Posterior Fossa Group A (PFA) Ependymoma

for Posterior Fossa Ependymal Tumor

Sites in Durham +9 more locations

Sponsor: University of California, San Francisco

Sex: All·Age: 1 - 39

Code: NCT07226453·Phase 2·Recruiting·Listed Nov 2025

Apply to this trial

Idiopathic Pulmonary Fibrosis and Interstitial Lung Disease Prospective Outcomes Registry

for Idiopathic Pulmonary Fibrosis, Interstitial Lung Disease

Sites in Durham, Chapel Hill +37 more locations

Sponsor: Duke University

Sex: All·Age: 21+

Code: NCT01915511·Recruiting·Listed Aug 2013

Apply to this trial

PREVENT ALL ALS Study

for Amyotrophic Lateral Sclerosis

Sites in Durham +30 more locations

Sponsor: St. Joseph's Hospital and Medical Center, Phoenix

Sex: All·Age: 18+·Accepts healthy volunteers

Code: NCT06581861·Recruiting·Listed Sep 2024

Apply to this trial

DFMO as Maintenance Therapy for Molecular High/Very High Risk and Relapsed Medulloblastoma

for Medulloblastoma

Sites in Durham, Charlotte +23 more locations

Sponsor: Giselle Sholler

Sex: All·Age: Up to 21

Code: NCT04696029·Phase 2·Recruiting·Listed Jan 2021

Apply to this trial

Anticoagulation for New-Onset Post-Operative Atrial Fibrillation After CABG

for Atrial Fibrillation

Sites in Durham, Greenville +33 more locations

Sponsor: Icahn School of Medicine at Mount Sinai

Sex: All·Age: 18+

Code: NCT04045665·Phase 3·Recruiting·Listed Aug 2019

Apply to this trial

Naxitamab Added to Induction for Newly Diagnosed High-Risk Neuroblastoma

for Neuroblastoma

Sites in Durham, Charlotte +18 more locations

Sponsor: Giselle Sholler

Sex: All·Age: 12 Months - 21

Code: NCT05489887·Phase 2·Recruiting·Listed Aug 2022

Apply to this trial

Validation of a Platelet Proteomic Assay for Diagnosing and Monitoring Prostate Cancer

for Prostate Cancer (Diagnosis)

1 location in Durham

Sponsor: Duke University

Sex: Male·Age: 40+

Code: NCT07144228·Recruiting·Listed Aug 2025

Apply to this trial

Milrinone for Prevention of Post-ligation Cardiac Syndrome Trial

for Post-ligation Cardiac Syndrome

Sites in Durham +18 more locations

Sponsor: NICHD Neonatal Research Network

Sex: All·Age: Up to 3 Months

Code: NCT06679855·Phase 3·Recruiting·Listed Nov 2024

Apply to this trial

Follow-up Visit of High Risk Infants

for Infant, Newborn

Sites in Durham +18 more locations

Sponsor: NICHD Neonatal Research Network

Sex: All·Age: 18 Months - 26 Months

Code: NCT00009633·Recruiting·Listed Feb 2001

Apply to this trial

Multisite Inventory of Neonatal-Perinatal Interventions (MINI) Minimum Dataset

for Infant, Extremely Premature

Sites in Durham, Greenville +41 more locations

Sponsor: The University of Texas Health Science Center, Houston

Sex: All·Age: 0 - 1

Code: NCT05685745·Recruiting·Listed Jan 2023

Apply to this trial

International CRDS Registry

for Calcium Release Deficiency Syndrome

Sites in Durham +3 more locations

Sponsor: Population Health Research Institute

Sex: All·Age: All ages

Code: NCT06508164·Recruiting·Listed Jul 2024

Apply to this trial

Proton or Photon RT for Retroperitoneal Sarcomas

for Retroperitoneal Sarcoma

Sites in Durham +9 more locations

Sponsor: Massachusetts General Hospital

Sex: All·Age: 18+

Code: NCT01659203·Phase 1, Phase 2·Recruiting·Listed Aug 2012

Apply to this trial

A Multicenter Trial to Identify Optimal Atezolizumab Biomarkers in the Setting of Recurrent Glioblastoma. The MOAB Trial

for Recurrent Glioblastoma

Drug: Atezolizumab

Sites in Durham +2 more locations

Sponsor: Duke University

Sex: All·Age: 18+

Code: NCT06069726·Phase 2·Recruiting·Listed Oct 2023

Apply to this trial

Pragmatic Evaluation of Events And Benefits of Lipid-lowering in Older Adults

for Cognitive Impairment, Mild

Sites in Durham, Chapel Hill +89 more locations

Sponsor: Duke University

Sex: All·Age: 75+·Accepts healthy volunteers

Code: NCT04262206·Phase 4·Recruiting·Listed Feb 2020

Apply to this trial

Combination Therapy for the Treatment of Diffuse Midline Gliomas

for Diffuse Intrinsic Pontine Glioma

Sites in Durham +18 more locations

Sponsor: University of California, San Francisco

Sex: All·Age: 2 - 39

Code: NCT05009992·Phase 2·Recruiting·Listed Aug 2021

Apply to this trial

Phase 3 Study of Teclistamab in Combination With Lenalidomide and Teclistamab Alone Versus Lenalidomide Alone in Participants With Newly Diagnosed Multiple Myeloma as Maintenance Therapy Following Autologous Stem Cell Transplantation

for Multiple Myeloma

Drug: Teclistamab

Sites in Durham, Greenville +39 more locations

Sponsor: European Myeloma Network B.V.

Sex: All·Age: 18+

Code: NCT05243797·Phase 3·Recruiting·Listed Feb 2022

Apply to this trial

Deep Functional Phenotyping of the ALA Lung Health Cohort

for Lung Diseases

Sites in Durham, Winston-Salem +10 more locations

Sponsor: Johns Hopkins University

Sex: All·Age: 25 - 35·Accepts healthy volunteers

Code: NCT06177717·Recruiting·Listed Dec 2023

Apply to this trial

Rotator Cuff Repairs With or Without BioEnthesis™ Augmentation

for Rotator Cuff Tears

Sites in Durham, Chapel Hill +3 more locations

Sponsor: Brooke Army Medical Center

Sex: All·Age: 18 - 65

Code: NCT06289686·Phase 4·Recruiting·Listed Mar 2024

Apply to this trial

Trial of Glioblastoma Immunotherapy Advancement With Nivolumab and Relatlimab

for Newly Diagnosed Glioblastoma

Drug: Relatlimab

Sites in Durham +1 more location

Sponsor: Duke University

Sex: All·Age: 18+

Code: NCT06816927·Phase 2·Recruiting·Listed Feb 2025

Apply to this trial

Treatment of Antibody-Mediated Rejection (ABMR) With CarBel

for Kidney Transplant Rejection

Sites in Durham +10 more locations

Sponsor: National Institute of Allergy and Infectious Diseases (NIAID)

Sex: All·Age: 18 - 75

Code: NCT06918990·Phase 1·Recruiting·Listed Apr 2025

Apply to this trial

Intervention to Improve Communication and Medication Adherence in Lupus

for Systemic Lupus Erythematosus

1 location in Durham

Sponsor: Duke University

Sex: All·Age: 18 - 90

Code: NCT06458075·Recruiting·Listed Jun 2024

Apply to this trial

Prototyping a Device for Automating Stool and Urine Output Tracking

for Waste Output

1 location in Durham

Sponsor: Duke University

Sex: All·Age: 18+·Accepts healthy volunteers

Code: NCT05438199·Recruiting·Listed Jun 2022

Apply to this trial