As of September 2026, 1,053 paid clinical trials are recruiting in Durham, North Carolina. Compensation typically covers time, travel, and study visits, with stipends ranging from modest amounts for short outpatient studies to several thousand dollars for long or inpatient protocols.
Durham offers studies at sites including Duke University Medical Center for conditions such as Breast Cancer, Heart Failure, Prostate Cancer, Acute Myeloid Leukemia. Both patients with specific conditions and healthy volunteers can qualify. Most trials offer free study-related medical care alongside compensation.
Recruiting trial data synced daily from ClinicalTrials.gov. Last sync: .
Posted to ClinicalTrials.gov within the last 60 days — these studies are just starting to recruit.
Researchers run research studies in Durham, NC at 25 active sites. The clinics below currently host the largest number of recruiting studies — each name is followed by the conditions they focus on most.
| Site | Specializes in | Active trials |
|---|---|---|
| Duke University Medical Center | Acute Myeloid Leukemia, Pulmonary Arterial Hypertension, Sickle Cell Disease | 282 |
| Duke University | Heart Failure, Prostate Cancer, Coronary Artery Disease | 202 |
| Duke University Hospital | Heart Failure, Stroke, Traumatic Brain Injury | 57 |
| Duke University Health System | Diffuse Intrinsic Pontine Glioma, High Grade Glioma, WHO Grade III Glioma | 46 |
| Duke Cancer Institute | Breast Cancer, Advanced Solid Tumor, Cancer | 40 |
| Duke Cancer Center | Advanced Solid Tumor, Breast Cancer, Advanced Breast Cancer | 32 |
| Durham VA Medical Center, Durham, NC | Tobacco Use Disorder, Cancer, Hearing Loss | 32 |
| Durham VA Medical Center | ARDS, ARDS (Acute Respiratory Distress Syndrome), Acute Respiratory Distress Syndrome | 16 |
| Duke University School of Medicine | Accidental Falls/Prevention and Control, Acquired Resistance to KRAS G12C Inhibitor, Acute Respiratory Failure | 14 |
| Duke University Eye Center | Amblyopia, Glaucoma, Retinal Disease | 12 |
| Duke Eye Center | Geographic Atrophy, Stargardt Disease, Age - Related Macular Degeneration (AMD) | 11 |
| Duke Vaccine and Trials Unit | COVID -19, COVID-19 Infection, COVID-19 Vaccines | 7 |
| Clinical Trial Site | ATTR Amyloidosis, Breast Cancer, Cutaneous Sarcoidosis | 7 |
| Duke University Medical Center - Duke Cancer Center | Advanced Solid Tumor, Anal Squamous Cell Carcinoma, Bladder Cancer | 7 |
| GSK Investigational Site | Gastrointestinal Neoplasms, Colonic Neoplasms, HIV Infections | 7 |
| Duke University - Main Hospital and Clinics | Advanced Hepatocellular Carcinoma, COVID-19 Infection, Carcinoma, Hepatocellular | 6 |
| Duke Health | Breast Reconstruction, Cancer, Congestive Heart Failure Chronic | 6 |
| Duke | Advanced Ovarian Carcinoma, COPD (Chronic Obstructive Pulmonary Disease), Chronic Graft Versus Host Disease | 5 |
| Duke Children's Hospital | Adamantinomatous Craniopharyngioma, Becker Muscular Dystrophy, Cardiomyopathy | 5 |
| Duke Cancer Network | Advanced Breast Cancer, Advanced Colorectal Adenocarcinoma, Advanced Colorectal Carcinoma | 4 |
| Duke Children's Hospital & Health Center | Analgesics, Opioid, Congenital Heart Disease (CHD), Dravet Syndrome | 4 |
| Duke Lung Transplant Clinic - Clinic 2F/2G - PPDS | ARDS, ARDS (Acute Respiratory Distress Syndrome), Acute Respiratory Distress Syndrome | 4 |
| RTI International | Alcohol Misuse, Bystander Intervention, Community Reintegration | 4 |
| Duke Blood Cancer Center | AML With Mutated NPM1, Acute Myeloid Leukemia, Acute Myeloid Leukemia Recurrent | 3 |
| Duke Cancer Center Southpoint | Clear Cell Renal Cell Carcinoma, Muscle Invasive Bladder Urothelial Carcinoma, Muscle Invasive Renal Pelvis Urothelial Carcinoma | 3 |
Recruiting trials in Durham grouped by therapeutic area, drawn from ClinicalTrials.gov. Each bucket shows the most recent example studies.
There are approximately 1,053 recruiting clinical trials in Durham, North Carolina listed on ClinicalTrials.gov. The number changes weekly as new studies open and others close enrollment.
Most recruiting trials in Durham compensate participants for their time, travel, and study visits. Compensation varies by sponsor, study phase, and visit requirements — the exact amount is disclosed by the study team during the informed consent process.
Eligibility depends on the specific study. Each trial defines its own inclusion criteria (age, diagnosis, medical history, prior treatments) and exclusion criteria. Both patients with specific conditions and healthy volunteers can qualify, depending on the study design.
The most common conditions under active study in Durham include Breast Cancer (20), Heart Failure (20), Prostate Cancer (16), Cancer (12), among many others. Browse the list above to explore every recruiting trial.
Yes. Healthy-volunteer studies — often early-phase pharmacology or vaccine trials — recruit in Durham on an ongoing basis. Use the "Healthy volunteers only" filter above to view trials that accept participants without the study's target condition.
Click any study title above to see the full study record, including eligibility criteria, visit schedule, and the study team's contact information. Reach out to the central contact or recruiting site directly — they will guide you through screening and informed consent.
Recruiting research sites in Durham include Duke University Medical Center, Duke University, Duke University Hospital, among others. Each site lists its open studies and contact information on the study record above — call or email the site coordinator to ask about screening for a specific protocol.
The largest active categories in Durham are Cancer & tumors (292), Cardiovascular (97), Neurology & pain (68). Use the filters above to narrow by therapeutic area, phase, age, or healthy-volunteer eligibility.