Clinical Trials at Duke University Medical Center

As of August 2026, 251 paid clinical trials are recruiting at Duke University Medical Center, located at ERWIN RD, DURHAM, NC 27710-0001, phone (919) 684-2711 in Durham, North Carolina. Compensation typically covers time, travel, and study visits — most studies also offer study-related medical care at no cost to participants.

Recruiting trial data synced daily from ClinicalTrials.gov. Last sync: August 24, 2026.

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253 clinical trials at Duke University Medical Center

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Low Dose ColchicinE in pAtients With Peripheral Artery DiseasE to Address Residual Vascular Risk

for Peripheral Arterial Disease

Sites in Durham, Chapel Hill +17 more locations

Sponsor: Population Health Research Institute

Sex: All·Age: 18+

Code: NCT04774159·Phase 3·Recruiting·Listed Mar 2021

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Immunomodulation to Optimize Vascularized Composite Allograft Integration for Limb Loss Therapy

for Immunosuppression

1 location in Durham

Sponsor: Linda Cendales

Sex: All·Age: 18 - 65

Code: NCT02310867·Phase 2·Recruiting·Listed Dec 2014

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Clinical Trial of Omalizumab for Allergen Sensitized and Exposed Individuals With COPD

for Chronic Obstructive Pulmonary Disease (COPD)

Drug: Omalizumab

Sites in Durham +22 more locations

Sponsor: Johns Hopkins University

Sex: All·Age: 40+

Code: NCT07059091·Phase 2·Recruiting·Listed Jul 2025

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Determination of CRIM Status and Longitudinal Follow-up of Individuals With Pompe Disease

for Pompe Disease

1 location in Durham

Sponsor: Duke University

Sex: All·Age: All ages

Code: NCT01665326·Recruiting·Listed Aug 2012

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Neurobehavioral Mechanisms Linking Childhood Adversity to Increased Risk for Smoking

for Adverse Childhood Experiences

1 location in Durham

Sponsor: Duke University

Sex: All·Age: 18 - 21·Accepts healthy volunteers

Code: NCT05665465·EARLY_Phase 1·Recruiting·Listed Dec 2022

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Predictors of Pain in Sickle Cell Disease

for Sickle Cell Disease

1 location in Durham

Sponsor: Duke University

Sex: All·Age: 15 - 40

Code: NCT06139510·Recruiting·Listed Nov 2023

Apply to this trial

Zinc Supplementation in Sickle Cell Disease: A Precursor to the Think Zinc for Bones Trial

for Sickle Cell Disease

Sites in Durham +5 more locations

Sponsor: University of California, San Francisco

Sex: All·Age: 15 - 40

Code: NCT06260891·Phase 2·Recruiting·Listed Feb 2024

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A Study to Give Treatment Inside the Eye to Treat Retinoblastoma

for Bilateral Retinoblastoma

Sites in Durham +15 more locations

Sponsor: Children's Oncology Group

Sex: All·Age: Up to 18

Code: NCT05504291·Phase 2·Recruiting·Listed Aug 2022

Apply to this trial

Cervical Cancer Detection Using Optical Spectroscopy

for Cervical Cancer

1 location in Durham

Sponsor: Duke University

Sex: Female·Age: 18+·Accepts healthy volunteers

Code: NCT00900575·Recruiting·Listed May 2009

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Natural History Study of Patients With Hypophosphatasia (HPP)

for Hypophosphatasia

1 location in Durham

Sponsor: Duke University

Sex: All·Age: All ages

Code: NCT02237625·Recruiting·Listed Sep 2014

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Machine Learning for Handheld Vascular Studies

for Atherosclerosis

1 location in Durham

Sponsor: Duke University

Sex: All·Age: All ages·Accepts healthy volunteers

Code: NCT02932176·Recruiting·Listed Oct 2016

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Cognitive and Neurological Pathologies in Pompe Disease

for Pompe Disease

1 location in Durham

Sponsor: Duke University

Sex: All·Age: 0 - 18

Code: NCT04639336·Recruiting·Listed Nov 2020

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Neurostimulation Versus Therapy for Problems With Emotions

for Emotion Regulation

1 location in Durham

Sponsor: Duke University

Sex: All·Age: 18 - 55

Code: NCT05712057·Recruiting·Listed Feb 2023

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129 Xenon Imaging in Patients Treated With Sotatercept

for Pulmonary Hypertension

1 location in Durham

Sponsor: Bastiaan Driehuys

Sex: All·Age: 18 - 75

Code: NCT06351345·Phase 2·Recruiting·Listed Apr 2024

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Pulmonary Hypertension SOLAR

for Interstitial Lung Disease

1 location in Durham

Sponsor: Bastiaan Driehuys

Sex: All·Age: 18+

Code: NCT04778046·Phase 2·Recruiting·Listed Mar 2021

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129 Xenon MRI as a Biomarker for Diagnosis and Response to Therapy in Pulmonary Arterial Hypertension (PAH)

for Pulmonary Arterial Hypertension

1 location in Durham

Sponsor: Bastiaan Driehuys

Sex: All·Age: 18 - 75

Code: NCT06104228·Phase 2·Recruiting·Listed Oct 2023

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Determinants of Incident Stroke Cognitive Outcomes and Vascular Effects on RecoverY

for Ischemic Stroke

Sites in Durham +27 more locations

Sponsor: Massachusetts General Hospital

Sex: All·Age: 18+

Code: NCT04916210·Recruiting·Listed Jun 2021

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Role of Ablative Radiotherapy in the Management of Metastatic Disease: A Patient Data Registry

for Oligometastasis

Sites in Durham, Cary & Raleigh

Sponsor: Duke University

Sex: All·Age: 18+

Code: NCT04085029·Recruiting·Listed Sep 2019

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Retinal Imaging in Neurodegenerative Disease

for Alzheimer's Disease

1 location in Durham

Sponsor: Duke University

Sex: All·Age: 18+·Accepts healthy volunteers

Code: NCT03233646·Recruiting·Listed Jul 2017

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129Xe MRI Cardiopulmonary

for Interstitial Lung Disease

1 location in Durham

Sponsor: Bastiaan Driehuys

Sex: All·Age: 18+·Accepts healthy volunteers

Code: NCT06038630·Phase 2·Recruiting·Listed Sep 2023

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Downstream Effects of Airway Mucus Plugs on 129Xenon MRI in Severe Asthma

for Severe Asthma

1 location in Durham

Sponsor: Bastiaan Driehuys

Sex: All·Age: 18 - 65

Code: NCT07139899·Recruiting·Listed Aug 2025

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Hyperpolarized 129Xe MRI for Imaging Pulmonary Function

for Interstitial Lung Disease

1 location in Durham

Sponsor: Bastiaan Driehuys

Sex: All·Age: 18+·Accepts healthy volunteers

Code: NCT01280994·Phase 2·Recruiting·Listed Jan 2011

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Duke Lupus Registry

for Systemic Lupus Erythematosus

1 location in Durham

Sponsor: Duke University

Sex: All·Age: 18+

Code: NCT00512694·Recruiting·Listed Aug 2007

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Abdominal Wall Transplant

for Transplant

1 location in Durham

Sponsor: Duke University

Sex: All·Age: 18 - 65

Code: NCT03310905·Recruiting·Listed Oct 2017

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Multi-Site Trial of Navigation vs Treatment as Usual to Improve Initiation of Timely Adjuvant Therapy

for Head and Neck Cancer

Sites in Durham +3 more locations

Sponsor: Medical University of South Carolina

Sex: All·Age: 18+

Code: NCT05793151·Recruiting·Listed Mar 2023

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Optimization of Pediatric Tonsillectomy to IMprove AnaLgesia

for Pain, Postoperative

1 location in Durham

Sponsor: Duke University

Sex: All·Age: 3 - 17·Accepts healthy volunteers

Code: NCT06576830·Phase 4·Recruiting·Listed Aug 2024

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Melanoma Margins Trial-II: 1cm v 2cm Wide Surgical Excision Margins for AJCC Stage II Primary Cutaneous Melanoma

for Cutaneous Melanoma, Stage II

Sites in Durham, Chapel Hill +128 more locations

Sponsor: Melanoma and Skin Cancer Trials Limited

Sex: All·Age: 18+

Code: NCT03860883·Recruiting·Listed Mar 2019

Apply to this trial

Opportunistic PK/PD Trial in Critically Ill Children (OPTIC)

for Cardiac Disease

1 location in Durham

Sponsor: Duke University

Sex: All·Age: 0 Months - 20

Code: NCT05055830·Recruiting·Listed Sep 2021

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D2C7-IT + 2141-V11 Combination Post-resection in rGBM

for Recurrent Glioblastoma IDH Wildtype

1 location in Durham

Sponsor: Darell Bigner

Sex: All·Age: 18+

Code: NCT06455605·Phase 1·Recruiting·Listed Jun 2024

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ARCTIC: Liquid Biomarkers in the Prospective Androgen Receptor Signaling Inhibitors (ARSI) Resistance Clinical Trials

for Prostate Cancer

Sites in Durham +2 more locations

Sponsor: Duke University

Sex: Male·Age: 18+

Code: NCT06141993·Recruiting·Listed Nov 2023

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D2C7-IT and 2141-V11 in Newly Diagnosed GBM Patients

for Newly Diagnosed MGMT Unmethylated Glioblastoma

1 location in Durham

Sponsor: Darell Bigner

Sex: All·Age: 18+

Code: NCT05734560·Phase 1, Phase 2·Recruiting·Listed Feb 2023

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A Long-term Follow-up Study of Gaucher Disease

for Gaucher Disease

1 location in Durham

Sponsor: Duke University

Sex: All·Age: All ages

Code: NCT03190837·Recruiting·Listed Jun 2017

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UCB Transplant of Inherited Metabolic Diseases With Administration of Intrathecal UCB Derived Oligodendrocyte-Like Cells

for Adrenoleukodystrophy

1 location in Durham

Sponsor: Joanne Kurtzberg, MD

Sex: All·Age: 1 Week - 22

Code: NCT02254863·Phase 1·Recruiting·Listed Oct 2014

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ViCToRy: Vorasidenib in Combination With Tumor Specific Peptide Vaccine for Recurrent IDH1 Mutant Lower Grade Gliomas

for Low Grade Glioma of Brain

Drug: Vorasidenib

1 location in Durham

Sponsor: Katy Peters, MD, PhD

Sex: All·Age: 18+

Code: NCT05609994·Phase 1·Recruiting·Listed Nov 2022

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Effects of Combination Medical Therapy Followed by BPA on Right Ventricular-PA Coupling and Hemodynamics in CTEPH

for CTEPH

1 location in Durham

Sponsor: Dr Sudarshan Rajagopal

Sex: All·Age: 18+

Code: NCT05140525·Phase 3·Recruiting·Listed Dec 2021

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Delayed-Enhancement Cardiovascular Magnetic Resonance in Patients With Sarcoidosis

for Sarcoidosis

1 location in Durham

Sponsor: Duke University

Sex: All·Age: 18+

Code: NCT01745237·Recruiting·Listed Dec 2012

Apply to this trial

Duke APOL1 Research Biorepository

for End Stage Kidney Disease

1 location in Durham

Sponsor: Duke University

Sex: All·Age: 18+·Accepts healthy volunteers

Code: NCT04160507·Recruiting·Listed Nov 2019

Apply to this trial

Groningen International Study on Sentinel Nodes in Vulvar Cancer-III

for Vulvar Cancer

Sites in Durham, Raleigh +19 more locations

Sponsor: University Medical Center Groningen

Sex: Female·Age: 18+

Code: NCT05076942·Phase 2·Recruiting·Listed Oct 2021

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Pulmonary Hypertension Association Registry

for Pulmonary Arterial Hypertension

Sites in Durham, Chapel Hill +50 more locations

Sponsor: Pulmonary Hypertension Association, Inc.

Sex: All·Age: 0+

Code: NCT04071327·Recruiting·Listed Aug 2019

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Study to Test OBI-3424 in Patients With T-Cell Acute Lymphoblastic Leukemia (T-ALL) or T-Cell Lymphoblastic Lymphoma (T-LBL)

for Recurrent T Acute Lymphoblastic Leukemia

Sites in Durham +113 more locations

Sponsor: SWOG Cancer Research Network

Sex: All·Age: 12+

Code: NCT04315324·Phase 1, Phase 2·Recruiting·Listed Mar 2020

Apply to this trial