Paid Clinical Trials in Fort Smith, AR
As of August 2026, 51 paid clinical trials are recruiting in Fort Smith, Arkansas. Compensation typically covers time, travel, and study visits, with stipends ranging from modest amounts for short outpatient studies to several thousand dollars for long or inpatient protocols.
Fort Smith offers studies at sites including Mercy Hospital Fort Smith for conditions such as Malignant Solid Neoplasm, Advanced Lung Non-Small Cell Carcinoma, Hematopoietic and Lymphatic System Neoplasm, Stage IV Lung Cancer AJCC v8. Both patients with specific conditions and healthy volunteers can qualify. Most trials offer free study-related medical care alongside compensation.
Recruiting trial data synced daily from ClinicalTrials.gov. Last sync: .
Trials by specialty in Fort Smith
Trials by drug in Fort Smith
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50 clinical trials
Galleri® in the Medicare Population.
GEMINI-NSCLC: NSCLC Biomarker Study
A Study of Zasocitinib in Adults With Hidradenitis Suppurativa
Tempus CRC Surveillance Study: A ctDNA Biomarker Profiling Study of Patients With CRC Using NGS Assays
Predicting Response to Immunotherapy From Analysis of Live Tumor Biopsies (ELEPHAS-05)
Studying the PAGODA Algorithm for Chemotherapy Dose Changes to Prevent Unplanned Treatment Delays
Fasted vs. Fed State Exercise
Evaluating the Addition of Adjuvant Chemotherapy to Ovarian Function Suppression Plus Endocrine Therapy in Premenopausal Patients With pN0-1, ER-Positive/HER2-Negative Breast Cancer and an Oncotype Recurrence Score Less Than or Equal to 25
Family Communications After Genetic Testing
Colon Adjuvant Chemotherapy Based on Evaluation of Residual Disease
Radiation Therapy With or Without Cisplatin in Treating Patients With Stage III-IVA Squamous Cell Carcinoma of the Head and Neck Who Have Undergone Surgery
Vismodegib, FAK Inhibitor GSK2256098, Capivasertib, and Abemaciclib in Treating Patients With Progressive Meningiomas
mFOLFIRINOX Versus mFOLFOX With or Without Nivolumab for the Treatment of Advanced, Unresectable, or Metastatic HER2 Negative Esophageal, Gastroesophageal Junction, and Gastric Adenocarcinoma
Testing the Use of Combination Therapy in Adult Patients With Newly Diagnosed Multiple Myeloma, the EQUATE Trial
Collecting Blood Samples From Patients With and Without Cancer to Evaluate Tests for Early Cancer Detection
Ramucirumab and Paclitaxel or FOLFIRI in Advanced Small Bowel Cancers
Lenalidomide, and Dexamethasone With or Without Daratumumab in Treating Patients With High-Risk Smoldering Myeloma
Testing an Enhanced Digital Delivery Model for Inherited Cancer Genetic Testing in Young Adults With Cancer
Testing Olaparib for One or Two Years, With or Without Bevacizumab, to Treat Ovarian Cancer
Collection of Research Data and Samples From Patients Who Experience Immunotherapy Side Effects
Adding an Immunotherapy Drug, MEDI4736 (Durvalumab), to the Usual Chemotherapy Treatment (Paclitaxel, Cyclophosphamide, and Doxorubicin) for Stage II-III Breast Cancer
Five or Ten Year Colonoscopy for 1-2 Non-Advanced Adenomatous Polyps
Cost Communication and Financial Navigation in Cancer Patients (COSTCOM)
Treating Prostate Cancer That Has Come Back After Surgery With Apalutamide and Targeted Radiation Based on PET Imaging
Testing Shorter Duration Radiation Therapy Versus the Usual Radiation Therapy in Patients Receiving the Usual Chemotherapy Treatment for Bladder Cancer, ARCHER Study
E-Mindfulness Approaches for Living After Breast Cancer
Study of Targeted Therapy vs. Chemotherapy in Patients With Thyroid Cancer
Chemotherapy Combined With Immunotherapy Versus Immunotherapy Alone for Older Adults With Stage IIIB-IV Lung Cancer, The ACHIEVE Trial
Reaching Rural Cancer Survivors Who Smoke Using Text-Based Program
Triptorelin for the Prevention of Ovarian Damage in Adolescents and Young Adults With Cancer
Testing Osimertinib as a Treatment for Lung Cancers With an EGFR Exon 20 Change
Testing Longer Duration Radiation Therapy Versus the Usual Radiation Therapy in Patients With Cancer That Has Spread to the Brain
Evaluating the Impact of Social and Genetic Factors on Outcomes in Adolescent and Young Adult Cancer Survivors
Comparing Combinations of Drugs to Treat Newly Diagnosed Multiple Myeloma (NDMM) When a Stem Cell Transplant is Not a Medically Suitable Treatment
Immune Checkpoint Inhibitor Toxicity Risk Prediction in Solid Tumors
Surgical Thromboprophylaxis Practices in Oncology Patients Within the NCORP Network, STOP-VTE Study
S1703 Serum Tumor Marker Directed Disease Monitoring in Patients With Hormone Receptor Positive Her2 Negative Metastatic Breast Cancer
Evaluating Whether an Educational Website Called Current Together After Cancer (CTAC) Improves Follow-up Care for Colorectal Cancer Survivors
Assessing Benefits and Harms of Cannabis/Cannabinoid Use Among Cancer Patients Treated in Community Oncology Clinics
Top Research Study Locations in Fort Smith
Researchers run research studies in Fort Smith, AR at 11 active sites. The clinics below currently host the largest number of recruiting studies — each name is followed by the conditions they focus on most.
| Site | Specializes in | Active trials |
|---|---|---|
| Mercy Hospital Fort Smith | Malignant Solid Neoplasm, Advanced Lung Non-Small Cell Carcinoma, Hematopoietic and Lymphatic System Neoplasm | 40 |
| Johnson Dermatology | Hidradenitis Suppurativa | 2 |
| Mercy Clinic Oncology - Fort Smith | Colorectal Cancer, Non-Small Cell Lung Cancer | 2 |
| Arkansas Colleges of Health Education Research Institure Health and Wellness Center | Exercise, Obesity, Weight Loss | 1 |
| Mercy Cancer Center | Metastatic Pancreatic Adenocarcinoma, Metastatic Pancreatic Cancer, Pancreatic Cancer | 1 |
| Mercy Clinic Fort Smith Communities | Epidermal Growth Factor Receptor Gene Mutation, Non Small Cell Lung Cancer, Stage III Lung Cancer | 1 |
| Mercy Health - Fort Smith | Cancer | 1 |
| Mercy Hospital - FTS | Advanced Solid Tumors Cancer, Bladder Cancer, Cancer | 1 |
| Mercy Research | Epidermal Growth Factor Receptor Gene Mutation, Non Small Cell Lung Cancer, Stage III Lung Cancer | 1 |
| Novartis Investigative Site | Atopic Dermatitis | 1 |
| UAMS Fort Smith FMC | Maternal Health | 1 |
Active & Upcoming Studies in Fort Smith (2026)
Recruiting trials in Fort Smith grouped by therapeutic area, drawn from ClinicalTrials.gov. Each bucket shows the most recent example studies.
Cancer & tumors (35 active studies)
- Family Communications After Genetic Testing · Alliance for Clinical Trials in Oncology
- A Study to Evaluate the Effectiveness and Safety of Setidegrasib, Given With Either mFOLFIRINOX or NALIRIFOX Chemotherapies, in People With Pancreatic Cancer · Phase 3 · Astellas Pharma Global Development, Inc.
Mental health & behavior (2 active studies)
- E-Mindfulness Approaches for Living After Breast Cancer · Phase 3 · NRG Oncology
- Reaching Rural Cancer Survivors Who Smoke Using Text-Based Program · Phase 3 · Alliance for Clinical Trials in Oncology
Diabetes & metabolic (1 active study)
- Fasted vs. Fed State Exercise · Phase 2 · Arkansas Colleges of Health Education
Common conditions studied in Fort Smith
- Malignant Solid Neoplasm (6 active studies)
- Advanced Lung Non-Small Cell Carcinoma (3 active studies)
- Hematopoietic and Lymphatic System Neoplasm (3 active studies)
- Stage IV Lung Cancer AJCC v8 (3 active studies)
- Anatomic Stage II Breast Cancer AJCC v8 (2 active studies)
- Anatomic Stage IV Breast Cancer AJCC v8 (2 active studies)
Leading research sponsors in Fort Smith
- SWOG Cancer Research Network
- Alliance for Clinical Trials in Oncology
- ECOG-ACRIN Cancer Research Group
- NRG Oncology
- National Cancer Institute (NCI)
Frequently asked questions
How many paid clinical trials are currently recruiting in Fort Smith?
There are approximately 51 recruiting clinical trials in Fort Smith, Arkansas listed on ClinicalTrials.gov. The number changes weekly as new studies open and others close enrollment.
Do clinical trials in Fort Smith pay participants?
Most recruiting trials in Fort Smith compensate participants for their time, travel, and study visits. Compensation varies by sponsor, study phase, and visit requirements — the exact amount is disclosed by the study team during the informed consent process.
Who can participate in a clinical trial in Fort Smith?
Eligibility depends on the specific study. Each trial defines its own inclusion criteria (age, diagnosis, medical history, prior treatments) and exclusion criteria. Both patients with specific conditions and healthy volunteers can qualify, depending on the study design.
What conditions are most commonly studied in Fort Smith?
The most common conditions under active study in Fort Smith include Malignant Solid Neoplasm (6), Advanced Lung Non-Small Cell Carcinoma (3), Hematopoietic and Lymphatic System Neoplasm (3), Stage IV Lung Cancer AJCC v8 (3), among many others. Browse the list above to explore every recruiting trial.
Are there clinical trials for healthy volunteers in Fort Smith?
Yes. Healthy-volunteer studies — often early-phase pharmacology or vaccine trials — recruit in Fort Smith on an ongoing basis. Use the "Healthy volunteers only" filter above to view trials that accept participants without the study's target condition.
How do I enroll in a clinical trial in Fort Smith?
Click any study title above to see the full study record, including eligibility criteria, visit schedule, and the study team's contact information. Reach out to the central contact or recruiting site directly — they will guide you through screening and informed consent.
Where can I take part in paid clinical trials in Fort Smith?
Recruiting research sites in Fort Smith include Mercy Hospital Fort Smith, Johnson Dermatology, Mercy Clinic Oncology - Fort Smith, among others. Each site lists its open studies and contact information on the study record above — call or email the site coordinator to ask about screening for a specific protocol.
What kinds of studies are recruiting in Fort Smith right now?
The largest active categories in Fort Smith are Cancer & tumors (35), Mental health & behavior (2), Diabetes & metabolic (1). Use the filters above to narrow by therapeutic area, phase, age, or healthy-volunteer eligibility.