Oncology Clinical Trials in Gainesville, FL

As of July 2026, 78 paid clinical trials are recruiting for Oncology in Gainesville, Florida. Oncology trials evaluate immunotherapies, targeted therapies, antibody-drug conjugates, and combination regimens across solid tumors and blood cancers — from early-phase first-in-human studies to phase 3 registration trials. Compensation typically covers time, travel, and study visits, and many studies also include study-related medical care at no cost.

Recruiting trial data synced daily from ClinicalTrials.gov. Last sync: July 17, 2026.

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78 clinical trials for Oncology

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A Study to Compare Two Surgical Procedures in Individuals With BRCA1 Mutations to Assess Reduced Risk of Ovarian Cancer

for Ovarian Carcinoma

Sites in Gainesville, Tampa +471 more locations

Sponsor: NRG Oncology

Sex: Female·Age: 35 - 50

Code: NCT04251052·Recruiting·Listed Jan 2020

Apply to this trial

AD HOC Trial: Artificial Intelligence-Based Drug Dosing In Hepatocellular Carcinoma

for Hepatocellular Carcinoma

1 location in Gainesville

Sponsor: University of Florida

Sex: All·Age: 18 - 99

Code: NCT05669339·Phase 2·Recruiting·Listed Dec 2022

Apply to this trial

Atezolizumab Plus Tivozanib in Immunologically Cold Tumor Types

for Bile Duct Cancer

Drug: Atezolizumab

1 location in Gainesville

Sponsor: University of Florida

Sex: All·Age: 18 - 99

Code: NCT05000294·Phase 1, Phase 2·Recruiting·Listed Aug 2021

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Alpha/Beta T and B Cell Depletion With Zoledronic Acid for Solid Tumors

for Neuroblastoma

1 location in Gainesville

Sponsor: University of Florida

Sex: All·Age: 6 Months - 25

Code: NCT06625190·Phase 1, Phase 2·Recruiting·Listed Oct 2024

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Preoperative Nicotine Cessation for Women With Breast Cancer Recommended for Reconstruction

for Breast Cancer

1 location in Gainesville

Sponsor: University of Florida

Sex: Female·Age: 18 - 80

Code: NCT06461650·Recruiting·Listed Jun 2024

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High Intensity Focused Ultrasound in Prostate Cancer

for Prostate Cancer

1 location in Gainesville

Sponsor: University of Florida

Sex: Male·Age: 18+

Code: NCT06402357·Phase 2·Recruiting·Listed May 2024

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Personalized Antibody-Drug Conjugate Therapy Based on RNA and Protein Testing for the Treatment of Advanced or Metastatic Solid Tumors (The ADC MATCH Screening and Treatment Trial)

for Advanced Malignant Solid Neoplasm

Sites in Gainesville +26 more locations

Sponsor: National Cancer Institute (NCI)

Sex: All·Age: 18+

Code: NCT06311214·Phase 2·Recruiting·Listed Mar 2024

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Alpha/Beta T Cell and CD19+ B Cell Depletion in Allogeneic Stem Cell Transplantation in Patients With Malignant Diseases

for Acute Lymphoblastic Leukemia

1 location in Gainesville

Sponsor: University of Florida

Sex: All·Age: 6 Months - 39

Code: NCT05800210·Phase 2·Recruiting·Listed Apr 2023

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Testing A New Anti-cancer Drug Combination, Entinostat and ZEN003694, for Advanced and Refractory Solid Tumors

for Advanced Malignant Solid Neoplasm

Sites in Gainesville +2 more locations

Sponsor: National Cancer Institute (NCI)

Sex: All·Age: 18+

Code: NCT05053971·Phase 1, Phase 2·Recruiting·Listed Sep 2021

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A Study of RNA-lipid Particle (RNA-LP) Vaccines for Newly Diagnosed Pediatric High-Grade Gliomas (pHGG) and Adult Glioblastoma (GBM)

for Adult Glioblastoma

Sites in Gainesville +1 more location

Sponsor: University of Florida

Sex: All·Age: 4+

Code: NCT04573140·Phase 1·Recruiting·Listed Oct 2020

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Triptorelin for the Prevention of Ovarian Damage in Adolescents and Young Adults With Cancer

for Hematopoietic and Lymphatic System Neoplasm

Sites in Gainesville, Jacksonville +178 more locations

Sponsor: Children's Oncology Group

Sex: Female·Age: Up to 39

Code: NCT06513962·Phase 3·Recruiting·Listed Jul 2024

Apply to this trial

Using Plasma Human Papillomavirus (HPV)-Related Deoxyribonucleic Acid (DNA) and Ribonucleic Acid (RNA) to Follow Response of Cervical Cancer to Surgery, Radiation, and Chemotherapy

for Cervical Cancer

1 location in Gainesville

Sponsor: University of Florida

Sex: Female·Age: 18 - 89

Code: NCT07214584·Recruiting·Listed Oct 2025

Apply to this trial

RNA-Lipid Particle (RNA-LP) Vaccines for Recurrent Adult Glioblastoma (GBM)

for Recurrent Glioblastoma

1 location in Gainesville

Sponsor: University of Florida

Sex: All·Age: 18 - 80

Code: NCT06389591·Phase 1·Recruiting·Listed Apr 2024

Apply to this trial

IL-8 Receptor-modified CD70 CAR T Cell Therapy in CD70+ Adult Glioblastoma

for Glioblastoma Multiforme

1 location in Gainesville

Sponsor: University of Florida

Sex: All·Age: 18 - 80

Code: NCT05353530·Phase 1·Recruiting·Listed Apr 2022

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Testing the Addition of 131I-MIBG or Lorlatinib to Intensive Therapy in People With High-Risk Neuroblastoma (NBL)

for Ganglioneuroblastoma

Sites in Gainesville, Jacksonville +143 more locations

Sponsor: Children's Oncology Group

Sex: All·Age: 365 Days - 30

Code: NCT03126916·Phase 3·Recruiting·Listed Apr 2017

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Testing Drug Treatments After CAR T-cell Therapy in Patients With Relapsed/Refractory Diffuse Large B-cell Lymphoma

for Diffuse Large B-Cell Lymphoma

Sites in Gainesville +82 more locations

Sponsor: SWOG Cancer Research Network

Sex: All·Age: 18+

Code: NCT05633615·Phase 2·Recruiting·Listed Dec 2022

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A Multilevel Approach to Connecting Underrepresented Populations to Clinical Trials

for Cancer

Sites in Gainesville, Jacksonville & Miami

Sponsor: University of Florida

Sex: All·Age: 18 - 100·Accepts healthy volunteers

Code: NCT05655494·Recruiting·Listed Dec 2022

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Intravesical Gemcitabine and Docetaxel for Low Grade Intermediate Risk Bladder Cancer

for Bladder Cancer

1 location in Gainesville

Sponsor: University of Florida

Sex: All·Age: 18+

Code: NCT06488222·Phase 2·Recruiting·Listed Jul 2024

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Modernizing Instructions to Improve Treatment Participation of Subjects During Their First Radiotherapy

for Cancer

1 location in Gainesville

Sponsor: University of Florida

Sex: All·Age: 18 - 99

Code: NCT06246409·Recruiting·Listed Feb 2024

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A Study Evaluating the Feasibility and Compliance of Manual Lymphatic Drainage Comparing Indocyanine-Green (ICG) Guided vs. Traditional Guided in Patients Undergoing Axillary Node Dissection for the Treatment of Breast Cancer

for Breast Cancer

1 location in Gainesville

Sponsor: University of Florida

Sex: All·Age: 18 - 99

Code: NCT06327490·Phase 2·Recruiting·Listed Mar 2024

Apply to this trial

Pharmacokinetics and Safety of Epidiferphane and Taxanes in Breast Cancer Patients

for Breast Cancer

1 location in Gainesville

Sponsor: University of Florida

Sex: All·Age: 18 - 99

Code: NCT05074290·Phase 1, Phase 2·Recruiting·Listed Oct 2021

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TRPC6 Characterization to Predict and Prevent Chemotherapy Related Cardiomyopathy and Heart Failure With Breast Cancer

for Breast Carcinoma

Sites in Gainesville & Jacksonville

Sponsor: Mayo Clinic

Sex: All·Age: 18+

Code: NCT05507879·Recruiting·Listed Aug 2022

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Transdiagnostic Intervention to Reduce Internalized Health-Related Stigma

for Obesity

1 location in Gainesville

Sponsor: University of Florida

Sex: All·Age: 18+

Code: NCT05561595·Recruiting·Listed Sep 2022

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The Florida ASCENT Study

for Cancer

1 location in Gainesville

Sponsor: University of Florida

Sex: All·Age: 18 - 100

Code: NCT07042243·Recruiting·Listed Jun 2025

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Exercise to ReGain Stamina and Energy (The EXERGISE Study)

for Fatigue

1 location in Gainesville

Sponsor: University of Florida

Sex: Female·Age: 60 - 105

Code: NCT05684367·Recruiting·Listed Jan 2023

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Novel Cavity Marking Technique in Breast Cancer Patients Undergoing Breast Conservation Surgery With Oncoplastic Reconstruction for the Delivery of Adjuvant Radiotherapy and Accuracy of Recommended Re-excisions

for Ductal Carcinoma in Situ

1 location in Gainesville

Sponsor: University of Florida

Sex: All·Age: 18+

Code: NCT06903468·Recruiting·Listed Mar 2025

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OPTIMUS PRIME: Safety and Feasibility of OPTune GIO® Integrated With MRI-gUided Laser Ablation Surgery and Pembrolizumab for Recurrent GlIoblastoMa, A randomizEd Trial

for Recurrent Glioblastoma

1 location in Gainesville

Sponsor: University of Florida

Sex: All·Age: 18 - 90

Code: NCT06558214·Phase 2·Recruiting·Listed Aug 2024

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Nephroureterectomy With and Without Lymph Node Dissection for Upper Tract Urothelial Cell Carcinoma

for Urothelial Carcinoma

Sites in Gainesville +3 more locations

Sponsor: Case Comprehensive Cancer Center

Sex: All·Age: 19+

Code: NCT06262516·Recruiting·Listed Feb 2024

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All-extremity Exercise During Breast Cancer Chemotherapy

for Breast Cancer

1 location in Gainesville

Sponsor: University of Florida

Sex: Female·Age: 18 - 85

Code: NCT04914663·Recruiting·Listed Jun 2021

Apply to this trial

Clinical Orthopaedic Data Bank (Acute and Chronic)

for Osteoarthritis

1 location in Gainesville

Sponsor: University of Florida

Sex: All·Age: All ages

Code: NCT00411060·Recruiting·Listed Dec 2006

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High Dose Testosterone for ATM, CDK12 or CHEK2 Altered Prostate Cancers

for Metastatic Prostate Cancer

Sites in Gainesville, Orlando +15 more locations

Sponsor: VA Office of Research and Development

Sex: Male·Age: 18+

Code: NCT05011383·Phase 2·Recruiting·Listed Aug 2021

Apply to this trial

HIIT Following Breast Cancer Chemotherapy

for Breast Cancer

1 location in Gainesville

Sponsor: University of Florida

Sex: Female·Age: 18 - 85

Code: NCT05913713·Recruiting·Listed Jun 2023

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A Global Phase III Study of Rilvegostomig or Pembrolizumab Plus Chemotherapy for First-Line Treatment of Locally Advanced or Metastatic Squamous Non-small Cell Lung Cancer (NSCLC)

for Non-small Cell Lung Cancer

Drug: Rilvegostomig

Sites in Gainesville, Jacksonville +61 more locations

Sponsor: AstraZeneca

Sex: All·Age: 18+

Code: NCT06692738·Phase 3·Recruiting·Listed Nov 2024

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Phase III, Open-label, Study of First-line Dato-DXd in Combination With Rilvegostomig for Advanced Non-squamous NSCLC With High PD-L1 Expression (TC ≥ 50%) and Without Actionable Genomic Alterations

for Non-Small Cell Lung Cancer

Drug: Rilvegostomig

Sites in Gainesville, Orange City +47 more locations

Sponsor: AstraZeneca

Sex: All·Age: 18+

Code: NCT06357533·Phase 3·Recruiting·Listed Apr 2024

Apply to this trial

Novel RNA-lipid Particle (RNA-LP) Vaccine for Anti-PD-1 Antibody Therapy Sensitization

for Melanoma

1 location in Gainesville

Sponsor: University of Florida

Sex: All·Age: 18 - 99

Code: NCT05264974·Phase 1·Recruiting·Listed Mar 2022

Apply to this trial

Multi-analyte Blood Test Clinical Trial

for Liver Cirrhosis

Sites in Gainesville, Tampa +5 more locations

Sponsor: Helio Genomics

Sex: All·Age: 18+

Code: NCT05199259·Recruiting·Listed Jan 2022

Apply to this trial

PEACH TRIAL- Precision Medicine and Adoptive Cellular Therapy

for Neuroblastoma

Sites in Gainesville +1 more location

Sponsor: University of Florida

Sex: All·Age: 1 - 30

Code: NCT04837547·Phase 1·Recruiting·Listed Apr 2021

Apply to this trial

Study of Zanzalintinib in Combination With Immuno-Oncology Agents in Participants With Solid Tumors

for Renal Cell Carcinoma (RCC)

Sites in Gainesville, Jacksonville +42 more locations

Sponsor: Exelixis

Sex: All·Age: 18+

Code: NCT05176483·Phase 1·Recruiting·Listed Jan 2022

Apply to this trial

Conditions in Oncology (Gainesville, FL)

Breast cancer· 13 Solid tumor· 13 Non-small cell lung cancer (NSCLC)· 7 Acute myeloid leukemia (AML)· 6 Neuroblastoma· 6 Cancer (any)· 5 Prostate cancer· 4 Bladder cancer· 4 Ovarian cancer· 4 Glioblastoma· 4 Myelodysplastic syndromes (MDS)· 4 Lung cancer· 3 Glioma· 3 Non-Hodgkin lymphoma· 3 Osteosarcoma· 3 Colorectal cancer· 2 Pancreatic cancer· 2 Liver cancer· 2 Endometrial cancer· 2 Acute lymphoblastic leukemia· 2 Leukemia (other)· 2 Hematologic malignancy· 2 Melanoma· 2 Soft tissue sarcoma· 2 Ewing sarcoma· 2 Rhabdomyosarcoma· 2 Biliary tract cancer· 1 Gastrointestinal cancer· 1 Metastatic prostate cancer· 1 Cervical cancer· 1 Gynecologic cancer· 1 Brain metastases· 1 Multiple myeloma· 1 Chronic lymphocytic leukemia (CLL)· 1 Myeloproliferative neoplasm· 1 Hodgkin lymphoma· 1 Diffuse large B-cell lymphoma (DLBCL)· 1 Skin cancer· 1 Neuroendocrine tumors· 1