Oncology Clinical Trials in Hershey, PA

As of July 2026, 67 paid clinical trials are recruiting for Oncology in Hershey, Pennsylvania. Oncology trials evaluate immunotherapies, targeted therapies, antibody-drug conjugates, and combination regimens across solid tumors and blood cancers — from early-phase first-in-human studies to phase 3 registration trials. Compensation typically covers time, travel, and study visits, and many studies also include study-related medical care at no cost.

Recruiting trial data synced daily from ClinicalTrials.gov. Last sync: July 17, 2026.

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67 clinical trials for Oncology

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Testing Olaparib for One or Two Years, With or Without Bevacizumab, to Treat Ovarian Cancer

for Fallopian Tube Endometrioid Adenocarcinoma

Drug: Bevacizumab

Sites in Hershey, Lebanon +643 more locations

Sponsor: NRG Oncology

Sex: All·Age: 18+

Code: NCT06580314·Phase 3·Recruiting·Listed Aug 2024

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Ribociclib And Endocrine Treatment of Physician's Choice for Locoregional Recurrent, Resected Hormone Receptor Positive HER2 Negative Breast Cancer

for Locoregional Recurrence

Drug: Ribociclib

Sites in Hershey +18 more locations

Sponsor: Oana Danciu

Sex: All·Age: 18+

Code: NCT05467891·Phase 2·Recruiting·Listed Jul 2022

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Project: Every Child for Younger Patients With Cancer

for Adrenal Gland Pheochromocytoma

Sites in Hershey, Danville +231 more locations

Sponsor: Children's Oncology Group

Sex: All·Age: Up to 25

Code: NCT02402244·Recruiting·Listed Mar 2015

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Eflornithine (DFMO) and AMXT 1501 for Neuroblastoma, CNS Tumors, and Sarcomas

for Atypical Teratoid/Rhabdoid Tumor

Sites in Hershey +11 more locations

Sponsor: Milton S. Hershey Medical Center

Sex: All·Age: Up to 26

Code: NCT06465199·Phase 1, Phase 2·Recruiting·Listed Jun 2024

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A Study to Compare Two Surgical Procedures in Individuals With BRCA1 Mutations to Assess Reduced Risk of Ovarian Cancer

for Ovarian Carcinoma

Sites in Hershey, Lancaster +471 more locations

Sponsor: NRG Oncology

Sex: Female·Age: 35 - 50

Code: NCT04251052·Recruiting·Listed Jan 2020

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Thoracotomy Versus Thoracoscopic Management of Pulmonary Metastases in Patients With Osteosarcoma

for Metastatic Malignant Neoplasm in the Lung

Sites in Hershey, Danville +209 more locations

Sponsor: Children's Oncology Group

Sex: All·Age: Up to 50

Code: NCT05235165·Phase 3·Recruiting·Listed Feb 2022

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Pediatric Precision Laboratory Advanced Neuroblastoma Therapy

for Neuroblastoma

Sites in Hershey +19 more locations

Sponsor: Giselle Sholler

Sex: All·Age: Up to 22

Code: NCT02559778·Phase 2·Recruiting·Listed Sep 2015

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Study of Talazoparib in Combination With Chemotherapy in Relapsed Pediatric AML to Determine Safety and Efficacy

for Acute Myeloid Leukemia

Sites in Hershey +8 more locations

Sponsor: Norman J. Lacayo

Sex: All·Age: Up to 21

Code: NCT05101551·Phase 1·Recruiting·Listed Nov 2021

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Triptorelin for the Prevention of Ovarian Damage in Adolescents and Young Adults With Cancer

for Hematopoietic and Lymphatic System Neoplasm

Sites in Hershey, Chadds Ford +178 more locations

Sponsor: Children's Oncology Group

Sex: Female·Age: Up to 39

Code: NCT06513962·Phase 3·Recruiting·Listed Jul 2024

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Tipifarnib and Naxitamab for Relapsed/Refractory Neuroblastoma

for Neuroblastoma

Sites in Hershey +11 more locations

Sponsor: Giselle Sholler

Sex: All·Age: 1 - 21

Code: NCT06540963·Phase 2·Recruiting·Listed Aug 2024

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Testing the Addition of 131I-MIBG or Lorlatinib to Intensive Therapy in People With High-Risk Neuroblastoma (NBL)

for Ganglioneuroblastoma

Sites in Hershey, Danville +143 more locations

Sponsor: Children's Oncology Group

Sex: All·Age: 365 Days - 30

Code: NCT03126916·Phase 3·Recruiting·Listed Apr 2017

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Safety and Efficacy of AGN-INM176 in Prostate Patients With Rising PSA

for Prostate Cancer

1 location in Hershey

Sponsor: Milton S. Hershey Medical Center

Sex: Male·Age: 40+

Code: NCT06600698·Phase 1, Phase 2·Recruiting·Listed Sep 2024

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A Culturally-Tailored Mobile Health and Social Media Physical Activity Intervention for Improving Physical Activity in Hispanic or Latino/Latina Adolescent and Young Adult Childhood Cancer Survivors, Walking Juntos Study

for Hematopoietic and Lymphatic System Neoplasm

Sites in Hershey, Philadelphia +74 more locations

Sponsor: Children's Oncology Group

Sex: All·Age: 15 - 20

Code: NCT06410209·Phase 2·Recruiting·Listed May 2024

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Allogeneic HSCT With Low-Dose Post-Transplant Cyclophosphamide for GVHD Prevention

for Graft-versus-Host Disease (GVHD)

1 location in Hershey

Sponsor: Milton S. Hershey Medical Center

Sex: All·Age: 18+

Code: NCT06926595·Phase 2·Recruiting·Listed Apr 2025

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Beat Childhood Cancer Specimen Banking and Data Registry

for Pediatric Cancer

Sites in Hershey +16 more locations

Sponsor: Giselle Sholler

Sex: All·Age: All ages·Accepts healthy volunteers

Code: NCT04715178·Recruiting·Listed Jan 2021

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Building a Renewed ImaGe After Head & Neck Cancer Treatment (BRIGHT) Multi-Site RCT

for Head and Neck Cancer

Sites in Hershey +4 more locations

Sponsor: Medical University of South Carolina

Sex: All·Age: 18+

Code: NCT05442957·Recruiting·Listed Jul 2022

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Fusion or Cognitive Ultrasound-guided Biopsy to Detect Prostate Cancer

for Prostate Cancer

Sites in Hershey +2 more locations

Sponsor: Albany Medical College

Sex: Male·Age: 18+

Code: NCT06517901·Recruiting·Listed Jul 2024

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Trial of Pre-operative Neratinib and Endocrine Therapy With Trastuzumab in ER-Positive, HER-2 Positive Breast Cancers

for Breast Cancer

Sites in Hershey +3 more locations

Sponsor: Ruth O'Regan

Sex: All·Age: 18+

Code: NCT04886531·Phase 2·Recruiting·Listed May 2021

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Anti-inflammatory Drugs and Serum Prostate-Specific Antigen Test

for Prostate Cancer

Sites in Hershey +2 more locations

Sponsor: Albany Medical College

Sex: Male·Age: 18 - 80

Code: NCT05629494·Phase 4·Recruiting·Listed Nov 2022

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Sonesitatug Vedotin in Combination With Capecitabine With or Without Rilvegostomig in Participants With Advanced or Metastatic Gastric, Gastroesophageal Junction, or Esophageal Adenocarcinoma Expressing Claudin18.2

for Gastric Cancer

Drug: Sonesitatug vedotin

Sites in Hershey, York +70 more locations

Sponsor: AstraZeneca

Sex: All·Age: 18+

Code: NCT07431281·Phase 3·Recruiting·Listed Feb 2026

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Phase III Study of Datopotamab Deruxtecan Versus Docetaxel in Previously Treated TROP2-positive Advanced or Metastatic Non-squamous NSCLC Without Actionable Genomic Alterations

for Non-small Cell Lung Cancer (NSCLC)

Sites in Hershey, Lancaster +46 more locations

Sponsor: AstraZeneca

Sex: All·Age: 18+

Code: NCT07291037·Phase 3·Recruiting·Listed Dec 2025

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Puxitatug Samrotecan (AZD8205) Monotherapy vs Chemotherapy in B7-H4-selected Endometrial Cancer (Bluestar-Endometrial01)

for Endometrial Cancer

Sites in Hershey, York +64 more locations

Sponsor: AstraZeneca

Sex: Female·Age: 18+

Code: NCT07044336·Phase 3·Recruiting·Listed Jun 2025

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A Study of Metastases Free Survival With Saruparib vs Placebo Added to a Standard RT/ADT in Men With High-risk Prostate Cancer With a BRCA Mutation

for Prostate Cancer

Drug: Saruparib

Sites in Hershey, Lancaster +36 more locations

Sponsor: AstraZeneca

Sex: Male·Age: 18+

Code: NCT06952803·Phase 3·Recruiting·Listed May 2025

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A Global Phase III Study of Rilvegostomig or Pembrolizumab Plus Chemotherapy for First-Line Treatment of Locally Advanced or Metastatic Squamous Non-small Cell Lung Cancer (NSCLC)

for Non-small Cell Lung Cancer

Drug: Rilvegostomig

Sites in Hershey, York +61 more locations

Sponsor: AstraZeneca

Sex: All·Age: 18+

Code: NCT06692738·Phase 3·Recruiting·Listed Nov 2024

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PEACH TRIAL- Precision Medicine and Adoptive Cellular Therapy

for Neuroblastoma

Sites in Hershey +1 more location

Sponsor: University of Florida

Sex: All·Age: 1 - 30

Code: NCT04837547·Phase 1·Recruiting·Listed Apr 2021

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Saruparib (AZD5305) Plus Camizestrant Compared With CDK4/6 Inhibitor Plus Endocrine Therapy or Plus Camizestrant in HR-Positive, HER2-Negative (IHC 0, 1+, 2+/ ISH Non-amplified), BRCA1, BRCA2, or PALB2m Advanced Breast Cancer

for Advanced Breast Cancer

Drug: Camizestrant

Sites in Hershey, Philadelphia +37 more locations

Sponsor: AstraZeneca

Sex: All·Age: 18+

Code: NCT06380751·Phase 3·Recruiting·Listed Apr 2024

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Study of Zanzalintinib in Combination With Immuno-Oncology Agents in Participants With Solid Tumors

for Renal Cell Carcinoma (RCC)

Sites in Hershey, Philadelphia +42 more locations

Sponsor: Exelixis

Sex: All·Age: 18+

Code: NCT05176483·Phase 1·Recruiting·Listed Jan 2022

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Conditions in Oncology (Hershey, PA)

Non-small cell lung cancer (NSCLC)· 9 Prostate cancer· 7 Acute myeloid leukemia (AML)· 7 Neuroblastoma· 7 Breast cancer· 6 Solid tumor· 6 Metastatic breast cancer· 4 Hematologic malignancy· 4 Osteosarcoma· 4 Gastric cancer· 3 Gastroesophageal junction cancer· 3 Ovarian cancer· 3 Ewing sarcoma· 3 Colorectal cancer· 2 Esophageal cancer· 2 Kidney cancer· 2 Endometrial cancer· 2 Glioblastoma· 2 Brain cancer· 2 Leukemia (other)· 2 Myelodysplastic syndromes (MDS)· 2 Head and neck cancer· 2 Cancer (any)· 2 HER2-positive breast cancer· 1 HER2-negative breast cancer· 1 Lung cancer· 1 Colon cancer· 1 Rectal cancer· 1 Pancreatic cancer· 1 Metastatic prostate cancer· 1 Bladder cancer· 1 Multiple myeloma· 1 Chronic lymphocytic leukemia (CLL)· 1 Acute lymphoblastic leukemia· 1 Myeloproliferative neoplasm· 1 Hodgkin lymphoma· 1 Non-Hodgkin lymphoma· 1 Mantle cell lymphoma· 1 Small lymphocytic lymphoma· 1 Melanoma· 1 Thyroid cancer· 1 Rhabdomyosarcoma· 1 Pediatric cancer· 1