Oncology Clinical Trials in Hershey, PA
As of August 2026, 68 paid clinical trials are recruiting for Oncology in Hershey, Pennsylvania. Compensation typically covers time, travel, and study visits, and many studies also include study-related medical care at no cost.
Recruiting trial data synced daily from ClinicalTrials.gov. Last sync: .
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68 clinical trials for Oncology
·Clear filters·A Study of Elacestrant Versus Standard Endocrine Therapy in Women and Men With ER+,HER2-, Early Breast Cancer With High Risk of Recurrence
Study of Zanzalintinib in Combination With Immuno-Oncology or Other Agents in Participants With Solid Tumors
Study of Daraxonrasib (RMC-6236) in Patients With RAS Mutated NSCLC (RASolve 301)
A Study of Adagrasib Plus Pembrolizumab Plus Chemotherapy vs. Placebo Plus Pembrolizumab Plus Chemotherapy in Participants With Previously Untreated Non-squamous Non-small Cell Lung Cancer With KRAS G12C Mutation (KRYSTAL-4)
A Study to Investigate the Efficacy and Safety of Sonrotoclax Plus Zanubrutinib Compared With Placebo Plus Zanubrutinib in Adults With Relapsed/Refractory Mantle Cell Lymphoma (CELESTIAL-RRMCL)
Beamion BCGC-1: A Study to Find a Suitable Dose of Zongertinib Used Alone and in Combination With Other Treatments to Test Whether it Helps People With Different Types of HER2+ Cancer That Has Spread
A Study of Teclistamab in Combination With Daratumumab and Lenalidomide (Tec-DR) and Talquetamab in Combination With Daratumumab and Lenalidomide (Tal-DR) in Participants With Newly Diagnosed Multiple Myeloma
A Study of INCB123667 in Participants With Platinum-Resistant Ovarian Cancer With Cyclin E1 Overexpression
A Study to Investigate Progression-Free Survival With Sonrotoclax Plus Obinutuzumab Or Sonrotoclax Plus Rituximab Compared With Venetoclax Plus Rituximab Treatment In Patients With Relapsed and/or Refractory Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma (CELESTIAL-RRCLL)
A Study to Assess Efficacy and Safety of Pembrolizumab With or Without Sacituzumab Tirumotecan (MK- 2870) in Adult Participants With Resectable Non Small Cell Lung Cancer (NSCLC) Not Achieving Pathological Complete Response (pCR) (MK-2870-019)
Study of JANX007 in Subjects With Metastatic Castration-Resistant Prostate Cancer (ENGAGER-PSMA-01)
Registry of Patients With Brain Tumors Treated With STaRT (GammaTiles)
A Phase 3 Single-arm Study of UGN-104 for the Treatment of Low-grade Upper Tract Urothelial Cancer
EXActDNA-003 / NSABP B-64: Study of Molecular Residual Disease Detection in Breast Cancer (MRD)
Adjuvant Temozolomide ± 5-Aminolevulinic Acid + Low Intensity Diffuse Ultrasound Sonodynamic Therapy System for Newly Diagnosed Glioblastoma
A Study to Evaluate the Effect of GDC-4198 Alone and in Combination With Giredestrant Versus Abemaciclib and Giredestrant in Participants With Locally Advanced or Metastatic Estrogen Receptor-Positive (ER+), Human Epidermal Growth Factor Receptor-Negative (HER2-) Breast Cancer
Study of TDXd, Chemotherapy, Pembrolizumab, and Trastuzumab in First-Line Metastatic HER2-Positive Gastric or Gastroesophageal Junction Cancer
Evexomostat Plus PI3K or AKT Inhibitor and Fulvestrant in Patients With a PI3K Alteration and HR+/Her2- Breast Cancer
Safety and Effectiveness Evaluation of the COLO-BT as an Alternative Treatment to the Ileostomy
APL-101 Study of Subjects With NSCLC With c-Met EXON 14 Skip Mutations and c-Met Dysregulation Advanced Solid Tumors
Eflornithine (DFMO) for Ewing Sarcoma and Osteosarcoma
Evaluating the Addition of Adjuvant Chemotherapy to Ovarian Function Suppression Plus Endocrine Therapy in Premenopausal Patients With pN0-1, ER-Positive/HER2-Negative Breast Cancer and an Oncotype Recurrence Score Less Than or Equal to 25
Testing Olaparib for One or Two Years, With or Without Bevacizumab, to Treat Ovarian Cancer
Treating Prostate Cancer That Has Come Back After Surgery With Apalutamide and Targeted Radiation Based on PET Imaging
A Study to Compare Two Surgical Procedures in Individuals With BRCA1 Mutations to Assess Reduced Risk of Ovarian Cancer
E-Mindfulness Approaches for Living After Breast Cancer
MYELOMATCH: A Screening Study to Assign People With Myeloid Cancer to a Treatment Study or Standard of Care Treatment Within myeloMATCH (MyeloMATCH Screening Trial)
Testing the Addition of Stereotactic Radiation Therapy With Immune Therapy for the Treatment of Patients With Unresectable or Metastatic Renal Cell Cancer, SAMURAI Trial
Testing New Therapies for Patients With Acute Myeloid Leukemia Who Are Newly Diagnosed and Have Not Yet Started Treatment (A MyeloMATCH Treatment Trial)
Venetoclax and HMA Treatment of Older and Unfit Adults With FLT3 Mutated Acute Myeloid Leukemia (AML) (A MyeloMATCH Treatment Trial)
Testing the Addition of the Drug BMX-001, a Radioprotector, or a Placebo to the Usual Chemoradiation Therapy for Patients With Head and Neck Cancer
Comparing Cytarabine + Daunorubicin Therapy Versus Cytarabine + Daunorubicin + Venetoclax Versus Venetoclax + Azacitidine in Younger Patients With Intermediate Risk AML (A MyeloMATCH Treatment Trial)
Triptorelin for the Prevention of Ovarian Damage in Adolescents and Young Adults With Cancer
Testing Longer Duration Radiation Therapy Versus the Usual Radiation Therapy in Patients With Cancer That Has Spread to the Brain
Inotuzumab Ozogamicin and Post-Induction Chemotherapy in Treating Patients With High-Risk B-ALL, Mixed Phenotype Acute Leukemia, and B-LLy
A Study to Compare Standard Chemotherapy to Therapy With CPX-351 and/or Gilteritinib for Patients With Newly Diagnosed AML With or Without FLT3 Mutations
Project: Every Child for Younger Patients With Cancer
Adjuvant Therapy in POLE-Mutated and p53-Wildtype/NSMP Early Stage Endometrial Cancer RAINBO BLUE & TAPER
The Pediatric Acute Leukemia (PedAL) Screening Trial - A Study to Test Bone Marrow and Blood in Children With Leukemia That Has Come Back After Treatment or Is Difficult to Treat - A Leukemia & Lymphoma Society and Children's Oncology Group Study
Top Research Study Locations in Hershey
Researchers run research studies in Hershey, PA at 25 active sites. The clinics below currently host the largest number of recruiting studies — each name is followed by the conditions they focus on most.
| Site | Specializes in | Active trials |
|---|---|---|
| Penn State Milton S Hershey Medical Center | Acute Myeloid Leukemia, Anatomic Stage II Breast Cancer AJCC v8, Acute Myeloid Leukemia Arising From Previous Myelodysplastic/Myeloproliferative Neoplasm | 40 |
| Penn State Milton S. Hershey Medical Center | Blood Pressure, Gastroesophageal Junction Adenocarcinoma, NSCLC | 27 |
| Penn State Children's Hospital | Malignant Solid Neoplasm, Acute Myeloid Leukemia, B Acute Lymphoblastic Leukemia | 19 |
| Penn State Health Milton S. Hershey Medical Center | Alpha1-Antitrypsin Deficiency, Duchenne Muscular Dystrophy, Acute Ischemic Stroke | 18 |
| Penn State College of Medicine | Anorexia Nervosa, Oxidative Stress, Tobacco Use | 13 |
| Penn State Health | Amyotrophic Lateral Sclerosis, Endometriosis, Heart Failure | 12 |
| Penn State Cancer Institute | Breast Cancer, Allogeneic Stem Cell Transplantation, Chemotherapy-Induced Peripheral Neuropathy | 9 |
| Penn State Hershey Medical Center | Atrial Fibrillation, Cognitive Function, Contrast Media | 9 |
| Penn State Milton S. Hershey Medical Center and Children's Hospital | Neuroblastoma, Ewing Sarcoma, Osteosarcoma | 9 |
| Pennsylvania State University | Articular Fractures, Body Image, Body Image Disturbance | 8 |
| Penn State Health Milton South Hershey Medical Center | Crohn's Disease, Functional Hypothalamic Amenorrhea (FHA), Melanoma | 6 |
| Milton S. Hershey Medical Center | Anxiety, Caregiver Burden, Caregiver Burden of People With Dementia | 5 |
| Penn State Milton S Hershey Medical Ctr | Colitis, Ulcerative, Crohn Disease, Multiple Myeloma | 4 |
| Penn State University Milton S. Hershey Medical Center | Esophageal Squamous Cell Carcinoma, Gastric Cancer, Gastroesophageal Junction Cancer | 4 |
| Hershey Medical Center Pennsylvania State University | Cystic Fibrosis, Cystic Fibrosis (CF), Exocrine Pancreatic Insufficiency (EPI) | 3 |
| Penn State Hershey | Epilepsy, Neurologic Disorder, Rare Diseases | 3 |
| Penn State University | Ards, Blood Pressure, Blood Pressure, High | 3 |
| ADARx Clinical Site | HAE, Hereditary Angioedema - Type 1, Hereditary Angioedema - Type 2 | 2 |
| Akero Clinical Study Site | MASH - Metabolic Dysfunction-Associated Steatohepatitis, MASH With Fibrosis, NASH - Nonalcoholic Steatohepatitis | 2 |
| Penn State Health Dept of Psychiatry | ADHD, ADHD - Attention Deficit Disorder With Hyperactivity, Aggression Childhood | 2 |
| Penn State Health Medical Group - Psychiatry and Behavioral Health | Anxiety, Attention-Deficit/Hyperactivity Disorder, Chronic Stress | 2 |
| Penn State Health Milton S. Hershey Medical Center (Hershey) | Hematologic Tests | 2 |
| Penn State Health, Milton S. Hershey Medical Center | Deep Venous Thromboses, Hepatitis | 2 |
| Penn State Hershey Children's Hospital | Anesthesia, Children, Deep Venous Thrombosis | 2 |
| Penn State MS Hershey Med Ctr | Haemophilia A, Haemophilia A With Inhibitors | 2 |
Active & Upcoming Studies in Hershey (2026)
Recruiting trials in Hershey grouped by therapeutic area, drawn from ClinicalTrials.gov. Each bucket shows the most recent example studies.
Cancer & tumors (95 active studies)
- IGNITE: Study of Tirabrutinib vs Rituximab/Temozolomide for Relapsed/Refractory Primary Central Nervous System Lymphoma (PCNSL) · Phase 3 · Ono Pharmaceutical Co., Ltd.
- Eflornithine (DFMO) for Ewing Sarcoma and Osteosarcoma · Phase 2 · Milton S. Hershey Medical Center
Cardiovascular (14 active studies)
- The WiSE®-UP Registry (The WiSE System Utilization & Performance Registry) · EBR Systems, Inc.
- Left Atrial Imaging Prior to Cardioversion: Leveraging Computed Tomography to Rule Out Thrombus in The Emergency Department (LA CLOTTED) · Ottawa Heart Institute Research Corporation
Neurology & pain (11 active studies)
- Virtual Reality to Reduce Anxiety, Agitation and Delirium in Critically Ill Patients · Milton S. Hershey Medical Center
- Assess the Safety and Efficacy of Sovateltide in Patients With Acute Cerebral Ischemic Stroke · Phase 3 · Pharmazz, Inc.
Mental health & behavior (8 active studies)
- Impact of Electronic Cigarette Temperature and Solvent on Biomarkers · Milton S. Hershey Medical Center
- Virtual Reality to Reduce Anxiety, Agitation and Delirium in Critically Ill Patients · Milton S. Hershey Medical Center
Pediatric (6 active studies)
- Optimizing Pain Treatment in Children On Mechanical Ventilation · Phase 3 · Weill Medical College of Cornell University
- Optimizing Tracheal Intubation Outcomes and Neonatal Safety · Children's Hospital of Philadelphia
Diabetes & metabolic (5 active studies)
- Cardiovascular Effects of Angiotensin-(1-7) in Obesity Hypertension · EARLY_Phase 1 · Milton S. Hershey Medical Center
- A Study Evaluating Efruxifermin in Subjects With Compensated Cirrhosis Due to NASH/MASH · Phase 3 · Akero Therapeutics, Inc
HIV / STI (1 active study)
- Health-E You Efficacy Trial for Male Adolescents · Johns Hopkins University
Common conditions studied in Hershey
- Acute Myeloid Leukemia (7 active studies)
- Neuroblastoma (7 active studies)
- Breast Cancer (6 active studies)
- Heart Failure (5 active studies)
- Hereditary Angioedema (HAE) (5 active studies)
- Prostate Cancer (5 active studies)
Leading research sponsors in Hershey
- Milton S. Hershey Medical Center
- National Cancer Institute (NCI)
- Children's Oncology Group
- NRG Oncology
- AstraZeneca
Frequently asked questions
How many paid clinical trials are currently recruiting in Hershey?
There are approximately 268 recruiting clinical trials in Hershey, Pennsylvania listed on ClinicalTrials.gov. The number changes weekly as new studies open and others close enrollment.
Do clinical trials in Hershey pay participants?
Most recruiting trials in Hershey compensate participants for their time, travel, and study visits. Compensation varies by sponsor, study phase, and visit requirements — the exact amount is disclosed by the study team during the informed consent process.
Who can participate in a clinical trial in Hershey?
Eligibility depends on the specific study. Each trial defines its own inclusion criteria (age, diagnosis, medical history, prior treatments) and exclusion criteria. Both patients with specific conditions and healthy volunteers can qualify, depending on the study design.
What conditions are most commonly studied in Hershey?
The most common conditions under active study in Hershey include Acute Myeloid Leukemia (7), Neuroblastoma (7), Breast Cancer (6), Heart Failure (5), among many others. Browse the list above to explore every recruiting trial.
Are there clinical trials for healthy volunteers in Hershey?
Yes. Healthy-volunteer studies — often early-phase pharmacology or vaccine trials — recruit in Hershey on an ongoing basis. Use the "Healthy volunteers only" filter above to view trials that accept participants without the study's target condition.
How do I enroll in a clinical trial in Hershey?
Click any study title above to see the full study record, including eligibility criteria, visit schedule, and the study team's contact information. Reach out to the central contact or recruiting site directly — they will guide you through screening and informed consent.
Where can I take part in paid clinical trials in Hershey?
Recruiting research sites in Hershey include Penn State Milton S Hershey Medical Center, Penn State Milton S. Hershey Medical Center, Penn State Children's Hospital, among others. Each site lists its open studies and contact information on the study record above — call or email the site coordinator to ask about screening for a specific protocol.
What kinds of studies are recruiting in Hershey right now?
The largest active categories in Hershey are Cancer & tumors (95), Cardiovascular (14), Neurology & pain (11). Use the filters above to narrow by therapeutic area, phase, age, or healthy-volunteer eligibility.