Paid Clinical Trials in Hershey, PA
As of August 2026, 267 paid clinical trials are recruiting in Hershey, Pennsylvania. Compensation typically covers time, travel, and study visits, with stipends ranging from modest amounts for short outpatient studies to several thousand dollars for long or inpatient protocols.
Hershey offers studies at sites including Penn State Milton S Hershey Medical Center for conditions such as Acute Myeloid Leukemia, Neuroblastoma, Breast Cancer, Heart Failure. Both patients with specific conditions and healthy volunteers can qualify. Most trials offer free study-related medical care alongside compensation.
Recruiting trial data synced daily from ClinicalTrials.gov. Last sync: .
Trials by specialty in Hershey
Trials by drug in Hershey
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Newly added in Hershey
Posted to ClinicalTrials.gov within the last 60 days — these studies are just starting to recruit.
245 clinical trials
Phase 2 Study to Assess the Safety and Efficacy of ANG003
Study to Evaluate the Safety and Efficacy of Larsucosterol in Participants With Alcohol-associated Hepatitis (AH)
Parasternal Extravascular ICD System Pivotal Clinical Investigation (ALARION EV) Study
A Study to Evaluate the Efficacy and Safety of Standard-of-Care Chemotherapy and Bevacizumab With or Without INCA33890 in the First-Line Treatment of Metastatic Microsatellite Stable Colorectal Cancer
A Study of Pasritamig With Docetaxel Versus Docetaxel in Participants With Metastatic Castration-Resistant Prostate Cancer
CLEOPATTRA: A Research Study to Look at the Effects of Treatment With a Medicine Called Coramitug (NNC6019-0001) in People With Heart Failure Due to Transthyretin Amyloid (ATTR) Amyloidosis
A Study of Icotrokinra in Participants With Moderately to Severely Active Crohn's Disease
A Protocol of Icotrokinra Therapy in Adult and Adolescent Participants With Moderately to Severely Active Ulcerative Colitis
LIVERAGE™: A Study to Test Whether Survodutide Helps People With a Liver Disease Called NASH/MASH Who Have Moderate or Advanced Liver Fibrosis
Study of Zanzalintinib in Combination With Immuno-Oncology or Other Agents in Participants With Solid Tumors
LIVERAGE™ - Cirrhosis: A Study to Test Whether Survodutide Helps People With a Liver Disease Called NASH/MASH Who Have Cirrhosis
A Study of Elacestrant Versus Standard Endocrine Therapy in Women and Men With ER+,HER2-, Early Breast Cancer With High Risk of Recurrence
A Study to Evaluate the Efficacy and Safety of Tulisokibart (MK-7240) in Participants With Moderate to Severe Crohn's Disease (MK-7240-008)
Assessment of CCM in HF With Higher Ejection Fraction
MILD® Percutaneous Image-Guided Lumbar Decompression: A Medicare Claims Study
Study of Daraxonrasib (RMC-6236) in Patients With RAS Mutated NSCLC (RASolve 301)
Seladelpar in Subjects With Primary Biliary Cholangitis (PBC) and Compensated Cirrhosis
A Study of INCB123667 in Participants With Platinum-Resistant Ovarian Cancer With Cyclin E1 Overexpression
A Precision Medicine Approach Using Gene Silencing to Treat a Chronic Liver Disease Called Metabolic Dysfunction-Associated Steatohepatitis (MASH) in Adult Participants at Increased Genetic Risk for This Condition
Beamion BCGC-1: A Study to Find a Suitable Dose of Zongertinib Used Alone and in Combination With Other Treatments to Test Whether it Helps People With Different Types of HER2+ Cancer That Has Spread
A Study of Adagrasib Plus Pembrolizumab Plus Chemotherapy vs. Placebo Plus Pembrolizumab Plus Chemotherapy in Participants With Previously Untreated Non-squamous Non-small Cell Lung Cancer With KRAS G12C Mutation (KRYSTAL-4)
A Study to Investigate Progression-Free Survival With Sonrotoclax Plus Obinutuzumab Or Sonrotoclax Plus Rituximab Compared With Venetoclax Plus Rituximab Treatment In Patients With Relapsed and/or Refractory Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma (CELESTIAL-RRCLL)
A Study to Investigate the Efficacy and Safety of Sonrotoclax Plus Zanubrutinib Compared With Placebo Plus Zanubrutinib in Adults With Relapsed/Refractory Mantle Cell Lymphoma (CELESTIAL-RRMCL)
A Study to Assess the Efficacy and Safety of Induction and Maintenance Therapy With Afimkibart (RO7790121) in Participants With Moderately to Severely Active Crohn's Disease
A Study to Assess Efficacy and Safety of Pembrolizumab With or Without Sacituzumab Tirumotecan (MK- 2870) in Adult Participants With Resectable Non Small Cell Lung Cancer (NSCLC) Not Achieving Pathological Complete Response (pCR) (MK-2870-019)
Registry of Patients With Brain Tumors Treated With STaRT (GammaTiles)
A Study of Teclistamab in Combination With Daratumumab and Lenalidomide (Tec-DR) and Talquetamab in Combination With Daratumumab and Lenalidomide (Tal-DR) in Participants With Newly Diagnosed Multiple Myeloma
A Study to Test the Efficacy and Safety of Riliprubart Against the Usual Treatment of Intravenous Immunoglobulin (IVIg) in People With Chronic Inflammatory Demyelinating Polyneuropathy (CIDP)
Edwards PASCAL Transcatheter Valve Repair System Pivotal Clinical Trial
Study of the Efficacy and Safety of Inhaled Treprostinil in Subjects With Progressive Pulmonary Fibrosis (TETON-PPF)
Pompe Disease Registry Protocol
Study With Omecamtiv Mecarbil (CK-1827452) to Treat Chronic Heart Failure With Severely Reduced Ejection Fraction
SELUTION 4 De Novo Small Vessel IDE Trial
Fabry Disease Registry & Pregnancy Sub-registry
Study of Intralesional Cemiplimab in Adult Patients With Early Stage Cutaneous Squamous Cell Carcinoma
Trial to Evaluate Safety And Effectiveness of Mechanical Circulatory Support in Patients With Advancing Heart Failure
PROACTIVE-HF-2 Trial Heart Failure NYHA Class II and III
Study of the Long-Term Safety and Outcomes of Treating Pulmonary Embolism With the Indigo Aspiration System
A Phase 3 Single-arm Study of UGN-104 for the Treatment of Low-grade Upper Tract Urothelial Cancer
A Study Evaluating Efruxifermin in Subjects With Non-Cirrhotic Nonalcoholic Steatohepatitis (NASH)/Metabolic Dysfunction-Associated Steatohepatitis (MASH) and Fibrosis
Top Research Study Locations in Hershey
Researchers run research studies in Hershey, PA at 25 active sites. The clinics below currently host the largest number of recruiting studies — each name is followed by the conditions they focus on most.
| Site | Specializes in | Active trials |
|---|---|---|
| Penn State Milton S Hershey Medical Center | Acute Myeloid Leukemia, Anatomic Stage II Breast Cancer AJCC v8, Acute Myeloid Leukemia Arising From Previous Myelodysplastic/Myeloproliferative Neoplasm | 40 |
| Penn State Milton S. Hershey Medical Center | Blood Pressure, Gastroesophageal Junction Adenocarcinoma, NSCLC | 25 |
| Penn State Children's Hospital | Malignant Solid Neoplasm, Acute Myeloid Leukemia, B Acute Lymphoblastic Leukemia | 20 |
| Penn State Health Milton S. Hershey Medical Center | Alpha1-Antitrypsin Deficiency, Duchenne Muscular Dystrophy, Acute Ischemic Stroke | 18 |
| Penn State College of Medicine | Anorexia Nervosa, Oxidative Stress, Tobacco Use | 14 |
| Penn State Health | Amyotrophic Lateral Sclerosis, Endometriosis, Heart Failure | 12 |
| Penn State Cancer Institute | Breast Cancer, Allogeneic Stem Cell Transplantation, Chemotherapy-Induced Peripheral Neuropathy | 9 |
| Penn State Hershey Medical Center | Atrial Fibrillation, Cognitive Function, Contrast Media | 9 |
| Penn State Milton S. Hershey Medical Center and Children's Hospital | Neuroblastoma, Ewing Sarcoma, Osteosarcoma | 9 |
| Pennsylvania State University | Articular Fractures, Body Image, Body Image Disturbance | 8 |
| Milton S. Hershey Medical Center | Anxiety, Caregiver Burden, Caregiver Burden of People With Dementia | 5 |
| Penn State Health Milton South Hershey Medical Center | Crohn's Disease, Functional Hypothalamic Amenorrhea (FHA), Ulcerative Colitis | 5 |
| Penn State Milton S Hershey Medical Ctr | Colitis, Ulcerative, Crohn Disease, Multiple Myeloma | 4 |
| Penn State University Milton S. Hershey Medical Center | Esophageal Squamous Cell Carcinoma, Gastric Cancer, Gastroesophageal Junction Cancer | 4 |
| Hershey Medical Center Pennsylvania State University | Cystic Fibrosis, Cystic Fibrosis (CF), Exocrine Pancreatic Insufficiency (EPI) | 3 |
| Penn State Hershey | Epilepsy, Neurologic Disorder, Rare Diseases | 3 |
| Penn State University | Ards, Blood Pressure, Blood Pressure, High | 3 |
| ADARx Clinical Site | HAE, Hereditary Angioedema - Type 1, Hereditary Angioedema - Type 2 | 2 |
| Akero Clinical Study Site | MASH - Metabolic Dysfunction-Associated Steatohepatitis, MASH With Fibrosis, NASH - Nonalcoholic Steatohepatitis | 2 |
| Penn State Health Dept of Psychiatry | ADHD, ADHD - Attention Deficit Disorder With Hyperactivity, Aggression Childhood | 2 |
| Penn State Health Medical Group - Psychiatry and Behavioral Health | Anxiety, Attention-Deficit/Hyperactivity Disorder, Chronic Stress | 2 |
| Penn State Health Milton S. Hershey Medical Center (Hershey) | Hematologic Tests | 2 |
| Penn State Health, Milton S. Hershey Medical Center | Deep Venous Thromboses, Hepatitis | 2 |
| Penn State Hershey Children's Hospital | Anesthesia, Children, Deep Venous Thrombosis | 2 |
| Penn State MS Hershey Med Ctr | Haemophilia A, Haemophilia A With Inhibitors | 2 |
Active & Upcoming Studies in Hershey (2026)
Recruiting trials in Hershey grouped by therapeutic area, drawn from ClinicalTrials.gov. Each bucket shows the most recent example studies.
Cancer & tumors (93 active studies)
- IGNITE: Study of Tirabrutinib vs Rituximab/Temozolomide for Relapsed/Refractory Primary Central Nervous System Lymphoma (PCNSL) · Phase 3 · Ono Pharmaceutical Co., Ltd.
- Eflornithine (DFMO) for Ewing Sarcoma and Osteosarcoma · Phase 2 · Milton S. Hershey Medical Center
Cardiovascular (14 active studies)
- The WiSE®-UP Registry (The WiSE System Utilization & Performance Registry) · EBR Systems, Inc.
- Left Atrial Imaging Prior to Cardioversion: Leveraging Computed Tomography to Rule Out Thrombus in The Emergency Department (LA CLOTTED) · Ottawa Heart Institute Research Corporation
Neurology & pain (10 active studies)
- Virtual Reality to Reduce Anxiety, Agitation and Delirium in Critically Ill Patients · Milton S. Hershey Medical Center
- Assess the Safety and Efficacy of Sovateltide in Patients With Acute Cerebral Ischemic Stroke · Phase 3 · Pharmazz, Inc.
Mental health & behavior (8 active studies)
- Impact of Electronic Cigarette Temperature and Solvent on Biomarkers · Milton S. Hershey Medical Center
- Virtual Reality to Reduce Anxiety, Agitation and Delirium in Critically Ill Patients · Milton S. Hershey Medical Center
Pediatric (6 active studies)
- Optimizing Pain Treatment in Children On Mechanical Ventilation · Phase 3 · Weill Medical College of Cornell University
- Optimizing Tracheal Intubation Outcomes and Neonatal Safety · Children's Hospital of Philadelphia
Diabetes & metabolic (5 active studies)
- Cardiovascular Effects of Angiotensin-(1-7) in Obesity Hypertension · EARLY_Phase 1 · Milton S. Hershey Medical Center
- A Study Evaluating Efruxifermin in Subjects With Compensated Cirrhosis Due to NASH/MASH · Phase 3 · Akero Therapeutics, Inc
HIV / STI (1 active study)
- Health-E You Efficacy Trial for Male Adolescents · Johns Hopkins University
Common conditions studied in Hershey
- Acute Myeloid Leukemia (7 active studies)
- Neuroblastoma (7 active studies)
- Breast Cancer (6 active studies)
- Heart Failure (5 active studies)
- Hereditary Angioedema (HAE) (5 active studies)
- Prostate Cancer (5 active studies)
Leading research sponsors in Hershey
- Milton S. Hershey Medical Center
- National Cancer Institute (NCI)
- Children's Oncology Group
- NRG Oncology
- AstraZeneca
Frequently asked questions
How many paid clinical trials are currently recruiting in Hershey?
There are approximately 267 recruiting clinical trials in Hershey, Pennsylvania listed on ClinicalTrials.gov. The number changes weekly as new studies open and others close enrollment.
Do clinical trials in Hershey pay participants?
Most recruiting trials in Hershey compensate participants for their time, travel, and study visits. Compensation varies by sponsor, study phase, and visit requirements — the exact amount is disclosed by the study team during the informed consent process.
Who can participate in a clinical trial in Hershey?
Eligibility depends on the specific study. Each trial defines its own inclusion criteria (age, diagnosis, medical history, prior treatments) and exclusion criteria. Both patients with specific conditions and healthy volunteers can qualify, depending on the study design.
What conditions are most commonly studied in Hershey?
The most common conditions under active study in Hershey include Acute Myeloid Leukemia (7), Neuroblastoma (7), Breast Cancer (6), Heart Failure (5), among many others. Browse the list above to explore every recruiting trial.
Are there clinical trials for healthy volunteers in Hershey?
Yes. Healthy-volunteer studies — often early-phase pharmacology or vaccine trials — recruit in Hershey on an ongoing basis. Use the "Healthy volunteers only" filter above to view trials that accept participants without the study's target condition.
How do I enroll in a clinical trial in Hershey?
Click any study title above to see the full study record, including eligibility criteria, visit schedule, and the study team's contact information. Reach out to the central contact or recruiting site directly — they will guide you through screening and informed consent.
Where can I take part in paid clinical trials in Hershey?
Recruiting research sites in Hershey include Penn State Milton S Hershey Medical Center, Penn State Milton S. Hershey Medical Center, Penn State Children's Hospital, among others. Each site lists its open studies and contact information on the study record above — call or email the site coordinator to ask about screening for a specific protocol.
What kinds of studies are recruiting in Hershey right now?
The largest active categories in Hershey are Cancer & tumors (93), Cardiovascular (14), Neurology & pain (10). Use the filters above to narrow by therapeutic area, phase, age, or healthy-volunteer eligibility.