Paid Clinical Trials in Hershey, PA
As of July 2026, 293 paid clinical trials are recruiting in Hershey, Pennsylvania. Compensation typically covers time, travel, and study visits, with stipends ranging from modest amounts for short outpatient studies to several thousand dollars for long or inpatient protocols.
Hershey offers studies at sites including Penn State Milton S Hershey Medical Center for conditions such as Acute Myeloid Leukemia, Breast Cancer, Heart Failure, Neuroblastoma. Both patients with specific conditions and healthy volunteers can qualify. Most trials offer free study-related medical care alongside compensation.
Recruiting trial data synced daily from ClinicalTrials.gov. Last sync: .
Trials by specialty in Hershey
Trials by drug in Hershey
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273 clinical trials
↓ Download CSVA Study of Elacestrant Versus Standard Endocrine Therapy in Women and Men With ER+,HER2-, Early Breast Cancer With High Risk of Recurrence
LIVERAGE™ - Cirrhosis: A Study to Test Whether Survodutide Helps People With a Liver Disease Called NASH/MASH Who Have Cirrhosis
MILD® Percutaneous Image-Guided Lumbar Decompression: A Medicare Claims Study
A Study to Evaluate the Efficacy and Safety of Tulisokibart (MK-7240) in Participants With Moderate to Severe Crohn's Disease (MK-7240-008)
A Study to Evaluate the Efficacy and Safety of Standard-of-Care Chemotherapy and Bevacizumab With or Without INCA33890 in the First-Line Treatment of Metastatic Microsatellite Stable Colorectal Cancer
A Precision Medicine Approach Using Gene Silencing to Treat a Chronic Liver Disease Called Metabolic Dysfunction-Associated Steatohepatitis (MASH) in Adult Participants at Increased Genetic Risk for This Condition
Assessment of CCM in HF With Higher Ejection Fraction
A Study of Pasritamig With Docetaxel Versus Docetaxel in Participants With Metastatic Castration-Resistant Prostate Cancer
Study of Daraxonrasib (RMC-6236) in Patients With RAS Mutated NSCLC (RASolve 301)
ARTEMIS - A Research Study to Look at How Ziltivekimab Works Compared to Placebo in People With a Heart Attack
A Study to Assess Change in Disease Activity and Adverse Events of Oral Upadacitinib in Adult and Adolescent Participants With Moderate to Severe Hidradenitis Suppurativa Who Have Failed Anti-TNF Therapy
A Study of Adagrasib Plus Pembrolizumab Plus Chemotherapy vs. Placebo Plus Pembrolizumab Plus Chemotherapy in Participants With Previously Untreated Non-squamous Non-small Cell Lung Cancer With KRAS G12C Mutation (KRYSTAL-4)
Phase 2 Study to Evaluate Safety and Efficacy of Cretostimogene Grenadenorepvec in High-Risk NMIBC
A Study to Investigate Progression-Free Survival With Sonrotoclax Plus Obinutuzumab Or Sonrotoclax Plus Rituximab Compared With Venetoclax Plus Rituximab Treatment In Patients With Relapsed and/or Refractory Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma (CELESTIAL-RRCLL)
Study of Targeted Therapies for the Treatment of Adult Participants With Moderate to Severe Crohn's Disease
Seladelpar in Subjects With Primary Biliary Cholangitis (PBC) and Compensated Cirrhosis
A Study to Investigate the Efficacy and Safety of Sonrotoclax Plus Zanubrutinib Compared With Placebo Plus Zanubrutinib in Adults With Relapsed/Refractory Mantle Cell Lymphoma (CELESTIAL-RRMCL)
CLEOPATTRA: A Research Study to Look at the Effects of Treatment With a Medicine Called Coramitug (NNC6019-0001) in People With Heart Failure Due to Transthyretin Amyloid (ATTR) Amyloidosis
Evaluation of SPN-812 (Viloxazine Extended-release Capsule) in Preschool-age Children With ADHD
Pompe Disease Registry Protocol
A Study to Assess the Efficacy and Safety of Induction and Maintenance Therapy With Afimkibart (RO7790121) in Participants With Moderately to Severely Active Crohn's Disease
Beamion BCGC-1: A Study to Find a Suitable Dose of Zongertinib Used Alone and in Combination With Other Treatments to Test Whether it Helps People With Different Types of HER2+ Cancer That Has Spread
A Study of INCB123667 in Participants With Platinum-Resistant Ovarian Cancer With Cyclin E1 Overexpression
Fabry Disease Registry & Pregnancy Sub-registry
Registry of Patients With a Diagnosis of Spinal Muscular Atrophy (SMA)
Trial to Evaluate Safety And Effectiveness of Mechanical Circulatory Support in Patients With Advancing Heart Failure
A Research Study to Look at How Ziltivekimab Works Compared to Placebo in People With Heart Failure and Inflammation
A Study of Teclistamab in Combination With Daratumumab and Lenalidomide (Tec-DR) and Talquetamab in Combination With Daratumumab and Lenalidomide (Tal-DR) in Participants With Newly Diagnosed Multiple Myeloma
Edwards PASCAL Transcatheter Valve Repair System Pivotal Clinical Trial
International Collaborative Gaucher Group (ICGG) Gaucher Disease Registry & Pregnancy Sub-registry
A Study to Assess Efficacy and Safety of Pembrolizumab With or Without Sacituzumab Tirumotecan (MK- 2870) in Adult Participants With Resectable Non Small Cell Lung Cancer (NSCLC) Not Achieving Pathological Complete Response (pCR) (MK-2870-019)
Study to Evaluate the Safety and Efficacy of Larsucosterol in Participants With Alcohol-associated Hepatitis (AH)
A Study to Test the Effects and Safety of Riliprubart in People With Chronic Inflammatory Demyelinating Polyneuropathy (CIDP) for Which the Usual Treatments do Not Work
EXActDNA-003 / NSABP B-64: Study of Molecular Residual Disease Detection in Breast Cancer (MRD)
Safety Study of Viaskin® Peanut Patch in Peanut-Allergic Children 1 Through 3 Years of Age (COMFORT Toddlers)
Registry of Patients With Brain Tumors Treated With STaRT (GammaTiles)
A Study to Test the Efficacy and Safety of Riliprubart Against the Usual Treatment of Intravenous Immunoglobulin (IVIg) in People With Chronic Inflammatory Demyelinating Polyneuropathy (CIDP)
A Study Comparing Talquetamab Plus Pomalidomide, Talquetamab Plus Teclistamab, and Elotuzumab, Pomalidomide, and Dexamethasone or Pomalidomide, Bortezomib, and Dexamethasone in Participants With Relapsed or Refractory Myeloma Who Have Received an Anti-CD38 Antibody and Lenalidomide
Study of the Efficacy and Safety of Inhaled Treprostinil in Subjects With Progressive Pulmonary Fibrosis (TETON-PPF)
About research studies in Hershey
Hershey has approximately 293 recruiting research studies across a wide range of therapeutic areas. Pennsylvania hosts UPenn's Perelman School of Medicine and Children's Hospital of Philadelphia — pioneers in CAR-T cell therapy — alongside UPMC, Thomas Jefferson University, and Penn State Hershey.
Top Research Study Locations in Hershey
Researchers run research studies in Hershey, PA at 25 active sites. The clinics below currently host the largest number of recruiting studies — each name is followed by the conditions they focus on most.
| Site | Specializes in | Active trials |
|---|---|---|
| Penn State Milton S Hershey Medical Center | Acute Myeloid Leukemia, Breast Cancer, Anatomic Stage II Breast Cancer AJCC v8 | 43 |
| Penn State Milton S. Hershey Medical Center | Blood Pressure, Gastroesophageal Junction Adenocarcinoma, NSCLC | 26 |
| Penn State Children's Hospital | Malignant Solid Neoplasm, Acute Myeloid Leukemia, B Acute Lymphoblastic Leukemia | 22 |
| Penn State Health Milton S. Hershey Medical Center | Alpha1-Antitrypsin Deficiency, Duchenne Muscular Dystrophy, Acute Ischemic Stroke | 17 |
| Penn State Health | Amyotrophic Lateral Sclerosis, Endometriosis, Heart Failure | 15 |
| Penn State College of Medicine | Anorexia Nervosa, Oxidative Stress, Tobacco Use | 14 |
| Penn State Hershey Medical Center | Acute Kidney Injury (AKI), Acute Myocardial Infarction (AMI), Atrial Fibrillation | 13 |
| Penn State Cancer Institute | Breast Cancer, Allogeneic Stem Cell Transplantation, Chemotherapy-Induced Peripheral Neuropathy | 9 |
| Penn State Milton S. Hershey Medical Center and Children's Hospital | Neuroblastoma, Ewing Sarcoma, Osteosarcoma | 8 |
| Pennsylvania State University | Articular Fractures, Body Image, Body Image Disturbance | 8 |
| Penn State Health Milton South Hershey Medical Center | Chronic Inflammatory Demyelinating Polyneuropathy, Chronic Inflammatory Demyelinating Polyradiculoneuropathy, Polyneuropathy, Inflammatory Demyelinating, Chronic | 7 |
| Milton S. Hershey Medical Center | Anxiety, Caregiver Burden, Caregiver Burden of People With Dementia | 5 |
| Penn State Milton S Hershey Medical Ctr | Multiple Myeloma, Colitis, Ulcerative, Crohn Disease | 5 |
| Penn State Hershey | Amyotrophic Lateral Sclerosis, Epilepsy, Neurologic Disorder | 4 |
| Hershey Medical Center Pennsylvania State University | Cystic Fibrosis, Cystic Fibrosis (CF), Exocrine Pancreatic Insufficiency (EPI) | 3 |
| Penn State University | Ards, Blood Pressure, Blood Pressure, High | 3 |
| ADARx Clinical Site | HAE, Hereditary Angioedema - Type 1, Hereditary Angioedema - Type 2 | 2 |
| Akero Clinical Study Site | MASH - Metabolic Dysfunction-Associated Steatohepatitis, MASH With Fibrosis, NASH - Nonalcoholic Steatohepatitis | 2 |
| Penn State Health Dept of Psychiatry | ADHD, ADHD - Attention Deficit Disorder With Hyperactivity, Aggression Childhood | 2 |
| Penn State Health Medical Group - Psychiatry and Behavioral Health | Anxiety, Attention-Deficit/Hyperactivity Disorder, Chronic Stress | 2 |
| Penn State Health Milton S. Hershey Medical Center (Hershey) | Hematologic Tests | 2 |
| Penn State Health, Milton S. Hershey Medical Center | Deep Venous Thromboses, Hepatitis | 2 |
| Penn State Hershey Children's Hospital | Anesthesia, Children, Deep Venous Thrombosis | 2 |
| Penn State MS Hershey Med Ctr | Haemophilia A, Haemophilia A With Inhibitors | 2 |
| Penn State Milton S. Hershey Medical Center / Penn State College of Medicine | Child Abuse, Child Maltreatment, Child Neglect | 2 |
Active & Upcoming Studies in Hershey (2026)
Recruiting trials in Hershey grouped by therapeutic area, drawn from ClinicalTrials.gov. Each bucket shows the most recent example studies.
Cancer & tumors (100 active studies)
- Eflornithine (DFMO) for Ewing Sarcoma and Osteosarcoma · Phase 2 · Milton S. Hershey Medical Center
- Eflornithine (DFMO) and AMXT 1501 for Neuroblastoma, CNS Tumors, and Sarcomas · Phase 1, Phase 2 · Milton S. Hershey Medical Center
Cardiovascular (17 active studies)
- The WiSE®-UP Registry (The WiSE System Utilization & Performance Registry) · EBR Systems, Inc.
- Left Atrial Imaging Prior to Cardioversion: Leveraging Computed Tomography to Rule Out Thrombus in The Emergency Department (LA CLOTTED) · Ottawa Heart Institute Research Corporation
Neurology & pain (11 active studies)
- Virtual Reality to Reduce Anxiety, Agitation and Delirium in Critically Ill Patients · Milton S. Hershey Medical Center
- Assess the Safety and Efficacy of Sovateltide in Patients With Acute Cerebral Ischemic Stroke · Phase 3 · Pharmazz, Inc.
Mental health & behavior (8 active studies)
- Impact of Electronic Cigarette Temperature and Solvent on Biomarkers · Milton S. Hershey Medical Center
- Virtual Reality to Reduce Anxiety, Agitation and Delirium in Critically Ill Patients · Milton S. Hershey Medical Center
Pediatric (8 active studies)
- Optimizing Pain Treatment in Children On Mechanical Ventilation · Phase 3 · Weill Medical College of Cornell University
- Optimizing Tracheal Intubation Outcomes and Neonatal Safety · Children's Hospital of Philadelphia
Diabetes & metabolic (5 active studies)
- Cardiovascular Effects of Angiotensin-(1-7) in Obesity Hypertension · EARLY_Phase 1 · Milton S. Hershey Medical Center
- A Study Evaluating Efruxifermin in Subjects With Compensated Cirrhosis Due to NASH/MASH · Phase 3 · Akero Therapeutics, Inc
Vaccines (1 active study)
HIV / STI (1 active study)
- Health-E You Efficacy Trial for Male Adolescents · Johns Hopkins University
Common conditions studied in Hershey
- Acute Myeloid Leukemia (7 active studies). Leukemia trials evaluate targeted inhibitors, CAR-T cell therapies, and novel combinations for acute and chronic forms of the disease.
- Breast Cancer (7 active studies). Breast cancer trials evaluate new hormone therapies, targeted drugs, and immunotherapy combinations aimed at improving survival and reducing recurrence.
- Heart Failure (7 active studies). Heart failure trials explore SGLT-2 inhibitors, novel myosin modulators, and device-based therapies for both reduced and preserved ejection fraction.
- Neuroblastoma (6 active studies). Recruiting Neuroblastoma studies evaluate investigational treatments, diagnostics, and supportive care approaches to improve patient outcomes.
- Crohn's Disease (5 active studies). Recruiting Crohn's Disease studies evaluate investigational treatments, diagnostics, and supportive care approaches to improve patient outcomes.
- Hereditary Angioedema (HAE) (5 active studies). Recruiting Hereditary Angioedema (HAE) studies evaluate investigational treatments, diagnostics, and supportive care approaches to improve patient outcomes.
Leading research sponsors in Hershey
- Milton S. Hershey Medical Center
- National Cancer Institute (NCI)
- Children's Oncology Group
- NRG Oncology
- AstraZeneca
Local regulations and guidelines
Clinical trials in Pennsylvania are governed by U.S. Food and Drug Administration (FDA) regulations, Office for Human Research Protections (OHRP) standards, and federal HIPAA privacy rules. Every study is reviewed by an Institutional Review Board (IRB) to protect participant safety and ensure informed consent. Pennsylvania research additionally follows state public health department oversight and any applicable state privacy statutes.
Compensation & what to expect
- How payment typically works
- Compensation is most often provided through reloadable electronic study cards or direct deposit, paid out per completed visit rather than as a lump sum. Amounts vary by the time required, the number of visits, and the study's complexity — overnight stays and inpatient pharmacology studies generally pay more than short outpatient surveys. The exact amount is disclosed in writing during informed consent before any visit.
- Healthy volunteers
- Healthy participants aged 18 and older can earn compensation by joining vaccine, pharmacology, and biomarker studies in Hershey. These trials check how a new drug or vaccine behaves in healthy bodies before later-phase testing. Many sites maintain a healthy-volunteer registry so you hear about new opportunities first.
- What's included beyond payment
- Most trials cover study-related medical care at no cost — physical exams, lab work, imaging, the investigational treatment itself, and follow-up visits with the research team. Insurance is not required to participate. Free check-ups and access to specialists are common reasons participants return for additional studies.
- Travel and time
- Many sponsors reimburse travel, parking, mileage, and lost wages for visit days. Long-running studies and trials that require frequent visits often raise stipends accordingly. Ask the study coordinator for the visit schedule and reimbursement policy before you commit.
- Asking about compensation
- Compensation is set per protocol and per site, so figures are not published in trial registries. The fastest way to confirm payment for a specific study is to contact the recruiting site listed on the study record. Coordinators are accustomed to this question and will quote the per-visit and total amounts up front.
How to find a clinical trial in Hershey
Hipa.ai aggregates every recruiting study in Hershey from ClinicalTrials.gov and refreshes the list daily. Use the filters above to narrow by condition, facility, age, phase, or healthy-volunteer eligibility, then click any study title to view full details — eligibility criteria, intervention, location, and sponsor contact information. To enroll, reach out to the central study contact listed on the study detail page; the research coordinator will walk you through the screening process.
Frequently asked questions
How many paid clinical trials are currently recruiting in Hershey?
There are approximately 293 recruiting clinical trials in Hershey, Pennsylvania listed on ClinicalTrials.gov. The number changes weekly as new studies open and others close enrollment.
Do clinical trials in Hershey pay participants?
Most recruiting trials in Hershey compensate participants for their time, travel, and study visits. Compensation varies by sponsor, study phase, and visit requirements — the exact amount is disclosed by the study team during the informed consent process.
Who can participate in a clinical trial in Hershey?
Eligibility depends on the specific study. Each trial defines its own inclusion criteria (age, diagnosis, medical history, prior treatments) and exclusion criteria. Both patients with specific conditions and healthy volunteers can qualify, depending on the study design.
What conditions are most commonly studied in Hershey?
The most common conditions under active study in Hershey include Acute Myeloid Leukemia (7), Breast Cancer (7), Heart Failure (7), Neuroblastoma (6), among many others. Browse the list above to explore every recruiting trial.
Are there clinical trials for healthy volunteers in Hershey?
Yes. Healthy-volunteer studies — often early-phase pharmacology or vaccine trials — recruit in Hershey on an ongoing basis. Use the "Healthy volunteers only" filter above to view trials that accept participants without the study's target condition.
How do I enroll in a clinical trial in Hershey?
Click any study title above to see the full study record, including eligibility criteria, visit schedule, and the study team's contact information. Reach out to the central contact or recruiting site directly — they will guide you through screening and informed consent.
Where can I take part in paid clinical trials in Hershey?
Recruiting research sites in Hershey include Penn State Milton S Hershey Medical Center, Penn State Milton S. Hershey Medical Center, Penn State Children's Hospital, among others. Each site lists its open studies and contact information on the study record above — call or email the site coordinator to ask about screening for a specific protocol.
What kinds of studies are recruiting in Hershey right now?
The largest active categories in Hershey are Cancer & tumors (100), Cardiovascular (17), Neurology & pain (11). Use the filters above to narrow by therapeutic area, phase, age, or healthy-volunteer eligibility.