Paid Clinical Trials in Iowa

Iowa has 761 paid clinical trials enrolling now across cities including Iowa City, Des Moines and Waukee. Search by condition, age, or phase to find compensated research studies accepting participants near you.

Both patients and healthy volunteers may qualify. Most studies offer compensation for time and travel.

Recruiting trial data synced daily from ClinicalTrials.gov. Last sync: July 30, 2026.

Filter results

State

City

Recruitment status

Phase

Study type

Intervention

Condition

Sex

Age

Healthy volunteers only

703 clinical trials

Study to Assess Adverse Events and Disease Activity of Oral Ubrogepant Tablets for the Acute Treatment of Migraine in Children and Adolescents (Ages 6-17)

for Migraine

Drug: Ubrogepant

Sites in Ames, Waterloo +89 more locations

Sponsor: AbbVie

Sex: All·Age: 6 - 17

Code: NCT05125302·Phase 3·Recruiting·Listed Nov 2021

Apply to this trial

A Study of Amivantamab and FOLFIRI Versus Cetuximab/Bevacizumab and FOLFIRI in Participants With KRAS/NRAS and BRAF Wild-type Colorectal Cancer Who Have Previously Received Chemotherapy

for Colorectal Neoplasms

Drug: Amivantamab

Sites in Iowa City, Waukee +66 more locations

Sponsor: Janssen Research & Development, LLC

Sex: All·Age: 18+

Code: NCT06750094·Phase 3·Recruiting·Listed Dec 2024

Apply to this trial

A Study to Test Whether Vicadrostat (BI 690517) in Combination With Empagliflozin Helps People With Heart Failure and a Weak Pumping Function of the Left Side of the Heart

for Heart Failure

Drug: Empagliflozin

Sites in West Des Moines +98 more locations

Sponsor: Boehringer Ingelheim

Sex: All·Age: 18+

Code: NCT06935370·Phase 3·Recruiting·Listed Apr 2025

Apply to this trial

An Induction Study to Investigate the Efficacy and Safety of Duvakitug in Participants With Moderately to Severely Active Ulcerative Colitis

for Ulcerative Colitis

Drug: Duvakitug

Sites in Waterloo +90 more locations

Sponsor: Sanofi

Sex: All·Age: 16 - 80

Code: NCT07184996·Phase 3·Recruiting·Listed Sep 2025

Apply to this trial

Phase IIIb Study of Ribociclib + ET in Early Breast Cancer

for Early Breast Cancer

Drug: Ribociclib

Sites in Waukee +84 more locations

Sponsor: Novartis Pharmaceuticals

Sex: All·Age: 18 - 100

Code: NCT05827081·Phase 3·Recruiting·Listed Apr 2023

Apply to this trial

A Master Protocol Study (LY900038) of Multiple Intervention-Specific-Appendices (ISAs) in Adult Participants With Obesity or Overweight

for Obesity

Sites in West Des Moines +42 more locations

Sponsor: Eli Lilly and Company

Sex: All·Age: 18 - 75

Code: NCT06143956·Phase 2·Recruiting·Listed Nov 2023

Apply to this trial

Long-term Safety Study of Rimegepant in Pediatric Subjects for the Acute Treatment of Migraine

for Acute Treatment of Migraine

Drug: Rimegepant

Sites in West Des Moines +63 more locations

Sponsor: Pfizer

Sex: All·Age: 6 - 17

Code: NCT04743141·Phase 3·Recruiting·Listed Feb 2021

Apply to this trial

A Clinical Study of Zilovertamab Vedotin (MK-2140) Plus Rituximab Plus Cyclophosphamide, Doxorubicin, and Prednisone (R-CHP) Versus Polatuzumab Vedotin Plus R-CHP in People With Diffuse Large B-cell Lymphoma (DLBCL) (MK-2140-011/waveLINE-011)

for Lymphoma, Large B-Cell, Diffuse

Drug: Polatuzumab Vedotin

Sites in Iowa City, Waukee +69 more locations

Sponsor: Merck Sharp & Dohme LLC

Sex: All·Age: 18+

Code: NCT06890884·Phase 2·Recruiting·Listed Mar 2025

Apply to this trial

Study to Assess the Injection Burden, Adverse Events, Change in Disease Activity, and Long-Term Preservation of Visual Acuity of Surabgene Lomparvovec in Adult Participants With Neovascular Age-Related Macular Degeneration (nAMD)

for Neovascular Age-related Macular Degeneration

Drug: Surabgene Lomparvovec

Sites in West Des Moines +50 more locations

Sponsor: AbbVie

Sex: All·Age: 50+

Code: NCT07007065·Phase 3·Recruiting·Listed Jun 2025

Apply to this trial

A Study of Amivantamab and mFOLFOX6 or FOLFIRI Versus Cetuximab and mFOLFOX6 or FOLFIRI as First-line Treatment in Participants With KRAS/NRAS and BRAF Wild-type Unresectable or Metastatic Left-sided Colorectal Cancer

for Colorectal Neoplasms

Drug: Amivantamab

Sites in Iowa City, Waukee +77 more locations

Sponsor: Janssen Research & Development, LLC

Sex: All·Age: 18+

Code: NCT06662786·Phase 3·Recruiting·Listed Oct 2024

Apply to this trial

A Study to Evaluate the Efficacy and Safety of Tulisokibart (MK-7240) in Participants With Moderate to Severe Crohn's Disease (MK-7240-008)

for Crohn's Disease

Drug: Tulisokibart

Sites in Clive +70 more locations

Sponsor: Merck Sharp & Dohme LLC

Sex: All·Age: 16 - 80

Code: NCT06430801·Phase 3·Recruiting·Listed May 2024

Apply to this trial

A Study to Evaluate Efficacy of Remibrutinib Compared to Dupilumab at Early Timepoints in Adults With Chronic Spontaneous Urticaria Inadequately Controlled by Second Generation H1-antihistamines

for Chronic Spontaneous Urticaria (CSU)

Drug: Remibrutinib

Sites in Ames +127 more locations

Sponsor: Novartis Pharmaceuticals

Sex: All·Age: 18+

Code: NCT06868212·Phase 3·Recruiting·Listed Mar 2025

Apply to this trial

A Study to Evaluate the Optimization of the Cytokine Release Syndrome Profile for Glofitamab in Combination With Gemcitabine Plus Oxaliplatin in Participants With Relapsed/Refractory Aggressive B-Cell Non-Hodgkin's Lymphoma

for B-Cell Non-Hodgkins Lymphoma

Drug: Glofitamab

Sites in Waukee +32 more locations

Sponsor: Hoffmann-La Roche

Sex: All·Age: 18+

Code: NCT06806033·Phase 2·Recruiting·Listed Feb 2025

Apply to this trial

Study of Subcutaneous Epcoritamab in Combination With Intravenous Rituximab and Oral Lenalidomide (R2) to Assess Adverse Events and Change in Disease Activity in Adult Participants With Previously Untreated Follicular Lymphoma

for Follicular Lymphoma (FL)

Drug: Epcoritamab

Sites in Des Moines +31 more locations

Sponsor: Genmab

Sex: All·Age: 18+

Code: NCT06191744·Phase 3·Recruiting·Listed Jan 2024

Apply to this trial

A Clinical Study of Calderasib (MK-1084) With Targeted Therapy and Chemotherapy in People With Colorectal Cancer (MK-1084-012/KANDLELIT-012)

for Colon Adenocarcinoma

Drug: Calderasib

Sites in Iowa City +31 more locations

Sponsor: Merck Sharp & Dohme LLC

Sex: All·Age: 18+

Code: NCT06997497·Phase 3·Recruiting·Listed May 2025

Apply to this trial

Studies to Assess Ziftomenib in Combination With Ven+Aza or 7+3 in Patients With Untreated NPM1-m or KMT2A-r AML

for Acute Myeloid Leukemia (AML)

Sites in Iowa City +41 more locations

Sponsor: Kura Oncology, Inc.

Sex: All·Age: 18+

Code: NCT07007312·Phase 3·Recruiting·Listed Jun 2025

Apply to this trial

A Randomized Comparison of Stage-Based Care Versus Risk Factor-Based Care for Prevention of Cardiovascular Events

for Diabetes Mellitus, Type 2

Sites in West Des Moines +122 more locations

Sponsor: Cleerly, Inc.

Sex: All·Age: 55+·Accepts healthy volunteers

Code: NCT06112418·Recruiting·Listed Nov 2023

Apply to this trial

A Study to Evaluate Efficacy and Safety of Giredestrant Compared With Fulvestrant (Plus a CDK4/6 Inhibitor), in Participants With ER-Positive, HER2-Negative Advanced Breast Cancer Resistant to Adjuvant Endocrine Therapy (pionERA Breast Cancer)

for Estrogen Receptor-Positive, HER2-Negative Advanced Breast Cancer

Drug: Giredestrant

Sites in Des Moines +53 more locations

Sponsor: Hoffmann-La Roche

Sex: All·Age: 18+

Code: NCT06065748·Phase 3·Recruiting·Listed Oct 2023

Apply to this trial

Study of Daraxonrasib (RMC-6236) in Patients With RAS Mutated NSCLC (RASolve 301)

for NSCLC (Non-small Cell Lung Cancer)

Drug: daraxonrasib

Sites in Iowa City, Waukee +41 more locations

Sponsor: Revolution Medicines, Inc.

Sex: All·Age: 18+

Code: NCT06881784·Phase 3·Recruiting·Listed Mar 2025

Apply to this trial

MILD® Percutaneous Image-Guided Lumbar Decompression: A Medicare Claims Study

for Lumbar Spinal Stenosis

Sites in Des Moines, West Des Moines +2341 more locations

Sponsor: Stryker Instruments

Sex: All·Age: 18+

Code: NCT03072927·Recruiting·Listed Mar 2017

Apply to this trial

Long-term Safety and Efficacy Extension Study for Participants With Advanced Tumors Who Are Currently on Treatment or in Follow-up in a Pembrolizumab (MK-3475) Study (MK-3475-587/KEYNOTE-587)

for Solid Tumors

Sites in Iowa City +42 more locations

Sponsor: Merck Sharp & Dohme LLC

Sex: All·Age: 18+

Code: NCT03486873·Phase 3·Recruiting·Listed Apr 2018

Apply to this trial

A Study of Nemtabrutinib (MK-1026) Versus Comparator (Investigator's Choice of Ibrutinib or Acalabrutinib) in First Line (1L) Chronic Lymphocytic Leukemia (CLL)/ Small Lymphocytic Lymphoma (SLL) (MK-1026-011/BELLWAVE-011)

for Chronic Lymphocytic Leukemia

Drug: Nemtabrutinib

Sites in Iowa City, Waukee +41 more locations

Sponsor: Merck Sharp & Dohme LLC

Sex: All·Age: 18+

Code: NCT06136559·Phase 3·Recruiting·Listed Nov 2023

Apply to this trial

A Study of INCB123667 in Participants With Platinum-Resistant Ovarian Cancer With Cyclin E1 Overexpression

for Ovarian Cancer

Drug: INCB123667

Sites in Iowa City +37 more locations

Sponsor: Incyte Corporation

Sex: Female·Age: 18 - 99

Code: NCT07023627·Phase 2·Recruiting·Listed Jun 2025

Apply to this trial

A Phase 3 Study of Revaccination in Subsequent Pregnancies With Bivalent RSV Vaccine and Duration of Protection of a Single Dose

for RSV Infection

Sites in Ames +80 more locations

Sponsor: Pfizer

Sex: All·Age: 0+·Accepts healthy volunteers

Code: NCT06866405·Phase 3·Recruiting·Listed Mar 2025

Apply to this trial

Assessment of CCM in HF With Higher Ejection Fraction

for Heart Failure

Sites in Iowa City, West Des Moines +74 more locations

Sponsor: Impulse Dynamics

Sex: All·Age: 18+

Code: NCT05064709·Recruiting·Listed Oct 2021

Apply to this trial

A Study to Test Whether Vicadrostat in Combination With Empagliflozin Helps People With Heart Failure

for Heart Failure

Drug: Empagliflozin

Sites in West Des Moines +94 more locations

Sponsor: Boehringer Ingelheim

Sex: All·Age: 18+

Code: NCT06424288·Phase 3·Recruiting·Listed May 2024

Apply to this trial

A Study of Adagrasib Plus Pembrolizumab Plus Chemotherapy vs. Placebo Plus Pembrolizumab Plus Chemotherapy in Participants With Previously Untreated Non-squamous Non-small Cell Lung Cancer With KRAS G12C Mutation (KRYSTAL-4)

for Carcinoma, Non-Small-Cell Lung

Drug: Adagrasib

Sites in Cedar Rapids +49 more locations

Sponsor: Mirati Therapeutics Inc.

Sex: All·Age: 18+

Code: NCT06875310·Phase 3·Recruiting·Listed Mar 2025

Apply to this trial

Phase 2a Study of VX-407 in Participants With ADPKD Who Have a Subset of PKD1 Gene Variants (AGLOW)

for Autosomal Dominant Polycystic Kidney Disease (ADPKD)

Sites in Iowa City +25 more locations

Sponsor: Vertex Pharmaceuticals Incorporated

Sex: All·Age: 18 - 65

Code: NCT07161037·Phase 2·Recruiting·Listed Sep 2025

Apply to this trial

Study of Opevesostat (MK-5684) Versus Alternative NHA in mCRPC (MK-5684-003)

for Prostate Cancer Metastatic

Sites in Iowa City +30 more locations

Sponsor: Merck Sharp & Dohme LLC

Sex: All·Age: 18+

Code: NCT06136624·Phase 3·Recruiting·Listed Nov 2023

Apply to this trial

Seladelpar in Subjects With Primary Biliary Cholangitis (PBC) and Compensated Cirrhosis

for Primary Biliary Cholangitis

Sites in Iowa City +50 more locations

Sponsor: Gilead Sciences

Sex: All·Age: 18+

Code: NCT06051617·Phase 3·Recruiting·Listed Sep 2023

Apply to this trial

A Study to Investigate Progression-Free Survival With Sonrotoclax Plus Obinutuzumab Or Sonrotoclax Plus Rituximab Compared With Venetoclax Plus Rituximab Treatment In Patients With Relapsed and/or Refractory Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma (CELESTIAL-RRCLL)

for Chronic Lymphocytic Leukemia

Drug: Sonrotoclax

Sites in Iowa City, Waukee +36 more locations

Sponsor: BeOne Medicines

Sex: All·Age: 18+

Code: NCT06943872·Phase 3·Recruiting·Listed Apr 2025

Apply to this trial

A Study to Customize Ibrutinib Treatment Regimens for Participants With Previously Untreated Chronic Lymphocytic Leukemia

for Leukemia, Lymphocytic, Chronic, B-Cell

Drug: Ibrutinib

Sites in Iowa City +27 more locations

Sponsor: Janssen Research & Development, LLC

Sex: All·Age: 18+

Code: NCT05963074·Phase 2·Recruiting·Listed Jul 2023

Apply to this trial

A Study to Investigate the Efficacy and Safety of Sonrotoclax Plus Zanubrutinib Compared With Placebo Plus Zanubrutinib in Adults With Relapsed/Refractory Mantle Cell Lymphoma (CELESTIAL-RRMCL)

for Mantle Cell Lymphoma

Drug: Sonrotoclax

Sites in Waukee +40 more locations

Sponsor: BeOne Medicines

Sex: All·Age: 18+

Code: NCT06742996·Phase 3·Recruiting·Listed Dec 2024

Apply to this trial

A Study Evaluating the Efficacy and Safety of Divarasib and Pembrolizumab Versus Pembrolizumab and Pemetrexed and Carboplatin or Cisplatin in Participants With Previously Untreated, KRAS G12C-Mutated, Advanced or Metastatic Non-Squamous Non-Small Cell Lung Cancer

for Non-Small Cell Lung Cancer

Drug: Divarasib

Sites in Iowa City, Des Moines +48 more locations

Sponsor: Hoffmann-La Roche

Sex: All·Age: 18+

Code: NCT06793215·Phase 3·Recruiting·Listed Jan 2025

Apply to this trial

Beamion BCGC-1: A Study to Find a Suitable Dose of Zongertinib Used Alone and in Combination With Other Treatments to Test Whether it Helps People With Different Types of HER2+ Cancer That Has Spread

for Metastatic Breast Cancer

Drug: Zongertinib

Sites in Iowa City +25 more locations

Sponsor: Boehringer Ingelheim

Sex: All·Age: 18+

Code: NCT06324357·Phase 1, Phase 2·Recruiting·Listed Mar 2024

Apply to this trial

A Study of Intismeran Autogene (V940) Plus Pembrolizumab (MK-3475) Versus Placebo Plus Pembrolizumab in Participants With Non-small Cell Lung Cancer (V940-002)

for Non-small Cell Lung Cancer

Drug: Intismeran autogene

Sites in Iowa City +57 more locations

Sponsor: Merck Sharp & Dohme LLC

Sex: All·Age: 18+

Code: NCT06077760·Phase 3·Recruiting·Listed Oct 2023

Apply to this trial

A Study to Learn How Avacincaptad Pegol (Izervay™) is Used in Clinical Practice in People Who Have Geographic Atrophy

for Geographic Atrophy

Sites in West Des Moines +52 more locations

Sponsor: Astellas Pharma Global Development, Inc.

Sex: All·Age: All ages

Code: NCT06779773·Recruiting·Listed Jan 2025

Apply to this trial

A Study to Evaluate Avacopan in Participants With ANCA-associated Vasculitis

for Antineutrophil Cytoplasmic Antibody-associated Vasculitis

Drug: Avacopan

Sites in Iowa City, Sioux City +56 more locations

Sponsor: Amgen

Sex: All·Age: 18 - 100

Code: NCT06072482·Phase 4·Recruiting·Listed Oct 2023

Apply to this trial

VO and Nivolumab vs Physician's Choice in Advanced Melanoma That Progressed on Anti-PD-1 & Anti-CTLA-4 Drugs [IGNYTE-3]

for Advanced Melanoma

Drug: Nivolumab

Sites in Iowa City +43 more locations

Sponsor: Replimune, Inc.

Sex: All·Age: 12+

Code: NCT06264180·Phase 3·Recruiting·Listed Feb 2024

Apply to this trial

Trial of Nadofaragene Firadenovec vs. Observation in Participants With Intermediate Risk Non-Muscle Invasive Bladder Cancer

for Intermediate Risk Non-Muscle Invasive Bladder Cancer

Drug: Nadofaragene Firadenovec

Sites in Clive +48 more locations

Sponsor: Ferring Pharmaceuticals

Sex: All·Age: 18+

Code: NCT06510374·Phase 3·Recruiting·Listed Jul 2024

Apply to this trial