Paid Clinical Trials in Illinois

Illinois has 2,968 paid clinical trials enrolling now across cities including Chicago, Peoria and Springfield. Search by condition, age, or phase to find compensated research studies accepting participants near you.

Research sites in Illinois include Northwestern Medicine, University of Chicago Medicine and Rush, running studies across oncology, cardiology, neurology, and more. Both patients and healthy volunteers may qualify. Most studies offer compensation for time and travel.

Recruiting trial data synced daily from ClinicalTrials.gov. Last sync: June 18, 2026.

Filter results

Filter results

State

City

Phase

Study type

Intervention

Recruitment status

Condition

Sex

Age

Healthy volunteers only

2,968 clinical trials

↓ Download CSV

Horizon 360 Protocol for the Treatment of Paroxysmal Atrial Fibrillation With the Sphere-360™ Catheter and Affera™ Mapping and Ablation System (Horizon 360)

for Paroxysmal AF

22 locations incl. Jonesboro

Sponsor: Medtronic Cardiac Ablation Solutions

Sex: All·Age: 18 - 80

Code: NCT07308847·Recruiting

Apply to this trial

A Study to Evaluate the Efficacy and Safety of JNJ-88545223 for the Treatment of Participants With Active Psoriatic Arthritis

for Arthritis, Psoriatic

16 locations incl. Searcy

Sponsor: Janssen Research & Development, LLC

Sex: All·Age: 18+

Code: NCT07321873·Phase 2·Recruiting

Apply to this trial

Sleep, Dreaming, and Virtual Reality for Mental Health

for Anxiety

2 locations incl. Evanston

Sponsor: Northwestern University

Sex: All·Age: 18+·Accepts healthy volunteers

Code: NCT07408206·EARLY_Phase 1·Recruiting

Apply to this trial

Comparing the Efficacy and Safety of Holmium Laser Lithotripsy Versus Electrohydraulic Lithotripsy for the Treatment of Difficult Choledocholithiasis and Pancreatic Duct Stones

for Choledocholithiasis

1 location in Chicago

Sponsor: Rush University Medical Center

Sex: All·Age: 19 - 85

Code: NCT07418112·Phase 4·Recruiting

Apply to this trial

Non-inferiority Study of Frexalimab Subcutaneous Administration Compared to Intravenous Administration in Adult Participants With Multiple Sclerosis

for Multiple Sclerosis

Drug: Frexalimab

21 locations incl. Cullman

Sponsor: Sanofi

Sex: All·Age: 18 - 60

Code: NCT07325292·Phase 3·Recruiting

Apply to this trial

Delivering Patient-Facing Evidence-Based Guidelines Through mHealth to Adults With Sickle Cell Disease

for Sickle Cell Disease

4 locations incl. Chicago

Sponsor: Ohio State University

Sex: All·Age: 18+

Code: NCT06919224·Recruiting

Apply to this trial

Thera-Clean® Microbubbles System in Patients With Skin Diseases

for Epidermolysis Bullosa

1 location in Chicago

Sponsor: Northwestern University

Sex: All·Age: 2+

Code: NCT07050810·EARLY_Phase 1·Enrolling By Invitation

A Study to Evaluate the Efficacy and Safety of Veverimer for the Treatment of Metabolic Acidosis

for CKD

19 locations incl. Chula Vista

Sponsor: Renibus Therapeutics, Inc.

Sex: All·Age: 18+

Code: NCT07355062·Phase 3·Recruiting

Apply to this trial

A 26-Wk Study to Assess Safety & Efficacy of Tenapanor for T/t of Chronic Idiopathic Constipation in Adults

for Chronic Idiopathic Constipation (CIC)

Drug: Tenapanor

109 locations incl. Foley

Sponsor: Ardelyx

Sex: All·Age: 18 - 80

Code: NCT07382167·Phase 3·Recruiting

Apply to this trial

Moon and Sun Brothers: A Community Prevention Intervention (Hermanos de Luna y Sol)

for Help-Seeking Behavior

2 locations incl. San Francisco

Sponsor: San Francisco State University

Sex: All·Age: 18+·Accepts healthy volunteers

Code: NCT07475702·Recruiting

Apply to this trial

Family Navigator Plus for Foster Parents

for Intervention

1 location in Chicago

Sponsor: Northwestern University

Sex: All·Age: 18+·Accepts healthy volunteers

Code: NCT06978959·Recruiting

Apply to this trial

A Study to Investigate Ronde-cel Versus Investigator's Choice CD19 CAR T-Cell Therapy

for Large B-cell Lymphoma

38 locations incl. Gilbert

Sponsor: Lyell Immunopharma, Inc.

Sex: All·Age: 18+

Code: NCT07188558·Phase 3·Recruiting

Apply to this trial

PATH (Peer Advanced Training in Harm Reduction) to Reducing Burnout Among Peers Who Deliver Harm Reduction Services (R61 Phase Pilot)

for Burnout

1 location in Chicago

Sponsor: Chestnut Health Systems

Sex: All·Age: 18+·Accepts healthy volunteers

Code: NCT07218562·Phase 2·Enrolling By Invitation

Efficacy and Safety of KAI-9531 Administered Once Weekly in Participants Living With Obesity or Overweight and Diabetes

for Obesity With Diabetes

34 locations incl. Cullman

Sponsor: Kailera

Sex: All·Age: 18+

Code: NCT07284901·Phase 3·Recruiting

Apply to this trial

Carotid Implants for PreveNtion of STrokE ReCurrEnce From Large Vessel Occlusion in Atrial Fibrillation Patients Treated With Oral Anticoagulation

for Atrial Fibrillation

5 locations incl. Rockford

Sponsor: Javelin Medical

Sex: All·Age: 18+

Code: NCT05723926·Recruiting

Apply to this trial

Assessing Post-operative Outcomes After Children's Sistrunk Procedure With or Without a Drain

for Thyroglossal Duct Cysts

5 locations incl. Los Angeles

Sponsor: University of Rochester

Sex: All·Age: 3 - 17

Code: NCT07148895·Enrolling By Invitation

Study of AZD3632 Monotherapy or in Combination With Anticancer Agents in Participants With Advanced Haematologic Malignancies With KMT2Ar, NPM1m, or Other Genotypes Associated With HOX Overexpression

for Acute Lymphoblastic Leukaemia

6 locations incl. Decatur

Sponsor: AstraZeneca

Sex: All·Age: 16+

Code: NCT07155226·Phase 1, Phase 2·Recruiting

Apply to this trial

Study to Assess the Effects of Angiopoietin-like Protein 3 (ANGPTL3) Inhibition in Adult Participants With Diabetic Kidney Disease

for Diabetic Kidney Disease (DKD)

51 locations incl. Huntsville

Sponsor: Regeneron Pharmaceuticals

Sex: All·Age: 18 - 80

Code: NCT07271186·Phase 2·Recruiting

Apply to this trial

A Study of AZD0120 in Autoimmune Diseases

for Systemic Sclerosis

8 locations incl. Tucson

Sponsor: AstraZeneca

Sex: All·Age: 18 - 75

Code: NCT07295847·Phase 1·Recruiting

Apply to this trial

Clinical Outcome Assessment for AT & BCI

for Spinal Cord Injury

1 location in Chicago

Sponsor: Shirley Ryan AbilityLab

Sex: All·Age: 18+·Accepts healthy volunteers

Code: NCT07407725·Recruiting

Apply to this trial

An External Control Arm Study in Non-Small Cell Lung Cancer

for Non Small Cell Lung Cancer

8 locations incl. Monterey

Sponsor: N-Power Medicine

Sex: All·Age: 18+

Code: NCT07174388·Recruiting

Apply to this trial

A Novel mHealth Intervention to Improve Outcomes of Children With Medical Complexity

for Children With Medical Complexity

2 locations incl. Chicago

Sponsor: University of Utah

Sex: All·Age: 1 - 18

Code: NCT06883045·Recruiting

Apply to this trial

Symbiotic-Lung-01 : A Study to Learn About the Study Medicine Called PF-08634404 in Combination With Chemotherapy in Adult Participants With Locally Advanced or Metastatic Non-Small Cell Lung Cancer

for Advanced Non-Small Cell Lung Cancer

Drug: PF-08634404

184 locations incl. Bullhead City

Sponsor: Pfizer

Sex: All·Age: 18+

Code: NCT07222566·Phase 3·Recruiting

Apply to this trial

Study of Allo-QuadCAR01-T, an Allogeneic CAR-T Targeting CD19/CD20, in Patients With Relapsed or Refractory B-Cell Malignancies

for Lymphoma Diffuse Large B-cell

5 locations incl. Chicago

Sponsor: AvenCell Therapeutics, Inc.

Sex: All·Age: 18+

Code: NCT07284433·Phase 1, Phase 2·Recruiting

Apply to this trial

Safety and Pharmacokinetics Study of PGT121.414.LS Alone and in Combination With VRC07-523LS in Infants Exposed to HIV-1

for HIV-1

11 locations incl. Los Angeles

Sponsor: National Institute of Allergy and Infectious Diseases (NIAID)

Sex: All·Age: Up to 72 Hours·Accepts healthy volunteers

Code: NCT06517693·Phase 1·Recruiting

Apply to this trial

A Phase 2 Study of Zelquistinel or Placebo for the Reduction of Symptoms of Major Depressive Disorder

for Major Depressive Disorder

32 locations incl. Phoenix

Sponsor: Syndeio Biosciences, Inc

Sex: All·Age: 18 - 64

Code: NCT07115329·Phase 2·Recruiting

Apply to this trial

Comparative Efficacy of Nipocalimab and Efgartigimod in Participants With Generalized Myasthenia Gravis

for Myasthenia Gravis

Drug: Nipocalimab

11 locations incl. Fullerton

Sponsor: Janssen Research & Development, LLC

Sex: All·Age: 18 - 74

Code: NCT07217587·Phase 3·Recruiting

Apply to this trial

A Multi-Site Feasibility Trial of Embedded Emergency Department Physical Therapy

for Low Back Pain

2 locations incl. Chicago

Sponsor: Northwestern University

Sex: All·Age: 18+

Code: NCT07224945·Recruiting

Apply to this trial

A Study to Compare the Combination of Navlimetostat (BMS-986504) With Pembrolizumab and Chemotherapy Versus Placebo Plus Pembrolizumab and Chemotherapy in First-line Metastatic Non-small Cell Lung Cancer Participants With Homozygous MTAP Deletion

for Metastatic Non-small Cell Lung Cancer With MTAP Deletion

Drug: Navlimetostat

42 locations incl. Anchorage

Sponsor: Bristol-Myers Squibb

Sex: All·Age: 18+

Code: NCT07063745·Phase 2, Phase 3·Recruiting

Apply to this trial

Short-Term Health Outcomes of Cooking UFP Exposure

for Cognitive Function Decline

1 location in Chicago

Sponsor: University of Illinois at Chicago

Sex: All·Age: 18+·Accepts healthy volunteers

Code: NCT07311967·Not Yet Recruiting

Neuromusculoskeletal Interface for Bionic Arms

for Amputation

1 location in Chicago

Sponsor: Shirley Ryan AbilityLab

Sex: All·Age: 18 - 70

Code: NCT07032753·Not Yet Recruiting

Supraglottic Airway for Resuscitation Trial

for Neonatal Resuscitation

30 locations incl. Birmingham

Sponsor: Children's Hospital of Philadelphia

Sex: All·Age: 0 Days+

Code: NCT07150923·Recruiting

Apply to this trial

Assessment of a Method to Improve Cochlear Implant Users' Speech Perception in Noisy Environments While Maintaining Their Ability to Determine Where a Sound Originates From

for Cochlear Implant Users

1 location in Champaign

Sponsor: University of Illinois at Urbana-Champaign

Sex: All·Age: 18+

Code: NCT07323862·Not Yet Recruiting

Arm and Leg Cycling for Accelerated SCI Recovery

for Spinal Cord Injury

1 location in Chicago

Sponsor: Shirley Ryan AbilityLab

Sex: All·Age: 18 - 75

Code: NCT06873776·Enrolling By Invitation

Caring Contacts Via Text Message for Suicidal Adolescents After Emergency Department Discharge

for Suicide Prevention

1 location in Chicago

Sponsor: Ann & Robert H Lurie Children's Hospital of Chicago

Sex: All·Age: 12 - 17

Code: NCT07043764·Not Yet Recruiting

A Sequential Phase 2/3 Study of APL2 in Patients With Focal Segmental Glomerulosclerosis

for FSGS

2 locations incl. Chicago

Sponsor: Apellis Pharmaceuticals, Inc.

Sex: All·Age: 18+

Code: NCT07213960·Phase 2, Phase 3·Not Yet Recruiting

A Study to Evaluate the Safety and Efficacy of Pumitamig in Combination With Chemotherapy Versus Bevacizumab in Combination With Chemotherapy in Participants With Previously Untreated, Unresectable, or Metastatic Colorectal Cancer

for Untreated, Unresectable, or Metastatic Colorectal Cancer

Drug: Bevacizumab

49 locations incl. Tucson

Sponsor: Bristol-Myers Squibb

Sex: All·Age: 18+

Code: NCT07221357·Phase 2, Phase 3·Recruiting

Apply to this trial

Clinical Utility of an Amniotic Membrane Allograft for Diabetic Foot Ulcer Wound Management

for Diabetic Foot Ulcer

8 locations incl. Palm Springs

Sponsor: Legacy Medical Consultants

Sex: All·Age: 50 - 85

Code: NCT06420245·Recruiting

Apply to this trial

Hyperangulated Versus Standard Geometry Laryngoscope Blade Trial

for Acute Respiratory Failure

16 locations incl. Los Angeles

Sponsor: Vanderbilt University Medical Center

Sex: All·Age: 18+

Code: NCT07223762·Enrolling By Invitation

Efficacy and Safety of KAI-9531 Administered Once Weekly Compared With Semaglutide and Placebo in Participants Living With Obesity Who Do Not Have Diabetes

for Obesity

Drug: Semaglutide

26 locations incl. Glendale

Sponsor: Kailera

Sex: All·Age: 18+

Code: NCT07284979·Phase 3·Recruiting

Apply to this trial