Paid Clinical Trials in Illinois

Illinois has 2,847 paid clinical trials enrolling now across cities including Chicago, Peoria and Evanston. Search by condition, age, or phase to find compensated research studies accepting participants near you.

Research sites in Illinois include Northwestern Medicine, University of Chicago Medicine and Rush, running studies across oncology, cardiology, neurology, and more. Both patients and healthy volunteers may qualify. Most studies offer compensation for time and travel.

Recruiting trial data synced daily from ClinicalTrials.gov. Last sync: September 14, 2026.

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2,519 clinical trials

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Efficacy and Safety Study of Halneuron in the Treatment of Chemotherapy-Induced Neuropathic Pain

for Chemotherapy Induced Neuropathic Pain

Sites in Gurnee +24 more locations

Sponsor: Dogwood Therapeutics Inc.

Sex: All·Age: 18+

Code: NCT06848348·Phase 2·Recruiting·Listed Feb 2025

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CA-4948-101: Open-Label, Dose Escalation and Expansion Trial of Emavusertib (CA-4948) in Relapsed or Refractory Primary Central Nervous System Lymphoma (R/R PCNSL)

for Relapsed Hematologic Malignancy

Drug: Emavusertib

Sites in Chicago +17 more locations

Sponsor: Curis, Inc.

Sex: All·Age: 18+

Code: NCT03328078·Phase 1, Phase 2·Recruiting·Listed Nov 2017

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Prospective Study to Assess a Diagnostic Aid for Cancer

for Cancer

Sites in Hinsdale, Champaign +33 more locations

Sponsor: Harbinger Health

Sex: All·Age: 45+

Code: NCT07046260·Recruiting·Listed Jul 2025

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Fontan Udenafil Exercise Longitudinal Assessment Trial - 2

for Single Ventricle Heart Disease

Sites in Chicago +36 more locations

Sponsor: Mezzion Pharma Co. Ltd

Sex: All·Age: 12 - 18

Code: NCT05918211·Phase 3·Recruiting·Listed Jun 2023

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NEXUS Aortic Arch Clinical Study to Evaluate Safety and Effectiveness

for Aortic Dissection

Sites in Chicago +23 more locations

Sponsor: Endospan Ltd.

Sex: All·Age: 18+

Code: NCT04471909·Recruiting·Listed Jul 2020

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Assessment of the Safety and Efficacy of 0.1% RGN-259 Ophthalmic Solution for the Treatment of NK: SEER-2

for Neurotrophic Keratopathy

Sites in Chicago +23 more locations

Sponsor: ReGenTree, LLC

Sex: All·Age: 18+

Code: NCT05555589·Phase 3·Recruiting·Listed Sep 2022

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Efficacy of Fusidic Acid 1% in the Treatment of Bacterial Conjunctivitis

for Bacterial Conjunctivitis

Sites in Orland Park +20 more locations

Sponsor: Baxis Pharmaceuticals, Inc.

Sex: All·Age: All ages

Code: NCT06911424·Phase 3·Recruiting·Listed Apr 2025

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EPIC-Peds: A Study to Learn About the Study Medicine Called PF-07321332 (Nirmatrelvir)/Ritonavir in Patients Under 18 Years of Age With COVID-19 That Are Not Hospitalized But Are at Risk for Severe Disease

for COVID-19

Sites in Chicago +23 more locations

Sponsor: Pfizer

Sex: All·Age: 0 - 17

Code: NCT05261139·Phase 3·Recruiting·Listed Mar 2022

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A Study of CREXONT (Carbidopa and Levodopa) Extended-Release Capsules in Participants With Parkinson's Disease

for Parkinson Disease

Sites in Winfield +26 more locations

Sponsor: Impax Laboratories, LLC

Sex: All·Age: 18+

Code: NCT06765668·Phase 4·Recruiting·Listed Jan 2025

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Clinical Validation of Freenome Multiomics Blood Test for Lung Cancer Screening

for Lung Cancer Diagnosis

Sites in Chicago, Springfield +34 more locations

Sponsor: Freenome Holdings Inc.

Sex: All·Age: 50+

Code: NCT06122077·Recruiting·Listed Nov 2023

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To Evaluate the Safety and Efficacy of MANP in Subjects With Difficult to Control/ Resistant Hypertension

for Difficult to Control Hypertension

Sites in Chicago +25 more locations

Sponsor: E-Star BioTech, LLC

Sex: All·Age: 18 - 80

Code: NCT06343298·Phase 2·Recruiting·Listed Apr 2024

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AN INTERNATIONAL, OBSERVATIONAL, BLINDED STUDY TO ASSESS THE PERFORMANCE OF THE CORDIO HEARO SYSTEM

for Heart Failure

Sites in Chicago, Naperville +35 more locations

Sponsor: Cordio Medical

Sex: All·Age: 22+

Code: NCT06378632·Recruiting·Listed Apr 2024

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C-Brace Prospective Registry

for Pareses

Sites in Fairview Heights +36 more locations

Sponsor: Otto Bock Healthcare Products GmbH

Sex: All·Age: All ages

Code: NCT04640584·Recruiting·Listed Nov 2020

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A Study of T-Cell Receptor Engineered Donor T Cells in Subjects Undergoing Allogeneic Peripheral Blood Stem Cell Transplantation

for AML

Sites in Chicago +25 more locations

Sponsor: TScan Therapeutics, Inc.

Sex: All·Age: 18+

Code: NCT07702578·Phase 3·Recruiting·Listed Jul 2026

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A Phase 3 Efficacy and Safety Study of HBS-301 in Participants With Narcolepsy

for EDS

Sites in Peoria, Glenview +49 more locations

Sponsor: Harmony Biosciences Management, Inc.

Sex: All·Age: 18+

Code: NCT07675135·Phase 3·Recruiting·Listed Jun 2026

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Trial Comparing the Safety and Efficacy of Two Different Oral VPV Doses With Placebo as Treatment for RV in Participants With COPD

for Rhinovirus Infection

Sites in Naperville +33 more locations

Sponsor: Altesa Biosciences, Inc.

Sex: All·Age: 40 - 85

Code: NCT07610395·Phase 2·Recruiting·Listed May 2026

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A Study to Assess Adverse Events, How the Drug Moves Through the Body and Effectiveness of Intravenous Infusions and Subcutaneous Injections of ABBV-519 in Adult Participants With Systemic Lupus Erythematosus (SLE) or Rheumatoid Arthritis (RA)

for Systemic Lupus Erythematosus

Sites in Orland Park +8 more locations

Sponsor: AbbVie

Sex: All·Age: 18 - 75

Code: NCT07607964·Phase 1·Recruiting·Listed May 2026

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A Study to Learn About the Study Medicine Called Berobenatide (PF-08653944) in People With Overweight or Obesity

for Obesity

Sites in Chicago, Evanston +32 more locations

Sponsor: Pfizer

Sex: All·Age: 18+

Code: NCT07595549·Phase 3·Recruiting·Listed May 2026

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A Research Study Comparing Different Ways of Increasing the Dose of NNC0662-0419 in Participants With Obesity

for Obesity

Drug: NNC0662-0419

Sites in Chicago +23 more locations

Sponsor: Novo Nordisk A/S

Sex: All·Age: 18+

Code: NCT07639021·Phase 2·Recruiting·Listed Jun 2026

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Atebimetinib + GnP as a First Line Treatment in Patients With Metastatic Pancreatic Adenocarcinoma

for Pancreatic Cancer

Drug: Atebimetinib

Sites in Chicago, Peoria +37 more locations

Sponsor: Immuneering Corporation

Sex: All·Age: 18+

Code: NCT07562152·Phase 3·Recruiting·Listed May 2026

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Enfortumab Vedotin in Combination With Pembrolizumab vs. Concurrent Chemoradiotherapy (cCRT) in People With Muscle Invasive Bladder Cancer (EV-309)

for Urothelial Cancer

Sites in Niles +12 more locations

Sponsor: Astellas Pharma Global Development, Inc.

Sex: All·Age: 18+

Code: NCT07566156·Phase 3·Recruiting·Listed May 2026

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Surabgene Lomparvovec Administered in the Suprachoroidal Space in Adult Participants With Diabetic Retinopathy Without Center-Involved Diabetic Macular Edema

for Diabetic Retinopathy

Drug: Surabgene Lomparvovec

Sites in Chicago, Springfield +28 more locations

Sponsor: AbbVie

Sex: All·Age: 18+

Code: NCT07592273·Phase 2, Phase 3·Recruiting·Listed May 2026

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A Study of Seltorexant as Monotherapy in Adults and Elderly Participants With Major Depressive Disorder

for Depressive Disorder, Major

Drug: Seltorexant

Sites in Chicago +30 more locations

Sponsor: Janssen Research & Development, LLC

Sex: All·Age: 18 - 74

Code: NCT07573176·Phase 3·Recruiting·Listed May 2026

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AMAZE 3: A Research Study Investigating How Well the Medicine NNC0487-0111 Helps People With Excess Body Weight and Obstructive Sleep Apnoea Not Treated With Positive Airway Pressure Lose Weight and Improve Sleep Apnoea

for Obesity

Drug: NNC0487-0111

Sites in Chicago +16 more locations

Sponsor: Novo Nordisk A/S

Sex: All·Age: 18+

Code: NCT07571005·Phase 3·Recruiting·Listed May 2026

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AMAZE 4: A Research Study Investigating How Well the Medicine NNC0487-0111 Helps People With Excess Body Weight and Obstructive Sleep Apnoea Treated With Positive Airway Pressure Lose Weight and Improve Sleep Apnoea

for Obesity

Drug: NNC0487-0111

Sites in Chicago +19 more locations

Sponsor: Novo Nordisk A/S

Sex: All·Age: 18+

Code: NCT07571109·Phase 3·Recruiting·Listed May 2026

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Efficacy of the Omnipod® 6 System Compared With the Omnipod® 5 System

for Type 2 Diabetes Mellitus

Sites in Chicago +10 more locations

Sponsor: Insulet Corporation

Sex: All·Age: 14 - 75

Code: NCT07579702·Recruiting·Listed May 2026

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A Study of Brenipatide (LY3537031) in Participants With Irritable Bowel Syndrome-Constipation (IBS-C)

for Irritable Bowel Syndrome

Drug: Brenipatide

Sites in Springfield +13 more locations

Sponsor: Eli Lilly and Company

Sex: All·Age: 18 - 75

Code: NCT07545772·Phase 2·Recruiting·Listed Apr 2026

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A Study to Learn About the Safety of an Expanded Pneumococcal Vaccine in Healthy Infants

for Pneumococcal Disease

Sites in Chicago +20 more locations

Sponsor: Pfizer

Sex: All·Age: 42 Days - 98 Days·Accepts healthy volunteers

Code: NCT07573462·Phase 3·Recruiting·Listed May 2026

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A Study of Brenipatide (LY3537031) in Participants With Irritable Bowel Syndrome-Diarrhea (IBS-D)

for Irritable Bowel Syndrome

Drug: Brenipatide

Sites in Springfield +14 more locations

Sponsor: Eli Lilly and Company

Sex: All·Age: 18 - 75

Code: NCT07545759·Phase 2·Recruiting·Listed Apr 2026

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A Phase 2 Trial of Dotinurad in Xanthine Oxidase Inhibitor (XOI) Intolerant/Uricase Failure Gout Participants

for Gout

Drug: Dotinurad

Sites in Chicago +37 more locations

Sponsor: Crystalys Therapeutics

Sex: All·Age: 18 - 75

Code: NCT07535034·Phase 2·Recruiting·Listed Apr 2026

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A Study Comparing JNJ-79635322 and Teclistamab in Participants With Relapsed or Refractory Multiple Myeloma

for Multiple Myeloma

Drug: Teclistamab

Sites in Chicago +34 more locations

Sponsor: Janssen Research & Development, LLC

Sex: All·Age: 18+

Code: NCT07518186·Phase 3·Recruiting·Listed Apr 2026

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A Study of VARIPULSE Pulsed Field Ablation (PFA) Catheter and FARAWAVE PFA Catheter in the Treatment of Participants With Persistent Atrial Fibrillation

for Atrial Fibrillation

Sites in Glenview, Oak Lawn +28 more locations

Sponsor: Biosense Webster, Inc.

Sex: All·Age: 18 - 80

Code: NCT07523750·Recruiting·Listed Apr 2026

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Evaluation of the Fully Closed Loop Omnipod® System in Type 2 Diabetes

for Type 2 Diabetes Mellitus

Sites in Chicago +25 more locations

Sponsor: Insulet Corporation

Sex: All·Age: 18 - 75

Code: NCT07521475·Recruiting·Listed Apr 2026

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AMAZE 6: A Research Study Investigating How Well the Medicine NNC0487-0111 Helps People With Excess Body Weight and Knee Osteoarthritis Lose Weight and Reduce Pain

for Obesity

Drug: NNC0487-0111

Sites in Skokie, Gurnee +17 more locations

Sponsor: Novo Nordisk A/S

Sex: All·Age: 18+

Code: NCT07509307·Phase 3·Recruiting·Listed Apr 2026

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A Master Protocol (IIBD): A Study of Multiple Drugs in Adults With Ulcerative Colitis or Crohn's Disease

for Colitis, Ulcerative

Sites in Chicago +12 more locations

Sponsor: Eli Lilly and Company

Sex: All·Age: 18 - 80

Code: NCT07483073·Phase 2·Recruiting·Listed Mar 2026

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A Study of LY4395089 and Mirikizumab (LY3074828) Given Together and Mirikizumab (Alone) in Adults With Crohn's Disease

for Crohn Disease

Drug: LY4395089

Sites in Chicago +12 more locations

Sponsor: Eli Lilly and Company

Sex: All·Age: 18 - 80

Code: NCT07483099·Phase 2·Recruiting·Listed Mar 2026

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BGB-43395 Plus Letrozole Versus CDK4/6i Plus Letrozole for Patients With Advanced or Metastatic HR+/HER2- Breast Cancer Who Have Not Received Prior Treatment for Advanced or Metastatic Disease

for HR+/HER2- Breast Cancer

Sites in Hinsdale, OFallon +34 more locations

Sponsor: BeOne Medicines

Sex: All·Age: 18+

Code: NCT07492641·Phase 3·Recruiting·Listed Mar 2026

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RE104 Safety and Efficacy Study in Generalized Anxiety Disorder

for Generalized Anxiety Disorder

Sites in Chicago +27 more locations

Sponsor: Reunion Neuroscience Inc

Sex: All·Age: 18 - 74

Code: NCT07489651·Phase 2·Recruiting·Listed Mar 2026

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A Phase 2 Study to Evaluate Povetacicept in Adults With Generalized Myasthenia Gravis

for Myasthenia Gravis, Generalized

Sites in O'Fallon +14 more locations

Sponsor: Vertex Pharmaceuticals Incorporated

Sex: All·Age: 18+

Code: NCT07501702·Phase 2·Recruiting·Listed Mar 2026

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A Study of MUC16-Directed Antibody Drug Conjugate HWK-016 in Participants With Advanced Solid Tumors.

for PROC

Sites in Peoria +11 more locations

Sponsor: Whitehawk Therapeutics, Inc.

Sex: All·Age: 18+

Code: NCT07470853·Phase 1·Recruiting·Listed Mar 2026

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