Paid Clinical Trials in Illinois

Illinois has 2,971 paid clinical trials enrolling now across cities including Chicago, Peoria and Springfield. Search by condition, age, or phase to find compensated research studies accepting participants near you.

Research sites in Illinois include Northwestern Medicine, University of Chicago Medicine and Rush, running studies across oncology, cardiology, neurology, and more. Both patients and healthy volunteers may qualify. Most studies offer compensation for time and travel.

Recruiting trial data synced daily from ClinicalTrials.gov. Last sync: June 19, 2026.

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2,971 clinical trials

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A Three-Part Phase 3 Study of Sofetabart Mipitecan in Participants With Platinum-Resistant (Part A) and Platinum-Sensitive (Parts B and C) Ovarian Cancer

for Ovarian Neoplasms

83 locations incl. Birmingham

Sponsor: Eli Lilly and Company

Sex: All·Age: 18+

Code: NCT07213804·Phase 3·Recruiting

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A Study to Evaluate Brenipatide Compared With Placebo in Adult Participants With Uncontrolled Moderate to Severe Asthma

for Asthma

Drug: Brenipatide

17 locations incl. Tempe

Sponsor: Eli Lilly and Company

Sex: All·Age: 18 - 75

Code: NCT07219173·Phase 2·Recruiting

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A Study of JNT-517 in Participants With Phenylketonuria (PKU)

for Phenylketonuria

10 locations incl. Los Angeles

Sponsor: Otsuka Pharmaceutical Development & Commercialization, Inc.

Sex: All·Age: 18+

Code: NCT06971731·Phase 3·Recruiting

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Screening Study for KIT D816V Mutated Mast Cell Disease in Select Populations

for Clonal Mast Cell Disease

18 locations incl. Birmingham

Sponsor: Blueprint Medicines Corporation

Sex: All·Age: 18+

Code: NCT07143669·Recruiting

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A Study of Brenipatide in Participants With Alcohol Use Disorder

for Alcohol Use Disorder

Drug: Brenipatide

29 locations incl. Scottsdale

Sponsor: Eli Lilly and Company

Sex: All·Age: 18 - 75

Code: NCT07219953·Phase 3·Recruiting

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Evaluating Whether an Educational Website Called Current Together After Cancer (CTAC) Improves Follow-up Care for Colorectal Cancer Survivors

for Colorectal Cancer Stage II

376 locations incl. Anchorage

Sponsor: SWOG Cancer Research Network

Sex: All·Age: 18+·Accepts healthy volunteers

Code: NCT07018869·Phase 3·Recruiting

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A Study of Brenipatide in Participants With Moderate-to-Severe Alcohol Use Disorder

for Alcohol Use Disorder

Drug: Brenipatide

30 locations incl. Birmingham

Sponsor: Eli Lilly and Company

Sex: All·Age: 18 - 75

Code: NCT07219966·Phase 3·Recruiting

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A Study of IDE849 in Patients With DLL3 Expressing Tumors Including Small Cell Lung Cancer

for Small-cell Lung Cancer

20 locations incl. Denver

Sponsor: IDEAYA Biosciences

Sex: All·Age: 18+

Code: NCT07174583·Phase 1, Phase 2·Recruiting

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A Study to Evaluate the Efficacy and Safey of PTP-001 (MOTYS™) in Knee Osteoarthritis Patients

for Knee Osteoarthritis

8 locations incl. Birmingham

Sponsor: Doron Therapeutics Inc.

Sex: All·Age: 40 - 80

Code: NCT07219771·Phase 3·Recruiting

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Use of Bedside Imaging and Community Health Workers for Early Screening and Referral of Pre-symptomatic Stage B Heart Failure in the Emergency Department

for Heart Diseases

1 location in Chicago

Sponsor: Rush University Medical Center

Sex: All·Age: 45+·Accepts healthy volunteers

Code: NCT06769880·Recruiting

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A Safety and Efficacy Study of GTX-102 in Subjects With Deletion- or Nondeletion-type Angelman Syndrome (AS)

for Angelman Syndrome

8 locations incl. Los Angeles

Sponsor: Ultragenyx Pharmaceutical Inc

Sex: All·Age: 1 - 64

Code: NCT07157254·Phase 2·Recruiting

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Asparaginase Erwinia Chrysanthemi With Chemotherapy for the Treatment of High-Risk Adults With Newly Diagnosed Acute Lymphoblastic Leukemia or Lymphoblastic Lymphoma

for B Acute Lymphoblastic Leukemia, Philadelphia Chromosome Negative

8 locations incl. Phoenix

Sponsor: City of Hope Medical Center

Sex: All·Age: 18 - 54

Code: NCT06918431·Phase 2·Recruiting

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Novel On-body Evaluation of Cardiac Health for Oncology

for Cardiotoxicity

7 locations incl. Golden

Sponsor: Skribe Medical

Sex: All·Age: 18+·Accepts healthy volunteers

Code: NCT07158450·Enrolling By Invitation

A Safety and Efficacy Study of a One-time Intravitreal Injection of SAR446597 in Participants With Geographic Atrophy Secondary to Age-related Macular Degeneration

for Geographic Atrophy

14 locations incl. Peoria

Sponsor: Sanofi

Sex: All·Age: 60+

Code: NCT07215234·Phase 1, Phase 2·Recruiting

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A Study to Evaluate the Efficacy and Safety of Adjunctive KarXT for the Treatment of Mania, With or Without Mixed Features, in Participants With Bipolar-I Disorder Taking Lithium, Valproate, or Lamotrigine

for Mania

Drug: KarXT

20 locations incl. Bentonville

Sponsor: Bristol-Myers Squibb

Sex: All·Age: 18 - 65

Code: NCT07140913·Phase 3·Recruiting

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A Study in Participants With Active Systemic Lupus Erythematosus With Inadequate Response to Glucocorticoids and ≥2 Immunosuppressants

for Systemic Lupus Erythematosus (SLE)

25 locations incl. Mesa

Sponsor: Bristol-Myers Squibb

Sex: All·Age: 16+

Code: NCT07175285·Recruiting

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An Induction Study to Investigate the Efficacy and Safety of Duvakitug in Participants With Moderately to Severely Active Ulcerative Colitis

for Ulcerative Colitis

Drug: Duvakitug

91 locations incl. Peoria

Sponsor: Sanofi

Sex: All·Age: 16 - 80

Code: NCT07184996·Phase 3·Recruiting

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A Study to Assess the Adverse Events and How Oral Emraclidine Moves Through the Body of Healthy Elderly Adult Participants

for Healthy Volunteer

4 locations incl. Cypress

Sponsor: AbbVie

Sex: All·Age: 65 - 85·Accepts healthy volunteers

Code: NCT07219030·Phase 1·Recruiting

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Testing the Effectiveness of a Combination Targeted Therapy (ViPOR) for Patients With Relapsed and/or Refractory Aggressive B-cell Lymphoma

for High Grade B-Cell Lymphoma With MYC and BCL6 Rearrangements

84 locations incl. Tucson

Sponsor: National Cancer Institute (NCI)

Sex: All·Age: 18+

Code: NCT06649812·Phase 2·Recruiting

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Response-Adaptive Treatment in Untreated Locoregional HPV-Negative Head and Neck Cancer

for Head and Neck Cancer

1 location in Chicago

Sponsor: University of Chicago

Sex: All·Age: 18+

Code: NCT07065630·Phase 2·Recruiting

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A Study of CTD402 in T-ALL/LBL Patients

for Acute Lymphocytic Leukemia Refractory

8 locations incl. Palo Alto

Sponsor: BIOHENG THERAPEUTICS US LLC

Sex: All·Age: 12+

Code: NCT07070219·Phase 1, Phase 2·Recruiting

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Testing Shorter Duration Radiation Therapy Versus the Usual Radiation Therapy in Patients Receiving the Usual Chemotherapy Treatment for Bladder Cancer, ARCHER Study

for Muscle Invasive Bladder Urothelial Carcinoma

211 locations incl. Fort Smith

Sponsor: NRG Oncology

Sex: All·Age: 18+

Code: NCT07097142·Phase 3·Recruiting

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A Study to Evaluate the Effect of GDC-4198 Alone and in Combination With Giredestrant Versus Abemaciclib and Giredestrant in Participants With Locally Advanced or Metastatic Estrogen Receptor-Positive (ER+), Human Epidermal Growth Factor Receptor-Negative (HER2-) Breast Cancer

for Breast Cancer

Drug: Giredestrant

17 locations incl. Duarte

Sponsor: Genentech, Inc.

Sex: All·Age: 18+

Code: NCT07100106·Phase 1, Phase 2·Recruiting

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Evaluating Evidenced Based Options for PTSD Treatment

for PTSD - Post Traumatic Stress Disorder

1 location in Chicago

Sponsor: Rush University Medical Center

Sex: All·Age: 18+

Code: NCT06733376·Recruiting

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Partnering With Antenatal Navigators to Transform Health in Pregnancy

for Maternal Morbidity

1 location in Chicago

Sponsor: Northwestern University

Sex: Female·Age: 16 - 50

Code: NCT06941974·Recruiting

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A Trial to Evaluate the Efficacy and Safety of Ninerafaxstat in Patients With Symptomatic Non-obstructive Hypertrophic Cardiomyopathy

for Non-obstructive Hypertrophic Cardiomyopathy

22 locations incl. La Jolla

Sponsor: Imbria Pharmaceuticals, Inc.

Sex: All·Age: 18+

Code: NCT07023614·Phase 2·Recruiting

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A Study to Learn About the Medicine Ponsegromab in Adults With Cancer of the Pancreas Which Has Spread and Caused Significant Body Weight Loss and Fatigue

for Cachexia

Drug: ponsegromab

72 locations incl. Birmingham

Sponsor: Pfizer

Sex: All·Age: 18+

Code: NCT06989437·Phase 2, Phase 3·Recruiting

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The Lilac Device Trial - IMPACT: A Clinical Investigation on IMproving Peripheral Neuropathy Induced by Chemotherapy With Advanced Compression Technology - A Safety and Efficacy Study

for Chemotherapy Induced Peripheral Neuropathy (CIPN)

17 locations incl. Poway

Sponsor: Luminate Medical, Inc.

Sex: All·Age: 18+

Code: NCT07142304·Recruiting

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Clinical Study of Neflamapimod in Patients With Primary Progressive Aphasia

for Nonfluent Variant Primary Progressive Aphasia (nfvPPA)

5 locations incl. Chicago

Sponsor: EIP Pharma Inc

Sex: All·Age: 40 - 85

Code: NCT07033481·Phase 2·Recruiting

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CLEOPATTRA: A Research Study to Look at the Effects of Treatment With a Medicine Called Coramitug (NNC6019-0001) in People With Heart Failure Due to Transthyretin Amyloid (ATTR) Amyloidosis

for Transthyretin Amyloid Cardiomyopathy (ATTR CM)

Drug: Coramitug

61 locations incl. Phoenix

Sponsor: Novo Nordisk A/S

Sex: All·Age: 18+

Code: NCT07207811·Phase 3·Recruiting

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Accelerometer Measured Early Recovery After Prolapse Surgery

for Pelvic Organ Prolapse

7 locations incl. San Diego

Sponsor: NICHD Pelvic Floor Disorders Network

Sex: Female·Age: 18 - 99

Code: NCT07218016·Recruiting

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Oxalate and Citrate in Humans - Response to Citrate

for Kidney Stone

1 location in Chicago

Sponsor: University of Chicago

Sex: All·Age: 18 - 70·Accepts healthy volunteers

Code: NCT06944223·Recruiting

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Investigating Periprosthetic Fracture Cultures in Arthroplasty

for Periprosthetic Fracture Around Prosthetic Joint Implant

1 location in Chicago

Sponsor: University of Chicago

Sex: All·Age: 18+

Code: NCT06952738·Recruiting

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A Study to Evaluate INCA035784 in Participants With Myeloproliferative Neoplasms

for Myeloproliferative Neoplasms

12 locations incl. Phoenix

Sponsor: Incyte Corporation

Sex: All·Age: 18+

Code: NCT07008118·Phase 1·Recruiting

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Study of COYA 302 for the Treatment of ALS

for Amyotrophic Lateral Sclerosis (ALS)

21 locations incl. Phoenix

Sponsor: Coya Therapeutics

Sex: All·Age: 18 - 80

Code: NCT07161999·Phase 2·Recruiting

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An Induction Study to Investigate the Efficacy and Safety of Duvakitug in Participants With Moderately to Severely Active Crohn's Disease

for Crohn's Disease

Drug: Duvakitug

93 locations incl. Peoria

Sponsor: Sanofi

Sex: All·Age: 16 - 80

Code: NCT07184931·Phase 3·Recruiting

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A Phase II, Placebo Controlled, Clinical Trial of Topical TolaSure Targeting Aggregated Mutant Keratin in Epidermolysis Bullosa Simplex

for Epidermolysis Bullosa Simplex

2 locations incl. Palo Alto

Sponsor: BioMendics, LLC

Sex: All·Age: 4+

Code: NCT07027345·Phase 2·Recruiting

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Evaluation of a Non-Implanted Electrical Stimulation Device for Overactive Bladder (OAB)

for Overactive Bladder (OAB)

15 locations incl. Beverly Hills

Sponsor: FemPulse Corporation

Sex: Female·Age: 21+

Code: NCT07195656·Recruiting

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Evaluation of Efficacy, Safety, and Tolerability of Povetacicept in Participants With Primary Membranous Nephropathy (pMN)

for Primary Membranous Nephropathy

22 locations incl. Montgomery

Sponsor: Vertex Pharmaceuticals Incorporated

Sex: All·Age: 18 - 75

Code: NCT07204275·Phase 2, Phase 3·Recruiting

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Study to Assess the Adverse Events of Oral ABBV-932 in Adult Participants With Depressive Episodes Associated With Bipolar I or II Disorder

for Bipolar I or II Disorder

47 locations incl. Phoenix

Sponsor: AbbVie

Sex: All·Age: 18 - 65

Code: NCT07220460·Phase 2·Recruiting

Apply to this trial