Paid Clinical Trials in Illinois

Illinois has 2,847 paid clinical trials enrolling now across cities including Chicago, Peoria and Evanston. Search by condition, age, or phase to find compensated research studies accepting participants near you.

Research sites in Illinois include Northwestern Medicine, University of Chicago Medicine and Rush, running studies across oncology, cardiology, neurology, and more. Both patients and healthy volunteers may qualify. Most studies offer compensation for time and travel.

Recruiting trial data synced daily from ClinicalTrials.gov. Last sync: September 14, 2026.

Filter results

Filter results

State

City

Recruitment status

Phase

Study type

Intervention

Condition

Sex

Age

Healthy volunteers only

2,519 clinical trials

Get a weekly email when new trials open in Chicago, IL.

Evaluation of Treatment Satisfaction and KarXT Utilization Registry (RESKU)

for Schizophrenia

Drug: KarXT

Sites in Evanston +16 more locations

Sponsor: Bristol-Myers Squibb

Sex: All·Age: 18+

Code: NCT07101094·Recruiting·Listed Aug 2025

Apply to this trial

A Study to Learn About Ritlecitinib for the Potential Treatment of Chronic Spontaneous Urticaria in Adults.

for Chronic Spontaneous Urticaria

Drug: Ritlecitinib

Sites in River Forest +14 more locations

Sponsor: Pfizer

Sex: All·Age: 18+

Code: NCT07219615·Phase 2·Recruiting·Listed Oct 2025

Apply to this trial

A Study of Nipocalimab or Intravenous Immunoglobulin (IVIG) in Pregnancies At Risk of Fetal and Neonatal Alloimmune Thrombocytopenia (FNAIT)

for Thrombocytopenia, Neonatal Alloimmune

Drug: Nipocalimab

Sites in Park Ridge +11 more locations

Sponsor: Janssen Research & Development, LLC

Sex: Female·Age: 18 - 45

Code: NCT06533098·Phase 3·Recruiting·Listed Aug 2024

Apply to this trial

Efficacy and Safety of 4F-PCC (4-Factor Prothrombin Complex Concentrate) in Adult Patients Undergoing Complex Cardiovascular Surgery With Cardiopulmonary Bypass (CPB)

for Complex Cardiovascular Surgery With Cardiopulmonary Bypass

Sites in Chicago +15 more locations

Sponsor: CSL Behring

Sex: All·Age: 18+

Code: NCT07094087·Phase 3·Recruiting·Listed Jul 2025

Apply to this trial

RESET-SLE: A Phase 1/2 Open-Label Study to Evaluate the Safety and Efficacy of CABA-201 in Subjects With Active Systemic Lupus Erythematosus

for Systemic Lupus Erythematosus

Sites in Chicago +17 more locations

Sponsor: Cabaletta Bio

Sex: All·Age: 18 - 65

Code: NCT06121297·Phase 1, Phase 2·Recruiting·Listed Nov 2023

Apply to this trial

Inobrodib, Pomalidomide and Dexamethasone in Relapsed or Refractory Multiple Myeloma

for Multiple Myeloma Refractory

Sites in Chicago +19 more locations

Sponsor: CellCentric Ltd.

Sex: All·Age: 18+

Code: NCT07096778·Phase 2·Recruiting·Listed Jul 2025

Apply to this trial

A Study to Evaluate Safety, Pharmacokinetics, and Activity of GDC-7035 as a Single Agent and in Combination in Patients With Advanced Solid Tumors

for Solid Tumor

Sites in Chicago +10 more locations

Sponsor: Genentech, Inc.

Sex: All·Age: 18+

Code: NCT06619587·Phase 1·Recruiting·Listed Oct 2024

Apply to this trial

A Study to See if Giving Fianlimab and Cemiplimab Together is Better Than Cemiplimab Alone at Treating Recurrent or Metastatic Head and Neck Squamous Cell Carcinoma

for Head and Neck Squamous Cell Carcinoma (HNSCC)

Drug: Cemiplimab

Sites in Evanston +17 more locations

Sponsor: Regeneron Pharmaceuticals

Sex: All·Age: 18+

Code: NCT06769698·Phase 2·Recruiting·Listed Jan 2025

Apply to this trial

A Study to Investigate the Efficacy and Safety of Crizanlizumab (5 mg/kg) Compared With Placebo in Adolescent and Adult Sickle Cell Disease Patients Who Experience Frequent Vaso-Occlusive Crises (SPARKLE)

for Sickle Cell Disease

Sites in Chicago +15 more locations

Sponsor: Novartis Pharmaceuticals

Sex: All·Age: 12 - 100

Code: NCT06439082·Phase 3·Recruiting·Listed Jun 2024

Apply to this trial

A Study to Evaluate BMS-986470 in Healthy Volunteers and Participants With Sickle Cell Disease

for Anemia, Sickle Cell

Sites in Chicago +17 more locations

Sponsor: Bristol-Myers Squibb

Sex: All·Age: 18+·Accepts healthy volunteers

Code: NCT06481306·Phase 1, Phase 2·Recruiting·Listed Jul 2024

Apply to this trial

Post-market Safety and Effectiveness of the CORUS-LX System in Improving Lumbar Interbody Fusion Outcomes

for Radiculopathy Lumbar

Sites in Hinsdale +8 more locations

Sponsor: Providence Medical Technology, Inc.

Sex: All·Age: 18 - 80

Code: NCT07222787·Recruiting·Listed Oct 2025

Apply to this trial

A Study of the Efficacy and Safety of Lisocabtagene Maraleucel (Liso-cel) as First-Line Therapy in Adults With Transplant-Ineligible Primary Central Nervous System Lymphoma

for Lymphoma

Sites in Chicago +13 more locations

Sponsor: Juno Therapeutics, Inc., a Bristol-Myers Squibb Company

Sex: All·Age: 18+

Code: NCT07015242·Phase 2·Recruiting·Listed Jun 2025

Apply to this trial

A Phase 2 Study to Evaluate the Effects of ASP5541 in Participants With Prostate Cancer

for Prostate Cancer

Sites in Evanston, Chicago Ridge +10 more locations

Sponsor: Astellas Pharma Global Development, Inc.

Sex: Male·Age: 18+

Code: NCT07005154·Phase 2·Recruiting·Listed Jun 2025

Apply to this trial

Study of ORIC-944 in Patients With Metastatic Prostate Cancer

for Metastatic Prostate Cancer

Sites in Arlington Heights, Lake Barrington +18 more locations

Sponsor: ORIC Pharmaceuticals

Sex: Male·Age: 18+

Code: NCT05413421·Phase 1·Recruiting·Listed Jun 2022

Apply to this trial

Safety, Efficacy, and Pharmacokinetics of CSL889 in Adults and Adolescents With Sickle Cell Disease During Vaso-Occlusive Crisis

for Sickle Cell Disease Vaso-occlusive Crisis

Sites in Chicago +18 more locations

Sponsor: CSL Behring

Sex: All·Age: 12+

Code: NCT06699849·Phase 2·Recruiting·Listed Nov 2024

Apply to this trial

A Phase 1b/2a Study of Pocenbrodib as Monotherapy and in Combination With Darolutamide in Participants With mCRPC

for mCRPC (Metastatic Castration-resistant Prostate Cancer)

Sites in Chicago +18 more locations

Sponsor: Pathos AI, Inc.

Sex: Male·Age: 18+

Code: NCT06785636·Phase 1, Phase 2·Recruiting·Listed Jan 2025

Apply to this trial

Study of Sacituzumab Govitecan Versus Standard of Care in Participants With Previously Treated Extensive Stage Small Cell Lung Cancer

for Extensive Stage Small Cell Lung Cancer (ES-SCLC)

Sites in Springfield, Hinsdale +21 more locations

Sponsor: Gilead Sciences

Sex: All·Age: 18+

Code: NCT06801834·Phase 3·Recruiting·Listed Jan 2025

Apply to this trial

Investigation of Ubamatamab Combination Therapy in Adult Participants With Platinum-Resistant Ovarian Cancer

for Ovarian Cancer

Sites in Chicago +20 more locations

Sponsor: Regeneron Pharmaceuticals

Sex: Female·Age: 18+

Code: NCT06787612·Phase 2·Recruiting·Listed Jan 2025

Apply to this trial

Study of Trastuzumab Deruxtecan, Pembrolizumab, and Platinum-based Chemotherapy in First-line HER2 Overexpressing Non-small Cell Lung Cancer

for Non-small Cell Lung Cancer

Sites in Hinsdale +24 more locations

Sponsor: Daiichi Sankyo

Sex: All·Age: 18+

Code: NCT06899126·Phase 3·Recruiting·Listed Mar 2025

Apply to this trial

Evaluate the Clinical Performance of the Flow Cytometry - FlowPath Lung Test as a Sensitive and Specific Non-invasive Diagnostic of Sputum Samples to Identify/Detect the Presence of Lung Cancer in High-risk Individuals Who Have Existing Lung Nodules, 6 to <30 mm in Diameter, Determined by LDCT.

for Lung Cancer (Diagnosis)

Sites in North Chicago +10 more locations

Sponsor: bioAffinity Technologies Inc.

Sex: All·Age: 50 - 80

Code: NCT07168993·Recruiting·Listed Sep 2025

Apply to this trial

A Phase 2, Open-Label Study to Evaluate the Safety and Effects of HLX-1502 in Patients With Neurofibromatosis Type 1

for Neurofibromatosis Type 1

Sites in Chicago +13 more locations

Sponsor: Healx Limited

Sex: All·Age: 12+

Code: NCT06541847·Phase 2·Recruiting·Listed Aug 2024

Apply to this trial

A Real-world Chronic Myelogenous Leukemia (CML) Patient Disease Registry to Describe Patient Experience and Clinical Outcomes Among Patients With CML Receiving Approved First or Second Line Tyrosine Kinase Inhibitor (TKI) Therapy

for Chronic Myelogenous Leukemia - Chronic Phase

Sites in Decatur +16 more locations

Sponsor: Novartis Pharmaceuticals

Sex: All·Age: 18 - 100

Code: NCT07091019·Recruiting·Listed Jul 2025

Apply to this trial

Study to Evaluate the Effectiveness and Safety of Ozanimod Compared to Fingolimod in Children and Adolescents With Relapsing Remitting Multiple Sclerosis

for Multiple Sclerosis, Relapsing-Remitting

Sites in Chicago +8 more locations

Sponsor: Bristol-Myers Squibb

Sex: All·Age: 10 - 17

Code: NCT06408259·Phase 3·Recruiting·Listed May 2024

Apply to this trial

Study of ORIC-114 in Patients With Advanced Solid Tumors Harboring an EGFR or HER2 Alteration

for Solid Tumors

Sites in Chicago +16 more locations

Sponsor: ORIC Pharmaceuticals

Sex: All·Age: 18+

Code: NCT05315700·Phase 1, Phase 2·Recruiting·Listed Apr 2022

Apply to this trial

Belzutifan/MK-6482 for the Treatment of Advanced Pheochromocytoma/Paraganglioma (PPGL), Pancreatic Neuroendocrine Tumor (pNET), Von Hippel-Lindau (VHL) Disease-Associated Tumors, Advanced Gastrointestinal Stromal Tumor (wt GIST), or Solid Tumors With HIF-2α Related Genetic Alterations (MK-6482-015)

for Pheochromocytoma/Paraganglioma

Sites in Chicago, Warrenville +9 more locations

Sponsor: Merck Sharp & Dohme LLC

Sex: All·Age: 12+

Code: NCT04924075·Phase 2·Recruiting·Listed Jun 2021

Apply to this trial

A Study Evaluating the Effectiveness and Safety of Risdiplam Administered as an Early Intervention in Pediatric Participants With Spinal Muscular Atrophy After Gene Therapy

for Muscular Atrophy, Spinal

Sites in Chicago +9 more locations

Sponsor: Hoffmann-La Roche

Sex: All·Age: 3 Months - 24 Months

Code: NCT05861986·Phase 4·Recruiting·Listed May 2023

Apply to this trial

Oral Ifetroban in Patients With Idiopathic Pulmonary Fibrosis (IPF)

for Idiopathic Pulmonary Fibrosis

Sites in Chicago +17 more locations

Sponsor: Cumberland Pharmaceuticals

Sex: All·Age: 40+

Code: NCT05571059·Phase 2·Recruiting·Listed Oct 2022

Apply to this trial

Comparing The Safety And Efficacy Of DEFENCATH® In Reducing Central-Line Bloodstream Infections (CLABSIs) In Adults Receiving Total Parenteral Nutrition Through A Central Venous Catheter (CVC)

for Central Line Associated Blood Stream Infections (CLABSI)

Sites in Chicago +15 more locations

Sponsor: CorMedix Therapeutics

Sex: All·Age: 18+

Code: NCT06822426·Phase 3·Recruiting·Listed Feb 2025

Apply to this trial

A Safety, Tolerability, and Efficacy Study of VX-880 and VX-017 in Participants With Type 1 Diabetes

for Diabetes Mellitus, Type 1

Sites in Chicago +9 more locations

Sponsor: Vertex Pharmaceuticals Incorporated

Sex: All·Age: 18 - 65

Code: NCT04786262·Phase 3·Recruiting·Listed Mar 2021

Apply to this trial

Study of Olutasidenib and Temozolomide in HGG

for High Grade Glioma

Sites in Chicago +10 more locations

Sponsor: Rigel Pharmaceuticals

Sex: All·Age: 12 - 39

Code: NCT06161974·Phase 2·Recruiting·Listed Dec 2023

Apply to this trial

Study to Evaluate ARINA-1 in the Prevention of Bronchiolitis Obliterans Progression in Participants With Bilateral Lung Transplant

for Pre-Bronchiolitis Obliterans Syndrome

Sites in Maywood +19 more locations

Sponsor: Renovion, Inc.

Sex: All·Age: 18 - 75

Code: NCT05654922·Phase 3·Recruiting·Listed Dec 2022

Apply to this trial

A Study of Nipocalimab in Pregnancies at Risk for Severe Hemolytic Disease of the Fetus and Newborn (HDFN)

for Hemolytic Disease of the Fetus and Newborn

Drug: Nipocalimab

Sites in Park Ridge +18 more locations

Sponsor: Janssen Research & Development, LLC

Sex: Female·Age: 18 - 45

Code: NCT05912517·Phase 3·Recruiting·Listed Jun 2023

Apply to this trial

A Phase 1b/2 Study of Sonrotoclax (BGB-11417) as Monotherapy and in Various Combinations With Dexamethasone Plus Carfilzomib, Dexamethasone Plus Daratumumab, and Dexamethasone Plus Pomalidomide in Multiple Myeloma

for Relapsed/Refractory Multiple Myeloma

Drug: Daratumumab

Sites in Chicago +14 more locations

Sponsor: BeOne Medicines

Sex: All·Age: 18+

Code: NCT04973605·Phase 1, Phase 2·Recruiting·Listed Jul 2021

Apply to this trial

The Efficacy and Safety of Rilzabrutinib in Participants Aged 10 to 65 Years With Sickle-cell Disease

for Sickle Cell Disease

Sites in Chicago +15 more locations

Sponsor: Sanofi

Sex: All·Age: 10 - 65

Code: NCT06975865·Phase 3·Recruiting·Listed May 2025

Apply to this trial

A Pivotal Phase II Clinical Trial of Utidelone Injection Plus Capecitabine in HER2-negative Breast Cancer Patients With Brain Metastases

for HER2-negative Breast Cancer Patients With Brain Metastases

Sites in Chicago +11 more locations

Sponsor: Biostar Pharma, Inc.

Sex: All·Age: 18+

Code: NCT06764940·Phase 2·Recruiting·Listed Jan 2025

Apply to this trial

The RAPID - PE Study: RESCUE Advanced Protocol for the Treatment of Pulmonary Embolism

for Pulmonary Embolism

Sites in Chicago +22 more locations

Sponsor: Thrombolex, Inc.

Sex: All·Age: All ages

Code: NCT06433011·Recruiting·Listed May 2024

Apply to this trial

Study of SLS009 (Formerly GFH009) a Potent Highly Selective CDK9 Inhibitor in Patients With Hematologic Malignancies and High-Risk Newly Diagnosed AML

for Hematologic Malignancies

Sites in Zion +15 more locations

Sponsor: Sellas Life Sciences Group

Sex: All·Age: 12+

Code: NCT04588922·Phase 1, Phase 2·Recruiting·Listed Oct 2020

Apply to this trial

A Phase 3 Efficacy and Safety Study of Fosmanogepix for the Treatment of Adult Patients With Invasive Mold Infections.

for Invasive Mold Infections

Sites in Chicago +18 more locations

Sponsor: Basilea Pharmaceutica

Sex: All·Age: 18+

Code: NCT06925321·Phase 3·Recruiting·Listed Apr 2025

Apply to this trial

Phase 3 Extension Study to Evaluate Long-term Safety of Ianalumab in Participants With Systemic Lupus Erythematosus (SIRIUS-SLE Extension).

for Systemic Lupus Erythematosus

Drug: Ianalumab

Sites in Skokie, Willowbrook +17 more locations

Sponsor: Novartis Pharmaceuticals

Sex: All·Age: 12 - 100

Code: NCT06133972·Phase 3·Recruiting·Listed Nov 2023

Apply to this trial

Evaluating the Efficacy of OCM™ (Omeza® Complete Matrix) in the Treatment of Diabetic Foot Ulcers

for Diabetic Foot Ulcer

Sites in Evergreen Park +9 more locations

Sponsor: Omeza, LLC

Sex: All·Age: 18+

Code: NCT07161830·Recruiting·Listed Sep 2025

Apply to this trial