Paid Clinical Trials in Illinois

Illinois has 2,971 paid clinical trials enrolling now across cities including Chicago, Peoria and Springfield. Search by condition, age, or phase to find compensated research studies accepting participants near you.

Research sites in Illinois include Northwestern Medicine, University of Chicago Medicine and Rush, running studies across oncology, cardiology, neurology, and more. Both patients and healthy volunteers may qualify. Most studies offer compensation for time and travel.

Recruiting trial data synced daily from ClinicalTrials.gov. Last sync: June 19, 2026.

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2,971 clinical trials

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Evaluation of ELU42 Topical Spray for the Treatment of Diabetic Foot Ulcers

for Diabetic Foot Ulcer

4 locations incl. O'Fallon

Sponsor: Eluciderm Inc

Sex: All·Age: 18 - 75

Code: NCT07396376·Phase 1, Phase 2·Recruiting

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A Global Study Comparing Pulsed Field Ablation With Electrographic Flow Mapping Versus Posterior Wall Ablation for Persistent Atrial Fibrillation

for Atrial Fibrillation (AF)

32 locations incl. Birmingham

Sponsor: Boston Scientific Corporation

Sex: All·Age: 18+

Code: NCT07187115·Recruiting

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Safety and Effectiveness of the BrainsWay Deep Transcranial Magnetic Stimulation (Deep TMS) for Treatment of Alcohol Use Disorder (AUD)

for Alcohol Use Disorder

8 locations incl. Tuscaloosa

Sponsor: Brainsway

Sex: All·Age: 18 - 86

Code: NCT07216872·Recruiting

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Using Biomarker Tests to Select and Test New, Personalized Treatments for Extensive Stage Small Cell Lung Cancer, PRISM Study

for Extensive Stage Lung Small Cell Carcinoma

148 locations incl. Loma Linda

Sponsor: SWOG Cancer Research Network

Sex: All·Age: 18+

Code: NCT06769126·Phase 2·Recruiting

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A Study of the Efficacy and Safety of Lisocabtagene Maraleucel (Liso-cel) as First-Line Therapy in Adults With Transplant-Ineligible Primary Central Nervous System Lymphoma

for Lymphoma

14 locations incl. Aurora

Sponsor: Juno Therapeutics, Inc., a Bristol-Myers Squibb Company

Sex: All·Age: 18+

Code: NCT07015242·Phase 2·Recruiting

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A Study to Learn About the Study Medicine PF-08052667 in People With Bladder Cancer

for Non-muscle Invasive Bladder Cancer

39 locations incl. Birmingham

Sponsor: Pfizer

Sex: All·Age: 18+

Code: NCT07206225·Phase 1·Recruiting

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Comparing the Safety and Efficacy of ASI-02 to Agitated Saline for Suspected Right-to-left Shunt

for Right-To-Left Shunt

5 locations incl. Chicago

Sponsor: Agitated Solutions, Inc.

Sex: All·Age: 18+

Code: NCT06938347·Phase 3·Recruiting

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Study to Assess the Injection Burden, Adverse Events, Change in Disease Activity, and Long-Term Preservation of Visual Acuity of Surabgene Lomparvovec in Adult Participants With Neovascular Age-Related Macular Degeneration (nAMD)

for Neovascular Age-related Macular Degeneration

Drug: Surabgene Lomparvovec

53 locations incl. Mesa

Sponsor: AbbVie

Sex: All·Age: 50+

Code: NCT07007065·Phase 3·Recruiting

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Induction Pembrolizumab and Chemotherapy Followed by Pembrolizumab Before Chemoradiation and Pembrolizumab Maintenance Compared to Standard Chemoradiation With Pembrolizumab Followed by Pembrolizumab Maintenance in High-Risk Cervical Cancer

for Locally Advanced Cervical Adenocarcinoma

271 locations incl. Birmingham

Sponsor: National Cancer Institute (NCI)

Sex: Female·Age: 18+

Code: NCT07061977·Phase 3·Recruiting

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Study of Izalontamab Brengitecan (BMS-986507) Versus Platinum-Pemetrexed for EGFR-mutated Non-small Cell Lung Cancer After Failure of EGFR TKI Therapy (IZABRIGHT-Lung01)

for Non-Small Cell Lung Cancer

28 locations incl. Irvine

Sponsor: Bristol-Myers Squibb

Sex: All·Age: 18+

Code: NCT07100080·Phase 2, Phase 3·Recruiting

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Clinical Study to Evaluate the Safety and Effectiveness of Arcevo LSA

for Aortic Arch Aneurysm

19 locations incl. Birmingham

Sponsor: Artivion Inc.

Sex: All·Age: 18 - 80

Code: NCT07089576·Recruiting

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A Safety, Tolerability, and Biomarker Trial of VS-041 in Participants With Heart Failure With Preserved Ejection Fraction (HFpEF)

for Heart

21 locations incl. Little Rock

Sponsor: Vasa Therapeutics

Sex: All·Age: 50+

Code: NCT07219511·Phase 1·Recruiting

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Palazestrant in Combination With Ribociclib for the First-line Treatment of ER+/HER2- Advanced Breast Cancer

for Breast Cancer

Drug: Palazestrant

37 locations incl. Hot Springs

Sponsor: Olema Pharmaceuticals, Inc.

Sex: All·Age: 18+

Code: NCT07085767·Phase 3·Recruiting

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Mirai-MRI: Validation of AI Models for Breast Cancer Risk

for Cancer Risk

4 locations incl. San Diego

Sponsor: University of California, San Francisco

Sex: Female·Age: 40 - 89·Accepts healthy volunteers

Code: NCT07121972·Recruiting

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Multisensory Early Oral Administration of Human Milk (M-MILK) for Very Preterm Infants

for Infant, Premature, Diseases

2 locations incl. Maywood

Sponsor: Loyola University

Sex: All·Age: 23 Weeks - 32 Weeks

Code: NCT07216664·Recruiting

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Human Menopausal Gonadotropin Research in Infertility Assessing Cumulative Live Birth With Frozen Embryo Transfer.

for Infertility (IVF Patients)

16 locations incl. Encino

Sponsor: Granata Bio Corporation

Sex: Female·Age: 18 - 42

Code: NCT07216742·Phase 3·Recruiting

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Effects of Core Strengthening Exercises for Treating TMD

for Temporomandibular Joint Dysfunction

1 location in Maywood

Sponsor: Loyola University

Sex: All·Age: 18 - 80

Code: NCT07226505·Not Yet Recruiting

Evaluating the Status of Complex Aneuploidy to Locate Additional Transferrable Embryos

for Complex Aneuploidy

11 locations incl. Margate

Sponsor: Shady Grove Fertility Reproductive Science Center

Sex: All·Age: All ages·Accepts healthy volunteers

Code: NCT07227116·Recruiting

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I-DECIDE After Bronchiolitis Hospitalization

for Bronchiolitis Acute

56 locations incl. Birmingham

Sponsor: Seattle Children's Hospital

Sex: All·Age: 0 Months - 24 Months

Code: NCT07243652·Recruiting

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Enhancing Rehabilitation Participation in Patients With SCI/D Using Motivational Interviewing

for Spinal Cord Injuries (SCI)

3 locations incl. Chicago

Sponsor: Shirley Ryan AbilityLab

Sex: All·Age: 18+

Code: NCT07364773·Recruiting

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Bio-Integrative, Fiber-Reinforced Kneebar for Treating Subchondral Insufficiency of the Knee

for Subchondral Insufficiency Fracture

2 locations incl. Stanford

Sponsor: Stanford University

Sex: All·Age: 18+

Code: NCT06138548·Enrolling By Invitation

Effects of Myoelectric Channel Count and Targeting for Upper Limb Prosthetic Control

for Amputation

2 locations incl. Chicago

Sponsor: Liberating Technologies, Inc.

Sex: All·Age: 18+

Code: NCT07011420·Recruiting

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Use of GI Genius™ XR Software in Virtual Reality Headset During Routine Colonoscopy

for Colonoscopy (Procedure)

1 location in Chicago

Sponsor: Cosmo Artificial Intelligence-AI Ltd

Sex: All·Age: 45+·Accepts healthy volunteers

Code: NCT07220174·Not Yet Recruiting

Phase III Study of Datopotamab Deruxtecan Versus Docetaxel in Previously Treated TROP2-positive Advanced or Metastatic Non-squamous NSCLC Without Actionable Genomic Alterations

for Non-small Cell Lung Cancer (NSCLC)

50 locations incl. Chandler

Sponsor: AstraZeneca

Sex: All·Age: 18+

Code: NCT07291037·Phase 3·Recruiting

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A Study in Adult Participants With EoE to Evaluate Vonoprazan 20 mg Compared to Placebo After 12 Weeks and to Evaluate Vonoprazan 20 mg Up to 24 Weeks

for Eosinophilic Esophagitis

41 locations incl. Little Rock

Sponsor: Phathom Pharmaceuticals, Inc.

Sex: All·Age: 18+

Code: NCT06851559·Phase 2·Recruiting

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ROSETTA Breast-01: The Effects and Safety of Pumitamig in Patients With Triple-Negative Breast Cancer

for Breast Neoplasms

Drug: Pumitamig

26 locations incl. Springdale

Sponsor: BioNTech SE

Sex: All·Age: 18+

Code: NCT07173751·Phase 3·Recruiting

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A Study to Learn About Ritlecitinib for the Potential Treatment of Chronic Spontaneous Urticaria in Adults.

for Chronic Spontaneous Urticaria

Drug: Ritlecitinib

15 locations incl. Phoenix

Sponsor: Pfizer

Sex: All·Age: 18+

Code: NCT07219615·Phase 2·Recruiting

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Study of the Progression of Chronic Cardiovascular Conditions

for Cardiovascular Disease (CVD)

1 location in Chicago

Sponsor: Prolaio

Sex: All·Age: 18+

Code: NCT07420907·Recruiting

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Study to Evaluate the Safety and Efficacy of the 10 GE Xenokidney in Patients With ESRD

for ESRD (End-Stage Renal Disease)

2 locations incl. Chicago

Sponsor: United Therapeutics

Sex: All·Age: 40 - 70

Code: NCT06878560·Phase 1, Phase 2·Recruiting

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Study to Evaluate Efficacy and Safety of ONL1204 in Patients With GA Associated With AMD

for Geographic Atrophy (GA)

27 locations incl. Gilbert

Sponsor: ONL Therapeutics

Sex: All·Age: 55+

Code: NCT06659445·Phase 2·Recruiting

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JUST BREATHE, Breathing Life Into Innovative Therapies for ARDS- Cohort C: Bevacizumab

for Acute Respiratory Distress Syndrome (ARDS)

Drug: Bevacizumab

40 locations incl. Birmingham

Sponsor: PPD Development, LP

Sex: All·Age: 18+

Code: NCT06701656·Phase 2·Recruiting

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Reducing Overdose and Substance Use-related Stigma by Training Non-substance-using Friends and Family Members of People Who Use Opioids to Be Harm Reduction Champions

for Opioid Overdose Prevention

1 location in Chicago

Sponsor: University of Illinois at Chicago

Sex: All·Age: 18+·Accepts healthy volunteers

Code: NCT06823453·Recruiting

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Evaluating a Fasting-mimicking Diet in Combination With Immunotherapy in Patients With Non-small Cell Lung Cancer

for Stage IV NSCLC

4 locations incl. Long Beach

Sponsor: VA Office of Research and Development

Sex: All·Age: 18+

Code: NCT06671613·Recruiting

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Intraoperative Fluorescence-Guided Aspirate Tissue Monitoring of 5-ALA During Brain Tumor Surgery

for Brain Neoplasms

1 location in Chicago

Sponsor: University of Illinois at Chicago

Sex: All·Age: 18 - 99

Code: NCT07111182·Recruiting

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Evaluating Minimal Residual Disease (MRD) Through Longitudinal Circulating Tumor DNA (ctDNA) Profiling in Breast Malignancies

for Breast Cancer

14 locations incl. Birmingham

Sponsor: Tempus AI

Sex: All·Age: 18 - 99

Code: NCT07211178·Recruiting

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A Study to Assess the Adverse Events and How Oral ABBV-1042 Moves Through the Body of Healthy Adult Participants

for Healthy Volunteer

Drug: ABBV-1042

1 location in Grayslake

Sponsor: AbbVie

Sex: All·Age: 18 - 55·Accepts healthy volunteers

Code: NCT07222709·Phase 1·Recruiting

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A Study Evaluating the Efficacy and Safety of Divarasib and Pembrolizumab Versus Pembrolizumab and Pemetrexed and Carboplatin or Cisplatin in Participants With Previously Untreated, KRAS G12C-Mutated, Advanced or Metastatic Non-Squamous Non-Small Cell Lung Cancer

for Non-Small Cell Lung Cancer

Drug: Divarasib

50 locations incl. Anchorage

Sponsor: Hoffmann-La Roche

Sex: All·Age: 18+

Code: NCT06793215·Phase 3·Recruiting

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Study of Trastuzumab Deruxtecan, Pembrolizumab, and Platinum-based Chemotherapy in First-line HER2 Overexpressing Non-small Cell Lung Cancer

for Non-small Cell Lung Cancer

18 locations incl. Anchorage

Sponsor: Daiichi Sankyo

Sex: All·Age: 18+

Code: NCT06899126·Phase 3·Recruiting

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A Study Evaluating the Real-World Experience of Givinostat in Patients With Duchenne Muscular Dystrophy

for Duchene Muscular Dystrophy

Drug: Givinostat

7 locations incl. Little Rock

Sponsor: ITF Therapeutics LLC

Sex: All·Age: 6+

Code: NCT07127978·Recruiting

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Safety and Effectiveness of Left Bundle Branch Area Pacing Versus Conventional Cardiac Resynchronization Therapy in Heart Failure

for Heart Failure - NYHA II - IV

32 locations incl. Huntsville

Sponsor: Boston Scientific Corporation

Sex: All·Age: 18+

Code: NCT07069738·Recruiting

Apply to this trial