Paid Clinical Trials in Illinois

Illinois has 2,971 paid clinical trials enrolling now across cities including Chicago, Peoria and Springfield. Search by condition, age, or phase to find compensated research studies accepting participants near you.

Research sites in Illinois include Northwestern Medicine, University of Chicago Medicine and Rush, running studies across oncology, cardiology, neurology, and more. Both patients and healthy volunteers may qualify. Most studies offer compensation for time and travel.

Recruiting trial data synced daily from ClinicalTrials.gov. Last sync: June 19, 2026.

Filter results

Filter results

State

City

Phase

Study type

Intervention

Recruitment status

Condition

Sex

Age

Healthy volunteers only

2,971 clinical trials

↓ Download CSV

Testing Proton Craniospinal Radiation Therapy Versus the Usual Radiation Therapy for Leptomeningeal Metastasis, RADIATE-LM Trial

for Anatomic Stage IV Breast Cancer AJCC v8

58 locations incl. Phoenix

Sponsor: NRG Oncology

Sex: All·Age: 18+

Code: NCT06500481·Phase 3·Recruiting

Apply to this trial

Validating Innovative Biosensors for Rett Autonomic Symptom Tracking

for Rett Syndrome

3 locations incl. Chicago

Sponsor: Rett Syndrome Research Trust

Sex: All·Age: All ages

Code: NCT06338267·Recruiting

Apply to this trial

Study in Participants With Heart Failure With Preserved Ejection Fraction (HFpEF)

for Heart Failure With Preserved Ejection Fraction (HFpEF)

2 locations incl. Chicago

Sponsor: Secretome Therapeutics

Sex: All·Age: 18+

Code: NCT06560762·Phase 1·Recruiting

Apply to this trial

A Study of Zasocitinib in Adults With Psoriatic Arthritis Who Have Not Taken Biologic Medicines

for Psoriatic Arthritis

Drug: Zasocitinib

54 locations incl. Chandler

Sponsor: Takeda

Sex: All·Age: 18+

Code: NCT06671483·Phase 3·Recruiting

Apply to this trial

A Phase III Renal Outcomes and Cardiovascular Mortality Study to Investigate the Efficacy and Safety of Baxdrostat in Combination With Dapagliflozin in Participants With Chronic Kidney Disease and High Blood Pressure

for Chronic Kidney Disease and Hypertension

Drug: Dapagliflozin

132 locations incl. Fairhope

Sponsor: AstraZeneca

Sex: All·Age: 18+

Code: NCT06742723·Phase 3·Recruiting

Apply to this trial

Evaluation of Efficacy and Safety of Milsaperidone as Adjunctive Therapy in Patients With Major Depressive Disorder

for Major Depressive Disorder (MDD)

21 locations incl. Phoenix

Sponsor: Vanda Pharmaceuticals

Sex: All·Age: 18 - 65

Code: NCT06830044·Phase 3·Recruiting

Apply to this trial

Non-invasive Brain Stimulation for Treating Symptomatic Convergence Insufficiency

for Convergence Insufficiency

1 location in Downers Grove

Sponsor: Midwestern University

Sex: All·Age: 18 - 40·Accepts healthy volunteers

Code: NCT05877560·Recruiting

Apply to this trial

Race-Based Stress and Cognitive Training for MCI

for Mild Cognitive Impairment

1 location in Chicago

Sponsor: Rosalind Franklin University of Medicine and Science

Sex: All·Age: 65+

Code: NCT06330844·Recruiting

Apply to this trial

Review of Infant Oral Feeding and Skills

for Nutrition Disorders

1 location in Chicago

Sponsor: Wake Forest University Health Sciences

Sex: All·Age: 22 Weeks - 42 Weeks

Code: NCT06736743·Enrolling By Invitation

A Phase Ⅲ Study of Rilvegostomig in Combination With Fluoropyrimidine and Trastuzumab Deruxtecan as the First-line Treatment for HER2-positive Gastric Cancer

for HER2-positive Gastric Cancer

Drug: Rilvegostomig

55 locations incl. Anchorage

Sponsor: AstraZeneca

Sex: All·Age: 18+

Code: NCT06764875·Phase 3·Recruiting

Apply to this trial

Assessment of Worldwide Acute Kidney Injury Epidemiology in Neonates 2.0

for Acute Kidney Injury

50 locations incl. Birmingham

Sponsor: Indiana University

Sex: All·Age: 0 Minutes - 2 Weeks

Code: NCT06823115·Enrolling By Invitation

A Study of CLSP-1025 in Adult Patients With Solid Tumors That Harbor the p53 R175H Mutation

for Advanced Solid Tumor

21 locations incl. Scottsdale

Sponsor: Clasp Therapeutics, Inc.

Sex: All·Age: 18+

Code: NCT06778863·Phase 1·Recruiting

Apply to this trial

Rollover Study for Participants Previously Enrolled in Clinical Trials of Povorcitinib

for Hidradenitis Suppurativa (HS)

Drug: Povorcitinib

108 locations incl. Birmingham

Sponsor: Incyte Corporation

Sex: All·Age: 18+

Code: NCT06855498·Phase 3·Recruiting

Apply to this trial

A Trial of the Efficacy and Safety of SEP-363856 in Acutely Psychotic Participants With Schizophrenia

for Schizophrenia

35 locations incl. Bentonville

Sponsor: Otsuka Pharmaceutical Development & Commercialization, Inc.

Sex: All·Age: 18 - 65

Code: NCT06894212·Phase 3·Recruiting

Apply to this trial

Triptorelin for the Prevention of Ovarian Damage in Adolescents and Young Adults With Cancer

for Hematopoietic and Lymphatic System Neoplasm

190 locations incl. Birmingham

Sponsor: Children's Oncology Group

Sex: Female·Age: Up to 39

Code: NCT06513962·Phase 3·Recruiting

Apply to this trial

Study of TDXd, Chemotherapy, Pembrolizumab, and Trastuzumab in First-Line Metastatic HER2-Positive Gastric or Gastroesophageal Junction Cancer

for Gastric Cancer

18 locations incl. New Haven

Sponsor: Daiichi Sankyo

Sex: All·Age: 18+

Code: NCT06731478·Phase 3·Recruiting

Apply to this trial

Clinical Study of Ivonescimab for First-line Treatment of Metastatic NSCLC Patients With High PD-L1

for Non-Small Cell Lung Cancer

Drug: Ivonescimab

89 locations incl. Chandler

Sponsor: Summit Therapeutics

Sex: All·Age: 18+

Code: NCT06767514·Phase 3·Recruiting

Apply to this trial

A Study to Evaluate the Safety and Efficacy of Gocatamig (MK-6070) and Ifinatamab Deruxtecan (I-DXd) in Participants With Relapsed/Refractory Extensive-Stage Small Cell Lung Cancer (MK-6070-002)

for Small Cell Lung Cancer

Drug: Gocatamig

9 locations incl. Aurora

Sponsor: Merck Sharp & Dohme LLC

Sex: All·Age: 18+

Code: NCT06780137·Phase 1, Phase 2·Recruiting

Apply to this trial

Validation and Scaling of Screening Program for Undiagnosed Myasthenia Gravis-Social Media Campaign Paired With a Self-moderated Assessment

for Myasthenia Gravis

1 location in Evanston

Sponsor: ZS Associates

Sex: All·Age: 18+·Accepts healthy volunteers

Code: NCT06866483·Recruiting

Apply to this trial

A Study to Compare the Efficacy and Safety of BMS-986489 (BMS-986012+ Nivolumab Fixed Dose Combination) in Combination With Carboplatin Plus Etoposide to That of Atezolizumab With Carboplatin Plus Etoposide as First-Line Therapy in Participants With Extensive-Stage Small Cell Lung Cancer (TIGOS).

for Extensive-Stage Small Cell Lung Cancer

Drug: Atezolizumab

20 locations incl. Daphne

Sponsor: Bristol-Myers Squibb

Sex: All·Age: 18+

Code: NCT06646276·Phase 3·Recruiting

Apply to this trial

Prevail Global Study

for Coronary Artery Disease

51 locations incl. Birmingham

Sponsor: Medtronic Vascular

Sex: All·Age: 18+

Code: NCT06535854·Recruiting

Apply to this trial

A Clinical Trial to Assess Cognitive Effects of Cognitive Nutritional Supplement in General Population

for Cognition

1 location in Addison

Sponsor: Pharmavite LLC

Sex: All·Age: 25 - 65·Accepts healthy volunteers

Code: NCT06837246·Recruiting

Apply to this trial

Efficacy and Safety Study of Halneuron in the Treatment of Chemotherapy-Induced Neuropathic Pain

for Chemotherapy Induced Neuropathic Pain

25 locations incl. Sheffield

Sponsor: Dogwood Therapeutics Inc.

Sex: All·Age: 18+

Code: NCT06848348·Phase 2·Recruiting

Apply to this trial

Exalt Single-use Duodenoscope Vs Reusable Scope, a Randomized Controlled Trial

for Biliary Diseases

1 location in Chicago

Sponsor: Rush University Medical Center

Sex: All·Age: 19+

Code: NCT06895785·Recruiting

Apply to this trial

Telehealth Education Leveraging Electronic Transitions Of Care for COPD Patients

for COPD Exacerbation

1 location in Chicago

Sponsor: University of Chicago

Sex: All·Age: 18+

Code: NCT05897125·Enrolling By Invitation

A Study to Evaluate How Well Etavopivat Works in People With Sickle Cell Disease

for Sickle Cell Disease

Drug: Etavopivat

50 locations incl. Birmingham

Sponsor: Novo Nordisk A/S

Sex: All·Age: 12+

Code: NCT06612268·Phase 3·Recruiting

Apply to this trial

An Investigational Scan (rhPSMA-7.3 PET/CT) for Detecting Biochemically Recurrent Prostate Cancer, ENLIGHTEN Trial

for Biochemically Recurrent Prostate Carcinoma

1 location in Chicago

Sponsor: Northwestern University

Sex: Male·Age: All ages

Code: NCT06813898·EARLY_Phase 1·Recruiting

Apply to this trial

Non-healing Venous Leg Ulcers Treated With Standard Care With or Without BR-AC

for Non-infected Venous Leg Ulcer

23 locations incl. Guntersville

Sponsor: BioStem Technologies

Sex: All·Age: 18+

Code: NCT06811909·Recruiting

Apply to this trial

Immune Cell Therapy (CAR-T) for the Treatment of Patients With HIV and B-Cell Non-Hodgkin Lymphoma

for AIDS-Related Diffuse Large B-cell Lymphoma

6 locations incl. Duarte

Sponsor: AIDS Malignancy Consortium

Sex: All·Age: 18+

Code: NCT05077527·Phase 1·Recruiting

Apply to this trial

MOTION Clinical Trial

for Osteoarthritis, Knee

8 locations incl. Davis

Sponsor: Moximed

Sex: All·Age: All ages

Code: NCT06843980·Recruiting

Apply to this trial

A Study of CREXONT (Carbidopa and Levodopa) Extended-Release Capsules in Participants With Parkinson's Disease

for Parkinson Disease

27 locations incl. Phoenix

Sponsor: Impax Laboratories, LLC

Sex: All·Age: 18+

Code: NCT06765668·Phase 4·Recruiting

Apply to this trial

A Study to Evaluate the Efficacy and Safety of Orally Administered VX-01

for Diabetic Retinopathy

8 locations incl. Beverly Hills

Sponsor: Vantage Biosciences Ltd

Sex: All·Age: 18+

Code: NCT06770933·Phase 2·Recruiting

Apply to this trial

A Study to Assess Adverse Events and Effectiveness of Gel Stent (XEN63) Implantation Using Ab Interno and Ab Externo Approaches in Adult Participants With Glaucoma

for Primary Open Angle Glaucoma

25 locations incl. Glendale

Sponsor: AbbVie

Sex: All·Age: 45+

Code: NCT06822738·Phase 3·Recruiting

Apply to this trial

KRONOS Versus Breg T-Scope Post-operative Knee Braces Following Anterior Cruciate Ligament (ACL) Reconstruction

for Anterior Cruciate Ligament (ACL) Reconstruction Surgery

1 location in Chicago

Sponsor: Rush University Medical Center

Sex: All·Age: 18+

Code: NCT07090616·Recruiting

Apply to this trial

A Study of Nipocalimab or Intravenous Immunoglobulin (IVIG) in Pregnancies At Risk of Fetal and Neonatal Alloimmune Thrombocytopenia (FNAIT)

for Thrombocytopenia, Neonatal Alloimmune

Drug: Nipocalimab

12 locations incl. Birmingham

Sponsor: Janssen Research & Development, LLC

Sex: Female·Age: 18 - 45

Code: NCT06533098·Phase 3·Recruiting

Apply to this trial

A Phase 2, Open-Label Study to Evaluate the Safety and Effects of HLX-1502 in Patients With Neurofibromatosis Type 1

for Neurofibromatosis Type 1

14 locations incl. Birmingham

Sponsor: Healx Limited

Sex: All·Age: 12+

Code: NCT06541847·Phase 2·Recruiting

Apply to this trial

This Study Will Evaluate the Effectiveness of NTX-001, a Surgical Nerve Repair Product When Used in People With Upper Extremity Nerve Lacerations.

for Peripheral Nerve Injury Upper Limb

18 locations incl. Orlando

Sponsor: Neuraptive Therapeutics Inc.

Sex: All·Age: 18 - 80

Code: NCT06616025·Phase 3·Recruiting

Apply to this trial

Recovery Legal Care Clinical Trial

for Firearm Injury

1 location in Chicago

Sponsor: University of Chicago

Sex: All·Age: 14+

Code: NCT06618794·Recruiting

Apply to this trial

A Clinical Study to Evaluate the Safety and Efficacy of the FloStent in Men With Benign Prostatic Hyperplasia Symptoms

for Benign Prostatic Hyperplasia

19 locations incl. Bakersfield

Sponsor: Rivermark Medical

Sex: Male·Age: 45+

Code: NCT06849258·Recruiting

Apply to this trial

A Study to Evaluate the Efficacy and Safety of DNTH103 in Adults With Chronic Inflammatory Demyelinating Polyneuropathy (CAPTIVATE)

for Chronic Inflammatory Demyelinating Polyneuropathy

31 locations incl. Birmingham

Sponsor: Dianthus Therapeutics

Sex: All·Age: 18 - 75

Code: NCT06858579·Phase 3·Recruiting

Apply to this trial