Oncology Clinical Trials in Iowa City, IA

As of September 2026, 107 paid clinical trials are recruiting for Oncology in Iowa City, Iowa. Compensation typically covers time, travel, and study visits, and many studies also include study-related medical care at no cost.

Recruiting trial data synced daily from ClinicalTrials.gov. Last sync: September 1, 2026.

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108 clinical trials for Oncology

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Spevatamig (PT886) as Monotherapy or in Combination With Chemo and/or ICI, for the Treatment of Patients With Advanced Gastric, Gastroesophageal Junction, Pancreatic Ductal or Biliary Tract Carcinomas (the TWINPEAK Study)

for Gastric or Gastroesophageal Junction Adenocarcinoma

Sites in Iowa City +9 more locations

Sponsor: Phanes Therapeutics

Sex: All·Age: 18+

Code: NCT05482893·Phase 1, Phase 2·Recruiting·Listed Aug 2022

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MC1R-targeted Alpha-particle Monotherapy and Combination Therapy Trial With Nivolumab in Adults With Advanced Melanoma

for Recurrent Melanoma (Skin)

Drug: Nivolumab

Sites in Iowa City +11 more locations

Sponsor: Perspective Therapeutics

Sex: All·Age: 18 - 90

Code: NCT05655312·Phase 1, Phase 2·Recruiting·Listed Dec 2022

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A Study of [225Ac]Ac-AKY-1189 in Patients With Solid Tumors

for Urothelial Carcinoma Bladder

Sites in Iowa City +11 more locations

Sponsor: Aktis Oncology, Inc.

Sex: All·Age: 18+

Code: NCT07020117·Phase 1·Recruiting·Listed Jun 2025

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Study to Evaluate the Safety, Tolerability & Efficacy of TNG462 in Combination in PDAC & NSCLC Patients

for PDAC

Sites in Iowa City +17 more locations

Sponsor: Tango Therapeutics, Inc.

Sex: All·Age: 18+

Code: NCT06922591·Phase 1, Phase 2·Recruiting·Listed Apr 2025

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A Study of Revumenib in R/R Leukemias Including Those With an MLL/KMT2A Gene Rearrangement or NPM1 Mutation

for Acute Myeloid Leukemia

Drug: Revumenib

Sites in Iowa City +9 more locations

Sponsor: Syndax Pharmaceuticals

Sex: All·Age: 30 Days+

Code: NCT04065399·Phase 1, Phase 2·Recruiting·Listed Aug 2019

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Evaluate BL-B01D1 in Patients With Metastatic or Unresectable Non-Small Cell Lung Cancer (NSCLC) and Other Solid Tumors

for Non Small Cell Lung Cancer

Sites in Iowa City +23 more locations

Sponsor: SystImmune Inc.

Sex: All·Age: 18+

Code: NCT05983432·Phase 1·Recruiting·Listed Aug 2023

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Phase 1b Study of OP-1250 (Palazestrant) in Combination With Ribociclib, Alpelisib, Everolimus, or Atirmociclib in ER+, HER2- Breast Cancer

for Metastatic Breast Cancer

Drug: Palazestrant

Sites in Iowa City +13 more locations

Sponsor: Olema Pharmaceuticals, Inc.

Sex: All·Age: 18+

Code: NCT05508906·Phase 1·Recruiting·Listed Aug 2022

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uTRACT Jelmyto Registry: A Registry of Patients With Upper Tract Urothelial Cancer (UTUC) Treated With Jelmyto

for Urothelial Carcinoma

Sites in Iowa City +21 more locations

Sponsor: UroGen Pharma Ltd.

Sex: All·Age: 18+

Code: NCT05874921·Recruiting·Listed May 2023

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A Study of Ifinatamab Deruxtecan in Pediatric Participants With Relapsed or Refractory Solid Tumors (MK-9999-01D/LIGHTBEAM-U01)

for Malignant Neoplasm

Sites in Iowa City +7 more locations

Sponsor: Merck Sharp & Dohme LLC

Sex: All·Age: 1 Month - 17

Code: NCT07630974·Phase 1, Phase 2·Recruiting·Listed Jun 2026

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A Study to Test Inavolisib Treatment in Participants With Metastatic Castration-Resistant Prostate Cancer

for Metastatic Castration-Resistant Prostate Cancer

Sites in Iowa City +5 more locations

Sponsor: Hoffmann-La Roche

Sex: Male·Age: 18+

Code: NCT07287150·Phase 2·Recruiting·Listed Dec 2025

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Study of RYZ401 in Subjects With Solid Tumors Expressing SSTRs.

for GEP-NET

Sites in Iowa City +6 more locations

Sponsor: RayzeBio, Inc.

Sex: All·Age: 18+

Code: NCT07165132·Phase 1·Recruiting·Listed Sep 2025

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Safety and Tolerability of ²¹²Pb-DOTAM-GRPR1 in Adult Subjects With Recurrent or Metastatic GRPR-expressing Tumors

for Cervical Cancer

Sites in Iowa City +6 more locations

Sponsor: Orano Med Theranostics, SAS

Sex: All·Age: 18+

Code: NCT05283330·Phase 1·Recruiting·Listed Mar 2022

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A First-in-human, Dose Escalation and Dose Expansion Study of SAR445877 in Adult Participants With Advanced Solid Tumors

for Solid Tumor

Sites in Iowa City +8 more locations

Sponsor: Sanofi

Sex: All·Age: 18+

Code: NCT05584670·Phase 1, Phase 2·Recruiting·Listed Oct 2022

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BGB-21447 (Bcl-2 Inhibitor) Combinations for Adults With Hormone-Receptor Positive (HR+)/Human Epidermal Growth Factor Receptor 2 Negative (HER2-) Metastatic Breast Cancer

for Hormone-receptor-positive Breast Cancer

Sites in Iowa City +2 more locations

Sponsor: BeOne Medicines

Sex: All·Age: 18+

Code: NCT06756932·Phase 1·Recruiting·Listed Jan 2025

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Test-retest Evaluation of [18F]F-AraG PET

for Non-small Cell Lung Cancer

1 location in Iowa City

Sponsor: CellSight Technologies, Inc.

Sex: All·Age: 18+

Code: NCT06084806·Phase 2·Recruiting·Listed Oct 2023

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CHAMP Lung Cancer Screening Program

for Lung Cancer

Sites in Iowa City & Waterloo

Sponsor: Jill Kolesar

Sex: All·Age: 50 - 77

Code: NCT07572773·Recruiting·Listed May 2026

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Sirolimus Pre-conditioning on T Cell Activity and T-cell Engaging Bispecific Antibody Efficacy in Multiple Myeloma

for Multiple Myeloma

1 location in Iowa City

Sponsor: Christopher Strouse

Sex: All·Age: 18+

Code: NCT07581704·Phase 1·Recruiting·Listed May 2026

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Sitagliptin in Recurrent/Progressive Grade 4 Glioma

for Glioma

1 location in Iowa City

Sponsor: Kailin Yang, MD, PhD

Sex: All·Age: 18+

Code: NCT07541781·Phase 1·Recruiting·Listed Apr 2026

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5-Azacitidine Plus PD-1/PD-L1 Inhibitor With PD-1/PD-L1 Refractory Tumors

for Solid Tumor

1 location in Iowa City

Sponsor: Mohammed Milhem

Sex: All·Age: 18 - 99

Code: NCT07404332·Phase 1·Recruiting·Listed Feb 2026

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Evaluating the Addition of Adjuvant Chemotherapy to Ovarian Function Suppression Plus Endocrine Therapy in Premenopausal Patients With pN0-1, ER-Positive/HER2-Negative Breast Cancer and an Oncotype Recurrence Score Less Than or Equal to 25

for Breast Cancer

Sites in Iowa City, Cedar Rapids +1098 more locations

Sponsor: NRG Oncology

Sex: Female·Age: 18 - 60

Code: NCT05879926·Phase 3·Recruiting·Listed May 2023

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Testing Olaparib for One or Two Years, With or Without Bevacizumab, to Treat Ovarian Cancer

for Fallopian Tube Endometrioid Adenocarcinoma

Drug: Bevacizumab

Sites in Iowa City, Cedar Rapids +653 more locations

Sponsor: NRG Oncology

Sex: All·Age: 18+

Code: NCT06580314·Phase 3·Recruiting·Listed Aug 2024

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A Study to Compare Two Surgical Procedures in Individuals With BRCA1 Mutations to Assess Reduced Risk of Ovarian Cancer

for Ovarian Carcinoma

Sites in Iowa City, Council Bluffs +479 more locations

Sponsor: NRG Oncology

Sex: Female·Age: 35 - 50

Code: NCT04251052·Recruiting·Listed Jan 2020

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E-Mindfulness Approaches for Living After Breast Cancer

for Breast Cancer

Sites in Iowa City, Cedar Rapids +372 more locations

Sponsor: NRG Oncology

Sex: All·Age: 18 - 50

Code: NCT06748222·Phase 3·Recruiting·Listed Dec 2024

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MYELOMATCH: A Screening Study to Assign People With Myeloid Cancer to a Treatment Study or Standard of Care Treatment Within myeloMATCH (MyeloMATCH Screening Trial)

for Acute Myeloid Leukemia

Sites in Iowa City, Pella +328 more locations

Sponsor: National Cancer Institute (NCI)

Sex: All·Age: 18+

Code: NCT05564390·Phase 2·Recruiting·Listed Oct 2022

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Testing Continuous Versus Intermittent Treatment With the Study Drug Zanubrutinib for Older Patients With Previously Untreated Mantle Cell Lymphoma

for Mantle Cell Lymphoma

Sites in Iowa City, Marshalltown +228 more locations

Sponsor: Alliance for Clinical Trials in Oncology

Sex: All·Age: 60+

Code: NCT05976763·Phase 3·Recruiting·Listed Aug 2023

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Testing New Therapies for Patients With Acute Myeloid Leukemia Who Are Newly Diagnosed and Have Not Yet Started Treatment (A MyeloMATCH Treatment Trial)

for Acute Myeloid Leukemia

Sites in Iowa City +205 more locations

Sponsor: National Cancer Institute (NCI)

Sex: All·Age: 18 - 59

Code: NCT05554406·Phase 2·Recruiting·Listed Sep 2022

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Venetoclax and HMA Treatment of Older and Unfit Adults With FLT3 Mutated Acute Myeloid Leukemia (AML) (A MyeloMATCH Treatment Trial)

for Acute Myeloid Leukemia

Drug: Venetoclax

Sites in Iowa City +215 more locations

Sponsor: National Cancer Institute (NCI)

Sex: All·Age: 18+

Code: NCT06317649·Phase 2·Recruiting·Listed Mar 2024

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Testing the Addition of an IDH2 Inhibitor, Enasidenib, to Usual Treatment (Cedazuridine-Decitabine) for Higher-Risk Myelodysplastic Syndrome (MDS) With IDH2 Mutation (A MyeloMATCH Treatment Trial)

for Myelodysplastic Syndrome

Sites in Iowa City, Pella +136 more locations

Sponsor: National Cancer Institute (NCI)

Sex: All·Age: 18+

Code: NCT06577441·Phase 2·Recruiting·Listed Aug 2024

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Testing the Addition of the Drug BMX-001, a Radioprotector, or a Placebo to the Usual Chemoradiation Therapy for Patients With Head and Neck Cancer

for Clinical Stage I HPV-Mediated (p16-Positive) Oropharyngeal Carcinoma AJCC v8

Sites in Iowa City, Cedar Rapids +144 more locations

Sponsor: NRG Oncology

Sex: All·Age: 18+

Code: NCT06532279·Phase 2·Recruiting·Listed Aug 2024

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Triptorelin for the Prevention of Ovarian Damage in Adolescents and Young Adults With Cancer

for Hematopoietic and Lymphatic System Neoplasm

Sites in Iowa City, Pella +189 more locations

Sponsor: Children's Oncology Group

Sex: Female·Age: Up to 39

Code: NCT06513962·Phase 3·Recruiting·Listed Jul 2024

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Comparing Cytarabine + Daunorubicin Therapy Versus Cytarabine + Daunorubicin + Venetoclax Versus Venetoclax + Azacitidine in Younger Patients With Intermediate Risk AML (A MyeloMATCH Treatment Trial)

for Acute Myeloid Leukemia

Drug: Venetoclax

Sites in Iowa City +171 more locations

Sponsor: National Cancer Institute (NCI)

Sex: All·Age: 18 - 59

Code: NCT05554393·Phase 2·Recruiting·Listed Sep 2022

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Testing Longer Duration Radiation Therapy Versus the Usual Radiation Therapy in Patients With Cancer That Has Spread to the Brain

for Anatomic Stage IV Breast Cancer AJCC v8

Sites in Iowa City, Ames +255 more locations

Sponsor: NRG Oncology

Sex: All·Age: 18+

Code: NCT06500455·Phase 3·Recruiting·Listed Jul 2024

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Inotuzumab Ozogamicin and Post-Induction Chemotherapy in Treating Patients With High-Risk B-ALL, Mixed Phenotype Acute Leukemia, and B-LLy

for B Acute Lymphoblastic Leukemia

Sites in Iowa City, Des Moines +185 more locations

Sponsor: Children's Oncology Group

Sex: All·Age: 365 Days - 25

Code: NCT03959085·Phase 3·Recruiting·Listed May 2019

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Comparison of Intravesical Therapy and Surgery as Treatment Options for Bladder Cancer 2

for Bladder Cancer

Sites in Iowa City +5 more locations

Sponsor: University of Washington

Sex: All·Age: 18+

Code: NCT07225127·Recruiting·Listed Nov 2025

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A Study to Compare Standard Chemotherapy to Therapy With CPX-351 and/or Gilteritinib for Patients With Newly Diagnosed AML With or Without FLT3 Mutations

for Acute Myeloid Leukemia

Sites in Iowa City, Des Moines +167 more locations

Sponsor: Children's Oncology Group

Sex: All·Age: Up to 21

Code: NCT04293562·Phase 3·Recruiting·Listed Mar 2020

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Project: Every Child for Younger Patients With Cancer

for Adrenal Gland Pheochromocytoma

Sites in Iowa City, Des Moines +225 more locations

Sponsor: Children's Oncology Group

Sex: All·Age: Up to 25

Code: NCT02402244·Recruiting·Listed Mar 2015

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Intravesical GEM/DOCE for HR BCG-Unresponsive NMIBC

for Bladder Cancer

1 location in Iowa City

Sponsor: Michael A. O'Donnell

Sex: All·Age: 18 - 99

Code: NCT07322263·Phase 2·Recruiting·Listed Jan 2026

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Venetoclax in Children With Relapsed Acute Myeloid Leukemia (AML)

for Acute Myeloid Leukemia

Drug: Venetoclax

Sites in Iowa City +44 more locations

Sponsor: PedAL BCU, LLC

Sex: All·Age: 29 Days - 21

Code: NCT05183035·Phase 3·Recruiting·Listed Jan 2022

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The Pediatric Acute Leukemia (PedAL) Screening Trial - A Study to Test Bone Marrow and Blood in Children With Leukemia That Has Come Back After Treatment or Is Difficult to Treat - A Leukemia & Lymphoma Society and Children's Oncology Group Study

for Acute Lymphoblastic Leukemia

Sites in Iowa City, Des Moines +154 more locations

Sponsor: PedAL BCU, LLC

Sex: All·Age: Up to 22

Code: NCT04726241·Phase 1, Phase 2·Recruiting·Listed Jan 2021

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Thoracotomy Versus Thoracoscopic Management of Pulmonary Metastases in Patients With Osteosarcoma

for Metastatic Malignant Neoplasm in the Lung

Sites in Iowa City, Des Moines +200 more locations

Sponsor: Children's Oncology Group

Sex: All·Age: Up to 50

Code: NCT05235165·Phase 3·Recruiting·Listed Feb 2022

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Conditions in Oncology (Iowa City, IA)

Non-small cell lung cancer (NSCLC)· 14 Breast cancer· 13 Acute myeloid leukemia (AML)· 11 Non-Hodgkin lymphoma· 10 Solid tumor· 10 Multiple myeloma· 8 Hematologic malignancy· 7 Bladder cancer· 6 Leukemia (other)· 6 Myelodysplastic syndromes (MDS)· 6 Melanoma· 6 Metastatic breast cancer· 5 Ovarian cancer· 5 Diffuse large B-cell lymphoma (DLBCL)· 5 Cancer (any)· 5 Lung cancer· 4 Colorectal cancer· 4 Neuroendocrine tumors· 4 Triple-negative breast cancer· 3 HER2-negative breast cancer· 3 Pancreatic cancer· 3 Prostate cancer· 3 Endometrial cancer· 3 Cervical cancer· 3 Glioblastoma· 3 Chronic lymphocytic leukemia (CLL)· 3 Acute lymphoblastic leukemia· 3 Myeloproliferative neoplasm· 3 Follicular lymphoma· 3 Mantle cell lymphoma· 3 Small lymphocytic lymphoma· 3 Head and neck cancer· 3 Neuroblastoma· 3 Small cell lung cancer· 2 Colon cancer· 2 Gastric cancer· 2 Esophageal cancer· 2 Kidney cancer· 2 Marginal zone lymphoma· 2 Osteosarcoma· 2 Ewing sarcoma· 2 Pediatric cancer· 2 Gastroesophageal junction cancer· 1 Liver cancer· 1 Biliary tract cancer· 1 Metastatic prostate cancer· 1 Gynecologic cancer· 1 Glioma· 1 Brain metastases· 1 Myelofibrosis· 1 Hodgkin lymphoma· 1 Burkitt lymphoma· 1 Sarcoma· 1 Soft tissue sarcoma· 1