Clinical Trials at University of Iowa

As of July 2026, 176 paid clinical trials are recruiting at University of Iowa, located at 200 HAWKINS DR, IOWA CITY, IA 52242, phone (319) 356-1616 in Iowa City, Iowa. Compensation typically covers time, travel, and study visits — most studies also offer study-related medical care at no cost to participants.

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Recruiting trial data synced daily from ClinicalTrials.gov. Last sync: July 19, 2026.

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178 clinical trials at University of Iowa

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MC1R-targeted Alpha-particle Monotherapy and Combination Therapy Trial With Nivolumab in Adults With Advanced Melanoma

for Recurrent Melanoma (Skin)

Drug: Nivolumab

Sites in Iowa City +11 more locations

Sponsor: Perspective Therapeutics

Sex: All·Age: 18 - 90

Code: NCT05655312·Phase 1, Phase 2·Recruiting·Listed Dec 2022

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A Study of CLN-978, a Subcutaneously Administered CD19-directed T Cell Engager, in Subjects With Systemic Lupus Erythematosus

for SLE

Sites in Iowa City +9 more locations

Sponsor: Cullinan Therapeutics Inc.

Sex: All·Age: 18 - 70

Code: NCT06613360·Phase 1·Recruiting·Listed Sep 2024

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A Study of SNP-ACTH (1-39) Gel in Patients With Primary Membranous Nephropathy

for Primary Membranous Nephropathy

Sites in Iowa City +18 more locations

Sponsor: Cerium Pharmaceuticals, Inc.

Sex: All·Age: 18+

Code: NCT05696613·Phase 3·Recruiting·Listed Jan 2023

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Belzutifan/MK-6482 for the Treatment of Advanced Pheochromocytoma/Paraganglioma (PPGL), Pancreatic Neuroendocrine Tumor (pNET), Von Hippel-Lindau (VHL) Disease-Associated Tumors, Advanced Gastrointestinal Stromal Tumor (wt GIST), or Solid Tumors With HIF-2α Related Genetic Alterations (MK-6482-015)

for Pheochromocytoma/Paraganglioma

Sites in Iowa City +10 more locations

Sponsor: Merck Sharp & Dohme LLC

Sex: All·Age: 12+

Code: NCT04924075·Phase 2·Recruiting·Listed Jun 2021

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A Study of BMS-986340 as Monotherapy and as Combination Therapy in Participants With Advanced Solid Tumors

for Cervical Cancer

Sites in Iowa City +8 more locations

Sponsor: Bristol-Myers Squibb

Sex: All·Age: 18+

Code: NCT04895709·Phase 1, Phase 2·Recruiting·Listed May 2021

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A Study to Evaluate How Apitegromab Works in Subjects Who Are Less Than 2 Years Old and Have Spinal Muscular Atrophy

for Spinal Muscular Atrophy

Drug: Apitegromab

Sites in Iowa City +13 more locations

Sponsor: Scholar Rock, Inc.

Sex: All·Age: Up to 2

Code: NCT07047144·Phase 2·Recruiting·Listed Jul 2025

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A Study of Rapcabtagene Autoleucel in Active, Refractory Systemic Lupus Erythematosus (SLE) or Lupus Nephritis (LN) Patients (AUTOGRAPH - SLE/LN)

for Lupus Erythematosus, Systemic

Sites in Iowa City +18 more locations

Sponsor: Novartis Pharmaceuticals

Sex: All·Age: 18 - 75

Code: NCT06581198·Phase 2·Recruiting·Listed Sep 2024

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A Study of [225Ac]Ac-AKY-1189 in Patients With Solid Tumors

for Urothelial Carcinoma Bladder

Sites in Iowa City +11 more locations

Sponsor: Aktis Oncology, Inc.

Sex: All·Age: 18+

Code: NCT07020117·Phase 1·Recruiting·Listed Jun 2025

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A Phase 1/2, Open-label, Safety and Dosing Study of Autologous CART Cells (Desmoglein 3 Chimeric Autoantibody Receptor T Cells [DSG3-CAART] or CD19-specific Chimeric Antigen Receptor T Cells [CABA-201]) in Subjects With Active, Pemphigus Vulgaris (RESET-PV)

for Pemphigus Vulgaris

Sites in Iowa City +9 more locations

Sponsor: Cabaletta Bio

Sex: All·Age: 18+

Code: NCT04422912·Phase 1, Phase 2·Recruiting·Listed Jun 2020

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A Study of Vosoritide in Children With Noonan Syndrome With Inadequate Growth During or After Human Growth Hormone Treatment

for Noonan Syndrome

Drug: Vosoritide

Sites in Iowa City +21 more locations

Sponsor: BioMarin Pharmaceutical

Sex: All·Age: 3 - 11

Code: NCT06668805·Phase 2·Recruiting·Listed Oct 2024

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Targeted Alpha-Particle Therapy for Advanced Somatostatin Receptor Type 2 (SSTR2) Positive Tumors

for Neuroendocrine Tumors Unresectable

Sites in Iowa City +18 more locations

Sponsor: Perspective Therapeutics

Sex: All·Age: 18 - 90

Code: NCT05636618·Phase 1, Phase 2·Recruiting·Listed Dec 2022

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Phase 2 Study Evaluating Rapcabtagene Autoleucel in Participants With Diffuse Cutaneous Systemic Sclerosis

for Scleroderma, Diffuse

Sites in Iowa City +13 more locations

Sponsor: Novartis Pharmaceuticals

Sex: All·Age: 18 - 70

Code: NCT06655896·Phase 2·Recruiting·Listed Oct 2024

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Soquelitinib vs Standard of Care in Participants With Relapsed/Refractory Peripheral T-cell Lymphoma Not Otherwise Specified, Follicular Helper T-cell Lymphomas, or Systemic Anaplastic Large-cell Lymphoma

for Peripheral T-Cell Lymphoma, Not Otherwise Specified

Drug: Soquelitinib

Sites in Iowa City +20 more locations

Sponsor: Corvus Pharmaceuticals, Inc.

Sex: All·Age: 18+

Code: NCT06561048·Phase 3·Recruiting·Listed Aug 2024

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A Study to Investigate the Safety and Efficacy of KQB168 as Monotherapy and in Combination in Participants With Advanced Solid Malignancies

for Solid Tumor Malignancies

Sites in Iowa City +14 more locations

Sponsor: Kumquat Biosciences Inc.

Sex: All·Age: 18+

Code: NCT06994806·Phase 1·Recruiting·Listed May 2025

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A Non-interventional, Post-authorisation Safety Study of Patients Treated With Efgartigimod Alfa

for Myasthenia Gravis

Sites in Iowa City +16 more locations

Sponsor: argenx

Sex: All·Age: 18+

Code: NCT06298565·Recruiting·Listed Mar 2024

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A Study of AAV2-hAQP1 Gene Therapy in Participants With Radiation-Induced Late Xerostomia

for Grade 2 and 3 Late Xerostomia Caused by Radiotherapy for Cancers of the Upper Aerodigestive Tract, Excluding the Parotid Glands

Sites in Iowa City +17 more locations

Sponsor: MeiraGTx, LLC

Sex: All·Age: 18+

Code: NCT05926765·Phase 2·Recruiting·Listed Jul 2023

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A Real World Study of eCoin for Urgency Urinary Incontinence: Post Approval Evaluation (RECIPE)

for Overactive Bladder

Sites in Iowa City, Ankeny +17 more locations

Sponsor: Valencia Technologies Corporation

Sex: All·Age: 18+

Code: NCT05685433·Recruiting·Listed Jan 2023

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Safety and Effectiveness of Mechanical Thrombectomy Using the Anaconda ANA Funnel Catheter

for Acute Ischemic Stroke From Large Vessel Occlusion

Sites in Iowa City +10 more locations

Sponsor: Anaconda Biomed S.L.

Sex: All·Age: 22 - 85

Code: NCT06370182·Recruiting·Listed Apr 2024

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Phase 1b Study of OP-1250 (Palazestrant) in Combination With Ribociclib, Alpelisib, Everolimus, or Atirmociclib in ER+, HER2- Breast Cancer

for Metastatic Breast Cancer

Drug: Palazestrant

Sites in Iowa City +13 more locations

Sponsor: Olema Pharmaceuticals, Inc.

Sex: All·Age: 18+

Code: NCT05508906·Phase 1·Recruiting·Listed Aug 2022

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A Study of RSLV-132 in Females With Sjögren's Disease

for Primary Sjögren Syndrome

Sites in Iowa City +23 more locations

Sponsor: Resolve Therapeutics

Sex: Female·Age: 18 - 75

Code: NCT06440525·Phase 2·Recruiting·Listed Jun 2024

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MB-105 in Patients With CD5 Positive T-cell Lymphoma

for Lymphoma, T-Cell

Sites in Iowa City +11 more locations

Sponsor: March Biosciences Inc

Sex: All·Age: 18+

Code: NCT06534060·Phase 2·Recruiting·Listed Aug 2024

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Treatment of Moderate to Severe Refractory Crohn's Disease

for Crohns Disease

Sites in Iowa City +12 more locations

Sponsor: Tr1X, Inc.

Sex: All·Age: 18 - 65

Code: NCT06721962·Phase 1, Phase 2·Recruiting·Listed Dec 2024

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Study of Intrathecal ELP-02 for Charcot-Marie-Tooth Disease Type 4J (CMT4J)

for Charcot-Marie-Tooth Disease Type 4J

Sites in Iowa City +1 more location

Sponsor: Elpida Therapeutics SPC

Sex: All·Age: 3 - 20

Code: NCT07447557·Phase 1, Phase 2·Recruiting·Listed Mar 2026

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A Study of Baricitinib (LY3009104) for the Delay of Stage 3 Type 1 Diabetes in At-Risk Children and Adults

for Diabetes Mellitus, Type 1

Drug: Baricitinib

Sites in Iowa City, West Des Moines +4 more locations

Sponsor: Eli Lilly and Company

Sex: All·Age: 1 - 35

Code: NCT07222137·Phase 3·Recruiting·Listed Oct 2025

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Long-term Follow-up of a Cochlear Implant With Dexamethasone Eluting Electrode Array

for Sensorineural Hearing Loss

Sites in Iowa City +2 more locations

Sponsor: Cochlear

Sex: All·Age: 18+

Code: NCT06936449·Recruiting·Listed Apr 2025

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A First-in-human, Dose Escalation and Dose Expansion Study of SAR445877 in Adult Participants With Advanced Solid Tumors

for Solid Tumor

Sites in Iowa City +8 more locations

Sponsor: Sanofi

Sex: All·Age: 18+

Code: NCT05584670·Phase 1, Phase 2·Recruiting·Listed Oct 2022

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SPI-1005 in Adults Receiving Cochlear Implant

for Hearing Loss

Sites in Iowa City +5 more locations

Sponsor: Sound Pharmaceuticals, Incorporated

Sex: All·Age: 18+

Code: NCT06340633·Phase 2·Recruiting·Listed Apr 2024

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Study to Evaluate Sepofarsen in Subjects With Leber Congenital Amaurosis (LCA) Type 10 (HYPERION)

for Leber Congenital Amaurosis 10

Sites in Iowa City +4 more locations

Sponsor: Laboratoires Thea

Sex: All·Age: 6+

Code: NCT06891443·Phase 3·Recruiting·Listed Mar 2025

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Phase I Study of [225Ac]Ac-ETN029 in Patients With Advanced DLL3-expressing Solid Tumors

for Small Cell Lung Carcinoma

Sites in Iowa City +3 more locations

Sponsor: Novartis Pharmaceuticals

Sex: All·Age: 18 - 100

Code: NCT07006727·Phase 1·Recruiting·Listed Jun 2025

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An Open-Label Study of CTI-1601 in Subjects With Friedreich's Ataxia

for Friedreich Ataxia

Sites in Iowa City +5 more locations

Sponsor: Larimar Therapeutics, Inc.

Sex: All·Age: 2 - 60

Code: NCT06447025·Phase 2·Recruiting·Listed Jun 2024

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Safety, Tolerability, Pharmacodynamic, Efficacy, and Pharmacokinetic Study of DYNE-101 in Participants With Myotonic Dystrophy Type 1

for Myotonic Dystrophy Type 1 (DM1)

Sites in Iowa City +7 more locations

Sponsor: Dyne Therapeutics

Sex: All·Age: 18 - 65

Code: NCT05481879·Phase 1, Phase 2·Recruiting·Listed Aug 2022

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A Study to Learn About the Safety and Effects of the Study Drug PRX-102 in Children and Adolescents With Fabry Disease

for Fabry Disease

Sites in Iowa City +5 more locations

Sponsor: Chiesi Farmaceutici S.p.A.

Sex: All·Age: 2 - 17

Code: NCT06328608·Phase 2, Phase 3·Recruiting·Listed Mar 2024

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Gene Therapy Trial for Otoferlin Gene-mediated Hearing Loss

for Sensorineural Hearing Loss, Bilateral

Sites in Iowa City +5 more locations

Sponsor: Akouos, Inc.

Sex: All·Age: All ages

Code: NCT05821959·Phase 1, Phase 2·Recruiting·Listed Apr 2023

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A Study to Evaluate the Safety of AB-1003 (Previously LION-101) in Subjects With Genetic Confirmation of LGMD2I/R9 (Part1)

for Limb Girdle Muscular Dystrophy

Sites in Iowa City +5 more locations

Sponsor: AskBio Inc

Sex: All·Age: 18 - 65

Code: NCT05230459·Phase 1, Phase 2·Recruiting·Listed Feb 2022

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Otoferlin Gene-mediated Hearing Loss Natural History Study

for Sensorineural Hearing Loss, Bilateral

Sites in Iowa City +3 more locations

Sponsor: Akouos, Inc.

Sex: All·Age: Up to 44

Code: NCT05572073·Recruiting·Listed Oct 2022

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Tibulizumab Systemic Sclerosis Understanding and Response Evaluation (TibuSURE)

for Systemic Sclerosis (SSc)

Sites in Iowa City +5 more locations

Sponsor: Zura Bio Inc

Sex: All·Age: 18 - 75

Code: NCT06843239·Phase 2·Recruiting·Listed Feb 2025

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Efanesoctocog Alfa Prophylaxis in Patients With Hemophilia A With Synovial Hypertrophy

for Factor VIII Deficiency

Sites in Iowa City +3 more locations

Sponsor: Sanofi

Sex: All·Age: 12+

Code: NCT06941870·Phase 4·Recruiting·Listed Apr 2025

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Single-Sided Deafness and Asymmetric Hearing Loss

for Hearing Loss, Unilateral

Sites in Iowa City +2 more locations

Sponsor: Med-El Corporation

Sex: All·Age: 5+

Code: NCT04506853·Recruiting·Listed Aug 2020

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Investigation to Evaluate the Safety and Effectiveness of Cochlear Implantation in Children and Adults With Unilateral Hearing Loss/Single-sided Deafness

for Hearing Loss, Unilateral

Sites in Iowa City +5 more locations

Sponsor: Cochlear

Sex: All·Age: 5+

Code: NCT05318417·Recruiting·Listed Apr 2022

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Post-Market Clinical Investigation of the IotaSOFT Insertion System

for Hearing Loss, Cochlear

Sites in Iowa City +2 more locations

Sponsor: iotaMotion, Inc.

Sex: All·Age: 12+

Code: NCT06664697·Recruiting·Listed Oct 2024

Apply to this trial