Paid Clinical Trials in Knoxville, TN
As of July 2026, 214 paid clinical trials are recruiting in Knoxville, Tennessee. Compensation typically covers time, travel, and study visits, with stipends ranging from modest amounts for short outpatient studies to several thousand dollars for long or inpatient protocols.
Knoxville offers studies at sites including University of Tennessee Medical Center for conditions such as Acute Myeloid Leukemia, Breast Cancer, Obesity, Carcinoma, Non-Small-Cell Lung. Both patients with specific conditions and healthy volunteers can qualify. Most trials offer free study-related medical care alongside compensation.
Recruiting trial data synced daily from ClinicalTrials.gov. Last sync: .
Trials by specialty in Knoxville
Filter results
0 clinical trials
·Clear filters·↓ Download CSVTop Research Study Locations in Knoxville
Researchers run research studies in Knoxville, TN at 25 active sites. The clinics below currently host the largest number of recruiting studies — each name is followed by the conditions they focus on most.
| Site | Specializes in | Active trials |
|---|---|---|
| University of Tennessee Medical Center | Carcinoma, Non-Small-Cell Lung, COPD Exacerbation, Hepatocellular Carcinoma | 29 |
| East Tennessee Childrens Hospital | Acute Myeloid Leukemia, B Acute Lymphoblastic Leukemia, Down Syndrome | 24 |
| University of Tennessee - Knoxville | Acute Myeloid Leukemia, Acute Myeloid Leukemia Arising From Previous Myelodysplastic/Myeloproliferative Neoplasm, Acute Myeloid Leukemia Post Cytotoxic Therapy | 18 |
| Tennessee Cancer Specialists | Breast Cancer, Advanced Breast Cancer, Carcinoma, Non-Small-Cell Lung | 11 |
| University of Tennessee | AI-Based Fitness, Advanced Melanoma, Carcinoma, Non-Small-Cell Lung | 8 |
| University of Tennessee Graduate School of Medicine | Cardiac Amyloidosis, Cardiometabolic Diseases, Carpal Tunnel Syndrome (CTS) | 7 |
| AMR Clinical | Cannabis Withdrawal, Focus of the Study: Safety of XFB19, Menstrual Migraine | 4 |
| Thompson Proton Center | Breast Cancer, Breast Cancer Stage I, Breast Cancer Stage II | 4 |
| Alliance for Multispecialty Research, LLC | ALS, Healthy Participants, Menstrual Migraine | 3 |
| Southeastern Retina Associates, P.C. | Macular Degeneration, Age-Related Macular Degeneration, Choroidal Neovascularization | 3 |
| Covenant Health Cancer Centers | Anatomic Stage II Breast Cancer AJCC v8, Anatomic Stage III Breast Cancer AJCC v8, Clinical Stage I Esophageal Adenocarcinoma AJCC v8 | 3 |
| Covenant Health Cancer Centers - West | Anatomic Stage II Breast Cancer AJCC v8, Anatomic Stage III Breast Cancer AJCC v8, Clinical Stage I Esophageal Adenocarcinoma AJCC v8 | 3 |
| GSK Investigational Site | Gastrointestinal Neoplasms, Irritable Bowel Syndrome, Pulmonary Disease, Chronic Obstructive | 3 |
| Parkwest Medical Center | AMI Cardiogenic Shock, Aortic Stenosis, Aortic Stenosis, Calcific | 3 |
| Tennova Healthcare - Turkey Creek Medical Center | Heart Failure, Atrial Fibrillation, Stroke | 3 |
| The University of Tennessee Medical Center | Hernia, Ventral, Locally Advanced Unresectable Gastric Adenocarcinoma or Cancer, Locally Advanced Unresectable Gastroesophageal Junction (GEJ) Adenocarcinoma or Cancer | 3 |
| Hope Neurology | Multiple Sclerosis, Multiple Sclerosis Spasticity | 3 |
| Clinical Trial Site | Generalized Myasthenia Gravis, High Cardiovascular Risk, High Risk Cardiovascular Disease | 2 |
| Accellacare of Knoxville | Atherosclerotic Cardiovascular Disease, Chronic Idiopathic Constipation (CIC), Obesity | 2 |
| Fort Sanders Regional Medical Center | Alzheimer Dementia, Alzheimer Disease, Atrial Fibrillation | 2 |
| Genesis Neuroscience Clinic | Alzheimers Disease | 2 |
| Healthy Eating and Activity Laboratory | Obesity, Childhood Obesity | 2 |
| Knoxville Kidney Center, PLLC | Immunoglobulin A Nephropathy (IgAN), Primary Membranous Nephropathy | 2 |
| StatCare Pulmonary Consultants, PLLC | Interstitial Lung Disease, Progressive Pulmonary Fibrosis, Idiopathic Pulmonary Fibrosis | 2 |
| TG Therapeutics Investigational Trial Site | Relapsing Multiple Sclerosis, Multiple Sclerosis | 2 |
Active & Upcoming Studies in Knoxville (2026)
Recruiting trials in Knoxville grouped by therapeutic area, drawn from ClinicalTrials.gov. Each bucket shows the most recent example studies.
Cancer & tumors (93 active studies)
- DAREON®-NEC-1: A Study in People With Advanced Extrapulmonary Neuroendocrine Cancer (epNEC) to Compare Obrixtamig Plus Carboplatin and Etoposide Treatment With Standard Chemotherapy · Phase 3 · Boehringer Ingelheim
- Testing the SurVaxM Vaccine for Lung Cancer Prevention · Phase 2 · National Cancer Institute (NCI)
Cardiovascular (17 active studies)
- Zilebesiran in Patients With Hypertension Not Adequately Controlled and With Either Established Cardiovascular Disease or High Risk for Cardiovascular Disease · Phase 3 · Alnylam Pharmaceuticals
- Multi-site Study of the Clinical Impact of an AI-assisted Approach to Referring Patients With Interstitial Lung Disease for Diagnostic Evaluation of Pulmonary Hypertension · Tempus AI
Diabetes & metabolic (13 active studies)
- Efficacy and Safety of Aleniglipron in Participants With Obesity or Overweight With a Weight-Related Comorbidity (ACCOMPLISH-1) · Phase 3 · Gasherbrum Bio, Inc., a wholly owned subsidiary of Structure Therapeutics
- A Phase III Study to Investigate the Efficacy and Safety of Elecoglipron Alone or in Combination With Dapagliflozin Compared With Placebo in Adults With Type 2 Diabetes Mellitus · Phase 3 · AstraZeneca
Neurology & pain (12 active studies)
- Non-inferiority Study of Frexalimab Subcutaneous Administration Compared to Intravenous Administration in Adult Participants With Multiple Sclerosis · Phase 3 · Sanofi
- A Study to Assess Bioequivalence of Two Subcutaneous (SC) Formulations of Ocrelizumab in Participants With Multiple Sclerosis (MS) · Phase 2 · Hoffmann-La Roche
Eye & vision (4 active studies)
- A Clinical Trial of EYE201/MK-8748 in People With Macular Degeneration (MK-8748-003) · Phase 2, Phase 3 · EyeBiotech Ltd.
- Phase 4 Study: Long-term Safety and Efficacy of NT-501 in MacTel Type 2, Including Sham Procedure Participants · Phase 4 · Neurotech Pharmaceuticals
Mental health & behavior (3 active studies)
- Nordic Spirit Pouch Nicotine Pharmacokinetics Abuse Liability · Phase 1 · JT International SA
- E-Mindfulness Approaches for Living After Breast Cancer · Phase 3 · NRG Oncology
Vaccines (1 active study)
- Safety and Immunogenicity Study of Revaccination With SCB-1019T in Healthy Adults · Phase 1 · Clover Biopharmaceuticals USA, LLC
Common conditions studied in Knoxville
- Acute Myeloid Leukemia (6 active studies)
- Breast Cancer (6 active studies)
- Obesity (6 active studies)
- Carcinoma, Non-Small-Cell Lung (5 active studies)
- Hypertension (4 active studies)
- Pulmonary Hypertension (4 active studies)
Leading research sponsors in Knoxville
- National Cancer Institute (NCI)
- Children's Oncology Group
- University of Tennessee Graduate School of Medicine
- Merck Sharp & Dohme LLC
- AstraZeneca
Frequently asked questions
How many paid clinical trials are currently recruiting in Knoxville?
There are approximately 214 recruiting clinical trials in Knoxville, Tennessee listed on ClinicalTrials.gov. The number changes weekly as new studies open and others close enrollment.
Do clinical trials in Knoxville pay participants?
Most recruiting trials in Knoxville compensate participants for their time, travel, and study visits. Compensation varies by sponsor, study phase, and visit requirements — the exact amount is disclosed by the study team during the informed consent process.
Who can participate in a clinical trial in Knoxville?
Eligibility depends on the specific study. Each trial defines its own inclusion criteria (age, diagnosis, medical history, prior treatments) and exclusion criteria. Both patients with specific conditions and healthy volunteers can qualify, depending on the study design.
What conditions are most commonly studied in Knoxville?
The most common conditions under active study in Knoxville include Acute Myeloid Leukemia (6), Breast Cancer (6), Obesity (6), Carcinoma, Non-Small-Cell Lung (5), among many others. Browse the list above to explore every recruiting trial.
Are there clinical trials for healthy volunteers in Knoxville?
Yes. Healthy-volunteer studies — often early-phase pharmacology or vaccine trials — recruit in Knoxville on an ongoing basis. Use the "Healthy volunteers only" filter above to view trials that accept participants without the study's target condition.
How do I enroll in a clinical trial in Knoxville?
Click any study title above to see the full study record, including eligibility criteria, visit schedule, and the study team's contact information. Reach out to the central contact or recruiting site directly — they will guide you through screening and informed consent.
Where can I take part in paid clinical trials in Knoxville?
Recruiting research sites in Knoxville include University of Tennessee Medical Center, East Tennessee Childrens Hospital, University of Tennessee - Knoxville, among others. Each site lists its open studies and contact information on the study record above — call or email the site coordinator to ask about screening for a specific protocol.
What kinds of studies are recruiting in Knoxville right now?
The largest active categories in Knoxville are Cancer & tumors (93), Cardiovascular (17), Diabetes & metabolic (13). Use the filters above to narrow by therapeutic area, phase, age, or healthy-volunteer eligibility.