As of September 2026, 223 paid clinical trials are recruiting in Knoxville, Tennessee. Compensation typically covers time, travel, and study visits, with stipends ranging from modest amounts for short outpatient studies to several thousand dollars for long or inpatient protocols.
Knoxville offers studies at sites including University of Tennessee Medical Center for conditions such as Acute Myeloid Leukemia, Obesity, Breast Cancer, Overweight. Both patients with specific conditions and healthy volunteers can qualify. Most trials offer free study-related medical care alongside compensation.
Recruiting trial data synced daily from ClinicalTrials.gov. Last sync: .
Posted to ClinicalTrials.gov within the last 60 days — these studies are just starting to recruit.
Researchers run research studies in Knoxville, TN at 25 active sites. The clinics below currently host the largest number of recruiting studies — each name is followed by the conditions they focus on most.
| Site | Specializes in | Active trials |
|---|---|---|
| University of Tennessee Medical Center | Carcinoma, Non-Small-Cell Lung, Metastatic Non Small Cell Lung Cancer, Carcinoma, Non-Small-Cell Lung (NSCLC) | 28 |
| East Tennessee Childrens Hospital | Acute Myeloid Leukemia, B Acute Lymphoblastic Leukemia, Down Syndrome | 27 |
| University of Tennessee - Knoxville | Acute Myeloid Leukemia, Acute Myeloid Leukemia Arising From Previous Myelodysplastic/Myeloproliferative Neoplasm, Acute Myeloid Leukemia Post Cytotoxic Therapy | 19 |
| Tennessee Cancer Specialists | Breast Cancer, Advanced Breast Cancer, Carcinoma, Non-Small-Cell Lung | 11 |
| University of Tennessee | AI-Based Fitness, Advanced Melanoma, Carcinoma, Non-Small-Cell Lung | 8 |
| University of Tennessee Graduate School of Medicine | Cardiac Amyloidosis, Cardiometabolic Diseases, Carpal Tunnel Syndrome (CTS) | 7 |
| GSK Investigational Site | Pulmonary Disease, Chronic Obstructive, Bronchiectasis, Gastrointestinal Neoplasms | 6 |
| AMR Clinical | Cannabis Withdrawal, Focus of the Study: Safety of XFB19, Menstrual Migraine | 4 |
| Thompson Proton Center | Breast Cancer, Breast Cancer Stage I, Breast Cancer Stage II | 4 |
| Alliance for Multispecialty Research, LLC | ALS, Healthy Participants, Menstrual Migraine | 3 |
| Southeastern Retina Associates, P.C. | Macular Degeneration, Age-Related Macular Degeneration, Choroidal Neovascularization | 3 |
| Fort Sanders Regional Medical Center | Acute Ischemic Stroke, Acute Ischemic Stroke (AIS) Related to a Distal Occlusion, Alzheimer Dementia | 3 |
| New Phase Research and Development | Overweight, Clostridoides Difficile Associated Disease, Obesity | 3 |
| Parkwest Medical Center | AMI Cardiogenic Shock, Aortic Stenosis, Aortic Stenosis, Calcific | 3 |
| The University of Tennessee Medical Center | Hernia, Ventral, Locally Advanced Unresectable Gastric Adenocarcinoma or Cancer, Locally Advanced Unresectable Gastroesophageal Junction (GEJ) Adenocarcinoma or Cancer | 3 |
| Tennessee Cancer Specialists - Knoxville - Old Weisgarber Road | Non-Small Cell Lung Cancer, Small Cell Lung Cancer, Plasma Cell Myeloma Refractory | 3 |
| Clinical Trial Site | Generalized Myasthenia Gravis, High Cardiovascular Risk, High Risk Cardiovascular Disease | 2 |
| Accellacare of Knoxville | Atherosclerotic Cardiovascular Disease, Chronic Idiopathic Constipation (CIC), Obesity | 2 |
| Covenant Health Cancer Centers | Anatomic Stage II Breast Cancer AJCC v8, Anatomic Stage III Breast Cancer AJCC v8, HER2-Negative Breast Carcinoma | 2 |
| Covenant Health Cancer Centers - West | Anatomic Stage II Breast Cancer AJCC v8, Anatomic Stage III Breast Cancer AJCC v8, HER2-Negative Breast Carcinoma | 2 |
| Genesis Neuroscience Clinic | Alzheimers Disease | 2 |
| Healthy Eating and Activity Laboratory | Obesity, Childhood Obesity | 2 |
| Knoxville Kidney Center, PLLC | Immunoglobulin A Nephropathy (IgAN), Primary Membranous Nephropathy | 2 |
| StatCare Pulmonary Consultants, PLLC | Interstitial Lung Disease, Progressive Pulmonary Fibrosis, Idiopathic Pulmonary Fibrosis | 2 |
| TG Therapeutics Investigational Trial Site | Relapsing Multiple Sclerosis, Multiple Sclerosis | 2 |
Recruiting trials in Knoxville grouped by therapeutic area, drawn from ClinicalTrials.gov. Each bucket shows the most recent example studies.
There are approximately 223 recruiting clinical trials in Knoxville, Tennessee listed on ClinicalTrials.gov. The number changes weekly as new studies open and others close enrollment.
Most recruiting trials in Knoxville compensate participants for their time, travel, and study visits. Compensation varies by sponsor, study phase, and visit requirements — the exact amount is disclosed by the study team during the informed consent process.
Eligibility depends on the specific study. Each trial defines its own inclusion criteria (age, diagnosis, medical history, prior treatments) and exclusion criteria. Both patients with specific conditions and healthy volunteers can qualify, depending on the study design.
The most common conditions under active study in Knoxville include Acute Myeloid Leukemia (8), Obesity (8), Breast Cancer (6), Overweight (6), among many others. Browse the list above to explore every recruiting trial.
Yes. Healthy-volunteer studies — often early-phase pharmacology or vaccine trials — recruit in Knoxville on an ongoing basis. Use the "Healthy volunteers only" filter above to view trials that accept participants without the study's target condition.
Click any study title above to see the full study record, including eligibility criteria, visit schedule, and the study team's contact information. Reach out to the central contact or recruiting site directly — they will guide you through screening and informed consent.
Recruiting research sites in Knoxville include University of Tennessee Medical Center, East Tennessee Childrens Hospital, University of Tennessee - Knoxville, among others. Each site lists its open studies and contact information on the study record above — call or email the site coordinator to ask about screening for a specific protocol.
The largest active categories in Knoxville are Cancer & tumors (92), Diabetes & metabolic (18), Cardiovascular (17). Use the filters above to narrow by therapeutic area, phase, age, or healthy-volunteer eligibility.