Clinical Trials at University of Tennessee Medical Center
As of September 2026, 31 paid clinical trials are recruiting at University of Tennessee Medical Center, located at 444 S STADIUM HL, KNOXVILLE, TN 37996-0001, phone (269) 921-0470 in Knoxville, Tennessee. Active studies at this site cover conditions such as Acute Myeloid Leukemia, Obesity and Breast Cancer. Compensation typically covers time, travel, and study visits — most studies also offer study-related medical care at no cost to participants.
Recruiting trial data synced daily from ClinicalTrials.gov. Last sync: .
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Newly added in Knoxville
Posted to ClinicalTrials.gov within the last 60 days — these studies are just starting to recruit.
32 clinical trials at University of Tennessee Medical Center
·Clear filters·Symbiotic-Lung-01 : A Study to Learn About the Study Medicine Called PF-08634404 in Combination With Chemotherapy in Adult Participants With Locally Advanced or Metastatic Non-Small Cell Lung Cancer
BEATRIX: A Study to Learn About a Group B Streptococcus Vaccine in Healthy Pregnant Women and Their Babies
A Study With Combinations of Anti-LAG-3 and Anti-PD-1 Antibodies in Adult Participants With Advanced or Metastatic Melanoma (Harmony Head-to-Head)
Study of Olomorasib (LY3537982) in Combination With Standard of Care in Participants With Resected or Unresectable KRAS G12C-mutant Non-Small Cell Lung Cancer
A Study of Disitamab Vedotin Alone or With Pembrolizumab in Urothelial Cancer That Expresses HER2
A Study of First-Line Olomorasib (LY3537982) and Pembrolizumab With or Without Chemotherapy in Patients With Advanced KRAS G12C-Mutant Non-small Cell Lung Cancer
A Randomized Comparison of Stage-Based Care Versus Risk Factor-Based Care for Prevention of Cardiovascular Events
A Study to Assess Adverse Events and Change in Disease Activity of Multiple Treatment Combinations With Intravenous Mirvetuximab Soravtansine in Adult Participants With Ovarian Cancer
Zanzalintinib Versus Everolimus in Participants With Locally Advanced or Metastatic Neuroendocrine Tumors
Safety, Efficacy, and Pharmacokinetics of BNT327 in Combination With Chemotherapy and Other Investigational Agents for Lung Cancer
Safety and Efficacy of BNT327, an Investigational Therapy in Combination With Chemotherapy for Patients With Untreated Small-cell Lung Cancer
A Phase 1/2 Study of Bleximenib in Participants With Acute Leukemia (cAMeLot-1)
Autologous LN-145 in Patients With Metastatic Non-Small-Cell Lung Cancer
A Study to Investigate Subcutaneous Isatuximab in Combination With Weekly Carfilzomib and Dexamethasone in Adult Participants With Relapsed and/or Refractory Multiple Myeloma
A Randomized, Phase 2/3 Study to Investigate the Efficacy and Safety of RP2 in Combination With Nivolumab in Immune Checkpoint Inhibitor-Naïve Adult Patients With Metastatic Uveal Melanoma
Tebentafusp Regimen Versus Investigator's Choice in Previously Treated Advanced Melanoma (TEBE-AM)
A Clinical Trial of Sac-TMT in People With Non-HRD Positive Advanced Ovarian Cancer (MK-2870-021)
A Clinical Study of Sacituzumab Tirumotecan (MK-2870) in Combination With Pembrolizumab (MK-3475) as First-line Maintenance Treatment of Cervical Cancer (MK-2870-036/TroFuse-036/GOG-3123/ENGOT-cx22)
A Study to Investigate Ubamatamab With and Without Marlotamig (REGN7075) in Adult Participants With Advanced/Metastatic Non-Small Cell Lung Cancer (NSCLC)
AtraUmatic Laparoscopic HerNia Repair Clinical Investigation to Evaluate the Safety and Performance of The ECLIPSIUM System for Mesh Fixation IDE
A Study to See if Giving Fianlimab and Cemiplimab Together is Better Than Cemiplimab Alone at Treating Recurrent or Metastatic Head and Neck Squamous Cell Carcinoma
A Study to Evaluate the Safety, Tolerability, Drug Levels, and Preliminary Efficacy of BMS-986507 Combinations in Adult Participants With Advanced Solid Tumors
Study of RP2 in Combination With Second-line Therapy in Patients With Locally Advanced or Metastatic HCC
Symbiotic-Lung-10: A Study to Learn About PF-08634404 Alone or in Combination in Early-stage or Locally Advanced NSCLC
Improved Outcomes With Pre-Procedure Shockwave IVL of Common Femoral Artery Access Site Prior to Large Bore Access and Pre-Closure
REVASC-PAD: REstricted VASCular Exercise for Peripheral Arterial Disease - A Feasibility Study at University of Tennessee Medical Center
ESP Block vs Control for Pain Control Following Percutaneous Nephrolithotomy
Pharmacy-led Transitions of Care Intervention to Improve Medication Adherence
Relationship Between Aspirin Metabolism and Markers of Metabolic Dysfunction Among Pregnant Persons at Risk of Pre-eclampsia
Y90 Radioembolization Dose Delivery and Radiation Exposure Assessment
A Study to Evaluate Adverse Events and Change in Disease Activity of Intravenous ABBV-706 Versus Standard of Care in Adult Participants With Relapsed/Refractory Small Cell Lung Cancer
Common conditions studied in Knoxville
- Acute Myeloid Leukemia (8 active studies)
- Obesity (7 active studies)
- Breast Cancer (6 active studies)
- Carcinoma, Non-Small-Cell Lung (5 active studies)
- Hypertension (5 active studies)
- Overweight (4 active studies)
Leading research sponsors in Knoxville
- Children's Oncology Group
- National Cancer Institute (NCI)
- Merck Sharp & Dohme LLC
- University of Tennessee Graduate School of Medicine
- AstraZeneca
Frequently asked questions
How many paid clinical trials are currently recruiting in Knoxville?
There are approximately 221 recruiting clinical trials in Knoxville, Tennessee listed on ClinicalTrials.gov. The number changes weekly as new studies open and others close enrollment.
Do clinical trials in Knoxville pay participants?
Most recruiting trials in Knoxville compensate participants for their time, travel, and study visits. Compensation varies by sponsor, study phase, and visit requirements — the exact amount is disclosed by the study team during the informed consent process.
Who can participate in a clinical trial in Knoxville?
Eligibility depends on the specific study. Each trial defines its own inclusion criteria (age, diagnosis, medical history, prior treatments) and exclusion criteria. Both patients with specific conditions and healthy volunteers can qualify, depending on the study design.
What conditions are most commonly studied in Knoxville?
The most common conditions under active study in Knoxville include Acute Myeloid Leukemia (8), Obesity (7), Breast Cancer (6), Carcinoma, Non-Small-Cell Lung (5), among many others. Browse the list above to explore every recruiting trial.
Are there clinical trials for healthy volunteers in Knoxville?
Yes. Healthy-volunteer studies — often early-phase pharmacology or vaccine trials — recruit in Knoxville on an ongoing basis. Use the "Healthy volunteers only" filter above to view trials that accept participants without the study's target condition.
How do I enroll in a clinical trial in Knoxville?
Click any study title above to see the full study record, including eligibility criteria, visit schedule, and the study team's contact information. Reach out to the central contact or recruiting site directly — they will guide you through screening and informed consent.
Where can I take part in paid clinical trials in Knoxville?
Recruiting research sites in Knoxville include University of Tennessee Medical Center, East Tennessee Childrens Hospital, University of Tennessee - Knoxville, among others. Each site lists its open studies and contact information on the study record above — call or email the site coordinator to ask about screening for a specific protocol.
What kinds of studies are recruiting in Knoxville right now?
The largest active categories in Knoxville are Cancer & tumors (93), Cardiovascular (17), Diabetes & metabolic (15). Use the filters above to narrow by therapeutic area, phase, age, or healthy-volunteer eligibility.
What is the address of University of Tennessee Medical Center?
University of Tennessee Medical Center is located at 444 S STADIUM HL, KNOXVILLE, TN 37996-0001. Use the Google Maps link in the intro above to get directions.
How do I contact University of Tennessee Medical Center?
You can reach University of Tennessee Medical Center by phone at (269) 921-0470. For questions about a specific trial, use the study coordinator contact listed on the individual study record — click any trial title above to open it.