A Study to Investigate Ubamatamab With and Without Marlotamig (REGN7075) in Adult Participants With Advanced/Metastatic Non-Small Cell Lung Cancer (NSCLC)

Part of paid clinical trials in Goodyear, Arizona.

Sponsor
Regeneron Pharmaceuticals
Study ID
NCT07154290
Phase
PHASE2
Status
Recruiting
Apply to this trial

Conditions

Eligibility Criteria

Sex
ALL
Age
18 Years - N/A
Healthy Volunteers
Not accepted

Interventions

  • Ubamatamab — DRUG
    Administered per the protocol
  • Marlotamig — DRUG
    Administered per the protocol
  • Sarilumab — DRUG
    Administered per the protocol

Study Details

This study will evaluate two study drugs called ubamatamab and marlotamig, to see if they can help treat advanced or metastatic Non-Small Cell Lung Cancer (NSCLC), and sarilumab, to evaluate to see if it can help with immune-related side effects from ubamatamab. The study is looking at: * How well ubamatamab and marlotamig work(s) * The side effects that ubamatamab and marlotamig might cause * How much ubamatamab and marlotamig is in the blood at different times * If the body makes antibodies to ubamatamab and/or marlotamig, this may cause the ubamatamab to not work as well

Key Dates

First listed
Sep 4, 2025
Start date
Mar 18, 2026
Status verified
Aug 2026
Primary completion
Jun 10, 2030
Completion
Jun 10, 2030

Study Design

Enrollment
300 participants (estimated)
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT

Arms

  • Experimental: Arm 1A
  • Experimental: Arm 1B
  • Experimental: Arm 1C
  • Experimental: Arm 2A
  • Experimental: Arm 2B
  • Experimental: Arm 2C

Primary Outcome Measure

Objective response as assessed by the investigator per Response Evaluation Criteria in Solid Tumors (RECIST) v1.1 [ Time Frame: Up to 5 years ]

Central Contacts

Locations (15)

FacilityCityStateZIPSite coordinators
Cancer Treatment Centers of America, PhoenixGoodyearArizona85338-
The City of Hope Orange County Lennar Foundation Cancer CenterIrvineCalifornia92618-
Georgetown UniversityWashington D.C.District of Columbia20007-
Mayo Clinic JacksonvilleJacksonvilleFlorida32224-
Rush University Medical CenterChicagoIllinois60612-
University of Illinois ChicagoChicagoIllinois60612-
Franciscan HealthMunsterIndiana46321-
University of Maryland Greenebaum Comprehensive Cancer CenterBaltimoreMaryland21201-
Mayo ClinicRochesterMinnesota55905-
Washington University School of MedicineSt LouisMissouri63110-
University of Tennessee Medical CenterKnoxvilleTennessee37920-
Sarah Cannon Research InstituteNashvilleTennessee37203-
University of Texas Medical BranchGalvestonTexas77555-
The University of Texas MD Anderson Cancer CenterHoustonTexas77030-
Baylor Scott & White HealthTempleTexas76508-

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OncologyLung oncologyLung disease
By research site
Cancer Treatment Centers of America, Phoenix· Goodyear, AZThe City of Hope Orange County Lennar Foundation Cancer Center· Irvine, CAGeorgetown University· Washington D.C., DCMayo Clinic Jacksonville· Jacksonville, FLRush University Medical Center· Chicago, ILUniversity of Illinois Chicago· Chicago, IL

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