Oncology Clinical Trials in Lexington, KY

As of July 2026, 95 paid clinical trials are recruiting for Oncology in Lexington, Kentucky. Oncology trials evaluate immunotherapies, targeted therapies, antibody-drug conjugates, and combination regimens across solid tumors and blood cancers — from early-phase first-in-human studies to phase 3 registration trials. Compensation typically covers time, travel, and study visits, and many studies also include study-related medical care at no cost.

Recruiting trial data synced daily from ClinicalTrials.gov. Last sync: July 17, 2026.

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96 clinical trials for Oncology

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Testing the Addition of 131I-MIBG or Lorlatinib to Intensive Therapy in People With High-Risk Neuroblastoma (NBL)

for Ganglioneuroblastoma

Sites in Lexington +144 more locations

Sponsor: Children's Oncology Group

Sex: All·Age: 365 Days - 30

Code: NCT03126916·Phase 3·Recruiting·Listed Apr 2017

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An Internet-based Program to Help Cancer Survivors Manage Pain

for Cancer

Sites in Lexington, Bardstown +147 more locations

Sponsor: Wake Forest University Health Sciences

Sex: All·Age: 18+

Code: NCT04462302·Recruiting·Listed Jul 2020

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A Culturally-Tailored Mobile Health and Social Media Physical Activity Intervention for Improving Physical Activity in Hispanic or Latino/Latina Adolescent and Young Adult Childhood Cancer Survivors, Walking Juntos Study

for Hematopoietic and Lymphatic System Neoplasm

Sites in Lexington +75 more locations

Sponsor: Children's Oncology Group

Sex: All·Age: 15 - 20

Code: NCT06410209·Phase 2·Recruiting·Listed May 2024

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Carboplatin Chemotherapy Before Surgery for People With High-Risk Prostate Cancer and an Inherited BRCA1 or BRCA2 Gene Mutation

for Prostate Adenocarcinoma

Sites in Lexington, Mount Sterling +130 more locations

Sponsor: SWOG Cancer Research Network

Sex: Male·Age: 18+

Code: NCT05806515·Phase 2·Recruiting·Listed Apr 2023

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Comparing the Outcome of Immunotherapy-Based Drug Combination Therapy With or Without Surgery to Remove the Kidney in Metastatic Kidney Cancer, the PROBE Trial

for Metastatic Clear Cell Renal Cell Carcinoma

Sites in Lexington +339 more locations

Sponsor: SWOG Cancer Research Network

Sex: All·Age: 18+

Code: NCT04510597·Phase 3·Recruiting·Listed Aug 2020

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Nilotinib Plus Dabrafenib/Trametinib or Encorafenib/Binimetinib in Metastatic Melanoma

for Metastatic Melanoma

Drug: Dabrafenib

Sites in Lexington +3 more locations

Sponsor: Rina Plattner

Sex: All·Age: 18+

Code: NCT04903119·Phase 1·Recruiting·Listed May 2021

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Precision Lung Cancer Survivorship Care Intervention

for Lung Cancer

1 location in Lexington

Sponsor: Jerod L Stapleton, PhD

Sex: All·Age: 18+

Code: NCT05857995·Recruiting·Listed May 2023

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Abatacept in Immune Checkpoint Inhibitor Myocarditis

for Myocarditis Acute

Sites in Lexington +28 more locations

Sponsor: Massachusetts General Hospital

Sex: All·Age: 18+

Code: NCT05335928·Phase 3·Recruiting·Listed Apr 2022

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A Trial of Robotic Versus Open Hysterectomy Surgery in Cervix Cancer

for Cervical Cancer

Sites in Lexington, Edgewood +124 more locations

Sponsor: GOG Foundation

Sex: Female·Age: 18+

Code: NCT04831580·Recruiting·Listed Apr 2021

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GENOCARE: A Prospective, Randomized Clinical Trial of Genotype-Guided Dosing Versus Usual Care

for Colorectal Cancer

1 location in Lexington

Sponsor: Reema A. Patel

Sex: All·Age: 18+

Code: NCT05391126·Recruiting·Listed May 2022

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Transvaginal Ultrasonography as a Screening Method for Ovarian Cancer

for Ovarian Cancer

1 location in Lexington

Sponsor: John R van Nagell

Sex: Female·Age: 24+·Accepts healthy volunteers

Code: NCT04473833·Recruiting·Listed Jul 2020

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MCC-24-GYN-11: Comparison of Nodal Sampling in Endometrial Cancer

for Endometrial Cancer

1 location in Lexington

Sponsor: Rachel Miller

Sex: Female·Age: 18+

Code: NCT06677112·Recruiting·Listed Nov 2024

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Trial of the Efficacy and Safety of Short and Long Course Radiation Therapy With/Without BMX-001

for Rectal Cancer

Sites in Lexington +2 more locations

Sponsor: University of Nebraska

Sex: All·Age: 18+

Code: NCT05254327·Phase 2·Recruiting·Listed Feb 2022

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Sonesitatug Vedotin in Combination With Capecitabine With or Without Rilvegostomig in Participants With Advanced or Metastatic Gastric, Gastroesophageal Junction, or Esophageal Adenocarcinoma Expressing Claudin18.2

for Gastric Cancer

Drug: Sonesitatug vedotin

Sites in Lexington, Louisville +70 more locations

Sponsor: AstraZeneca

Sex: All·Age: 18+

Code: NCT07431281·Phase 3·Recruiting·Listed Feb 2026

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A Global Phase III Study of Rilvegostomig or Pembrolizumab Plus Chemotherapy for First-Line Treatment of Locally Advanced or Metastatic Squamous Non-small Cell Lung Cancer (NSCLC)

for Non-small Cell Lung Cancer

Drug: Rilvegostomig

Sites in Lexington, Louisville +61 more locations

Sponsor: AstraZeneca

Sex: All·Age: 18+

Code: NCT06692738·Phase 3·Recruiting·Listed Nov 2024

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Conditions in Oncology (Lexington, KY)

Non-small cell lung cancer (NSCLC)· 19 Breast cancer· 14 Solid tumor· 14 Ovarian cancer· 9 Prostate cancer· 8 Acute myeloid leukemia (AML)· 8 Cancer (any)· 8 Lung cancer· 7 Melanoma· 7 Colorectal cancer· 5 Pancreatic cancer· 5 Small cell lung cancer· 4 Non-Hodgkin lymphoma· 4 Diffuse large B-cell lymphoma (DLBCL)· 4 Hematologic malignancy· 4 Head and neck cancer· 4 Gastric cancer· 3 Esophageal cancer· 3 Gastroesophageal junction cancer· 3 Endometrial cancer· 3 Cervical cancer· 3 Glioblastoma· 3 Leukemia (other)· 3 Sarcoma· 3 Neuroendocrine tumors· 3 Colon cancer· 2 Bladder cancer· 2 Kidney cancer· 2 Gynecologic cancer· 2 Acute lymphoblastic leukemia· 2 Myelodysplastic syndromes (MDS)· 2 Neuroblastoma· 2 Metastatic breast cancer· 1 Rectal cancer· 1 Fallopian tube cancer· 1 Brain cancer· 1 Multiple myeloma· 1 Chronic lymphocytic leukemia (CLL)· 1 Myeloproliferative neoplasm· 1 Follicular lymphoma· 1 Thyroid cancer· 1 Osteosarcoma· 1 Mesothelioma· 1