Paid Clinical Trials in Massachusetts

Massachusetts has 3,586 paid clinical trials enrolling now across cities including Boston, Worcester and Springfield. Search by condition, age, or phase to find compensated research studies accepting participants near you.

Research sites in Massachusetts include Mass General Hospital, Dana-Farber and Brigham and Women's, running studies across oncology, cardiology, neurology, and more. Both patients and healthy volunteers may qualify. Most studies offer compensation for time and travel.

Recruiting trial data synced daily from ClinicalTrials.gov. Last sync: June 16, 2026.

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3,586 clinical trials

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Improving Jail Response to the Overdose Crisis: A Hybrid Trial of Jail ECHO to Improve MOUD Implementation and Public Health Outcomes

for Opioid Abuse (Disorder)

1 location in Worcester

Sponsor: University of Massachusetts, Worcester

Sex: All·Age: 18+·Accepts healthy volunteers

Code: NCT07637994·Not Yet Recruiting

Gabapentin and Oxcarbazepine for Chronic Neuropathic Pain in Children and Adolescents: A Clinical Effectiveness Study

for Pediatric Chronic Neuropathic Pain

1 location in Boston

Sponsor: Boston Children's Hospital

Sex: All·Age: 8 - 18

Code: NCT02219373·Phase 3·Not Yet Recruiting

Polarization Sensitive Optical Coherence Tomography (PS-OCT) for Retinal Imaging

for Healthy

1 location in Boston

Sponsor: Massachusetts General Hospital

Sex: All·Age: 18 - 85·Accepts healthy volunteers

Code: NCT02441777·Not Yet Recruiting

Cenobamate in the Intensive Care Unit

for Epilepsy

Drug: Cenobamate

1 location in Boston

Sponsor: Brigham and Women's Hospital

Sex: All·Age: 18 - 70·Accepts healthy volunteers

Code: NCT06352723·EARLY_Phase 1·Not Yet Recruiting

Carbohydrate Fluids and Post Operative Nausea and Vomiting

for Nausea, Postoperative

1 location in Boston

Sponsor: Boston Medical Center

Sex: All·Age: 19+

Code: NCT06481670·Not Yet Recruiting

Study to Image Inflammatory Activity of a Fluorescence Imaging Agent in Excised Human Artery Plaques

for Carotid Artery Diseases

1 location in Boston

Sponsor: Massachusetts General Hospital

Sex: All·Age: 18+

Code: NCT06957821·EARLY_Phase 1·Not Yet Recruiting

An Exploratory Study of the Potential for Rational Immune System Manipulation to Prevent Emergence of Synucleinopathy Manifestations in Persons With REM Sleep Behavior Disorder (RBD)

for REM Sleep Behavior Disorder

19 locations incl. Los Angeles

Sponsor: Yale University

Sex: All·Age: 50 - 80

Code: NCT06996652·Phase 2·Not Yet Recruiting

Increasing Resiliency Among Early Post-Treatment Lymphoma Survivors

for Lymphoma

1 location in Boston

Sponsor: Massachusetts General Hospital

Sex: All·Age: 18+

Code: NCT07014293·Not Yet Recruiting

Boston Medical Center Ultrasound Decongestion Study in Heart Failure

for Congestive Heart Failure

1 location in Boston

Sponsor: Boston Medical Center

Sex: All·Age: 18+

Code: NCT07096726·Not Yet Recruiting

A Study of LY4152199 in Participants With Previously Treated B-cell Malignancies (BAF_FRontier-1 )

for Lymphoma, Non-Hodgkin

23 locations incl. Duarte

Sponsor: Eli Lilly and Company

Sex: All·Age: 18+

Code: NCT07101328·Phase 1·Not Yet Recruiting

Total Neoadjuvant Therapy With Short Course Radiation Therapy in Gastric Cancer

for Gastric Cancer

4 locations incl. Los Angeles

Sponsor: Washington University School of Medicine

Sex: All·Age: 18+

Code: NCT07101666·Phase 2·Not Yet Recruiting

IGNITE: Study of Tirabrutinib vs Rituximab/Temozolomide for Relapsed/Refractory Primary Central Nervous System Lymphoma (PCNSL)

for Relapsed/Refractory Primary Central Nervous System Lymphoma

Drug: Rituximab

14 locations incl. Phoenix

Sponsor: Ono Pharmaceutical Co., Ltd.

Sex: All·Age: 18+

Code: NCT07104032·Phase 3·Recruiting

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Diagnosing Epilepsy To EffeCT Change Long-Term Follow-Up

for Epilepsy

12 locations incl. Phoenix

Sponsor: Epiminder America, Inc.

Sex: All·Age: 18 - 75

Code: NCT07110454·Recruiting

Apply to this trial

ACTIVATE: AI-driven Clinical-trial Trial-Information and Viability Assessment Tool for EHRs

for Cancer

1 location in Boston

Sponsor: Dana-Farber Cancer Institute

Sex: All·Age: 18+

Code: NCT07232043·Not Yet Recruiting

Impact of Federal and State Medications for Opioid Use Disorder (MOUD) Policy Changes During the Pandemic

for Substance Use Disorders

1 location in Boston

Sponsor: Boston University

Sex: All·Age: 18+

Code: NCT07232641·Recruiting

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A Study of CDX-622 in Participants With Mild to Moderate Asthma

for Mild to Moderate Asthma

4 locations incl. San Francisco

Sponsor: Celldex Therapeutics

Sex: All·Age: 18+

Code: NCT07330778·Phase 1·Recruiting

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Systemic Anti-Cancer Therapy Dose Modifications for Individuals With Duffy Null Phenotype

for Multiple Myeloma

1 location in Boston

Sponsor: Andrew Hantel, MD

Sex: All·Age: 18+

Code: NCT07341867·Phase 1·Not Yet Recruiting

WELL-MPN: A Digital Lifestyle App for Patients With MPNs

for Myeloproliferative Neoplasms (MPNs)

1 location in Boston

Sponsor: Brigham and Women's Hospital

Sex: All·Age: 18+

Code: NCT07349134·Not Yet Recruiting

B7-H3.CD28Z.CART in Solid Tumors

for Pediatric Solid Tumor

1 location in Boston

Sponsor: Robbie Majzner

Sex: All·Age: 9 Months - 30

Code: NCT07358260·Phase 1·Not Yet Recruiting

Propofol-Only Versus Dexmedetomidine-Propofol in Children Undergoing Magnetic Resonance Imaging

for MRI Sedation

1 location in Boston

Sponsor: Boston Children's Hospital

Sex: All·Age: 1 - 12

Code: NCT07369128·Phase 4·Recruiting

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A Natural History Study of Angelman Syndrome

for Angelman Syndrome

1 location in Lexington

Sponsor: Massachusetts General Hospital

Sex: All·Age: 1+

Code: NCT07417137·Recruiting

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Real Time Craniotomy Planning Using Mixed Reality

for Neurosurgery

1 location in Boston

Sponsor: Brainlab AG

Sex: All·Age: 18+

Code: NCT07468370·Not Yet Recruiting

Enhancing Cardiac Rehabilitation Attendance After Secondary Myocardial Infarction Through Clinician Messaging and Motivational Calls

for Type 2 Myocardial Infarction

1 location in Boston

Sponsor: Massachusetts General Hospital

Sex: All·Age: 18+

Code: NCT07485491·Not Yet Recruiting

A Nurse-Led, Coping and Supportive Intervention for Patients With Triple-Negative Breast Cancer

for Triple Negative Breast Cancer (TNBC)

1 location in Boston

Sponsor: Massachusetts General Hospital

Sex: All·Age: 18+

Code: NCT07513311·Recruiting

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PRISM-NLM: Prostatectomy Intraoperative Surgical Margin Assessment With Non-linear Microscopy

for Prostate Cancer

1 location in Boston

Sponsor: Beth Israel Deaconess Medical Center

Sex: Male·Age: 18+

Code: NCT07516808·Not Yet Recruiting

Clinical Trial in Patients With Barth Syndrome- 4TAZPower

for Barth Syndrome

1 location in Needham

Sponsor: Stealth BioTherapeutics Inc.

Sex: Male·Age: 5 - 55

Code: NCT07531251·Phase 4·Not Yet Recruiting

ANDREAS Registry (Assessment of Novel Drug-coated Balloon Revascularization: Effectiveness, Angiographic Outcomes, and Safety)

for Coronary Artery Disease

17 locations incl. Phoenix

Sponsor: Emory University

Sex: All·Age: 18+

Code: NCT07559903·Recruiting

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A Study to Investigate Weight Management With Macupatide and Eloralintide, Alone or in Combination, in Adult Participants With Obesity or Overweight

for Overweight

Drug: Eloralintide

40 locations incl. Chandler

Sponsor: Eli Lilly and Company

Sex: All·Age: 18 - 75

Code: NCT07589608·Phase 2·Not Yet Recruiting

A Study in Adults With Geographic Atrophy

for Geographic Atrophy

20 locations incl. Bakersfield

Sponsor: Sitala Bio LTD

Sex: All·Age: 60+

Code: NCT07606365·Phase 2·Not Yet Recruiting

A Study to Evaluate the Efficacy and Safety of Concomitant Use of Eplontersen and ALXN2220 Compared With Eplontersen and Placebo for Adults Participants With ATTR-CM

for Transthyretin Amyloid Cardiomyopathy (ATTR-CM)

24 locations incl. La Jolla

Sponsor: AstraZeneca

Sex: All·Age: 18 - 85

Code: NCT07608354·Phase 2·Not Yet Recruiting

A Study of CS231295 in Patients With Advanced Solid Tumors

for Advance Solid Tumors

4 locations incl. Denver

Sponsor: ThalassaX Therapeutics United States Ltd

Sex: All·Age: 18+

Code: NCT07612488·Phase 1·Not Yet Recruiting

An International Multicenter, Multivendor Evaluation of the Free-Running Framework for Cardiac Function

for Congenital Heart Diseases

9 locations incl. Los Angeles

Sponsor: Matthias Stuber

Sex: All·Age: All ages

Code: NCT07613398·Not Yet Recruiting

A Study to Evaluate TNX-102 SL Monotherapy Versus Placebo in Participants With Major Depressive Disorder (MDD)

for Major Depressive Episode (MDE)

25 locations incl. Phoenix

Sponsor: Tonix Pharmaceuticals, Inc.

Sex: All·Age: 18+

Code: NCT07621237·Phase 2·Recruiting

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Miro3D Wound Matrix for Treatment of Diabetic Foot Ulcers

for Diabetic Foot Ulcers (DFUs)

14 locations incl. Phoenix

Sponsor: Reprise Biomedical, Inc.

Sex: All·Age: 18+

Code: NCT07632001·Recruiting

Apply to this trial

Phase 1b/2: Isatuximab, Iberdomide, Bortezomib, Dexamethasone in Transplant Ineligible/Deferred Newly Diagnosed Myeloma

for Newly Diagnosed Multiple Myeloma

Drug: Iberdomide

2 locations incl. Boston

Sponsor: Dana-Farber Cancer Institute

Sex: All·Age: 18+

Code: NCT07601100·Phase 1, Phase 2·Not Yet Recruiting

I-SLEPT: Integrated Sleep and Life Engagement Program for Transitions

for Sleep

1 location in Boston

Sponsor: VA Office of Research and Development

Sex: All·Age: 50+

Code: NCT07317336·Not Yet Recruiting

A Study to Test Whether Nerandomilast Helps People With Systemic Sclerosis

for Systemic Sclerosis

Drug: Nerandomilast

30 locations incl. Birmingham

Sponsor: Boehringer Ingelheim

Sex: All·Age: 18+

Code: NCT07497087·Phase 3·Not Yet Recruiting

A Study to Test How Well BAY 3670549 Works and How Safe it is in Patients With Atrial Fibrillation

for Atrial Fibrillation

6 locations incl. San Francisco

Sponsor: Bayer

Sex: All·Age: 18 - 85

Code: NCT07625215·Phase 2·Not Yet Recruiting

A Study to Evaluate Next-Generation Sequencing (NGS) Testing and Monitoring of B-cell Recovery to Guide Management Following Chimeric Antigen Receptor T-cell (CART) Induced Remission in Children and Young Adults With B Lineage Acute Lymphoblastic Leu...

for B-All

8 locations incl. Los Angeles

Sponsor: National Cancer Institute (NCI)

Sex: All·Age: 1 - 25

Code: NCT05621291·Recruiting

Apply to this trial

Radiation Treatment Plan Evaluation Learning Tool Pilot Project

for Radiation Oncology

1 location in Boston

Sponsor: Massachusetts General Hospital

Sex: All·Age: All ages·Accepts healthy volunteers

Code: NCT06115811·Not Yet Recruiting