Paid Clinical Trials in North Carolina

North Carolina has 2,944 paid clinical trials enrolling now across cities including Durham, Chapel Hill and Winston-Salem. Search by condition, age, or phase to find compensated research studies accepting participants near you.

Research sites in North Carolina include Duke University Medical Center, UNC Health and Wake Forest Baptist, running studies across oncology, cardiology, neurology, and more. Both patients and healthy volunteers may qualify. Most studies offer compensation for time and travel.

Recruiting trial data synced daily from ClinicalTrials.gov. Last sync: June 17, 2026.

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2,944 clinical trials

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Matrion Decellularized Placental Membrane Versus Conventional Wound Management in Subjects With Diabetic Foot Ulcers

for Diabetic Foot Ulcer (DFU)

18 locations incl. Tucson

Sponsor: LifeNet Health

Sex: All·Age: 21 - 80

Code: NCT07116876·Recruiting

Apply to this trial

Identifying and Treating Depression in the Orthopaedic Trauma Population

for Depression

1 location in Winston-Salem

Sponsor: Wake Forest University Health Sciences

Sex: All·Age: 18+

Code: NCT05976347·Phase 4·Recruiting

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REGN7508 Versus Apixaban and Enoxaparin for Thromboprophylaxis After Total Knee Arthroplasty in Adults

for Venous Thromboembolism (VTE)

19 locations incl. Sheffield

Sponsor: Regeneron Pharmaceuticals

Sex: All·Age: 18+

Code: NCT07015905·Phase 3·Recruiting

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Maridebart Cafraglutide in Heart Failure With Preserved or Mildly Reduced Ejection Fraction and Obesity

for Heart Failure With Preserved Ejection Fraction

106 locations incl. Birmingham

Sponsor: Amgen

Sex: All·Age: 18 - 99

Code: NCT07037459·Phase 3·Recruiting

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Safety Study of Viaskin® Peanut Patch in Peanut-Allergic Children 1 Through 3 Years of Age (COMFORT Toddlers)

for Allergy

56 locations incl. Birmingham

Sponsor: DBV Technologies

Sex: All·Age: 1 - 3

Code: NCT07003919·Phase 3·Recruiting

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Galvanize Prospective/Retrospective Pulsed Electric Field Device Registry

for Soft Tissue Lesion

10 locations incl. Gilbert

Sponsor: Galvanize Therapeutics, Inc.

Sex: All·Age: 18 - 100

Code: NCT05851430·Recruiting

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Testing the Addition of the Drug BMX-001, a Radioprotector, or a Placebo to the Usual Chemoradiation Therapy for Patients With Head and Neck Cancer

for Clinical Stage I HPV-Mediated (p16-Positive) Oropharyngeal Carcinoma AJCC v8

149 locations incl. Gilbert

Sponsor: NRG Oncology

Sex: All·Age: 18+

Code: NCT06532279·Phase 2·Recruiting

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Study to Evaluate the Efficacy and Safety of Ruxolitinib Cream in Participants With Hidradenitis Suppurativa (TRuE-HS1)

for Hidradenitis Suppurativa

Drug: Ruxolitinib

59 locations incl. Phoenix

Sponsor: Incyte Corporation

Sex: All·Age: 12+

Code: NCT06959225·Phase 3·Recruiting

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Depemokimab as an Extended treatmeNt Duration Biologic in Adults With Chronic Obstructive Pulmonary Disease (COPD) and Type 2 Inflammation (ENDURA-2)

for Pulmonary Disease, Chronic Obstructive

Drug: Depemokimab

55 locations incl. Sheffield

Sponsor: GlaxoSmithKline

Sex: All·Age: 40 - 80

Code: NCT06961214·Phase 3·Recruiting

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JUST BREATHE, Breathing Life Into Innovative Therapies for ARDS- Cohort A: Vilobelimab

for Acute Respiratory Distress Syndrome (ARDS)

40 locations incl. Birmingham

Sponsor: PPD Development, LP

Sex: All·Age: 18+

Code: NCT06701682·Phase 2·Recruiting

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A Study to Evaluate Different Targeted Therapies for Patients With Rheumatoid Arthritis

for Rheumatoid Arthritis

53 locations incl. Peoria

Sponsor: AbbVie

Sex: All·Age: 18+

Code: NCT06972446·Phase 2·Recruiting

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Long-term Characterization of GORE® TAG® Conformable Thoracic Stent Graft With ACTIVE CONTROL System Performance

for Vascular Disease

24 locations incl. Tucson

Sponsor: W.L.Gore & Associates

Sex: All·Age: 18+

Code: NCT06658730·Recruiting

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Frailty and Muscle Strength Tests in Older Adults Undergoing Major Surgery

for Frailty

1 location in Chapel Hill

Sponsor: University of North Carolina, Chapel Hill

Sex: All·Age: 65+

Code: NCT06988176·Recruiting

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A Study to Assess the Efficacy, Safety, and Tolerability of IMVT-1402 as Treatment for Adult Participants With Graves' Disease

for Graves' Disease

Drug: IMVT-1402

33 locations incl. Tucson

Sponsor: Immunovant Sciences GmbH

Sex: All·Age: 18 - 75

Code: NCT07018323·Phase 2·Recruiting

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Brain-Gut Yoga for Functional Dyspepsia and Gastroparesis (FD-GP)

for Functional Dyspepsia

1 location in Charlotte

Sponsor: Wake Forest University Health Sciences

Sex: All·Age: 18+

Code: NCT06732453·Recruiting

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The Vanguard Study: Testing a New Way to Screen for Cancer

for Bladder Carcinoma

37 locations incl. Pleasanton

Sponsor: National Cancer Institute (NCI)

Sex: All·Age: 45 - 75·Accepts healthy volunteers

Code: NCT06995898·Recruiting

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Feasibility of an ADAPTive Intervention to Improve Food Security and Maternal-Child Health

for Food Insecurity

1 location in Winston-Salem

Sponsor: Wake Forest University Health Sciences

Sex: Female·Age: 18+·Accepts healthy volunteers

Code: NCT06942598·Recruiting

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A Study to Investigate the Efficacy and Safety of Bemdaneprocel in Adults Who Have Parkinson's Disease

for Parkinsons Disease (PD)

31 locations incl. Sun City

Sponsor: BlueRock Therapeutics

Sex: All·Age: 45 - 75

Code: NCT06944522·Phase 3·Recruiting

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Deflated and Inflated Cuff Endotracheal Extubations

for Anesthesia Airway Management

1 location in Marine Corps Base Camp Lejeune

Sponsor: Naval Medical Center Camp Lejeune

Sex: All·Age: 18 - 50·Accepts healthy volunteers

Code: NCT06990308·Enrolling By Invitation

A Study to Evaluate the Efficacy and Safety of IMG-007 in Adult Participants With Moderate-to-Severe Atopic Dermatitis

for Atopic Dermatitis

16 locations incl. Lancaster

Sponsor: Inmagene LLC

Sex: All·Age: 18 - 74

Code: NCT07037901·Phase 2·Recruiting

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19F MRI in Healthy Children and Children With Mild Cystic Fibrosis Lung Disease

for Cystic Fibrosis in Children

1 location in Chapel Hill

Sponsor: University of North Carolina, Chapel Hill

Sex: All·Age: 6 - 17·Accepts healthy volunteers

Code: NCT06066723·Recruiting

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RESTORE TRIAL: A Phase 2 Study Evaluating the Efficacy and Safety of Pemvidutide in the Treatment of Alcohol-Associated Liver Disease (ALD)

for Alcohol Liver Disease

Drug: Pemvidutide

42 locations incl. Peoria

Sponsor: Altimmune, Inc.

Sex: All·Age: 18 - 75

Code: NCT07009860·Phase 2·Recruiting

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Dose Escalation Study to Assess the Safety, Tolerability, Pharmacokinetics And Pharmacodynamics of SIF001 in Healthy Subjects and in Epilepsy Patients

for Epilepsy

10 locations incl. Tucson

Sponsor: Suninflam Inc

Sex: All·Age: 18 - 70·Accepts healthy volunteers

Code: NCT07051629·Phase 1·Recruiting

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Neonatal Platelet Transfusion Threshold Trial

for Thrombocytopenia

20 locations incl. Birmingham

Sponsor: NICHD Neonatal Research Network

Sex: All·Age: 1 Hour - 48 Hours·Accepts healthy volunteers

Code: NCT06676904·Recruiting

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Milrinone for Prevention of Post-ligation Cardiac Syndrome Trial

for Post-ligation Cardiac Syndrome

19 locations incl. Birmingham

Sponsor: NICHD Neonatal Research Network

Sex: All·Age: Up to 3 Months

Code: NCT06679855·Phase 3·Recruiting

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Pilot Study of Mindset Moments Among Adolescent and Young Adult Cancer Survivors

for Cancer

1 location in Durham

Sponsor: Duke University

Sex: All·Age: 19 - 25·Accepts healthy volunteers

Code: NCT06732375·Recruiting

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A Phase 2 Study of Mutant-selective PI3Kα Inhibitor, RLY-2608, in Adults and Children With PIK3CA Related Overgrowth Spectrum and Malformations Driven by PIK3CA Mutation (The ReInspire Study)

for PIK3CA-Related Overgrowth Spectrum (PROS)

20 locations incl. Phoenix

Sponsor: Relay Therapeutics, Inc.

Sex: All·Age: 2+

Code: NCT06789913·Phase 2·Recruiting

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A Study to Evaluate the Efficacy and Safety of KarXT for the Treatment of Manic Episodes in Bipolar-I Disorder (BALSAM-2)

for Bipolar Disorder Type I With Mania or Mania With Mixed Features

Drug: KarXT

28 locations incl. Little Rock

Sponsor: Bristol-Myers Squibb

Sex: All·Age: 18 - 65

Code: NCT06951711·Phase 3·Recruiting

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Testing the Addition of an IDH2 Inhibitor, Enasidenib, to Usual Treatment (Cedazuridine-Decitabine) for Higher-Risk Myelodysplastic Syndrome (MDS) With IDH2 Mutation (A MyeloMATCH Treatment Trial)

for Myelodysplastic Syndrome

138 locations incl. Berkeley

Sponsor: National Cancer Institute (NCI)

Sex: All·Age: 18+

Code: NCT06577441·Phase 2·Recruiting

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Study to Evaluate the Efficacy and Safety of Ruxolitinib Cream in Participants With Hidradenitis Suppurativa (TRuE-HS2)

for Hidradenitis Suppurativa

Drug: Ruxolitinib

67 locations incl. Birmingham

Sponsor: Incyte Corporation

Sex: All·Age: 12+

Code: NCT06958211·Phase 3·Recruiting

Apply to this trial

Engage Psychosocial Intervention for Cancer Symptoms

for Advanced Breast Cancer

1 location in Durham

Sponsor: Duke University

Sex: All·Age: 18+

Code: NCT06555588·Recruiting

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A Study to Test the Safety and Effectiveness of GSK5764227, Alone or With Other Treatments, in Participants With Advanced Gastrointestinal Cancers That Cannot be Surgically Removed

for Gastrointestinal Neoplasms

7 locations incl. Los Alamitos

Sponsor: GlaxoSmithKline

Sex: All·Age: 18+

Code: NCT06885034·Phase 1, Phase 2·Recruiting

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A Study to Investigate Progression-Free Survival With Sonrotoclax Plus Obinutuzumab Or Sonrotoclax Plus Rituximab Compared With Venetoclax Plus Rituximab Treatment In Patients With Relapsed and/or Refractory Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma (CELESTIAL-RRCLL)

for Chronic Lymphocytic Leukemia

Drug: Sonrotoclax

34 locations incl. Laguna Hills

Sponsor: BeOne Medicines

Sex: All·Age: 18+

Code: NCT06943872·Phase 3·Recruiting

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Contour Neurovascular System™ ContiNued Access Investigational Device EXempTion (IDE) Trial (NEXT Trial)

for Cerebral Aneurysms

9 locations incl. Park Ridge

Sponsor: Cerus Endovascular, Inc.

Sex: All·Age: 18 - 75

Code: NCT06693011·Recruiting

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JUST BREATHE, Breathing Life Into Innovative Therapies for ARDS- Cohort B: Paridiprubart

for Acute Respiratory Distress Syndrome (ARDS)

Drug: Cohort B: paridiprubart

40 locations incl. Birmingham

Sponsor: PPD Development, LP

Sex: All·Age: 18+

Code: NCT06701669·Phase 2·Recruiting

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JUST BREATHE, Breathing Life Into Innovative Therapies for ARDS (Master Record)

for Acute Respiratory Distress Syndrome (ARDS)

40 locations incl. Birmingham

Sponsor: PPD Development, LP

Sex: All·Age: 18+

Code: NCT06703073·Phase 2·Recruiting

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REVEAL: A Phase 3 Study of ION582 in Angelman Syndrome

for Angelman Syndrome

15 locations incl. Los Angeles

Sponsor: Ionis Pharmaceuticals, Inc.

Sex: All·Age: 2 - 50

Code: NCT06914609·Phase 3·Recruiting

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Phase 1/2 Study of ETX-636 in Participants With Advanced Solid Tumors

for Advanced Solid Tumors

10 locations incl. Newport Beach

Sponsor: Ensem Therapeutics

Sex: All·Age: 18+

Code: NCT06993844·Phase 1, Phase 2·Recruiting

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A Study to Evaluate Del-brax (Also Referred to as AOC 1020) in Participants With FSHD

for Facioscapulohumeral Muscular Dystrophy

14 locations incl. Orange

Sponsor: Avidity Biosciences, Inc.

Sex: All·Age: 16 - 70

Code: NCT07038200·Phase 3·Recruiting

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The Effect of Non-invasive Brain Stimulation rTMS on Hand Muscles in Chronic Stroke Patients.

for Stroke

1 location in Durham

Sponsor: Duke University

Sex: All·Age: 21+

Code: NCT06765642·Recruiting

Apply to this trial