Paid Clinical Trials in North Carolina

North Carolina has 2,811 paid clinical trials enrolling now across cities including Durham, Chapel Hill and Winston-Salem. Search by condition, age, or phase to find compensated research studies accepting participants near you.

Research sites in North Carolina include Duke University Medical Center, UNC Health and Wake Forest Baptist, running studies across oncology, cardiology, neurology, and more. Both patients and healthy volunteers may qualify. Most studies offer compensation for time and travel.

Recruiting trial data synced daily from ClinicalTrials.gov. Last sync: July 31, 2026.

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Healthy volunteers only

2,435 clinical trials

A Study of Healthy Donor CD19-targeted Allogeneic CAR T Cells in Participants With Severe, Refractory Autoimmune Diseases

for Refractory Autoimmune Diseases

Sites in Durham +1 more location

Sponsor: Juno Therapeutics, Inc., a Bristol-Myers Squibb Company

Sex: All·Age: 18+

Code: NCT07115745·Phase 1·Recruiting·Listed Aug 2025

Apply to this trial

Study of Trastuzumab Deruxtecan Versus Standard of Care Chemotherapy for HER2-Expressing (IHC 3+/2+) Endometrial Cancer

for Endometrial Cancer

Sites in Pinehurst +9 more locations

Sponsor: Daiichi Sankyo

Sex: Female·Age: 18+

Code: NCT07022483·Phase 3·Recruiting·Listed Jun 2025

Apply to this trial

Effectiveness and Safety of OviTex® PRS in Breast Reconstruction

for Breast Reconstruction

Sites in Raleigh +1 more location

Sponsor: Tela Bio Inc

Sex: Female·Age: 22 - 75

Code: NCT07135596·Recruiting·Listed Aug 2025

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Glycogen Storage Disease Type Ia (GSDIa) Disease Monitoring Program

for Glycogen Storage Disease Type Ia

Sites in Durham +8 more locations

Sponsor: Ultragenyx Pharmaceutical Inc

Sex: All·Age: 2+

Code: NCT06636383·Recruiting·Listed Oct 2024

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EMPHASYS Cup Positioning in THA With Non-Invasive Navigation (Velys Hip Navigation (VHN))

for Osteoarthritis

Sites in Gastonia +4 more locations

Sponsor: DePuy Orthopaedics

Sex: All·Age: 21+

Code: NCT06631638·Recruiting·Listed Oct 2024

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A Study to Evaluate the Efficacy, Safety, and Pharmacokinetics (PK) of RO7837195 in Participants With Moderately to Severely Active Ulcerative Colitis (UC)

for Ulcerative Colitis

Sites in Monroe +7 more locations

Sponsor: Genentech, Inc.

Sex: All·Age: 18+

Code: NCT06979336·Phase 2·Recruiting·Listed May 2025

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Detecting Pulmonary Hypertension With the Eko CORE 500 Digital Stethoscope

for Pulmnary Hypertension

Sites in Durham +1 more location

Sponsor: Eko Devices, Inc.

Sex: All·Age: 18+·Accepts healthy volunteers

Code: NCT07136623·Recruiting·Listed Aug 2025

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Blood-brain Barrier (BBB) Opening Using Exablate Focused Ultrasound With Standard of Care Treatment of NSCLC Brain Mets

for Brain Tumor

Sites in Winston-Salem +8 more locations

Sponsor: InSightec

Sex: All·Age: 18 - 100

Code: NCT05317858·Phase 3·Recruiting·Listed Apr 2022

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Trial Investigating Visugromab in Combination With Immunochemotherapy in 1L Treatment of Participants With Metastatic NSCLC

for Metastatic Non-Squamous Non-Small Cell Lung Cancer

Sites in Durham +6 more locations

Sponsor: CatalYm GmbH

Sex: All·Age: 18+

Code: NCT07098988·Phase 2·Recruiting·Listed Aug 2025

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A Study of MACI in Patients Aged 17 to 65 Years With Symptomatic Chondral or Osteochondral Defects of the Ankle

for Chondral Defect

Sites in Durham +6 more locations

Sponsor: Vericel Corporation

Sex: All·Age: 17 - 65

Code: NCT06915233·Phase 3·Recruiting·Listed Apr 2025

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A Study Investigating Intravenous Human Normal Immunoglobulin 10% in Adults With Chronic Immune Thrombocytopenia (ITP)

for Chronic Primary Immune Thrombocytopenia (ITP)

Sites in Greenville +2 more locations

Sponsor: Kedrion S.p.A.

Sex: All·Age: 18 - 70

Code: NCT07059000·Phase 3·Recruiting·Listed Jul 2025

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Study Evaluating Dosimetry, Randomized Dose Optimization, Dose Escalation and Efficacy of Ac-225 Rosopatamab Tetraxetan in Participants With PSMA PET-Positive Castration-Resistant Prostate Cancer (CRPC)

for PSMA PET-Positive Castration-Resistant Prostate Cancer

Sites in Durham +8 more locations

Sponsor: Convergent Therapeutics

Sex: Male·Age: 18+

Code: NCT06549465·Phase 2·Recruiting·Listed Aug 2024

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A Phase I/II Study of ITU512 in Healthy Participants and Patients With Sickle Cell Disease

for Sickle Cell Disease

Sites in Greenville +5 more locations

Sponsor: Novartis Pharmaceuticals

Sex: All·Age: 12 - 55·Accepts healthy volunteers

Code: NCT06546670·Phase 1, Phase 2·Recruiting·Listed Aug 2024

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A Study to Investigate the Safety and Efficacy of IOV-3001 in Adults With Advanced Melanoma Who Will Receive Lifileucel

for Unresectable Melanoma

Drug: Lifileucel

Sites in Chapel Hill +2 more locations

Sponsor: Iovance Biotherapeutics, Inc.

Sex: All·Age: 18 - 70

Code: NCT06940739·Phase 1, Phase 2·Recruiting·Listed Apr 2025

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Substudy 03C: A Study of Combination Therapies in Participants With Renal Cell Carcinoma With Recurrent Disease During or After Anti-PD-(L)1 Therapy (MK-3475-03C/KEYMAKER-U03)

for Renal Cell Carcinoma

Sites in Durham +6 more locations

Sponsor: Merck Sharp & Dohme LLC

Sex: All·Age: 18 - 120

Code: NCT07049926·Phase 1, Phase 2·Recruiting·Listed Jul 2025

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Infant Formula in Infants and Children With Cow's Milk Allergy

for Cow's Milk Allergy

Sites in Chapel Hill +7 more locations

Sponsor: Abbott Nutrition

Sex: All·Age: 3 Months - 12

Code: NCT06456541·Recruiting·Listed Jun 2024

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FIBERGRAFT Aeridyan Posterolateral Fusion Study

for Degenerative Spine Disease

Sites in Durham +7 more locations

Sponsor: DePuy Synthes Products, Inc.

Sex: All·Age: 18+

Code: NCT07059065·Recruiting·Listed Jul 2025

Apply to this trial

MISHA Post-Market Clinical Study

for Osteo Arthritis Knee

Sites in Raleigh +3 more locations

Sponsor: Moximed

Sex: All·Age: 25 - 65

Code: NCT06118892·Recruiting·Listed Nov 2023

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A Study Evaluating the Safety, Pharmacokinetics, and Efficacy of Mosunetuzumab or Glofitamab in Combination With CC-220 and/or CC-99282 in Participants With B-Cell Non-Hodgkin Lymphoma

for Non-Hodgkin Lymphoma

Drug: Mosunetuzumab

Sites in Charlotte +5 more locations

Sponsor: Hoffmann-La Roche

Sex: All·Age: 18+

Code: NCT05169515·Phase 1·Recruiting·Listed Dec 2021

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Study to Evaluate the Pharmacokinetics (PK), Safety and Tolerability up to 6 Years of Intravenous (i.v.) Secukinumab in Pediatric Participants With Juvenile Psoriatic Arthritis (JPsA).

for Juvenile Psoriatic Arthritis

Drug: Secukinumab

Sites in Charlotte +7 more locations

Sponsor: Novartis Pharmaceuticals

Sex: All·Age: 2 - 17

Code: NCT06751238·Phase 1·Recruiting·Listed Dec 2024

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Drug-Drug Interaction Study of ABP-671 in Gout Patients

for Gout Chronic

1 location in Cary

Sponsor: Atom Therapeutics Co., Ltd

Sex: All·Age: 18 - 75

Code: NCT07367971·Phase 1·Recruiting·Listed Jan 2026

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Phase 1 Trial of BTM-3566 in Relapsed/Refractory Mature B Cell Lymphomas

for Lymphoma, B-Cell

Sites in Charlotte +1 more location

Sponsor: Bantam Pharmaceuticals

Sex: All·Age: 18+

Code: NCT06792734·Phase 1·Recruiting·Listed Jan 2025

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MagnetOs Flex Matrix Compared to Trinity Elite Mixed With Local Autograft in Patients Undergoing up to Four-level Instrumented Posterolateral Fusion

for Degenerative Disc Disease

Sites in Pinehurst +7 more locations

Sponsor: Kuros Biosurgery AG

Sex: All·Age: 18+

Code: NCT05037968·Recruiting·Listed Sep 2021

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A Study to Test the Safety and Effects of Inhaled GDC-6988 in Participants With Muco-obstructive Disease

for Non-cystic Fibrosis Bronchiectasis

Sites in Chapel Hill +4 more locations

Sponsor: Genentech, Inc.

Sex: All·Age: 18+

Code: NCT06603246·Phase 1·Recruiting·Listed Sep 2024

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A Study of JNJ-79635322 in Participants With Relapsed or Refractory Multiple Myeloma or Previously Treated Amyloid Light-chain (AL) Amyloidosis

for Relapsed or Refractory Multiple Myeloma

Sites in Charlotte +8 more locations

Sponsor: Janssen Research & Development, LLC

Sex: All·Age: 18+

Code: NCT05652335·Phase 1·Recruiting·Listed Dec 2022

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A Study of ASP2138 Given Before Surgery, Then Chemotherapy After Surgery, in People With Pancreatic Ductal Cancer

for Pancreatic Ductal Adenocarcinoma

Sites in Durham +2 more locations

Sponsor: Astellas Pharma Global Development, Inc.

Sex: All·Age: 18+

Code: NCT07024615·Phase 1·Recruiting·Listed Jun 2025

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A Study to Compare the Efficacy and Safety of TachoSil and Surgicel Original as an Adjunct to Control Mild to Moderate Soft Tissue Bleeding During Surgery

for Hemorrhage

Sites in Charlotte +8 more locations

Sponsor: Corza Medical GmbH

Sex: All·Age: 1 Month+

Code: NCT06664775·Phase 3·Recruiting·Listed Oct 2024

Apply to this trial

Study of Orally Administered MOMA-341 in Participants With Advanced or Metastatic Solid Tumors

for Advanced Solid Tumor

Sites in Raleigh +7 more locations

Sponsor: MOMA Therapeutics

Sex: All·Age: 18+

Code: NCT06974110·Phase 1·Recruiting·Listed May 2025

Apply to this trial

Stone and Laser Therapies Post-Market Study (SALT)

for Benign Prostate Hypertrophy(BPH)

Sites in Durham +4 more locations

Sponsor: Boston Scientific Corporation

Sex: All·Age: All ages

Code: NCT06982235·Recruiting·Listed May 2025

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EPIK-P4: A Phase II Single-arm Study to Assess the Efficacy, Safety and Pharmacokinetics of Alpelisib (BYL719) in Pediatric and Adult Patients With PIK3CA-related Overgrowth Spectrum (PROS)

for PIK3CA-related Overgrowth Spectrum (PROS)

Sites in Chapel Hill +5 more locations

Sponsor: Novartis Pharmaceuticals

Sex: All·Age: 2 - 100

Code: NCT06997588·Phase 2·Recruiting·Listed May 2025

Apply to this trial

A Safety and Efficacy Study Evaluating CTX112 in Adult Subjects With Refractory Autoimmune Disease

for SLE (Systemic Lupus)

Sites in Chapel Hill +6 more locations

Sponsor: CRISPR Therapeutics

Sex: All·Age: 18 - 70

Code: NCT06925542·Phase 1·Recruiting·Listed Apr 2025

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REMASTer: REcurrent Brain Metastases After SRS Trial

for Brain Metastases

Sites in Winston-Salem +7 more locations

Sponsor: Monteris Medical

Sex: All·Age: 18+

Code: NCT05124912·Recruiting·Listed Nov 2021

Apply to this trial

APOL1 Genotyping CTA Clinical Performance Study

for APOL1-mediated Kidney Disease

1 location in Durham

Sponsor: Almac Diagnostic Services LLC

Sex: All·Age: 18 - 70·Accepts healthy volunteers

Code: NCT06839833·Recruiting·Listed Feb 2025

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A Study to Assess Change in Disease Activity and Adverse Events (AE)s in Adult Participants With Multiple Myeloma Receiving T Cell Engaging Bi/Tri-specific Antibodies Intravenously (IV)/Subcutaneously (SC) Alone or in Combinations

for Multiple Myeloma

Sites in Chapel Hill, Winston-Salem +12 more locations

Sponsor: AbbVie

Sex: All·Age: 18+

Code: NCT06892522·Phase 1, Phase 2·Recruiting·Listed Mar 2025

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A Study to Assess the Concentration of Bimekizumab in Mature Breast Milk From Mothers Receiving Treatment With Bimzelx® (Bimekizumab)

for Moderate to Severe Plaque Psoriasis

Drug: Bimekizumab

Sites in Durham, Chapel Hill +4 more locations

Sponsor: UCB Biopharma SRL

Sex: Female·Age: 18+

Code: NCT06888193·Phase 1·Recruiting·Listed Mar 2025

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Safety, Tolerability, and Efficacy of NVG-2089 in Participants With Immune Thrombocytopenia

for Immune Thrombocytopenia (ITP)

1 location in Greenville

Sponsor: Nuvig Therapeutics, Inc.

Sex: All·Age: 18 - 80

Code: NCT07095127·Phase 2·Recruiting·Listed Jul 2025

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A Study to Evaluate Efficacy, Safety, and PK of XEMBIFY®+Standard Medical Treatment (SMT) Compared to Placebo+SMT to Prevent Infections in Participants With HGG and Recurrent or Severe Infections Associated With B-cell Chronic Lymphocytic Leukemia, Multiple Myeloma, and Non-Hodgkin Lymphoma

for Hypogammaglobulinemia

Sites in Greenville, Morrisville +4 more locations

Sponsor: Grifols Therapeutics LLC

Sex: All·Age: 18+

Code: NCT05645107·Phase 3·Recruiting·Listed Dec 2022

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A Study Evaluating the Presence and Concentration of BRIUMVI™ (Ublituximab) in Breast Milk

for Relapsing Multiple Sclerosis

Sites in Wilmington +4 more locations

Sponsor: TG Therapeutics, Inc.

Sex: Female·Age: 18+

Code: NCT06143514·Recruiting·Listed Nov 2023

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A Study Evaluating the Effect of BRIUMVI® (Ublituximab) on Pregnancy and Infant Outcomes in Participants With Multiple Sclerosis (MS)

for Multiple Sclerosis

1 location in Wilmington

Sponsor: TG Therapeutics, Inc.

Sex: Female·Age: 15 - 50

Code: NCT06433765·Recruiting·Listed May 2024

Apply to this trial

Deep Brain Stimulation (DBS) Retrospective Outcomes Study

for Parkinson Disease

Sites in Winston-Salem +7 more locations

Sponsor: Boston Scientific Corporation

Sex: All·Age: All ages

Code: NCT03664609·Recruiting·Listed Sep 2018

Apply to this trial