Paid Clinical Trials in North Carolina

North Carolina has 2,804 paid clinical trials enrolling now across cities including Durham, Chapel Hill and Winston-Salem. Search by condition, age, or phase to find compensated research studies accepting participants near you.

Research sites in North Carolina include Duke University Medical Center, UNC Health and Wake Forest Baptist, running studies across oncology, cardiology, neurology, and more. Both patients and healthy volunteers may qualify. Most studies offer compensation for time and travel.

Recruiting trial data synced daily from ClinicalTrials.gov. Last sync: September 14, 2026.

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2,435 clinical trials

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An Open-label, Single-arm Study of Prophylaxis for Datopotamab Deruxtecan (Dato-DXd) -Related Stomatitis in Eligible Patients With Metastatic or Inoperable Locally Recurrent Breast Cancer or Locally Advanced or Metastatic Epidermal Growth Factor Receptor-Mutated Non-small Cell Lung Cancer.

for Stomatitis

Sites in Greensboro, Wilson +28 more locations

Sponsor: AstraZeneca

Sex: All·Age: 18+

Code: NCT07357597·Phase 4·Recruiting·Listed Jan 2026

Apply to this trial

A Usability Study of a Multi-channel ECG Monitoring Device

for Healthy Adult Participants

1 location in New London

Sponsor: Wearlinq

Sex: All·Age: 18+·Accepts healthy volunteers

Code: NCT07388355·Recruiting·Listed Feb 2026

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Building Relationship, Improving Dialogue, and Growing Empathy (BRIDGE): An Intervention to Support Decision Making for Critically Ill Children

for Decision Making

Sites in Durham +2 more locations

Sponsor: Duke University

Sex: All·Age: All ages

Code: NCT07390773·Recruiting·Listed Feb 2026

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Comparing the Effects of Front-of-Package Labeling Schemes in Indonesia

for Nutrition

1 location in Chapel Hill

Sponsor: University of North Carolina, Chapel Hill

Sex: All·Age: 18+·Accepts healthy volunteers

Code: NCT07526584·Recruiting·Listed Apr 2026

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NEXUS Study: A Study to Test Single and Multiple Doses of MER511 Given to Adults With Graves' Disease

for Graves Disease

Sites in Morehead City +10 more locations

Sponsor: Merida Biosciences

Sex: All·Age: 18 - 65

Code: NCT07305818·Phase 1·Recruiting·Listed Dec 2025

Apply to this trial

Prevention of Recurrent C. Difficile Infection Study With AZD5148 Monoclonal Antibody

for Clostridioides Difficile Infection

Sites in Winston-Salem, Salisbury +30 more locations

Sponsor: AstraZeneca

Sex: All·Age: 18+

Code: NCT07285213·Phase 2·Recruiting·Listed Dec 2025

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A Study of KT-621 Administered Orally to Adult Participants With Moderate to Severe Eosinophilic Asthma

for Eosinophilic Asthma

Sites in Durham, Chapel Hill +32 more locations

Sponsor: Kymera Therapeutics, Inc.

Sex: All·Age: 18 - 75

Code: NCT07323654·Phase 2·Recruiting·Listed Jan 2026

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Phase 3 Trial of VMX-C001 vs Usual Pharmacological Care in Patients Taking a FXa Direct Oral Anticoagulant Who Require Urgent Surgery With or Without Heparin.

for Blood Loss, Surgical

Sites in Durham +16 more locations

Sponsor: VarmX B.V.

Sex: All·Age: 18+

Code: NCT07288489·Phase 3·Recruiting·Listed Dec 2025

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LEVEL-2: LEVosimendan to Improve Exercise Limitation in Patients With PH-HFpEF-2

for Pulmonary Hypertension Associated With HFpEF

Sites in Durham, Winston-Salem +43 more locations

Sponsor: Tenax Therapeutics, Inc.

Sex: All·Age: 18 - 85

Code: NCT07288398·Phase 3·Recruiting·Listed Dec 2025

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Study of Oral Food Challenge Biomarkers (SAFER)

for Allergy

Sites in Chapel Hill +9 more locations

Sponsor: National Institute of Allergy and Infectious Diseases (NIAID)

Sex: All·Age: 12 Months - 17

Code: NCT07279467·Recruiting·Listed Dec 2025

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Study of ENV-294 in Adults With Moderate-to-Severe Atopic Dermatitis

for Atopic Dermatitis (AD)

Sites in Wilmington +31 more locations

Sponsor: Enveda Therapeutics

Sex: All·Age: 18 - 75

Code: NCT07298395·Phase 2·Recruiting·Listed Dec 2025

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A Study of AZD0120 in Autoimmune Diseases

for Systemic Sclerosis

Sites in Chapel Hill +7 more locations

Sponsor: AstraZeneca

Sex: All·Age: 18 - 75

Code: NCT07295847·Phase 1·Recruiting·Listed Dec 2025

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PRE-EMPT: Prospective RandomizEd Evaluation and Management of Premature aTherosclerosis

for Coronary Artery Disease Risk Factors Multiple

Sites in Durham, Winston-Salem +21 more locations

Sponsor: Duke University

Sex: All·Age: 30 - 60

Code: NCT07232069·Phase 3·Recruiting·Listed Nov 2025

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A Study of IDRX-42 (GSK6042981) Versus (vs) Sunitinib in Participants With Gastrointestinal Stromal Tumors After Imatinib Therapy

for Gastrointestinal Neoplasms

Sites in Durham, Charlotte +46 more locations

Sponsor: GlaxoSmithKline

Sex: All·Age: 18+

Code: NCT07218926·Phase 3·Recruiting·Listed Oct 2025

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Cessation or Reduction of Alcohol Consumption in Veterans: A Randomized Controlled Trial for Alcohol Use Disorder (CRAVE)

for Alcohol Use Disorder

Sites in Durham, Asheville +17 more locations

Sponsor: VA Office of Research and Development

Sex: All·Age: 18 - 80·Accepts healthy volunteers

Code: NCT07218354·Phase 3·Recruiting·Listed Oct 2025

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L19IL2/L19TNF in Patients With Cutaneous Squamous Cell Carcinoma

for Locally Advanced Cutaneous Squamous Cell Carcinoma

Sites in Durham +5 more locations

Sponsor: Philogen S.p.A.

Sex: All·Age: 18+

Code: NCT07228442·Phase 2·Recruiting·Listed Nov 2025

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First-in-Human Study of PLX-61639 in Locally Advanced or Metastatic Solid Tumors

for Esophageal Squamous Cell Carcinoma

Sites in Durham +9 more locations

Sponsor: Plexium, Inc.

Sex: All·Age: 18+

Code: NCT07284186·Phase 1·Recruiting·Listed Dec 2025

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A Study to Investigate the Efficacy, Safety, and Tolerability of AZD4144in Participants With Sepsis-associated Acute Kidney Injury.

for Sepsis

Sites in Chapel Hill, Winston-Salem +12 more locations

Sponsor: AstraZeneca

Sex: All·Age: 18 - 80

Code: NCT07215702·Phase 2·Recruiting·Listed Oct 2025

Apply to this trial

B6 Administration for Levetiracetam-Associated Neurobehavioral Changes and Epilepsy

for Brain Tumor Related Epilepsy (BTRE)

1 location in Durham

Sponsor: Duke University

Sex: All·Age: 18+

Code: NCT07271966·Recruiting·Listed Dec 2025

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Small Trial of Alendronate Impact on the Reservoir of HIV

for HIV

Sites in Chapel Hill +4 more locations

Sponsor: National Institute of Allergy and Infectious Diseases (NIAID)

Sex: All·Age: 18 - 65

Code: NCT07216794·Phase 2·Recruiting·Listed Oct 2025

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A Clinical Study to Investigate the Safety and Tolerability of Efimosfermin Alfa Injection in Participants With Known or Suspected F2- or F3-stage MASH

for Non-alcoholic Fatty Liver Disease

Sites in Morehead City +51 more locations

Sponsor: GlaxoSmithKline

Sex: All·Age: 18 - 75

Code: NCT07221188·Phase 3·Recruiting·Listed Oct 2025

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A Pivotal Clinical Study to Investigate Efimosfermin Alfa in Participants With Biopsy-confirmed F2- or F3-stage MASH

for Non-alcoholic Fatty Liver Disease

Sites in Morehead City, Fayetteville +74 more locations

Sponsor: GlaxoSmithKline

Sex: All·Age: 18 - 75

Code: NCT07221227·Phase 3·Recruiting·Listed Oct 2025

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A Study to Assess the Effectiveness and Safety of GSK3862995B in Adults With Bronchiectasis

for Bronchiectasis

Sites in Winston-Salem +30 more locations

Sponsor: GlaxoSmithKline

Sex: All·Age: 18 - 85

Code: NCT07201051·Phase 2·Recruiting·Listed Oct 2025

Apply to this trial

Geriatric Distal Femur

for Articular Fractures

1 location in Charlotte

Sponsor: Wake Forest University Health Sciences

Sex: All·Age: 55+

Code: NCT07237191·Recruiting·Listed Nov 2025

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AZD5335 vs. Mirvetuximab Soravtansine in FRα-high and AZD5335 vs. Chemotherapy in FRα-low Platinum-resistant Ovarian Cancer

for Epithelial Ovarian Cancer

Sites in Chapel Hill +38 more locations

Sponsor: AstraZeneca

Sex: Female·Age: 18+

Code: NCT07218809·Phase 3·Recruiting·Listed Oct 2025

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A Study to Investigate the Pharmacokinetics and Safety of Subcutaneous Rilvegostomig in Adult Participants With Advanced Solid Tumors Previously Treated With Standard of Care Therapy

for Advanced Solid Tumors

Drug: Rilvegostomig

Sites in Huntersville +2 more locations

Sponsor: AstraZeneca

Sex: All·Age: 18+

Code: NCT07161414·Phase 1·Recruiting·Listed Sep 2025

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OPI-NXYDLD-303 Safety and Efficacy of Phentolamine Ophthalmic Solution in Keratorefractive Surgery Participants With Decreased Mesopic Visual Acuity

for Vision Loss Night

Sites in Garner +19 more locations

Sponsor: Ocuphire Pharma, Inc.

Sex: All·Age: 18+

Code: NCT07140783·Phase 3·Recruiting·Listed Aug 2025

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Cognitive Rehabilitation for Treatment of Anger in Veterans With TBI and PTSD

for Traumatic Brain Injury (TBI)

1 location in Durham

Sponsor: Duke University

Sex: All·Age: 18+

Code: NCT07227987·Recruiting·Listed Nov 2025

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A Phase 2b Study Evaluating Oral VH4524184 Regimens in Treatment Naïve Persons With HIV-1 (INNOVATE Study)

for HIV Infections

Sites in Durham, Charlotte +33 more locations

Sponsor: ViiV Healthcare

Sex: All·Age: 18+

Code: NCT07202546·Phase 2·Recruiting·Listed Oct 2025

Apply to this trial

DESTINY-PANTUMOUR04

for Adenocarcinoma (NOS)

Sites in Durham, Wilson +16 more locations

Sponsor: AstraZeneca

Sex: All·Age: 18 - 130

Code: NCT07124000·Recruiting·Listed Aug 2025

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Study of Datopotamab Deruxtecan Plus Carboplatin or Cisplatin Versus Gemcitabine Plus Carboplatin or Cisplatin in Participants With Locally Advanced or Metastatic Urothelial Carcinoma

for Urothelial Cancer

Sites in Chapel Hill +7 more locations

Sponsor: Daiichi Sankyo

Sex: All·Age: 18+

Code: NCT07129993·Phase 2, Phase 3·Recruiting·Listed Aug 2025

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A Study of GSK5764227 in Participants With Relapsed Small Cell Lung Cancer (SCLC)

for Neoplasms, Lung

Sites in Wilson +1 more location

Sponsor: GlaxoSmithKline

Sex: All·Age: 18+

Code: NCT07099898·Phase 3·Recruiting·Listed Aug 2025

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A Study to Investigate the Effect of AZD6793 in Participants With Moderate to Very Severe Chronic Obstructive Pulmonary Disease

for Chronic Obstructive Pulmonary Disease (COPD)

Sites in New Bern +71 more locations

Sponsor: AstraZeneca

Sex: All·Age: 40+

Code: NCT07082738·Phase 2·Recruiting·Listed Jul 2025

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eValuating the Efficacy and Safety of InitiatinG depemokImab earLy therApy iN Chronic Obstructive Pulmonary Disorder (COPD) With Type 2 Inflammation

for Pulmonary Disease, Chronic Obstructive

Drug: Depemokimab

Sites in Winston-Salem +41 more locations

Sponsor: GlaxoSmithKline

Sex: All·Age: 40 - 75

Code: NCT07177339·Phase 3·Recruiting·Listed Sep 2025

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A Phase 3 Randomized Clinical Trial to Investigate the Safety and Efficacy of Palopegteriparatide at Doses Greater Than 30 μg/Day in Adult Participants With Hypoparathyroidism

for Hypoparathyroidism

Drug: Palopegteriparatide

Sites in Greenville +6 more locations

Sponsor: Ascendis Pharma Bone Diseases A/S

Sex: All·Age: 18+

Code: NCT07081997·Phase 3·Recruiting·Listed Jul 2025

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Imeroprubart in Adult Participants With Chronic Inflammatory Demyelinating Polyneuropathy (CIDP)

for Chronic Inflammatory Demyelinating Polyneuropathy

Sites in Chapel Hill, Charlotte +31 more locations

Sponsor: Immunovant Sciences GmbH

Sex: All·Age: 18+

Code: NCT07032662·Phase 2·Recruiting·Listed Jun 2025

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A Study to Evaluate the Efficacy, Safety, and PK of AZD0292 Administered IV in Participants 12 Years of Age and Older With Bronchiectasis and Chronic Pseudomonas Aeruginosa Colonization

for Bronchiectasis With Pseudomonas Aeruginosa Colonization

Sites in Winston-Salem, New Bern +17 more locations

Sponsor: AstraZeneca

Sex: All·Age: 12+

Code: NCT07088926·Phase 2·Recruiting·Listed Jul 2025

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A Long-term Safety and Efficacy Study Evaluating APG777 in Atopic Dermatitis

for Atopic Dermatitis

Sites in Wilmington +22 more locations

Sponsor: Apogee Therapeutics, Inc.

Sex: All·Age: 18+

Code: NCT07003425·Phase 2·Recruiting·Listed Jun 2025

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Patient Navigation for HER2+ Metastatic Breast Cancer Patients Treated With Tucatinib

for HER2+ Metastatic Breast Cancer (MBC)

1 location in Durham

Sponsor: Duke University

Sex: Female·Age: 18+

Code: NCT06983691·Recruiting·Listed May 2025

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Usnoflast Neuromuscular Investigation for Treatment Efficacy in Amyotrophic Lateral Sclerosis

for Amyotrophic Lateral Sclerosis (ALS)

Sites in Winston-Salem +14 more locations

Sponsor: Zydus Therapeutics Inc.

Sex: All·Age: 18+

Code: NCT07023835·Phase 2·Recruiting·Listed Jun 2025

Apply to this trial