Paid Clinical Trials in North Carolina

North Carolina has 2,944 paid clinical trials enrolling now across cities including Durham, Chapel Hill and Winston-Salem. Search by condition, age, or phase to find compensated research studies accepting participants near you.

Research sites in North Carolina include Duke University Medical Center, UNC Health and Wake Forest Baptist, running studies across oncology, cardiology, neurology, and more. Both patients and healthy volunteers may qualify. Most studies offer compensation for time and travel.

Recruiting trial data synced daily from ClinicalTrials.gov. Last sync: June 19, 2026.

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2,944 clinical trials

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Outcomes Following Combined Adductoplasty™ and Lapiplasty® (MTA3D)

for Metatarsus Adductus

9 locations incl. Greeley

Sponsor: Treace Medical Concepts, Inc.

Sex: All·Age: 14 - 65·Accepts healthy volunteers

Code: NCT05587569·Recruiting

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A Study to Evaluate the Efficacy, Safety, Pharmacokinetics (PK), and Pharmacodynamics (PD) of Satralizumab in Participants With Anti-N-methyl-D-aspartic Acid Receptor (NMDAR) or Anti-leucine-rich Glioma-inactivated 1 (LGI1) Encephalitis

for NMDAR Autoimmune Encephalitis

20 locations incl. Birmingham

Sponsor: Hoffmann-La Roche

Sex: All·Age: 12+

Code: NCT05503264·Phase 3·Recruiting

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PREvention of CardIovascular and DiabEtic kidNey Disease in Type 2 Diabetes

for Type2Diabetes

36 locations incl. Huntsville

Sponsor: Brigham and Women's Hospital

Sex: All·Age: 40 - 80

Code: NCT05390892·Phase 4·Recruiting

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Efficacy and Safety Study of Nipocalimab for Adults With Chronic Inflammatory Demyelinating Polyneuropathy (CIDP)

for Polyradiculoneuropathy, Chronic Inflammatory Demyelinating

Drug: Nipocalimab

14 locations incl. Centennial

Sponsor: Janssen Research & Development, LLC

Sex: All·Age: 18+

Code: NCT05327114·Phase 2, Phase 3·Recruiting

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Wearable Spine Health System for Military Readiness

for Low Back Pain

6 locations incl. Luke Air Force Base

Sponsor: Ohio State University

Sex: All·Age: 18 - 64·Accepts healthy volunteers

Code: NCT05944354·Enrolling By Invitation

A Phase 2/3 Study in Adult and Adolescent Participants With SCD

for Sickle Cell Disease

24 locations incl. New Haven

Sponsor: Pfizer

Sex: All·Age: 12+

Code: NCT05431088·Phase 2, Phase 3·Recruiting

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A Study to Evaluate Mezigdomide, Bortezomib and Dexamethasone (MEZIVd) Versus Pomalidomide, Bortezomib and Dexamethasone (PVd) in Participants With Relapsed or Refractory Multiple Myeloma (RRMM)

for Relapsed or Refractory Multiple Myeloma

Drug: Mezigdomide

56 locations incl. Los Alamitos

Sponsor: Celgene

Sex: All·Age: 18+

Code: NCT05519085·Phase 3·Recruiting

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Testing the Addition of Ipatasertib to Usual Chemotherapy and Radiation for Head and Neck Cancer

for Clinical Stage III HPV-Mediated (p16-Positive) Oropharyngeal Carcinoma AJCC v8

17 locations incl. Tampa

Sponsor: National Cancer Institute (NCI)

Sex: All·Age: 18+

Code: NCT05172245·Phase 1·Recruiting

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Naxitamab Added to Induction for Newly Diagnosed High-Risk Neuroblastoma

for Neuroblastoma

20 locations incl. Birmingham

Sponsor: Giselle Sholler

Sex: All·Age: 12 Months - 21

Code: NCT05489887·Phase 2·Recruiting

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IDH Targeted/Non- Targeted vs Non-targeted/IDH-targeted Approaches in the Treatment of Newly Diagnosed IDH Mutated AML Patients Not Candidates for Intensive Induction Therapy (I- DATA Study)

for Acute Myeloid Leukemia

3 locations incl. Chapel Hill

Sponsor: Alice Mims

Sex: All·Age: 18+

Code: NCT05401097·Phase 2·Recruiting

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Study of R289 in Patients With Lower-risk Myelodysplastic Syndromes (LR MDS)

for Low Risk Myelodysplastic Syndromes

15 locations incl. Los Angeles

Sponsor: Rigel Pharmaceuticals

Sex: All·Age: 18+

Code: NCT05308264·Phase 1, Phase 2·Recruiting

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Tovorafenib for Treatment of Craniopharyngioma in Children and Young Adults

for Craniopharyngioma, Child

15 locations incl. Birmingham

Sponsor: Sabine Mueller, MD, PhD

Sex: All·Age: 1 - 39

Code: NCT05465174·Phase 2·Recruiting

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Phase 3 Study of Teclistamab in Combination With Lenalidomide and Teclistamab Alone Versus Lenalidomide Alone in Participants With Newly Diagnosed Multiple Myeloma as Maintenance Therapy Following Autologous Stem Cell Transplantation

for Multiple Myeloma

Drug: Teclistamab

42 locations incl. Phoenix

Sponsor: European Myeloma Network B.V.

Sex: All·Age: 18+

Code: NCT05243797·Phase 3·Recruiting

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You and Me Healthy

for COVID-19

3 locations incl. Merced

Sponsor: Duke University

Sex: All·Age: 2+·Accepts healthy volunteers

Code: NCT05589376·Enrolling By Invitation

Extension Study of Inhaled Treprostinil in Subjects With Fibrotic Lung Disease

for Idiopathic Pulmonary Fibrosis

86 locations incl. Birmingham

Sponsor: United Therapeutics

Sex: All·Age: 40+

Code: NCT04905693·Phase 3·Enrolling By Invitation

MRI in High-Grade Glioma Patients Undergoing Chemoradiation

for High Grade Glioma

1 location in Winston-Salem

Sponsor: Wake Forest University Health Sciences

Sex: All·Age: 18+

Code: NCT05212272·Recruiting

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Cardiac Outcomes With Near-Complete Estrogen Deprivation

for Breast Cancer

3 locations incl. Durham

Sponsor: Duke University

Sex: Female·Age: 18 - 55

Code: NCT05309655·Recruiting

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Autologous CAR-T Cells Targeting B7-H3 in Recurrent or Refractory GBM CAR.B7-H3Tc

for Glioblastoma Multiforme

1 location in Chapel Hill

Sponsor: UNC Lineberger Comprehensive Cancer Center

Sex: All·Age: 18+

Code: NCT05366179·Phase 1·Recruiting

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Study to Evaluate Sutetinib Maleate Capsule in Locally Advanced or Metastatic Non-small Cell Lung Cancer

for Non-small Cell Lung Cancer

6 locations incl. Glendale

Sponsor: Teligene US

Sex: All·Age: 18+

Code: NCT05168566·Phase 2·Recruiting

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Study of mRNA-4359 Administered Alone and in Combination With Immune Checkpoint Blockade in Participants With Advanced Solid Tumors

for Advanced Solid Tumors

16 locations incl. Los Angeles

Sponsor: ModernaTX, Inc.

Sex: All·Age: 12+

Code: NCT05533697·Phase 1, Phase 2·Recruiting

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Efficacy & Safety of Olvi-Vec and Platinum-doublet + Bevacizumab Compared to Physician's Choice of Chemotherapy and Bevacizumab in Platinum-Resistant/Refractory Ovarian Cancer (PRROC) (OnPrime, GOG-3076)

for Platinum-resistant Ovarian Cancer

Drug: Bevacizumab

31 locations incl. Mobile

Sponsor: Genelux Corporation

Sex: Female·Age: 18+

Code: NCT05281471·Phase 3·Recruiting

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Abiraterone, Enzalutamide, or Apalutamide in Castrate-sensitive Prostate Cancer.

for Metastatic Cancer

Drug: Apalutamide

12 locations incl. Los Angeles

Sponsor: Sun Pharmaceutical Industries Limited

Sex: Male·Age: 18+

Code: NCT05422911·Phase 2·Recruiting

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Phase 1b Study of OP-1250 (Palazestrant) in Combination With Ribociclib, Alpelisib, Everolimus, or Atirmociclib in ER+, HER2- Breast Cancer

for Metastatic Breast Cancer

Drug: Palazestrant

14 locations incl. Gilbert

Sponsor: Olema Pharmaceuticals, Inc.

Sex: All·Age: 18+

Code: NCT05508906·Phase 1·Recruiting

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Investigation of PEMF Therapy for Female Patients With IC/BPS

for Interstitial Cystitis

1 location in Winston-Salem

Sponsor: Wake Forest University Health Sciences

Sex: Female·Age: 18 - 80

Code: NCT05149573·Recruiting

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A Phase 2 Study of ACR-368 in Endometrial Adenocarcinoma

for Endometrial Adenocarcinoma

69 locations incl. Mobile

Sponsor: Acrivon Therapeutics

Sex: Female·Age: 18+

Code: NCT05548296·Phase 2·Recruiting

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A Study of TAK-330 to Reverse the Effects of Factor Xa Inhibitors For Adults Needing Urgent Surgery

for Coagulation Disorder

13 locations incl. Arkansas City

Sponsor: Takeda

Sex: All·Age: 18+

Code: NCT05156983·Phase 3·Recruiting

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A Comparison of Two Brief Suicide Prevention Interventions Tailored for Youth on the Autism Spectrum

for Suicidal Ideation

5 locations incl. Baltimore

Sponsor: University of North Carolina, Chapel Hill

Sex: All·Age: 12 - 99

Code: NCT05398250·Enrolling By Invitation

Investigation to Evaluate the Safety and Effectiveness of Cochlear Implantation in Children and Adults With Unilateral Hearing Loss/Single-sided Deafness

for Hearing Loss, Unilateral

8 locations incl. Palo Alto

Sponsor: Cochlear

Sex: All·Age: 5+

Code: NCT05318417·Recruiting

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Collecting Blood Samples From Patients With and Without Cancer to Evaluate Tests for Early Cancer Detection

for Acute Lymphoblastic Leukemia

746 locations incl. Anchorage

Sponsor: Alliance for Clinical Trials in Oncology

Sex: All·Age: 40 - 75·Accepts healthy volunteers

Code: NCT05334069·Recruiting

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Evaluating Long-term Safety of Efgartigimod Administered Intravenously and Efgartigimod PH20 Administered Subcutaneously in Children With Generalized Myasthenia Gravis

for Generalized Myasthenia Gravis

3 locations incl. Chicago

Sponsor: argenx

Sex: All·Age: 2 - 18

Code: NCT05374590·Phase 2, Phase 3·Enrolling By Invitation

A Study to Examine the Effects of Novel Therapy Linvoseltamab in Combination With Other Cancer Treatments for Adult Patients With Multiple Myeloma That is Resistant to Current Standard of Care Treatments

for Multiple Myeloma

Drug: Linvoseltamab

13 locations incl. La Jolla

Sponsor: Regeneron Pharmaceuticals

Sex: All·Age: 18+

Code: NCT05137054·Phase 1·Recruiting

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A Prospective Registry Study to Assess Real-world Patient Characteristics, Treatment Patterns, and Longitudinal Outcomes in Patients Receiving Mavacamten and Other Treatments for Symptomatic Obstructive Hypertrophic Cardiomyopathy (Obstructive-HCM)

for Obstructive Hypertrophic Cardiomyopathy

Drug: Mavacamten

62 locations incl. Anchorage

Sponsor: Bristol-Myers Squibb

Sex: All·Age: 18+

Code: NCT05489705·Recruiting

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MiSight 1 Day Safety Post-Approval Study

for Myopia

47 locations incl. Gilbert

Sponsor: CooperVision, Inc.

Sex: All·Age: 8 - 12·Accepts healthy volunteers

Code: NCT05285527·Recruiting

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Sitting Interruption and Whole-body Cardiovascular Health

for Sedentary Behavior

1 location in Chapel Hill

Sponsor: University of North Carolina, Chapel Hill

Sex: All·Age: 30 - 60·Accepts healthy volunteers

Code: NCT05316571·Recruiting

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Blood-brain Barrier (BBB) Opening Using Exablate Focused Ultrasound With Standard of Care Treatment of NSCLC Brain Mets

for Brain Tumor

9 locations incl. Phoenix

Sponsor: InSightec

Sex: All·Age: 18 - 100

Code: NCT05317858·Phase 3·Recruiting

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A Study of JNJ-90014496 in Participants With B-Cell Non-Hodgkin Lymphoma

for Lymphoma, Non-Hodgkin

14 locations incl. Duarte

Sponsor: Janssen Research & Development, LLC

Sex: All·Age: 18+

Code: NCT05421663·Phase 1, Phase 2·Recruiting

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Dose Escalation/Expansion Study of Mavrostobart (PT199), an Anti-CD73 mAb, Administered Alone and in Combination With a PD-1 Inhibitor or Chemotherapy (the MORNINGSTAR Study)

for Non Small Cell Lung Cancer

6 locations incl. Huntersville

Sponsor: Phanes Therapeutics

Sex: All·Age: 18+

Code: NCT05431270·Phase 1, Phase 2·Recruiting

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Perivenous Dexamethasone Therapy: Examining Reduction of Inflammation After Thrombus Removal to Yield Benefit in Subacute and Chronic Iliofemoral DVT

for Iliofemoral

13 locations incl. Darien

Sponsor: Mercator MedSystems, Inc.

Sex: All·Age: 18 - 89

Code: NCT04858776·Phase 2·Recruiting

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Immune Function and Response to Vaccination After Cancer Therapy in Pediatric Patients

for Pediatric Cancer

1 location in Charlotte

Sponsor: Wake Forest University Health Sciences

Sex: All·Age: 2 - 21

Code: NCT04948619·Phase 2·Recruiting

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Clinical Effectiveness of the "PICU Up!" Multifaceted Early Mobility Intervention for Critically Ill Children

for Child

11 locations incl. Madera

Sponsor: Johns Hopkins University

Sex: All·Age: Up to 18

Code: NCT04989790·Recruiting

Apply to this trial