DESTINY-PANTUMOUR04

Part of paid clinical trials in Birmingham, Alabama.

Sponsor
AstraZeneca
Study ID
NCT07124000
Status
Recruiting
Apply to this trial

Conditions

Eligibility Criteria

Sex
ALL
Age
18 Years - 130 Years
Healthy Volunteers
Not accepted

Interventions

  • Trastuzumab deruxtecan — DRUG
    Trastuzumab deruxtecan monotherapy

Study Details

This study will evaluate the effectiveness of T-DXd in patients with HER2-positive (IHC 3+) locally advanced, unresectable, or metastatic solid tumors who have received prior systemic treatment for metastatic or advanced disease and have no satisfactory alternative treatment options in a real-world setting in the US

Key Dates

First listed
Aug 15, 2025
Start date
Sep 18, 2025
Status verified
Aug 2026
Primary completion
Mar 30, 2028
Completion
Mar 30, 2028

Study Design

Enrollment
100 participants (estimated)

Arms

  • Arm: Trastuzumab deruxtecan
    Patients with locally advanced, unresectable, or metastatic HER-2 positive (IHC3+) solid tumours for whom a clinician decision has been made for treatment with T-DXd as part of routine clinical practice and in line with the FDA label

Primary Outcome Measure

Real world response rate (rwRR) [ Time Frame: Through study completion, up to 2.5 years after enrolment ]

Central Contacts

Locations (18)

FacilityCityStateZIPSite coordinators
Research SiteBirminghamAlabama35243-
Research SiteBullhead CityArizona86442-
Research SiteCasa GrandeArizona85122-
Research SiteSan DiegoCalifornia92123-
Research SiteBoulderColorado80309-
Research SiteCoral SpringsFlorida33065-
Research SiteSt. PetersburgFlorida33714-
Research SiteWest Palm BeachFlorida33401-
Research SiteDecaturIllinois62526-
Research SiteTopekaKansas66604-
Research SiteFarmingtonNew Mexico87401-
Research SiteDurhamNorth Carolina27708-
Research SiteWilsonNorth Carolina27893-
Research SiteCantonOhio44718-
Research SiteMaumeeOhio43537-
Research SitePhiladelphiaPennsylvania19104-
Research SiteNashvilleTennessee37203-
Research SiteDallasTexas75390-

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