Paid Clinical Trials in North Carolina

North Carolina has 2,812 paid clinical trials enrolling now across cities including Durham, Chapel Hill and Winston-Salem. Search by condition, age, or phase to find compensated research studies accepting participants near you.

Research sites in North Carolina include Duke University Medical Center, UNC Health and Wake Forest Baptist, running studies across oncology, cardiology, neurology, and more. Both patients and healthy volunteers may qualify. Most studies offer compensation for time and travel.

Recruiting trial data synced daily from ClinicalTrials.gov. Last sync: July 31, 2026.

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2,435 clinical trials

A Study of Oral Atogepant Tablets to Assess Adverse Events and Change in Disease Activity To Prevent Migraine in Participants Aged 12 to 17 Years

for Chronic Migraine

Drug: Atogepant

Sites in Greensboro +28 more locations

Sponsor: AbbVie

Sex: All·Age: 12 - 17

Code: NCT06810505·Phase 3·Recruiting·Listed Feb 2025

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SIGMA (Safusidenib in IDH1 Mutant Glioma Maintenance)

for Glioma

Sites in Durham +41 more locations

Sponsor: Nuvation Bio Inc.

Sex: All·Age: 18+

Code: NCT05303519·Phase 3·Recruiting·Listed Mar 2022

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A Phase 3 Study to Evaluate the Efficacy and Safety of Intravitreal KSI-101 in Participants With Macular Edema Secondary to Inflammation (MESI) - PINNACLE

for Macular Edema Secondary to Inflammation

Sites in Cary, Wake Forest +51 more locations

Sponsor: Kodiak Sciences Inc

Sex: All·Age: 18+

Code: NCT06996080·Phase 3·Recruiting·Listed May 2025

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SELUTION 4 De Novo Small Vessel IDE Trial

for Coronary Artery Disease

Sites in Raleigh +63 more locations

Sponsor: M.A. Med Alliance S.A.

Sex: All·Age: 18+

Code: NCT05946629·Recruiting·Listed Jul 2023

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A Phase 3 Study to Evaluate the Efficacy and Safety of Intravitreal KSI-101 in Participants With Macular Edema Secondary to Inflammation (MESI) - PEAK

for Macular Edema Secondary to Inflammation

Sites in Cary, Wake Forest +51 more locations

Sponsor: Kodiak Sciences Inc

Sex: All·Age: 18+

Code: NCT06990399·Phase 3·Recruiting·Listed May 2025

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An Observational Study of Etrasimod in Adult Patients With Moderate to Severe Ulcerative Colitis

for Colitis, Ulcerative

Sites in Chapel Hill, Charlotte +25 more locations

Sponsor: Pfizer

Sex: All·Age: 18 - 64

Code: NCT06398626·Recruiting·Listed May 2024

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MOONRAY-01, A Study of LY3962673 in Participants With KRAS G12D-Mutant Solid Tumors

for Pancreatic Ductal Adenocarcinoma

Sites in Durham +24 more locations

Sponsor: Eli Lilly and Company

Sex: All·Age: 18+

Code: NCT06586515·Phase 1·Recruiting·Listed Sep 2024

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A Study to Investigate Efficacy and Safety of Teplizumab Compared With Placebo in Participants 1 to 25 Years of Age With Stage 3 Type 1 Diabetes

for Type 1 Diabetes Mellitus

Sites in Asheville +31 more locations

Sponsor: Sanofi

Sex: All·Age: 1 - 25

Code: NCT07088068·Phase 3·Recruiting·Listed Jul 2025

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Study to Evaluate the Efficacy, Safety, and Tolerability of BMS-986368, for the Treatment of Agitation in Participants With Alzheimer's Disease

for Agitation

Sites in Charlotte, Raleigh +41 more locations

Sponsor: Celgene

Sex: All·Age: 55 - 90

Code: NCT06808984·Phase 2·Recruiting·Listed Feb 2025

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Study With Omecamtiv Mecarbil (CK-1827452) to Treat Chronic Heart Failure With Severely Reduced Ejection Fraction

for Heart Failure

Sites in Durham, Chapel Hill +81 more locations

Sponsor: Cytokinetics

Sex: All·Age: 18 - 85

Code: NCT06736574·Phase 3·Recruiting·Listed Dec 2024

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A Study of AAV2-GDNF in Adults With Moderate Parkinson's Disease (REGENERATE-PD)

for Parkinson Disease

Sites in Durham, Chapel Hill +25 more locations

Sponsor: AskBio Inc

Sex: All·Age: 45 - 75

Code: NCT06285643·Phase 2·Recruiting·Listed Feb 2024

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Study of RAS(ON) Inhibitors in Patients With Gastrointestinal Solid Tumors

for Colorectal Cancer

Sites in Durham +31 more locations

Sponsor: Revolution Medicines, Inc.

Sex: All·Age: 18+

Code: NCT06445062·Phase 1, Phase 2·Recruiting·Listed Jun 2024

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A Study to Assess the Efficacy and Safety of ITI-1284 in the Treatment of Psychosis Associated With Alzheimer's Disease

for Psychosis Associated With Alzheimer's Disease

Sites in Charlotte +15 more locations

Sponsor: Intra-Cellular Therapies, Inc.

Sex: All·Age: 55+

Code: NCT06540833·Phase 2·Recruiting·Listed Aug 2024

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Study of Trastuzumab Deruxtecan With Bevacizumab Versus Bevacizumab Monotherapy for First-line Maintenance in HER2-Expressing Ovarian Cancer (DESTINY-Ovarian01)

for Ovarian Cancer

Drug: Bevacizumab

Sites in Chapel Hill +31 more locations

Sponsor: Daiichi Sankyo

Sex: Female·Age: 18+

Code: NCT06819007·Phase 3·Recruiting·Listed Feb 2025

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A Study to Compare the Efficacy of Nivolumab and Relatlimab Plus Chemotherapy vs Pembrolizumab Plus Chemotherapy for Stage IV/Recurrent Non-squamous Non-small Cell Lung Cancer With PD-L1 Expression ≥ 1%

for Non-small Cell Lung Cancer

Drug: Relatlimab

Sites in Greenville +37 more locations

Sponsor: Bristol-Myers Squibb

Sex: All·Age: 18+

Code: NCT06561386·Phase 3·Recruiting·Listed Aug 2024

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A Phase 2 Study to Evaluate MORF-057 in Adults With Moderately to Severely Active Crohn's Disease

for Inflammatory Bowel Diseases

Sites in Raleigh, Fayetteville +23 more locations

Sponsor: Morphic Therapeutic, Inc. (A Wholly Owned Subsidiary of Eli Lilly and Company)

Sex: All·Age: 18 - 85

Code: NCT06226883·Phase 2·Recruiting·Listed Jan 2024

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An Open-label Study Comparing Lutetium (177Lu) Vipivotide Tetraxetan Versus Observation in PSMA Positive OMPC.

for Oligometastatic Prostate Cancer (OMPC)

Sites in Greenville +39 more locations

Sponsor: Novartis Pharmaceuticals

Sex: Male·Age: 18 - 100

Code: NCT05939414·Phase 3·Recruiting·Listed Jul 2023

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A Study to Assess the Efficacy and Safety of Induction Therapy With Afimkibart (Also Known as RO7790121) in Participants With Moderately to Severely Active Ulcerative Colitis

for Moderately to Severely Active Ulcerative Colitis

Drug: Afimkibart

Sites in Charlotte, High Point +68 more locations

Sponsor: Hoffmann-La Roche

Sex: All·Age: 16 - 80

Code: NCT06588855·Phase 3·Recruiting·Listed Sep 2024

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A Study to Evaluate the Long-Term Safety of Astegolimab in Participants With Chronic Obstructive Pulmonary Disease (COPD)

for Chronic Obstructive Pulmonary Disease

Sites in Winston-Salem, Charlotte +61 more locations

Sponsor: Hoffmann-La Roche

Sex: All·Age: 40 - 90

Code: NCT05878769·Phase 3·Recruiting·Listed May 2023

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A Study to Evaluate the Efficacy and Safety of KarXT + KarX-EC for Cognitive Impairment in Alzheimer's Disease

for Alzheimer's Disease

Drug: KarXT

Sites in Matthews +24 more locations

Sponsor: Bristol-Myers Squibb

Sex: All·Age: 60 - 85

Code: NCT06976216·Phase 3·Recruiting·Listed May 2025

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A U.S. Registry of Eosinophilic Esophagitis Pediatric, Adolescent and Adult Patients Treated With DUPIXENT® As Standard of Care

for Eosinophilic Esophagitis (EoE)

Sites in Chapel Hill, Winston-Salem +27 more locations

Sponsor: Regeneron Pharmaceuticals

Sex: All·Age: 1+

Code: NCT06693531·Recruiting·Listed Nov 2024

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Safety, Efficacy, and Pharmacokinetics of BNT327 in Combination With Chemotherapy and Other Investigational Agents for Lung Cancer

for Non-small Cell Lung Cancer

Sites in Hendersonville +38 more locations

Sponsor: BioNTech SE

Sex: All·Age: 18+

Code: NCT06712316·Phase 2, Phase 3·Recruiting·Listed Dec 2024

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Acoramidis Transthyretin Amyloidosis Prevention Trial in the Young (ACT-EARLY) Study in Asymptomatic Carriers of a Pathogenic TTR Variant

for Amyloidosis

Drug: Acoramidis

Sites in Durham +38 more locations

Sponsor: Eidos Therapeutics, a BridgeBio company

Sex: All·Age: 18 - 75

Code: NCT06563895·Phase 3·Recruiting·Listed Aug 2024

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A Study to Investigate the Efficacy and Safety of Bemdaneprocel in Adults Who Have Parkinson's Disease

for Parkinsons Disease (PD)

Sites in Durham +32 more locations

Sponsor: BlueRock Therapeutics

Sex: All·Age: 45 - 75

Code: NCT06944522·Phase 3·Recruiting·Listed Apr 2025

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A Study to Investigate the Effectiveness of Tirzepatide (LY3298176) Following Initiation of Ixekizumab (LY2439821) in Participants With Moderate-to-Severe Plaque PsO and Obesity or Overweight in Clinical Practice (TOGETHER AMPLIFY-PsO)

for Psoriasis

Drug: Tirzepatide

Sites in Huntersville, Cary +38 more locations

Sponsor: Eli Lilly and Company

Sex: All·Age: 18+

Code: NCT06857942·Phase 4·Recruiting·Listed Mar 2025

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Study of Sotorasib, Panitumumab and FOLFIRI Versus FOLFIRI With or Without Bevacizumab-awwb in Treatment-naïve Participants With Metastatic Colorectal Cancer With KRAS p.G12C Mutation

for Metastatic Colorectal Cancer

Drug: Bevacizumab

Sites in Durham +12 more locations

Sponsor: Amgen

Sex: All·Age: 18+

Code: NCT06252649·Phase 3·Recruiting·Listed Feb 2024

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EASi-KIDNEY™ (The Studies of Heart & Kidney Protection With BI 690517 in Combination With Empagliflozin)

for Kidney Disease, Chronic

Drug: Empagliflozin

Sites in Winston-Salem, Charlotte +40 more locations

Sponsor: Boehringer Ingelheim

Sex: All·Age: 18+

Code: NCT06531824·Phase 3·Recruiting·Listed Aug 2024

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RESET-Myositis: An Open-Label Study to Evaluate the Safety and Efficacy of CABA-201 in Subjects With Active Idiopathic Inflammatory Myopathy or Juvenile Idiopathic Inflammatory Myopathy

for Idiopathic Inflammatory Myopathy

Sites in Durham, Chapel Hill +29 more locations

Sponsor: Cabaletta Bio

Sex: All·Age: 6 - 75

Code: NCT06154252·Phase 2, Phase 3·Recruiting·Listed Dec 2023

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Lp(a) Lowering Study of Pelacarsen (TQJ230) With Background Inclisiran in Participants With Elevated Lp(a) and Established ASCVD

for Atherosclerotic Cardiovascular Disease (ASCVD)

Drug: Inclisiran

Sites in Winston-Salem +32 more locations

Sponsor: Novartis Pharmaceuticals

Sex: All·Age: 18 - 80

Code: NCT06813911·Phase 3·Recruiting·Listed Feb 2025

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A Study to Evaluate Axatilimab and Corticosteroids as Initial Treatment for Chronic Graft-Versus-Host Disease

for Chronic Graft-versus-host-disease

Sites in Winston-Salem +34 more locations

Sponsor: Incyte Corporation

Sex: All·Age: 12+

Code: NCT06585774·Phase 3·Recruiting·Listed Sep 2024

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Safety and Effectiveness of Left Bundle Branch Area Pacing Versus Conventional Cardiac Resynchronization Therapy in Heart Failure

for Heart Failure - NYHA II - IV

Sites in Durham +34 more locations

Sponsor: Boston Scientific Corporation

Sex: All·Age: 18+

Code: NCT07069738·Recruiting·Listed Jul 2025

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Trial to Evaluate Safety And Effectiveness of Mechanical Circulatory Support in Patients With Advancing Heart Failure

for Heart Failure

Sites in Chapel Hill, Charlotte +55 more locations

Sponsor: Abbott Medical Devices

Sex: All·Age: 18+

Code: NCT06526195·Recruiting·Listed Jul 2024

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CNP-103 in Adolescent and Adult Subjects Ages 12-35 With Recently Diagnosed (Within 6 Months) Stage 3 Type 1 Diabetes (T1D)

for Type 1 Diabetes Mellitus

Sites in Durham, Raleigh +30 more locations

Sponsor: COUR Pharmaceutical Development Company, Inc.

Sex: All·Age: 12 - 35

Code: NCT06783309·Phase 1, Phase 2·Recruiting·Listed Jan 2025

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THRIVE- THerapeutic IntravasculaR Ultrasound (TIVUS™) REnal Denervation System Versus Sham for the Adjunctive Treatment of Hypertension

for Hypertension

Sites in Raleigh +32 more locations

Sponsor: SoniVie Inc.

Sex: All·Age: 22 - 75

Code: NCT06559891·Recruiting·Listed Aug 2024

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An Extension Study of Subjects Who Received an Avalyn Inhaled Antifibrotic Agent (SAIL)

for Progressive Pulmonary Fibrosis

Sites in Winston-Salem, Statesville +23 more locations

Sponsor: Avalyn Pharma Inc.

Sex: All·Age: 18+

Code: NCT06951217·Phase 2·Recruiting·Listed Apr 2025

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Patient Retrospective Outcomes (PRO)

for Chronic Pain

Sites in Winston-Salem, New Bern +27 more locations

Sponsor: Boston Scientific Corporation

Sex: All·Age: 18+

Code: NCT01550575·Recruiting·Listed Mar 2012

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DALY II USA/ MB-CART2019.1 for DLBCL

for Refractory Diffuse Large B Cell Lymphoma (DLBCL)

Sites in Durham +27 more locations

Sponsor: Miltenyi Biomedicine GmbH

Sex: All·Age: 18+

Code: NCT04792489·Phase 2·Recruiting·Listed Mar 2021

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The Evaluation of PC14586 in Patients With Advanced Solid Tumors Harboring a TP53 Y220C Mutation (PYNNACLE)

for Advanced Solid Tumor

Sites in Durham +30 more locations

Sponsor: PMV Pharmaceuticals, Inc

Sex: All·Age: 12+

Code: NCT04585750·Phase 1, Phase 2·Recruiting·Listed Oct 2020

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Efficacy and Safety of TYRA-300 in Participants With FGFR3 Altered Low Grade, Intermediate Risk Non-Muscle Invasive Bladder Cancer

for Low-grade NMIBC

Sites in Durham, Raleigh +32 more locations

Sponsor: Tyra Biosciences, Inc

Sex: All·Age: 18+

Code: NCT06995677·Phase 2·Recruiting·Listed May 2025

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A Study to Test the Effects and Safety of Riliprubart in People With Chronic Inflammatory Demyelinating Polyneuropathy (CIDP) for Which the Usual Treatments do Not Work

for Chronic Inflammatory Demyelinating Polyradiculoneuropathy

Drug: riliprubart

Sites in Raleigh +27 more locations

Sponsor: Sanofi

Sex: All·Age: 18+

Code: NCT06290128·Phase 3·Recruiting·Listed Mar 2024

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