Paid Clinical Trials in North Carolina

North Carolina has 2,939 paid clinical trials enrolling now across cities including Durham, Chapel Hill and Winston-Salem. Search by condition, age, or phase to find compensated research studies accepting participants near you.

Research sites in North Carolina include Duke University Medical Center, UNC Health and Wake Forest Baptist, running studies across oncology, cardiology, neurology, and more. Both patients and healthy volunteers may qualify. Most studies offer compensation for time and travel.

Recruiting trial data synced daily from ClinicalTrials.gov. Last sync: June 16, 2026.

Filter results

Filter results

State

City

Phase

Study type

Intervention

Recruitment status

Condition

Sex

Age

Healthy volunteers only

2,939 clinical trials

↓ Download CSV

A Phase II Platform Study to Evaluate Treatment With Cemiplimab Monotherapy or Cemiplimab Plus Fianlimab or Other Novel Combinations in Patients With Colorectal Cancer With Minimal Residual Disease Following Definitive Surgery and Chemotherapy (EMPIRE)

for Colo-rectal Cancer

Drug: Cemiplimab

9 locations incl. Gainesville

Sponsor: NSABP Foundation Inc

Sex: All·Age: 18+

Code: NCT07058012·Phase 2·Recruiting

Apply to this trial

A Research Study Comparing How Well Different Doses of the Medicine NNC0662-0419 Lower Blood Sugar in People With Type 2 Diabetes

for Diabetes Mellitus, Type 2

Drug: NNC0662-0419

23 locations incl. Lancaster

Sponsor: Novo Nordisk A/S

Sex: All·Age: 18 - 75

Code: NCT07415954·Phase 2·Recruiting

Apply to this trial

Inhaled Nitric Oxide in Acute Ischemic Stroke Patients Undergoing Mechanical Thrombectomy

for Cerebrovascular Disorders

2 locations incl. Charlotte

Sponsor: Wake Forest University Health Sciences

Sex: All·Age: 18 - 80

Code: NCT05871606·Phase 1·Recruiting

Apply to this trial

HomeGrown: A Family-based Lifestyle Intervention to Support Healthy Development of Young Children With Down Syndrome

for Down Syndrome

1 location in Chapel Hill

Sponsor: UNC Lineberger Comprehensive Cancer Center

Sex: All·Age: All ages·Accepts healthy volunteers

Code: NCT07296861·Recruiting

Apply to this trial

A Clinical Study Evaluating Licaminlimab for Dry Eye Disease

for Dry Eye Disease (DED)

14 locations incl. Aliso Viejo

Sponsor: Oculis

Sex: All·Age: 18+

Code: NCT07548632·Phase 2, Phase 3·Recruiting

Apply to this trial

A Study to Evaluate Safety, Tolerability, and Efficacy of AB-1009 Gene Therapy (GAA Gene) in Adult Participants With Late Onset Pompe Disease (PROGRESS-GT LOPD)

for Pompe Disease (Late-onset)

9 locations incl. Phoenix

Sponsor: AskBio Inc

Sex: All·Age: 18+

Code: NCT07282847·Phase 1, Phase 2·Recruiting

Apply to this trial

Autus Valve Continued Access Study (CAS)

for Congenital Heart Disease

10 locations incl. Los Angeles

Sponsor: Autus Valve Technologies, Inc.

Sex: All·Age: 18 Months - 16

Code: NCT07466745·Not Yet Recruiting

Evaluation of IV AMBTX-01 (Neridronate) for Treatment of CRPS Type 1 (CRPS-RISE)

for Complex Regional Pain Syndrome Type I

12 locations incl. Phoenix

Sponsor: Ambros Therapeutics, Inc.

Sex: All·Age: 18+

Code: NCT07210515·Phase 3·Recruiting

Apply to this trial

CARED : A Novel Rapid Treatment Paradigm for Depression

for Major Depressive Disorder

1 location in Chapel Hill

Sponsor: University of North Carolina, Chapel Hill

Sex: All·Age: 18 - 70

Code: NCT07507370·Recruiting

Apply to this trial

CommunityRx-Kidney Health

for Chronic Kidney Disease (Stages 1-4)

1 location in Beulaville

Sponsor: University of North Carolina, Chapel Hill

Sex: All·Age: 18+

Code: NCT07237295·Recruiting

Apply to this trial

PROmega Pilot Study of Clinic-based DHA Blood Screening in Early Pregnancy

for Nutrient Deficiency

1 location in Winston-Salem

Sponsor: Wake Forest University Health Sciences

Sex: Female·Age: All ages

Code: NCT07271758·Enrolling By Invitation

A Research Study Investigating How Well the Medicine NNC0487-0111 Helps People With Excess Body Weight and Knee Osteoarthritis Lose Weight and Reduce Pain

for Obesity

Drug: NNC0487-0111

19 locations incl. Phoenix

Sponsor: Novo Nordisk A/S

Sex: All·Age: 18+

Code: NCT07481630·Phase 3·Recruiting

Apply to this trial

Physician Engagement in EMS Transport Refusal Rates

for Refusal of Transport

1 location in Charlotte

Sponsor: Wake Forest University Health Sciences

Sex: All·Age: 18+

Code: NCT07107737·Recruiting

Apply to this trial

Effectiveness and Safety of OviTex® PRS in Breast Reconstruction

for Breast Reconstruction

2 locations incl. Bowling Green

Sponsor: Tela Bio Inc

Sex: Female·Age: 22 - 75

Code: NCT07135596·Recruiting

Apply to this trial

Menopausal HT for Women Living With HIV (HoT)

for HIV Infection

23 locations incl. Birmingham

Sponsor: Advancing Clinical Therapeutics Globally for HIV/AIDS and Other Infections

Sex: Female·Age: 40 - 60

Code: NCT06856174·Phase 4·Recruiting

Apply to this trial

A Study to Evaluate Chemotherapy With or Without INCB161734 in Previously Untreated, KRAS G12D-Mutated Metastatic Pancreatic Ductal Adenocarcinoma

for Solid Tumors

Drug: INCB161734

68 locations incl. Birmingham

Sponsor: Incyte Corporation

Sex: All·Age: 18+

Code: NCT07522073·Phase 3·Recruiting

Apply to this trial

SickleFit Exercise and Nutrition Study

for Sickle Cell Disease

1 location in Durham

Sponsor: Duke University

Sex: All·Age: 35+

Code: NCT07442851·Recruiting

Apply to this trial

A Gaucher Disease Gene Therapy Trial With FLT201

for Gaucher Disease Type 1

3 locations incl. Durham

Sponsor: Spur Therapeutics

Sex: All·Age: 18+

Code: NCT07223944·Phase 3·Recruiting

Apply to this trial

Mind Your Heart Intervention for American Indian Women

for Cardiovascular Health

1 location in Pembroke

Sponsor: University of North Carolina, Chapel Hill

Sex: Female·Age: 18 - 55

Code: NCT07581899·Recruiting

Apply to this trial

Walk On! National Council on Aging Innovation Lab

for Falls Prevention

1 location in Winston-Salem

Sponsor: Wake Forest University Health Sciences

Sex: All·Age: 18+

Code: NCT07368907·Recruiting

Apply to this trial

Spot Compression Ultrasound Compared to Traditional Breast Ultrasound

for Breast Mass

1 location in Durham

Sponsor: Duke University

Sex: Female·Age: 30+

Code: NCT07471672·Not Yet Recruiting

The Impact of Music Intervention on Sleep

for Dementia

1 location in Durham

Sponsor: Duke University

Sex: All·Age: 18 - 100·Accepts healthy volunteers

Code: NCT06088810·Recruiting

Apply to this trial

Confirmatory Clinical Study in Active Ulcerative Colitis

for Colitis, Ulcerative

6 locations incl. Miami

Sponsor: MRM Health NV

Sex: All·Age: 16+

Code: NCT07296315·Phase 2·Recruiting

Apply to this trial

Extensively Hydrolyzed Formula Growth Monitioring Study (GMS)

for Growth

12 locations incl. Birmingham

Sponsor: Mead Johnson Nutrition

Sex: All·Age: 10 Days - 14 Days·Accepts healthy volunteers

Code: NCT07513506·Not Yet Recruiting

A Study of VARIPULSE Pulsed Field Ablation (PFA) Catheter and FARAWAVE PFA Catheter in the Treatment of Participants With Persistent Atrial Fibrillation

for Atrial Fibrillation

11 locations incl. Jonesboro

Sponsor: Biosense Webster, Inc.

Sex: All·Age: 18 - 80

Code: NCT07523750·Recruiting

Apply to this trial

Adapting and Implementing a Nurse Care Management Model to Care for Rural Patients With Chronic Pain

for Chronic Pain

1 location in Winston-Salem

Sponsor: University of Washington

Sex: All·Age: 18+

Code: NCT06407115·Enrolling By Invitation

INitiation and Titration of Guideline Directed Medical TheRApy in HearT Failure Cardiogenic Shock With ImpElla 5.5 for Cardiac Recovery

for Heart Failure

7 locations incl. Tampa

Sponsor: Abiomed Inc.

Sex: All·Age: 18 - 80

Code: NCT06965504·Not Yet Recruiting

Cognitive Rehabilitation for Treatment of Anger in Veterans With TBI and PTSD

for Traumatic Brain Injury (TBI)

1 location in Durham

Sponsor: Duke University

Sex: All·Age: 18+

Code: NCT07227987·Not Yet Recruiting

A U.S. Pilot Human Investigation of RadiofrEquency Vapor Ablation System to Evaluate Safety, TOleRability, and Effectiveness for Proximal Intestinal Mucosal Ablation in Patients With Type 2 Diabetes Mellitus (RESTORE-1 Study)

for Type-2 Diabetes Mellitus

4 locations incl. Scottsdale

Sponsor: Aqua Medical, Inc.

Sex: All·Age: 22 - 65

Code: NCT07355270·Recruiting

Apply to this trial

Culturally Tailored Program for Food-Insecure Adults: SPICE-D

for Type 2 Diabetes Mellitus (T2D)

1 location in Winston-Salem

Sponsor: Wake Forest University Health Sciences

Sex: All·Age: 18+

Code: NCT07361341·Recruiting

Apply to this trial

Bowel Continence Across the Lifespan in People With Spina Bifida

for Spina Bifida

24 locations incl. Birmingham

Sponsor: David Chu

Sex: All·Age: 5+

Code: NCT07390318·Recruiting

Apply to this trial

PKP2-ACM Natural History Study

for Cardiomyopathies

2 locations incl. Boston

Sponsor: Rocket Pharmaceuticals Inc.

Sex: All·Age: 12+

Code: NCT06644742·Recruiting

Apply to this trial

Evaluation of Efficacy and Safety of THRV-1268 in Long QT Syndrome Type 2 (LQTS 2)

for Long QT Syndrome (LQTS) 2

6 locations incl. Scottsdale

Sponsor: Thryv Therapeutics, Inc.

Sex: All·Age: 15+

Code: NCT07277582·Phase 2, Phase 3·Recruiting

Apply to this trial

Phase 3 Trial of VMX-C001 vs Usual Pharmacological Care in Patients Taking a FXa Direct Oral Anticoagulant Who Require Urgent Surgery With or Without Heparin.

for Blood Loss, Surgical

16 locations incl. Chandler

Sponsor: VarmX B.V.

Sex: All·Age: 18+

Code: NCT07288489·Phase 3·Not Yet Recruiting

AI-CARE: Artificial Intelligence for Cardiovascular Analysis and Risk Evaluation

for Aortic Aneurysm

2 locations incl. Chapel Hill

Sponsor: Aiatella Oy

Sex: All·Age: 22+·Accepts healthy volunteers

Code: NCT07438327·Recruiting

Apply to this trial

Prospective Analysis of Arteriovenous Access (AVA) Use for Continuous Renal Replacement Therapy (CRRT)

for Continuous Renal Replacement Therapy (CRRT)

1 location in Greenville

Sponsor: East Carolina University

Sex: All·Age: 18+

Code: NCT07447128·Not Yet Recruiting

Okami Medical ALPHA Registry

for Arterial Bleed

3 locations incl. Aurora

Sponsor: Okami Medical, Inc.

Sex: All·Age: 18+

Code: NCT07525518·Enrolling By Invitation

A Clinical Study of Letermovir (MK-8228) in Children and Adolescents Who Receive a Kidney Transplant (KT) (MK-8228-077)

for Cytomegalovirus Prophylaxis

17 locations incl. Birmingham

Sponsor: Merck Sharp & Dohme LLC

Sex: All·Age: Up to 17

Code: NCT07199465·Phase 1·Recruiting

Apply to this trial

AI Tool to Reduce Clinician Documentation Burden

for Burnout, Healthcare Workers

1 location in Chapel Hill

Sponsor: University of North Carolina, Chapel Hill

Sex: All·Age: All ages·Accepts healthy volunteers

Code: NCT07498582·Enrolling By Invitation

Leveraging Chatbot to Improve PrEP in the Southern United States

for HIV Prevention

4 locations incl. Miami

Sponsor: Yale University

Sex: Male·Age: 18+·Accepts healthy volunteers

Code: NCT05968755·Not Yet Recruiting