Oncology Clinical Trials in Newport Beach, CA

As of July 2026, 60 paid clinical trials are recruiting for Oncology in Newport Beach, California. Oncology trials evaluate immunotherapies, targeted therapies, antibody-drug conjugates, and combination regimens across solid tumors and blood cancers — from early-phase first-in-human studies to phase 3 registration trials. Compensation typically covers time, travel, and study visits, and many studies also include study-related medical care at no cost.

Recruiting trial data synced daily from ClinicalTrials.gov. Last sync: July 17, 2026.

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61 clinical trials for Oncology

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Immunotherapy Biomarkers to Predict First-line PD(L)1-based Immunotherapy Response and Selection of Second-line Treatment in Stage IIIB-IV Non-small Cell Lung Cancer, IMMUNO-BIOMAP Trial

for Lung Non-Small Cell Carcinoma

Sites in Newport Beach, Irvine +11 more locations

Sponsor: City of Hope Medical Center

Sex: All·Age: 18+

Code: NCT07288034·Phase 2·Recruiting·Listed Dec 2025

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Testing Early Treatment for Patients With High-Risk Chronic Lymphocytic Leukemia (CLL) or Small Lymphocytic Leukemia (SLL), EVOLVE CLL/SLL Study

for Chronic Lymphocytic Leukemia

Sites in Newport Beach, Costa Mesa +306 more locations

Sponsor: National Cancer Institute (NCI)

Sex: All·Age: 18+

Code: NCT04269902·Phase 3·Recruiting·Listed Feb 2020

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A Multicenter Prospective Observational Cohort Study Evaluating the Impact of Cancer-Directed Treatment and Medication Use, Including Cannabis Use, in Multiple Myeloma Patients

for Multiple Myeloma

Sites in Newport Beach, Irvine +9 more locations

Sponsor: City of Hope Medical Center

Sex: All·Age: 18+·Accepts healthy volunteers

Code: NCT07225738·Recruiting·Listed Nov 2025

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A Study to Compare Two Surgical Procedures in Individuals With BRCA1 Mutations to Assess Reduced Risk of Ovarian Cancer

for Ovarian Carcinoma

Sites in Newport Beach, Irvine +471 more locations

Sponsor: NRG Oncology

Sex: Female·Age: 35 - 50

Code: NCT04251052·Recruiting·Listed Jan 2020

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I-SPY TRIAL: Neoadjuvant and Personalized Adaptive Novel Agents to Treat Breast Cancer

for Breast Neoplasms

Sites in Newport Beach, Duarte +31 more locations

Sponsor: QuantumLeap Healthcare Collaborative

Sex: All·Age: 18+

Code: NCT01042379·Phase 2·Recruiting·Listed Jan 2010

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Pancreatic Cancer Detection Consortium

for Pancreatic Cancer

Sites in Newport Beach, Monrovia +7 more locations

Sponsor: City of Hope Medical Center

Sex: All·Age: 18+·Accepts healthy volunteers

Code: NCT06388967·Recruiting·Listed Apr 2024

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Pancreatic Cancer Early Detection Consortium

for Pancreas Cancer

Sites in Newport Beach, Orange +41 more locations

Sponsor: Arbor Research Collaborative for Health

Sex: All·Age: 18 - 90·Accepts healthy volunteers

Code: NCT04970056·Recruiting·Listed Jul 2021

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Testing the Safety and Efficacy of the Combination of Two Anti-cancer Drugs, ZEN003694 and Abemaciclib, for Adult and Pediatric Patients (12-17 Years) With Metastatic or Unresectable NUT Carcinoma, Breast Cancer and Other Solid Tumors

for Anatomic Stage III Breast Cancer AJCC v8

Sites in Newport Beach, Los Angeles +5 more locations

Sponsor: National Cancer Institute (NCI)

Sex: All·Age: 12+

Code: NCT05372640·Phase 1·Recruiting·Listed May 2022

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Mobile Health Intervention to Improve Adherence to Oral Anticancer Therapy

for Cancer

Sites in Newport Beach, Irvine +3 more locations

Sponsor: University of California, Irvine

Sex: All·Age: 18+

Code: NCT07073807·Recruiting·Listed Jul 2025

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A Validation Study to Determine Concordance of Liquid Biopsy and Breast Cancer Diagnosis

for Breast Carcinoma

Sites in Newport Beach & Los Angeles

Sponsor: University of Southern California

Sex: Female·Age: 18+

Code: NCT06336928·Recruiting·Listed Mar 2024

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Comparing the Outcome of Immunotherapy-Based Drug Combination Therapy With or Without Surgery to Remove the Kidney in Metastatic Kidney Cancer, the PROBE Trial

for Metastatic Clear Cell Renal Cell Carcinoma

Sites in Newport Beach, Huntington Beach +338 more locations

Sponsor: SWOG Cancer Research Network

Sex: All·Age: 18+

Code: NCT04510597·Phase 3·Recruiting·Listed Aug 2020

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A Novel Multiplex ELISA Assay for Evaluating Patients With Microscopic Hematuria for Bladder Cancer

for Bladder Cancer

Sites in Newport Beach, Long Beach +4 more locations

Sponsor: Cedars-Sinai Medical Center

Sex: All·Age: 18 - 90

Code: NCT03193541·Recruiting·Listed Jun 2017

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Study Adding Drugs to Usual Treatment for Large B-Cell Lymphoma That Returned or Did Not Respond to Treatment

for Grade 3b Follicular Lymphoma

Sites in Newport Beach, Huntington Beach +97 more locations

Sponsor: SWOG Cancer Research Network

Sex: All·Age: 18+

Code: NCT05890352·Phase 2·Recruiting·Listed Jun 2023

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A Trial of Robotic Versus Open Hysterectomy Surgery in Cervix Cancer

for Cervical Cancer

Sites in Newport Beach, Irvine +124 more locations

Sponsor: GOG Foundation

Sex: Female·Age: 18+

Code: NCT04831580·Recruiting·Listed Apr 2021

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Perioperative Mindfulness Proposal

for Breast Cancer

1 location in Newport Beach

Sponsor: Hoag Memorial Hospital Presbyterian

Sex: Female·Age: 18+

Code: NCT04049214·Recruiting·Listed Aug 2019

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A Phase 1 Study of BHV-1530 in Advanced Solid Tumors

for Solid Tumor

Sites in Newport Beach +15 more locations

Sponsor: Biohaven Therapeutics Ltd.

Sex: All·Age: 18+

Code: NCT06874335·Phase 1·Recruiting·Listed Mar 2025

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A Study of NT-175 in Adult Participants With Advanced Malignancies That Are Positive for HLA-A*02:01 and the TP53 R175H Mutation

for Non-small Cell Lung Cancer

Sites in Newport Beach, Duarte +12 more locations

Sponsor: AstraZeneca

Sex: All·Age: 18+

Code: NCT05877599·Phase 1·Recruiting·Listed May 2023

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Phase 1 Study to Investigate TCRTs KRAS Mutation in Unresectable, Advanced, and/or Metastatic Solid Tumors

for Non-small Cell Lung Cancer

Sites in Newport Beach, Duarte +16 more locations

Sponsor: AstraZeneca

Sex: All·Age: 18+

Code: NCT06218914·Phase 1·Recruiting·Listed Jan 2024

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Saruparib (AZD5305) Plus Camizestrant Compared With CDK4/6 Inhibitor Plus Endocrine Therapy or Plus Camizestrant in HR-Positive, HER2-Negative (IHC 0, 1+, 2+/ ISH Non-amplified), BRCA1, BRCA2, or PALB2m Advanced Breast Cancer

for Advanced Breast Cancer

Drug: Camizestrant

Sites in Newport Beach, Fountain Valley +37 more locations

Sponsor: AstraZeneca

Sex: All·Age: 18+

Code: NCT06380751·Phase 3·Recruiting·Listed Apr 2024

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First-in-human Study of DB-1419 for Advanced/Metastatic Solid Tumors

for Solid Tumor, Adult

Sites in Newport Beach, Los Angeles +7 more locations

Sponsor: DualityBio Inc.

Sex: All·Age: 18+

Code: NCT06554795·Phase 1, Phase 2·Recruiting·Listed Aug 2024

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Conditions in Oncology (Newport Beach, CA)

Non-small cell lung cancer (NSCLC)· 14 Breast cancer· 13 Solid tumor· 10 Pancreatic cancer· 9 Metastatic breast cancer· 5 Ovarian cancer· 4 Cancer (any)· 4 Colorectal cancer· 3 Gastric cancer· 3 Prostate cancer· 3 Bladder cancer· 3 Endometrial cancer· 3 Triple-negative breast cancer· 2 Biliary tract cancer· 2 Metastatic prostate cancer· 2 Kidney cancer· 2 Cervical cancer· 2 Multiple myeloma· 2 Head and neck cancer· 2 Neuroendocrine tumors· 2 HER2-positive breast cancer· 1 HER2-negative breast cancer· 1 Lung cancer· 1 Esophageal cancer· 1 Gastroesophageal junction cancer· 1 Fallopian tube cancer· 1 Glioblastoma· 1 Glioma· 1 Brain cancer· 1 Chronic lymphocytic leukemia (CLL)· 1 Myelodysplastic syndromes (MDS)· 1 Myelofibrosis· 1 Non-Hodgkin lymphoma· 1 Diffuse large B-cell lymphoma (DLBCL)· 1 Small lymphocytic lymphoma· 1 Melanoma· 1 Thyroid cancer· 1 Sarcoma· 1 Ewing sarcoma· 1