Clinical Trials at University of Oklahoma Health Sciences Center

As of July 2026, 191 paid clinical trials are recruiting at University of Oklahoma Health Sciences Center, located at 1200 N PHILLIPS AVE, SUITE 12109, OKLAHOMA CITY, OK 73104-4600, phone (405) 271-8685 in Oklahoma City, Oklahoma. Compensation typically covers time, travel, and study visits — most studies also offer study-related medical care at no cost to participants.

Recruiting trial data synced daily from ClinicalTrials.gov. Last sync: July 16, 2026.

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191 clinical trials at University of Oklahoma Health Sciences Center

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Testing the Combination of the Anti-Cancer Drugs Temozolomide and M1774 to Evaluate Their Safety and Effectiveness

for Advanced Malignant Solid Neoplasm

23 locations incl. Irvine

Sponsor: National Cancer Institute (NCI)

Sex: All·Age: 18+

Code: NCT05691491·Phase 1, Phase 2·Recruiting

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Testing the Anti-cancer Drug Erdafitinib for Brain Cancers That Have Returned or Progressed Following Treatment

for Recurrent Glioma

27 locations incl. Aurora

Sponsor: National Cancer Institute (NCI)

Sex: All·Age: 18+

Code: NCT05859334·Phase 2·Recruiting

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Testing the Addition of an Anti-cancer Drug, Selinexor, to the Usual Chemotherapy Treatment (Temozolomide) for Brain Tumors That Have Returned After Previous Treatment

for Recurrent Glioblastoma, IDH-Wildtype

Drug: Selinexor

36 locations incl. Phoenix

Sponsor: National Cancer Institute (NCI)

Sex: All·Age: 18+

Code: NCT05432804·Phase 1, Phase 2·Recruiting

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Testing Atezolizumab With Selinexor in People ≥ 12 Years Old With Alveolar Soft Part Sarcoma, AXIOM Trial

for Advanced Alveolar Soft Part Sarcoma

Drug: Atezolizumab

13 locations incl. Los Angeles

Sponsor: National Cancer Institute (NCI)

Sex: All·Age: 12+

Code: NCT05333458·Phase 2·Recruiting

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Testing the Addition of Abemaciclib to Olaparib for Women With Recurrent Ovarian Cancer

for Recurrent Ovarian High Grade Serous Adenocarcinoma

27 locations incl. Phoenix

Sponsor: National Cancer Institute (NCI)

Sex: Female·Age: 18+

Code: NCT04633239·Phase 1·Recruiting

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Testing the Addition of an Individualized Vaccine to Durvalumab and Tremelimumab and Chemotherapy in Patients With Metastatic Triple Negative Breast Cancer

for Anatomic Stage IV Breast Cancer AJCC v8

Drug: Tremelimumab

30 locations incl. Orange

Sponsor: National Cancer Institute (NCI)

Sex: All·Age: 18+

Code: NCT03606967·Phase 2·Recruiting

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Use of CA125 and Complementary Biomarkers for the Early Detection of Ovarian Cancer in Low Risk Women

for Ovarian Cancer

12 locations incl. Miami

Sponsor: M.D. Anderson Cancer Center

Sex: Female·Age: 50 - 74·Accepts healthy volunteers

Code: NCT00539162·Recruiting

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Groningen International Study on Sentinel Nodes in Vulvar Cancer-III

for Vulvar Cancer

21 locations incl. Orange

Sponsor: University Medical Center Groningen

Sex: Female·Age: 18+

Code: NCT05076942·Phase 2·Recruiting

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Postural Control in Adults

for Older

1 location in Oklahoma City

Sponsor: University of Oklahoma

Sex: All·Age: 65 - 80·Accepts healthy volunteers

Code: NCT07554118·Recruiting

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Cemiplimab or Cemiplimab and Fianlimab After Stereotactic Body Radiotherapy in Clear Cell Renal Cell Carcinoma

for Clear Cell Renal Cell Carcinoma

Drug: Cemiplimab

1 location in Oklahoma City

Sponsor: University of Oklahoma

Sex: All·Age: 18+

Code: NCT07223541·Phase 2·Recruiting

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iAmHealthy Clinical Practice Guideline (CPG)

for Pediatric Obesity

4 locations incl. Kansas City

Sponsor: University of Kansas Medical Center

Sex: All·Age: 6 - 11

Code: NCT06888011·Recruiting

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Clinical Trial of an Anti-cancer Drug, CA-4948 (Emavusertib), in Combination With Chemotherapy Treatment (FOLFOX Plus Bevacizumab) in Metastatic Colorectal Cancer

for Metastatic Colorectal Adenocarcinoma

Drug: Bevacizumab

13 locations incl. Gainesville

Sponsor: National Cancer Institute (NCI)

Sex: All·Age: 18+

Code: NCT06696768·Phase 1·Recruiting

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Antibiotic Prophylaxis to Prevent Obesity-Related Induction Complications in Nulliparae at Term 2.0

for Obesity in Pregnancy

1 location in Oklahoma City

Sponsor: University of Oklahoma

Sex: Female·Age: 15 - 45

Code: NCT06488781·Phase 2·Recruiting

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Efficacy of a Smartphone-Based JITAI to Reduce Drinking Among Adults Experiencing Homelessness

for Alcohol Misuse

1 location in Oklahoma City

Sponsor: University of Oklahoma

Sex: All·Age: 18+·Accepts healthy volunteers

Code: NCT06821295·Phase 2, Phase 3·Recruiting

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Testing the Combination of Anti-cancer Drugs Mosunetuzumab, Polatuzumab Vedotin, and Lenalidomide for the Treatment of Relapsed/Refractory Diffuse Large B-Cell Lymphoma

for Diffuse Large B-Cell Lymphoma, Not Otherwise Specified

Drug: Polatuzumab Vedotin

8 locations incl. Duarte

Sponsor: National Cancer Institute (NCI)

Sex: All·Age: 18+

Code: NCT06015880·Phase 1·Recruiting

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Testing Different Amounts of the Combination of Drugs M1774 and ZEN-3694 for the Treatment of Recurrent Ovarian and Endometrial Cancer

for Recurrent Endometrial Carcinoma

14 locations incl. Augusta

Sponsor: National Cancer Institute (NCI)

Sex: Female·Age: 18+

Code: NCT05950464·Phase 1·Recruiting

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Comparing the Effectiveness of the Immunotherapy Agents Rituximab or Mosunetuzumab in Patients With Nodular Lymphocyte-Predominant Hodgkin Lymphoma, NORM Trial

for Nodular Lymphocyte Predominant B-Cell Lymphoma

Drug: Mosunetuzumab

35 locations incl. Duarte

Sponsor: National Cancer Institute (NCI)

Sex: All·Age: 18+

Code: NCT05886036·Phase 2·Recruiting

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Testing A New Anti-cancer Drug Combination, Entinostat and ZEN003694, for Advanced and Refractory Solid Tumors

for Advanced Malignant Solid Neoplasm

3 locations incl. New Haven

Sponsor: National Cancer Institute (NCI)

Sex: All·Age: 18+

Code: NCT05053971·Phase 1, Phase 2·Recruiting

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Measuring the Effects of Talazoparib in Patients With Advanced Cancer and DNA Repair Variations

for Anatomic Stage III Breast Cancer AJCC v8

4 locations incl. Gainesville

Sponsor: National Cancer Institute (NCI)

Sex: All·Age: 18+

Code: NCT04550494·Phase 2·Recruiting

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Pilot Imaging Study of Leukemia

for Acute Lymphocytic Leukemia

3 locations incl. Washington D.C.

Sponsor: University of Oklahoma

Sex: All·Age: 4 - 80

Code: NCT03633955·Phase 1·Recruiting

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The Effect of NAD Supplementation on Brain Vascular Health in Aging

for Aging

1 location in Oklahoma City

Sponsor: University of Oklahoma

Sex: All·Age: 60 - 85·Accepts healthy volunteers

Code: NCT05483465·Phase 4·Recruiting

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Dapagliflozin in Patients With Atrial Fibrillation (DAPA-AF)

for Diabetes Mellitus

Drug: Dapagliflozin

1 location in Oklahoma City

Sponsor: University of Oklahoma

Sex: All·Age: 18 - 85

Code: NCT05174052·Phase 3·Recruiting

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Ketamine for Post-operative Analgesia in Hemorrhoidectomy

for Hemorrhoids

1 location in Oklahoma City

Sponsor: University of Oklahoma

Sex: All·Age: 18 - 100

Code: NCT04248205·Phase 4·Recruiting

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Neuromodulation to Regulate Inflammation and Autonomic Imbalance in Sepsis

for Septic Shock

1 location in Oklahoma City

Sponsor: University of Oklahoma

Sex: All·Age: 18+

Code: NCT03992378·Recruiting

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The TELENEO Trial: A Multicenter Trial of Telemedicine for Advanced Neonatal Resuscitations in Community Hospitals

for Death

21 locations incl. Anchorage

Sponsor: Mayo Clinic

Sex: All·Age: 0 Days+

Code: NCT06087224·Recruiting

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Meloxicam in Mohs Micrographic Surgery

for Postoperative Pain, Acute

1 location in Oklahoma City

Sponsor: University of Oklahoma

Sex: All·Age: 18 - 110

Code: NCT07200544·Phase 4·Recruiting

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International Penile Advanced Cancer Trial (International Rare Cancers Initiative Study)

for Squamous Cell Carcinoma of the Penis, Usual Type

11 locations incl. Los Angeles

Sponsor: Institute of Cancer Research, United Kingdom

Sex: Male·Age: 18+

Code: NCT02305654·Phase 3·Recruiting

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Neuromodulation of Inflammation and Endothelial Function

for Systolic Heart Failure

1 location in Oklahoma City

Sponsor: University of Oklahoma

Sex: All·Age: 18 - 85

Code: NCT05230732·Recruiting

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Substance Use Treatment and Access to Resources (STARS) Project

for Substance Use Disorders

1 location in Oklahoma City

Sponsor: University of Oklahoma

Sex: All·Age: Up to 55

Code: NCT04459000·Recruiting

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Azacitidine or Decitabine With Venetoclax for Acute Myeloid Leukemia With Prior Hypomethylating Agent Failure

for Acute Myeloid Leukemia

Drug: Venetoclax

4 locations incl. Clovis

Sponsor: Brian Jonas

Sex: All·Age: 18+

Code: NCT04905810·Phase 2·Recruiting

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Enhancing Smoking Cessation for African American People Everywhere

for ESCAPE Intervention+NRT

1 location in Oklahoma City

Sponsor: University of Houston

Sex: All·Age: 18+

Code: NCT07024992·Phase 2·Recruiting

Apply to this trial