Paid Clinical Trials in Pennsylvania

Pennsylvania has 3,479 paid clinical trials enrolling now across cities including Philadelphia, Pittsburgh and Hershey. Search by condition, age, or phase to find compensated research studies accepting participants near you.

Research sites in Pennsylvania include Penn Medicine, Children's Hospital of Philadelphia and UPMC, running studies across oncology, cardiology, neurology, and more. Both patients and healthy volunteers may qualify. Most studies offer compensation for time and travel.

Recruiting trial data synced daily from ClinicalTrials.gov. Last sync: September 4, 2026.

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3,012 clinical trials

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A Study to Test Whether Nerandomilast Can Help Slow Down Changes in the Lung in People With a Family History of Pulmonary Fibrosis

for Familial Pulmonary Fibrosis

Drug: Nerandomilast

Sites in Philadelphia +12 more locations

Sponsor: Boehringer Ingelheim

Sex: All·Age: 40+

Code: NCT07201922·Phase 3·Recruiting·Listed Oct 2025

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A Study of mRNA-2808 in Participants With Relapsed or Refractory Multiple Myeloma

for Relapsed or Refractory Multiple Myeloma

Sites in Philadelphia +9 more locations

Sponsor: ModernaTX, Inc.

Sex: All·Age: 18+

Code: NCT07116616·Phase 1, Phase 2·Recruiting·Listed Aug 2025

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A Study to Assess Adverse Events and Change in Disease Activity in Adult Participants Receiving Intravenously Infused Telisotuzumab Adizutecan Alone or With Standard of Care in Participants With Post Adjuvant Circulating Tumor DNA Positive Colorectal Cancer and No Radiographic Evidence of Disease

for Colorectal Cancer

Sites in Philadelphia +21 more locations

Sponsor: AbbVie

Sex: All·Age: 18+

Code: NCT07023289·Phase 2·Recruiting·Listed Jun 2025

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A Study of Tulmimetostat DZR123 (CPI-0209) in Patients With Advanced Solid Tumors and Lymphomas

for Advanced Solid Tumor

Drug: Tulmimetostat

Sites in Philadelphia +6 more locations

Sponsor: Novartis Pharmaceuticals

Sex: All·Age: 18+

Code: NCT04104776·Phase 1, Phase 2·Recruiting·Listed Sep 2019

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Study of an Intrathecal Port and Catheter System for Subjects With Spinal Muscular Atrophy

for Spinal Muscular Atrophy

Sites in Philadelphia, Hershey +13 more locations

Sponsor: Alcyone Therapeutics, Inc

Sex: All·Age: 3+

Code: NCT05866419·Recruiting·Listed May 2023

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A Study of Mavorixafor in Participants With Congenital and Acquired Primary Autoimmune and Idiopathic Chronic Neutropenic Disorders Who Are Experiencing Recurrent and/or Serious Infections

for Neutropenia

Sites in Philadelphia +20 more locations

Sponsor: X4 Pharmaceuticals

Sex: All·Age: 12+

Code: NCT06056297·Phase 3·Recruiting·Listed Sep 2023

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A Study of ROC-101 in Patients With Pulmonary Arterial Hypertension (PAH) and Pulmonary Hypertension Associated With Interstitial Lung Disease (ILD-PH) (ROCSTAR STUDY)

for Pulmonary Arterial Hypertension (PAH)

Sites in Philadelphia +10 more locations

Sponsor: AllRock Bio, Inc.

Sex: All·Age: 18 - 80

Code: NCT07175038·Phase 2·Recruiting·Listed Sep 2025

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A Study to Evaluate Axatilimab Versus Best Available Therapy in Pediatric Participants With Chronic Graft-Versus-Host Disease After at Least 2 Prior Lines of Systemic Therapy (AGAVE-256)

for Chronic Graft-versus-host-disease

Sites in Pittsburgh +10 more locations

Sponsor: Incyte Corporation

Sex: All·Age: 2 - 17

Code: NCT07124078·Phase 2·Recruiting·Listed Aug 2025

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GORE® Ascending Stent Graft in the Treatment of De Novo Type A Aortic Dissections

for Aortic Dissection

Sites in Philadelphia, Pittsburgh +20 more locations

Sponsor: W.L.Gore & Associates

Sex: All·Age: 18+

Code: NCT06827990·Recruiting·Listed Feb 2025

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SAFety and Efficacy of Human Anti-thymocyte ImmunoGlobUlin SAB-142 ARresting Progression of Type 1 Diabetes

for Type 1 Diabetes

Sites in Philadelphia, Pittsburgh +20 more locations

Sponsor: SAb Biotherapeutics, Inc.

Sex: All·Age: 5 - 40

Code: NCT07187531·Phase 2·Recruiting·Listed Sep 2025

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A Phase 2 Study of WU-CART-007, an Anti-CD7 Allogeneic CAR-T Cell Therapy in T-Cell Acute Lymphoblastic Leukemia and Lymphoblastic Lymphoma (T-RRex)

for T-cell Acute Lymphoblastic Leukemia

Sites in Philadelphia +15 more locations

Sponsor: Allotera Therapeutics

Sex: All·Age: 6 Months+

Code: NCT06514794·Phase 2·Recruiting·Listed Jul 2024

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A Study of the Safety and Tolerability of ASP7317 in Senior Adults Who Are Losing Their Clear, Sharp Central Vision Due to Geographic Atrophy Secondary to Dry Age-related Macular Degeneration

for Age-Related Macular Degeneration

Sites in Philadelphia +12 more locations

Sponsor: Astellas Institute for Regenerative Medicine

Sex: All·Age: 50+

Code: NCT03178149·Phase 1·Recruiting·Listed Jun 2017

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Pembrolizumab With or Without Maintenance Sacituzumab Tirumotecan (Sac-TMT; MK-2870) in Metastatic Squamous Non-small Cell Lung Cancer (NSCLC) [MK-2870-023]

for Non-small Cell Lung Cancer

Sites in Philadelphia, Bethlehem +14 more locations

Sponsor: Merck Sharp & Dohme LLC

Sex: All·Age: 18+

Code: NCT06422143·Phase 3·Recruiting·Listed May 2024

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A Study Evaluating the Efficacy and Safety of Multiple Treatment Combinations in Participants With Breast Cancer

for Inoperable, Locally Advanced or Metastatic, ER-positive Breast Cancer

Sites in Philadelphia +8 more locations

Sponsor: Hoffmann-La Roche

Sex: Female·Age: 18+

Code: NCT04802759·Phase 1, Phase 2·Recruiting·Listed Mar 2021

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A Study to Test Whether Spesolimab Helps People With a Skin Condition Called Pyoderma Gangrenosum

for Pyoderma Gangrenosum

Sites in Philadelphia +25 more locations

Sponsor: LEO Pharma

Sex: All·Age: 18+

Code: NCT06624670·Phase 3·Recruiting·Listed Oct 2024

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A Study of JNJ-90301900 in Combination With Chemoradiation Followed by Consolidation Immunotherapy for Non-Small Cell Lung Cancer (NSCLC)

for Carcinoma, Non-Small-Cell Lung

Sites in Philadelphia +17 more locations

Sponsor: Johnson & Johnson Enterprise Innovation Inc.

Sex: All·Age: 18+

Code: NCT06667908·Phase 2·Recruiting·Listed Oct 2024

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Treatment ResistAnt Depression Subcallosal CingulatE Network DBS (TRANSCEND)

for Treatment Resistant Depression

Sites in Philadelphia +24 more locations

Sponsor: Abbott Medical Devices

Sex: All·Age: 22 - 70

Code: NCT06423430·Recruiting·Listed May 2024

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A Study of Tacabrutideg (BGB-16673) Compared to Investigator's Choice in Participants With Chronic Lymphocytic Leukemia or Small Lymphocytic Lymphoma Previously Exposed to Both Bruton Tyrosine Kinase (BTK) and B-cell Leukemia/Lymphoma 2 Protein (BCL2) Inhibitors

for CLL

Sites in Pittsburgh, York +24 more locations

Sponsor: BeOne Medicines

Sex: All·Age: 18+

Code: NCT06846671·Phase 3·Recruiting·Listed Feb 2025

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Using 18F-FAPI PET to Detect Metastatic Disease in Patients That Have Gastric or Esophageal Cancer.

for Esophageal Cancer

Sites in Philadelphia +14 more locations

Sponsor: SOFIE

Sex: All·Age: 18+

Code: NCT07217704·Phase 3·Recruiting·Listed Oct 2025

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Using 18F-FAPI PET to Detect Metastatic Disease in Patients That Have Pancreatic Ductal Adenocarcinoma (PDAC)

for Pancreatic Ductal Adenocarcinoma (PDAC)

Sites in Philadelphia +14 more locations

Sponsor: SOFIE

Sex: All·Age: 18+

Code: NCT07217717·Phase 3·Recruiting·Listed Oct 2025

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The ArtixASCEND Study

for Acute Lower Limb Arterial Occlusion

Sites in Pittsburgh +19 more locations

Sponsor: Inari Medical

Sex: All·Age: 18+

Code: NCT07135895·Recruiting·Listed Aug 2025

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A Study to Investigate Efficacy and Safety of Pegtibatinase Compared With Placebo in Participants ≥12 to ≤65 Years of Age With Classical Homocystinuria (HCU) Due to Cystathionine Beta Synthase Deficiency Receiving Standard of Care Treatment

for Homocystinuria

Sites in Philadelphia, Pittsburgh +11 more locations

Sponsor: Travere Therapeutics, Inc.

Sex: All·Age: 12 - 65

Code: NCT06247085·Phase 3·Recruiting·Listed Feb 2024

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Diagnosing Epilepsy To EffeCT Change

for Epilepsy

Sites in Philadelphia +18 more locations

Sponsor: Epiminder America, Inc.

Sex: All·Age: 18 - 75

Code: NCT07110337·Recruiting·Listed Aug 2025

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Inobrodib, Pomalidomide and Dexamethasone in Relapsed or Refractory Multiple Myeloma

for Multiple Myeloma Refractory

Sites in Philadelphia +19 more locations

Sponsor: CellCentric Ltd.

Sex: All·Age: 18+

Code: NCT07096778·Phase 2·Recruiting·Listed Jul 2025

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A Maintenance Study to Investigate the Efficacy and Safety of Duvakitug in Participants With Moderately to Severely Active Crohn's Disease

for Crohn's Disease

Drug: Duvakitug

Sites in Philadelphia +21 more locations

Sponsor: Sanofi

Sex: All·Age: 16 - 80

Code: NCT07184944·Phase 3·Recruiting·Listed Sep 2025

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AMG 410 Alone and in Combination With Other Agents in Participants With KRAS Altered Advanced or Metastatic Solid Tumors

for KRAS Altered Advanced or Metastatic Solid Tumors

Sites in Philadelphia +9 more locations

Sponsor: Amgen

Sex: All·Age: 18+

Code: NCT07094113·Phase 1·Recruiting·Listed Jul 2025

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A Study to Optimize Subretinal Surgical Delivery and to Evaluate Safety and Activity of Opregen in Participants With Geographic Atrophy Secondary to Age-Related Macular Degeneration (GAlette); Adaptive Optics (AO) Retinal Imaging Substudy in Association With Study GR44251

for Geographic Atrophy

Sites in Philadelphia +14 more locations

Sponsor: Genentech, Inc.

Sex: All·Age: 50+

Code: NCT05626114·Phase 2·Recruiting·Listed Nov 2022

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A Study to Assess the Efficacy and Safety of Empasiprubart in Adults With CIDP

for Chronic Inflammatory Demyelinating Polyneuropathy

Sites in Philadelphia +9 more locations

Sponsor: argenx

Sex: All·Age: 18+

Code: NCT07091630·Phase 3·Recruiting·Listed Jul 2025

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Efficacy and Safety of 4F-PCC (4-Factor Prothrombin Complex Concentrate) in Adult Patients Undergoing Complex Cardiovascular Surgery With Cardiopulmonary Bypass (CPB)

for Complex Cardiovascular Surgery With Cardiopulmonary Bypass

Sites in Philadelphia +15 more locations

Sponsor: CSL Behring

Sex: All·Age: 18+

Code: NCT07094087·Phase 3·Recruiting·Listed Jul 2025

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A Study of Zasocitinib in Adults With Psoriatic Arthritis Who Have or Have Not Been Treated With Biologic Medicines

for Psoriatic Arthritis

Drug: Zasocitinib

Sites in Duncansville +20 more locations

Sponsor: Takeda

Sex: All·Age: 18+

Code: NCT06671496·Phase 3·Recruiting·Listed Nov 2024

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RevCore for In Stent Thrombosis

for In-stent Thrombosis

Sites in Philadelphia, Pittsburgh +14 more locations

Sponsor: Inari Medical

Sex: All·Age: 18+

Code: NCT06394739·Recruiting·Listed May 2024

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REGN7508 Versus Apixaban and Enoxaparin for Thromboprophylaxis After Total Knee Arthroplasty in Adults

for Venous Thromboembolism (VTE)

Sites in Plymouth Meeting +19 more locations

Sponsor: Regeneron Pharmaceuticals

Sex: All·Age: 18+

Code: NCT07015905·Phase 3·Recruiting·Listed Jun 2025

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A Study to Investigate the Efficacy, Safety, and Pharmacokinetics of Oral Rilzabrutinib Compared With Placebo in Participants 18 Years of Age and Older With Warm Autoimmune Hemolytic Anemia

for Autoimmune Haemolytic Anaemia

Sites in Philadelphia +22 more locations

Sponsor: Sanofi

Sex: All·Age: 18+

Code: NCT07086976·Phase 3·Recruiting·Listed Jul 2025

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A Study of Patritumab Deruxtecan in Pediatric Participants With Relapsed or Refractory Solid Tumors (MK-9999-01C/LIGHTBEAM-U01)

for Malignant Neoplasm

Sites in Philadelphia +15 more locations

Sponsor: Merck Sharp & Dohme LLC

Sex: All·Age: 1 Month - 17

Code: NCT06941272·Phase 1, Phase 2·Recruiting·Listed Apr 2025

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A Study to Evaluate INCB161734 in Participants With Advanced or Metastatic Solid Tumors With KRAS G12D Mutation

for Solid Tumors

Drug: INCB161734

Sites in Philadelphia +12 more locations

Sponsor: Incyte Corporation

Sex: All·Age: 18+

Code: NCT06179160·Phase 1·Recruiting·Listed Dec 2023

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Evaluate the Clinical Performance of the Flow Cytometry - FlowPath Lung Test as a Sensitive and Specific Non-invasive Diagnostic of Sputum Samples to Identify/Detect the Presence of Lung Cancer in High-risk Individuals Who Have Existing Lung Nodules, 6 to <30 mm in Diameter, Determined by LDCT.

for Lung Cancer (Diagnosis)

Sites in DuBois +10 more locations

Sponsor: bioAffinity Technologies Inc.

Sex: All·Age: 50 - 80

Code: NCT07168993·Recruiting·Listed Sep 2025

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REVEAL: A Phase 3 Study of Obudanersen (ION582) in Angelman Syndrome

for Angelman Syndrome

Sites in Philadelphia +17 more locations

Sponsor: Ionis Pharmaceuticals, Inc.

Sex: All·Age: 2 - 50

Code: NCT06914609·Phase 3·Recruiting·Listed Apr 2025

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A Study to Evaluate the Safety and Efficacy of Two Dose Levels of ONO-4578 With Opdivo®, in Combination With mFOLFOX6 and Bevacizumab Versus Standard of Care in Participants With Non-MSI-H/dMMR, PD-L1 Positive Advanced Colorectal Cancer

for Colorectal Cancer

Drug: Bevacizumab

Sites in Philadelphia +10 more locations

Sponsor: Ono Pharmaceutical Co., Ltd.

Sex: All·Age: 18+

Code: NCT06948448·Phase 2·Recruiting·Listed Apr 2025

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The Use of p48/64 MW HPC Flow Modulation Device in the Treatment of Wide-necked Intracranial Aneurysms

for Hemorrhagic Stroke

Sites in Philadelphia +21 more locations

Sponsor: phenox Inc.

Sex: All·Age: 18+

Code: NCT07143019·Recruiting·Listed Aug 2025

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Phase 1/2 Study of PYX-201 in Combination With Pembrolizumab in Advanced Solid Tumors

for Advanced Solid Tumors

Sites in Philadelphia, Pittsburgh +11 more locations

Sponsor: Pyxis Oncology, Inc

Sex: All·Age: 18+

Code: NCT06795412·Phase 1, Phase 2·Recruiting·Listed Jan 2025

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