Paid Clinical Trials in Pennsylvania

Pennsylvania has 3,479 paid clinical trials enrolling now across cities including Philadelphia, Pittsburgh and Hershey. Search by condition, age, or phase to find compensated research studies accepting participants near you.

Research sites in Pennsylvania include Penn Medicine, Children's Hospital of Philadelphia and UPMC, running studies across oncology, cardiology, neurology, and more. Both patients and healthy volunteers may qualify. Most studies offer compensation for time and travel.

Recruiting trial data synced daily from ClinicalTrials.gov. Last sync: September 4, 2026.

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3,012 clinical trials

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A Study of the Efficacy and Safety of Danicamtiv in Participants With Symptomatic Genetic and Familial Dilated Cardiomyopathy

for Symptomatic Genetic Dilated Cardiomyopathy

Sites in Philadelphia +27 more locations

Sponsor: Kardigan, Inc.

Sex: All·Age: 18+

Code: NCT07210723·Phase 2, Phase 3·Recruiting·Listed Oct 2025

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A Study of TAK-188 in Adults With Advanced or Spreading Solid Tumors

for Advanced or Metastatic Solid Tumors

Sites in Philadelphia +14 more locations

Sponsor: Takeda

Sex: All·Age: 18+

Code: NCT07205718·Phase 1, Phase 2·Recruiting·Listed Oct 2025

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Study to Evaluate the Maximal Use of Ruxolitinib Cream in Adult and Adolescent Participants With Hidradenitis Suppurativa

for Hidradenitis Suppurativa

Drug: Ruxolitinib

Sites in Philadelphia +18 more locations

Sponsor: Incyte Corporation

Sex: All·Age: 12 - 75

Code: NCT07049575·Phase 1·Recruiting·Listed Jul 2025

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IGNITE: Study of Tirabrutinib vs Rituximab/Temozolomide for Relapsed/Refractory Primary Central Nervous System Lymphoma (PCNSL)

for Relapsed/Refractory Primary Central Nervous System Lymphoma

Drug: Rituximab

Sites in Pittsburgh, Hershey +22 more locations

Sponsor: Ono Pharmaceutical Co., Ltd.

Sex: All·Age: 18+

Code: NCT07104032·Phase 3·Recruiting·Listed Aug 2025

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A Study to Assess the Efficacy and Safety of RO7790121 in Participants With Moderate to Severe Rheumatoid Arthritis Who Have Not Responded to or Who Cannot Tolerate Tumor Necrosis Factor (TNF) and/or Janus Kinase (JAK Inhibitors)

for Rheumatoid Arthritis

Drug: RO7790121

Sites in Duncansville +15 more locations

Sponsor: Hoffmann-La Roche

Sex: All·Age: 18+

Code: NCT07137598·Phase 2·Recruiting·Listed Aug 2025

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FebriDx® Pediatric Validation Study

for Acute Respiratory Infections (ARIs)

Sites in Pittsburgh +9 more locations

Sponsor: Lumos Diagnostics

Sex: All·Age: 2 - 11

Code: NCT07211997·Recruiting·Listed Oct 2025

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GORE® TAG® Thoracic Branch Endoprosthesis Zone 0/1 Post-Approval Study

for Aortic Arch Dissection

Sites in Philadelphia +15 more locations

Sponsor: W.L.Gore & Associates

Sex: All·Age: 18+

Code: NCT07166133·Recruiting·Listed Sep 2025

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Screening Study for KIT D816V Mutated Mast Cell Disease in Select Populations

for Clonal Mast Cell Disease

Sites in Pittsburgh +21 more locations

Sponsor: Blueprint Medicines Corporation

Sex: All·Age: 18+

Code: NCT07143669·Recruiting·Listed Aug 2025

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A Clinical Study to Test if an Investigational Treatment Called BNT326 is Safe and Potentially Beneficial When Used Alone or in Combination With Other Investigational Treatments Such as BNT327, for People With Advanced Malignant Tumors

for Advanced Solid Tumor

Sites in Pittsburgh +18 more locations

Sponsor: BioNTech SE

Sex: All·Age: 18+

Code: NCT07070232·Phase 1, Phase 2·Recruiting·Listed Jul 2025

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Beamion PANTUMOR-1: A Study to Test Whether Zongertinib Helps People With Advanced Cancers With HER2 Alterations

for Solid Tumours

Drug: Zongertinib

Sites in Wynnewood +17 more locations

Sponsor: Boehringer Ingelheim

Sex: All·Age: 18+

Code: NCT06581432·Phase 2·Recruiting·Listed Sep 2024

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A Study With NKT5097 for Adults With Advanced/Metastatic Solid Tumors

for HR+ Breast Cancer

Sites in Pittsburgh +17 more locations

Sponsor: NiKang Therapeutics, Inc.

Sex: All·Age: 18+

Code: NCT07029399·Phase 1·Recruiting·Listed Jun 2025

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A Study of LY4257496 in Participants With Cancer (OMNIRAY)

for Breast Neoplasms

Sites in Pittsburgh +14 more locations

Sponsor: Eli Lilly and Company

Sex: All·Age: 18+

Code: NCT07114601·Phase 1·Recruiting·Listed Aug 2025

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Long-term Characterization of GORE® TAG® Conformable Thoracic Stent Graft With ACTIVE CONTROL System Performance

for Vascular Disease

Sites in Philadelphia +23 more locations

Sponsor: W.L.Gore & Associates

Sex: All·Age: 18+

Code: NCT06658730·Recruiting·Listed Oct 2024

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A Study of IDE849 in Patients With DLL3 Expressing Tumors Including Small Cell Lung Cancer

for Small-cell Lung Cancer

Sites in Philadelphia +12 more locations

Sponsor: IDEAYA Biosciences

Sex: All·Age: 18+

Code: NCT07174583·Phase 1, Phase 2·Recruiting·Listed Sep 2025

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A Study of LY4152199 in Participants With Previously Treated B-cell Malignancies (BAF_FRontier-1 )

for Lymphoma, Non-Hodgkin

Sites in Philadelphia +22 more locations

Sponsor: Eli Lilly and Company

Sex: All·Age: 18+

Code: NCT07101328·Phase 1·Recruiting·Listed Aug 2025

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Neladalkib (NVL-655) for TKI-naive Patients With Advanced ALK-Positive NSCLC

for Non-small Cell Lung Cancer

Sites in Sellersville +21 more locations

Sponsor: Nuvalent Inc.

Sex: All·Age: 18+

Code: NCT06765109·Phase 3·Recruiting·Listed Jan 2025

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Phase 4 Study: Long-term Safety and Efficacy of NT-501 in MacTel Type 2, Including Sham Procedure Participants

for Macular Telangiectasia Type 2 (MacTel)

Sites in Philadelphia +22 more locations

Sponsor: Neurotech Pharmaceuticals

Sex: All·Age: 18+

Code: NCT06971939·Phase 4·Recruiting·Listed May 2025

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A Clinical Study of Letermovir (MK-8228) in Children and Adolescents Who Receive a Kidney Transplant (KT) (MK-8228-077)

for Cytomegalovirus Prophylaxis

Sites in Philadelphia +17 more locations

Sponsor: Merck Sharp & Dohme LLC

Sex: All·Age: Up to 17

Code: NCT07199465·Phase 1·Recruiting·Listed Sep 2025

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Study of TDXd, Chemotherapy, Pembrolizumab, and Trastuzumab in First-Line Metastatic HER2-Positive Gastric or Gastroesophageal Junction Cancer

for Gastric Cancer

Sites in Hershey +14 more locations

Sponsor: Daiichi Sankyo

Sex: All·Age: 18+

Code: NCT06731478·Phase 3·Recruiting·Listed Dec 2024

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Evaluation of PLG0206 in Prevention of Recurrent Infection in Patients Undergoing Debridement, Antibiotics, and Implant Retention (DAIR) for Treatment of a Periprosthetic Joint Infection (PJI) Following Knee Arthroplasty

for Prosthetic-joint Infection

Sites in Pittsburgh +14 more locations

Sponsor: Peptilogics

Sex: All·Age: 18 - 80

Code: NCT07214311·Phase 2, Phase 3·Recruiting·Listed Oct 2025

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A Study Evaluating Sotorasib Platinum Doublet Combination Versus Pembrolizumab Platinum Doublet Combination as a Front-Line Therapy in Participants With Stage IV or Advanced Stage IIIB/C Nonsquamous Non-Small Cell Lung Cancers (CodeBreaK 202)

for Non-Small Cell Lung Cancer (NSCLC)

Drug: Sotorasib

Sites in Media +20 more locations

Sponsor: Amgen

Sex: All·Age: 18 - 100

Code: NCT05920356·Phase 3·Recruiting·Listed Jun 2023

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A Platform Trial for Pediatric Participants With Obesity or Overweight (LY900040)

for Obesity

Sites in Pittsburgh +50 more locations

Sponsor: Eli Lilly and Company

Sex: All·Age: 6 - 17

Code: NCT06672549·Phase 3·Recruiting·Listed Nov 2024

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Gene Therapy for HER-Positive Cancer (SENTRY-HER2)

for HER2 Expressing Solid Tumors

Sites in Philadelphia +10 more locations

Sponsor: Vironexis Biotherapeutics Inc.

Sex: All·Age: 18+

Code: NCT07192432·Phase 1, Phase 2·Recruiting·Listed Sep 2025

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A Study of Dupilumab in Small Children With an Allergic Condition of the Esophagus (Food Pipe): Eosinophilic Esophagitis

for Eosinophilic Esophagitis (EoE)

Drug: Dupilumab

Sites in Philadelphia +12 more locations

Sponsor: Regeneron Pharmaceuticals

Sex: All·Age: 6 Months - 6

Code: NCT07112378·Phase 3·Recruiting·Listed Aug 2025

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Clinical Study to Evaluate the Safety and Effectiveness of Arcevo LSA

for Aortic Arch Aneurysm

Sites in Philadelphia, Pittsburgh +19 more locations

Sponsor: Artivion Inc.

Sex: All·Age: 18 - 80

Code: NCT07089576·Recruiting·Listed Jul 2025

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An Efficacy and Safety Study of Clemizole HCl in Patients With Lennox-Gastaut Syndrome

for Lennox Gastaut Syndrome

Sites in Philadelphia +15 more locations

Sponsor: Epygenix

Sex: All·Age: 2 - 55

Code: NCT05066217·Phase 3·Recruiting·Listed Oct 2021

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4D-150 in Patients With Neovascular (Wet) Age-Related Macular Degeneration

for Neovascular (Wet) Age-Related Macular Degeneration

Sites in Bethlehem +19 more locations

Sponsor: 4D Molecular Therapeutics

Sex: All·Age: 50+

Code: NCT05197270·Phase 1, Phase 2·Recruiting·Listed Jan 2022

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A Phase 2 Study of Mutant-selective PI3Kα Inhibitor, RLY-2608, in Adults and Children With PIK3CA Related Overgrowth Spectrum and Malformations Driven by PIK3CA Mutation (The ReInspire Study)

for PIK3CA-Related Overgrowth Spectrum (PROS)

Sites in Philadelphia +21 more locations

Sponsor: Relay Therapeutics, Inc.

Sex: All·Age: 2+

Code: NCT06789913·Phase 2·Recruiting·Listed Jan 2025

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A Study to Evaluate TAR-210 Versus Intravesical Chemotherapy Treatment in Participants With High Risk Non-Muscle-Invasive Bladder Cancer

for Non-Muscle Invasive Bladder Neoplasms

Sites in Pittsburgh, Lancaster +22 more locations

Sponsor: Janssen Research & Development, LLC

Sex: All·Age: 18+

Code: NCT06919965·Phase 3·Recruiting·Listed Apr 2025

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A Study of Bispecific Antibody MCLA-158 in Patients With Advanced Solid Tumors

for Advanced/Metastatic Solid Tumors

Sites in Philadelphia +25 more locations

Sponsor: Merus B.V.

Sex: All·Age: 18+

Code: NCT03526835·Phase 1, Phase 2·Recruiting·Listed May 2018

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Study of COYA 302 for the Treatment of ALS

for Amyotrophic Lateral Sclerosis (ALS)

Sites in Philadelphia +20 more locations

Sponsor: Coya Therapeutics

Sex: All·Age: 18 - 80

Code: NCT07161999·Phase 2, Phase 3·Recruiting·Listed Sep 2025

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Sacral Neuromodulation for Male Overactive Bladder (MOAB)

for Overactive Bladder

Sites in Bala-Cynwyd +19 more locations

Sponsor: Axonics, Inc.

Sex: Male·Age: 18+

Code: NCT06511141·Recruiting·Listed Jul 2024

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A Study to Evaluate the Efficacy and Safety of Icotrokinra (JNJ-77242113) in Biologic-experienced and Biologic-naive Participants With Active Psoriatic Arthritis

for Arthritis, Psoriatic

Sites in Philadelphia, Duncansville +19 more locations

Sponsor: Janssen Research & Development, LLC

Sex: All·Age: 18+

Code: NCT06807424·Phase 3·Recruiting·Listed Feb 2025

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A Clinical Study of Intismeran Autogene (V940) and BCG in People With Bladder Cancer (V940-011/INTerpath-011)

for Urinary Bladder Neoplasms

Drug: Intismeran autogene

Sites in Bala-Cynwyd +18 more locations

Sponsor: Merck Sharp & Dohme LLC

Sex: All·Age: 18+

Code: NCT06833073·Phase 2·Recruiting·Listed Feb 2025

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A Long-term Follow-up Study in Patients Who Received BEAM-101

for Hemoglobinopathy

Sites in Philadelphia +16 more locations

Sponsor: Beam Therapeutics Inc.

Sex: All·Age: 14 - 37

Code: NCT07373639·Recruiting·Listed Jan 2026

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A Study to Learn More About How Risankizumab Works in Young Participants With Ulcerative Colitis

for Ulcerative Colitis

Drug: Risankizumab

Sites in Philadelphia, Pittsburgh +10 more locations

Sponsor: AbbVie

Sex: All·Age: 2 - 17

Code: NCT07071519·Phase 3·Recruiting·Listed Jul 2025

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Phase 1, Safety and Tolerability Study of XmAb541 in Advanced Solid Tumors

for Ovarian Cancer

Sites in Pittsburgh +16 more locations

Sponsor: Xencor, Inc.

Sex: All·Age: 15+

Code: NCT06276491·Phase 1·Recruiting·Listed Feb 2024

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A Study to Learn More About How Safe Finerenone is, When it is Taken for a Longer Time With Standard Treatment, in Children and Young Adults With Heart Failure and Left Ventricular Systolic Dysfunction

for Left Ventricular Systolic Dysfunction

Drug: Finerenone

Sites in Philadelphia, Pittsburgh +20 more locations

Sponsor: Bayer

Sex: All·Age: Up to 18

Code: NCT07192952·Phase 3·Recruiting·Listed Sep 2025

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A Study of Vosoritide in Children With Noonan Syndrome With Inadequate Growth During or After Human Growth Hormone Treatment

for Noonan Syndrome

Drug: Vosoritide

Sites in Philadelphia +19 more locations

Sponsor: BioMarin Pharmaceutical

Sex: All·Age: 3 - 11

Code: NCT06668805·Phase 2·Recruiting·Listed Oct 2024

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AMT-260 Gene Therapy Study in Adults With Unilateral Refractory Mesial Temporal Lobe Epilepsy

for Mesial Temporal Lobe Epilepsy

Sites in Philadelphia, Pittsburgh +14 more locations

Sponsor: UniQure Biopharma B.V.

Sex: All·Age: 18 - 75

Code: NCT06063850·Phase 1, Phase 2·Recruiting·Listed Oct 2023

Apply to this trial