Paid Clinical Trials in Pennsylvania

Pennsylvania has 3,479 paid clinical trials enrolling now across cities including Philadelphia, Pittsburgh and Hershey. Search by condition, age, or phase to find compensated research studies accepting participants near you.

Research sites in Pennsylvania include Penn Medicine, Children's Hospital of Philadelphia and UPMC, running studies across oncology, cardiology, neurology, and more. Both patients and healthy volunteers may qualify. Most studies offer compensation for time and travel.

Recruiting trial data synced daily from ClinicalTrials.gov. Last sync: September 4, 2026.

Filter results

Filter results

State

City

Recruitment status

Phase

Study type

Intervention

Condition

Sex

Age

Healthy volunteers only

3,012 clinical trials

Get a weekly email when new trials open in Philadelphia, PA.

A Study Evaluating the Effectiveness and Safety of Risdiplam Administered as an Early Intervention in Pediatric Participants With Spinal Muscular Atrophy After Gene Therapy

for Muscular Atrophy, Spinal

Sites in Philadelphia +9 more locations

Sponsor: Hoffmann-La Roche

Sex: All·Age: 3 Months - 24 Months

Code: NCT05861986·Phase 4·Recruiting·Listed May 2023

Apply to this trial

A Study of Suvorexant (MK-4305) for the Treatment of Insomnia Disorder in Participants With Opioid Use Disorder (MK-4305-098)

for Insomnia

Sites in Philadelphia +12 more locations

Sponsor: Merck Sharp & Dohme LLC

Sex: All·Age: 18 - 70

Code: NCT06655883·Phase 3·Recruiting·Listed Oct 2024

Apply to this trial

Post Approval Study of Liposorber LA-15 System for the Treatment of Focal Segmental Glomerulosclerosis in Children

for Focal Segmental Glomerulosclerosis

Sites in Philadelphia +9 more locations

Sponsor: Kaneka Medical America LLC

Sex: All·Age: Up to 21

Code: NCT02235857·Recruiting·Listed Sep 2014

Apply to this trial

A Phase 3 Efficacy and Safety Study of Fosmanogepix for the Treatment of Adult Participants With Candidemia and/or Invasive Candidiasis.

for Candidemia

Sites in Philadelphia, Pittsburgh +21 more locations

Sponsor: Basilea Pharmaceutica

Sex: All·Age: 18+

Code: NCT05421858·Phase 3·Recruiting·Listed Jun 2022

Apply to this trial

A Study of Nipocalimab in Pregnancies at Risk for Severe Hemolytic Disease of the Fetus and Newborn (HDFN)

for Hemolytic Disease of the Fetus and Newborn

Drug: Nipocalimab

Sites in Allentown +18 more locations

Sponsor: Janssen Research & Development, LLC

Sex: Female·Age: 18 - 45

Code: NCT05912517·Phase 3·Recruiting·Listed Jun 2023

Apply to this trial

A Study of Guselkumab in Pediatric Participants With Moderately to Severely Active Crohn's Disease

for Crohn's Disease

Drug: Guselkumab

Sites in Philadelphia +12 more locations

Sponsor: Janssen Research & Development, LLC

Sex: All·Age: 2 - 17

Code: NCT05923073·Phase 3·Recruiting·Listed Jun 2023

Apply to this trial

INHANCE Stemless Reverse Shoulder IDE

for Arthroplasty

Sites in Philadelphia, Bethlehem +13 more locations

Sponsor: DePuy Orthopaedics

Sex: All·Age: 22+

Code: NCT06323980·Recruiting·Listed Mar 2024

Apply to this trial

KEYMAKER-U01 Substudy 01A: Efficacy and Safety Study of Pembrolizumab (MK-3475) With or Without Chemotherapy When Used With Investigational Agents in Treatment-naïve Participants With Stage IV Non-small Cell Lung Cancer (NSCLC) (MK-3475-01A/KEYMAKER-U01A)

for Carcinoma, Non-Small-Cell Lung

Sites in Philadelphia +5 more locations

Sponsor: Merck Sharp & Dohme LLC

Sex: All·Age: 18+

Code: NCT04165070·Phase 1, Phase 2·Recruiting·Listed Nov 2019

Apply to this trial

KEYMAKER-U01 Umbrella Master Study: Studies of Investigational Agents With Either Pembrolizumab (MK-3475) Alone or With Pembrolizumab PLUS Chemotherapy in Participants With Non-small Cell Lung Cancer (NSCLC) (MK-3475-U01/KEYMAKER-U01)

for Carcinoma, Non-Small-Cell Lung

Sites in Philadelphia +5 more locations

Sponsor: Merck Sharp & Dohme LLC

Sex: All·Age: 18+

Code: NCT04165798·Recruiting·Listed Nov 2019

Apply to this trial

A Phase 3 Efficacy and Safety Study of Fosmanogepix for the Treatment of Adult Patients With Invasive Mold Infections.

for Invasive Mold Infections

Sites in Philadelphia +18 more locations

Sponsor: Basilea Pharmaceutica

Sex: All·Age: 18+

Code: NCT06925321·Phase 3·Recruiting·Listed Apr 2025

Apply to this trial

A Master Protocol (AMAZ): A Study of Mirikizumab (LY3074828) in Pediatric Participants With Ulcerative Colitis or Crohn's Disease (SHINE-ON)

for Ulcerative Colitis

Sites in Philadelphia +10 more locations

Sponsor: Eli Lilly and Company

Sex: All·Age: 2 - 19

Code: NCT04844606·Phase 3·Recruiting·Listed Apr 2021

Apply to this trial

KYSA-6: A Study of Anti-CD19 Chimeric Antigen Receptor T-Cell Therapy, in Patients With Generalized Myasthenia Gravis

for Myasthenia Gravis

Sites in Philadelphia +9 more locations

Sponsor: Kyverna Therapeutics

Sex: All·Age: 18 - 75

Code: NCT06193889·Phase 2, Phase 3·Recruiting·Listed Jan 2024

Apply to this trial

BoxX-NoAF Clinical Trial

for Post Operative Atrial Fibrillation

Sites in Pittsburgh +23 more locations

Sponsor: AtriCure, Inc.

Sex: All·Age: 65+·Accepts healthy volunteers

Code: NCT06989775·Recruiting·Listed May 2025

Apply to this trial

A Study to Investigate Safety and Effectiveness of Tacabrutideg (BGB-16673) in Combination With Other Agents in Participants With Relapsed or Refractory B-Cell Malignancies

for B-cell Malignancy

Sites in Philadelphia +17 more locations

Sponsor: BeOne Medicines

Sex: All·Age: 18+

Code: NCT06634589·Phase 1, Phase 2·Recruiting·Listed Oct 2024

Apply to this trial

Patiromer for Treatment of Hyperkalaemia in Children Under 12 Years of Age

for Hyperkalemia

Drug: patiromer

Sites in Philadelphia +10 more locations

Sponsor: Vifor Pharma, Inc.

Sex: All·Age: 0 - 11

Code: NCT05766839·Phase 2·Recruiting·Listed Mar 2023

Apply to this trial

Diagnosing Epilepsy To EffeCT Change Long-Term Follow-Up

for Epilepsy

Sites in Philadelphia +15 more locations

Sponsor: Epiminder America, Inc.

Sex: All·Age: 18 - 75

Code: NCT07110454·Recruiting·Listed Aug 2025

Apply to this trial

A Clinical Trial to Learn About the Effects of VHB937 in People With Early Alzheimer's Disease

for Alzheimer's Disease

Sites in Willow Grove +23 more locations

Sponsor: Novartis Pharmaceuticals

Sex: All·Age: 50 - 85

Code: NCT07094516·Phase 2·Recruiting·Listed Jul 2025

Apply to this trial

The PERSEVERE Study

for Pulmonary Embolism

Sites in Philadelphia, Pittsburgh +13 more locations

Sponsor: Inari Medical

Sex: All·Age: 18+

Code: NCT06588634·Recruiting·Listed Sep 2024

Apply to this trial

A Study of 177Lu-FAP-2286 in Advanced Solid Tumors

for Solid Tumor

Sites in Pittsburgh +19 more locations

Sponsor: Novartis Pharmaceuticals

Sex: All·Age: 18+

Code: NCT04939610·Phase 1, Phase 2·Recruiting·Listed Jun 2021

Apply to this trial

A Study to Evaluate the Safety of INCA33890 in Participants With Advanced or Metastatic Solid Tumors

for Solid Tumors

Sites in Philadelphia +10 more locations

Sponsor: Incyte Corporation

Sex: All·Age: 18+

Code: NCT05836324·Phase 1·Recruiting·Listed May 2023

Apply to this trial

A Study Evaluating the Effectiveness and Safety of Risdiplam Administered in Pediatric Patients With Spinal Muscular Atrophy Who Experienced a Plateau or Decline in Function After Gene Therapy

for Muscular Atrophy, Spinal

Sites in Philadelphia +8 more locations

Sponsor: Hoffmann-La Roche

Sex: All·Age: 3 Months - 24 Months

Code: NCT05861999·Phase 4·Recruiting·Listed May 2023

Apply to this trial

Phase 1b Trial of RAY121 in Immunological Diseases (RAINBOW Trial)

for Antiphospholipid Syndrome (APS)

Sites in Philadelphia +6 more locations

Sponsor: Chugai Pharmaceutical

Sex: All·Age: 18 - 85

Code: NCT06371417·Phase 1·Recruiting·Listed Apr 2024

Apply to this trial

A Study to Learn About the Treatment LTP001 in Healthy Participants (Part A) and in Participants With PAH (Part B)

for Healthy Volunteers, Pulmonary Arterial Hypertension

Sites in Pittsburgh +19 more locations

Sponsor: Novartis Pharmaceuticals

Sex: All·Age: 18 - 100·Accepts healthy volunteers

Code: NCT06649110·Phase 1, Phase 2·Recruiting·Listed Oct 2024

Apply to this trial

BOOM-IBD2 Pivotal Clinical Trial

for Ulcerative Colitis

Sites in Philadelphia +16 more locations

Sponsor: Boomerang Medical

Sex: All·Age: 18 - 85

Code: NCT06571669·Recruiting·Listed Aug 2024

Apply to this trial

A Trial to Find Out if REGN5678 (Nezastomig) is Safe and How Well it Works Alone or in Combination With Cemiplimab for Adult Participants With Metastatic Castration-Resistant Prostate Cancer and Other Tumors

for Metastatic Castration-Resistant Prostate Cancer (mCRPC)

Drug: Cemiplimab

Sites in Philadelphia +22 more locations

Sponsor: Regeneron Pharmaceuticals

Sex: All·Age: 18+

Code: NCT03972657·Phase 1, Phase 2·Recruiting·Listed Jun 2019

Apply to this trial

Spevatamig (PT886) as Monotherapy or in Combination With Chemo and/or ICI, for the Treatment of Patients With Advanced Gastric, Gastroesophageal Junction, Pancreatic Ductal or Biliary Tract Carcinomas (the TWINPEAK Study)

for Gastric or Gastroesophageal Junction Adenocarcinoma

Sites in Pittsburgh +9 more locations

Sponsor: Phanes Therapeutics

Sex: All·Age: 18+

Code: NCT05482893·Phase 1, Phase 2·Recruiting·Listed Aug 2022

Apply to this trial

A Study to Investigate the Safety and Effectiveness of a Coagulation Factor IX Gene Insertion Therapy (REGV131-LNP1265) in Pediatric, Adolescent and Adult Participants With Hemophilia B

for Hemophilia B

Sites in Philadelphia +14 more locations

Sponsor: Regeneron Pharmaceuticals

Sex: Male·Age: 2+

Code: NCT06379789·Phase 1, Phase 2·Recruiting·Listed Apr 2024

Apply to this trial

Study to Assess the Impact of the Urine Test Cxbladder Triage Plus on the Number of Cystoscopies Performed on Patients With Invisible Blood in Their Urine.

for Hematuria - Cause Not Known

Sites in Hershey +17 more locations

Sponsor: Pacific Edge Limited

Sex: All·Age: 18 - 88

Code: NCT06394869·Recruiting·Listed May 2024

Apply to this trial

Efficacy of KL1333 in Adult Patients With Primary Mitochondrial Disease

for Primary Mitochondrial Disease

Sites in Philadelphia, Pittsburgh +18 more locations

Sponsor: Pharming Technologies B.V.

Sex: All·Age: 18+

Code: NCT05650229·Phase 2·Recruiting·Listed Dec 2022

Apply to this trial

Study to Investigate Lifileucel Regimen Plus Pembrolizumab Compared With Pembrolizumab Alone in Participants With Untreated Advanced Melanoma.

for Metastatic Melanoma

Drug: Lifileucel

Sites in Pittsburgh +17 more locations

Sponsor: Iovance Biotherapeutics, Inc.

Sex: All·Age: 18 - 70

Code: NCT05727904·Phase 3·Recruiting·Listed Feb 2023

Apply to this trial

4D-710 in Adult Patients With Cystic Fibrosis

for Cystic Fibrosis Lung

Sites in Philadelphia +17 more locations

Sponsor: 4D Molecular Therapeutics

Sex: All·Age: 18+

Code: NCT05248230·Phase 2·Recruiting·Listed Feb 2022

Apply to this trial

AVENTINE-1: Study of AVZO-1418 as a Single Agent and in Combination Therapy in Patients With Locally Advanced or Metastatic Solid Tumors (AVZO-1418-1001)

for Solid Tumor Cancer

Sites in Philadelphia +18 more locations

Sponsor: Avenzo Therapeutics, Inc.

Sex: All·Age: 18 - 75

Code: NCT07038343·Phase 1, Phase 2·Recruiting·Listed Jun 2025

Apply to this trial

Abbott Cephea Mitral Valve Disease Registry

for Mitral Regurgitation

Sites in Pittsburgh +22 more locations

Sponsor: Abbott Medical Devices

Sex: All·Age: 18+

Code: NCT07069673·Recruiting·Listed Jul 2025

Apply to this trial

A Study of Toripalimab in Combination With Cisplatin and Gemcitabine in Participants With Recurrent Metastatic Nasopharyngeal Cancer

for Nasopharyngeal Cancer Recurrent

Sites in Hershey +10 more locations

Sponsor: Coherus Oncology, Inc.

Sex: All·Age: 12+

Code: NCT06457503·Phase 4·Recruiting·Listed Jun 2024

Apply to this trial

A Study of JNT-517 in Participants With Phenylketonuria (PKU)

for Phenylketonuria

Sites in Pittsburgh +9 more locations

Sponsor: Otsuka Pharmaceutical Development & Commercialization, Inc.

Sex: All·Age: 18+

Code: NCT06971731·Phase 3·Recruiting·Listed May 2025

Apply to this trial

A Study to Investigate the Efficacy, Safety and Tolerability of Remibrutinib Versus Placebo in Adult Patients With Generalized Myasthenia Gravis

for Generalized Myasthenia Gravis

Drug: Remibrutinib

Sites in Pittsburgh +23 more locations

Sponsor: Novartis Pharmaceuticals

Sex: All·Age: 18 - 85

Code: NCT06744920·Phase 3·Recruiting·Listed Dec 2024

Apply to this trial

PULSED AF Post-Approval Study

for Atrial Fibrillation

Sites in Doylestown +15 more locations

Sponsor: Medtronic Cardiac Ablation Solutions

Sex: All·Age: 18+

Code: NCT06578104·Recruiting·Listed Aug 2024

Apply to this trial

Real-World Data Collection of the GORE® VIABAHN® VBX Balloon Expandable Endoprosthesis When Used in Covered Endovascular Reconstruction of the Aortic Bifurcation (CERAB) to Treat Aortoiliac Occlusive Disease

for Aortoiliac Occlusive Disease

Sites in Philadelphia, Danville +18 more locations

Sponsor: W.L.Gore & Associates

Sex: All·Age: 18 - 100

Code: NCT06872905·Recruiting·Listed Mar 2025

Apply to this trial

A Study to Investigate Efficacy and Safety of SAR441566 in Patients With Ulcerative Colitis

for Colitis Ulcerative

Drug: SAR441566

Sites in Uniontown +18 more locations

Sponsor: Sanofi

Sex: All·Age: 18 - 75

Code: NCT06867094·Phase 2·Recruiting·Listed Mar 2025

Apply to this trial

A Study of SGT-003 Gene Therapy in Duchenne Muscular Dystrophy (INSPIRE DUCHENNE)

for Duchenne Muscular Dystrophy

Sites in Philadelphia +11 more locations

Sponsor: Solid Biosciences Inc.

Sex: Male·Age: 0 - 17

Code: NCT06138639·Phase 1, Phase 2·Recruiting·Listed Nov 2023

Apply to this trial