Paid Clinical Trials in Pennsylvania

Pennsylvania has 3,479 paid clinical trials enrolling now across cities including Philadelphia, Pittsburgh and Hershey. Search by condition, age, or phase to find compensated research studies accepting participants near you.

Research sites in Pennsylvania include Penn Medicine, Children's Hospital of Philadelphia and UPMC, running studies across oncology, cardiology, neurology, and more. Both patients and healthy volunteers may qualify. Most studies offer compensation for time and travel.

Recruiting trial data synced daily from ClinicalTrials.gov. Last sync: September 4, 2026.

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3,012 clinical trials

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EMAGINE 2.0 - Electromagnetic Field Ischemic Stroke - Novel Subacute Treatment

for Ischemic Stroke

Sites in Elkins Park +13 more locations

Sponsor: BrainQ Technologies Ltd.

Sex: All·Age: 22 - 80

Code: NCT06386874·Recruiting·Listed Apr 2024

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Phase 1b/2 Study of IV Sarilumab in Adult With RA

for Rheumatoid Arthritis

Sites in Duncansville +3 more locations

Sponsor: Sanofi

Sex: All·Age: 18+

Code: NCT07704580·Phase 1, Phase 2·Recruiting·Listed Jul 15, 2026

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A Study of MZE782 in Adults With PKU

for Phenylketonuria (PKU)

Sites in Gordonville +5 more locations

Sponsor: Maze Therapeutics

Sex: All·Age: 18 - 75

Code: NCT07694440·Phase 2·Recruiting·Listed Jul 10, 2026

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Idiopathic Pulmonary Fibrosis (IPF)-Related Chronic Cough Reduction With Nalbuphine Extended-Release (NAL ER) Tablets

for Idiopathic Pulmonary Fibrosis

Sites in DuBois +14 more locations

Sponsor: Trevi Therapeutics

Sex: All·Age: 40+

Code: NCT07671911·Phase 3·Recruiting·Listed Jun 2026

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Data Collection of New Spectral CT Imaging Method

for Computed Tomography

1 location in Bethlehem

Sponsor: GE Healthcare

Sex: All·Age: 18+·Accepts healthy volunteers

Code: NCT07661706·Recruiting·Listed Jun 2026

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A Study of Ifinatamab Deruxtecan in Pediatric Participants With Relapsed or Refractory Solid Tumors (MK-9999-01D/LIGHTBEAM-U01)

for Malignant Neoplasm

Sites in Philadelphia +10 more locations

Sponsor: Merck Sharp & Dohme LLC

Sex: All·Age: 1 Month - 17

Code: NCT07630974·Phase 1, Phase 2·Recruiting·Listed Jun 2026

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A Study of GS-3242 in Combination With Lenacapavir Versus Biktarvy in Virologically Suppressed People With HIV-1

for HIV-1-infection

Sites in Philadelphia +29 more locations

Sponsor: Gilead Sciences

Sex: All·Age: 18+

Code: NCT07645287·Phase 2·Recruiting·Listed Jun 2026

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Open-label Study of SKY-GJB2 in Pediatric Subjects With GJB2-mediated Hearing Loss

for GJB2-mediated Hearing Loss

Sites in Allentown +3 more locations

Sponsor: Skylark Bio Inc.

Sex: All·Age: 9 Months - 7

Code: NCT07627971·Phase 1, Phase 2·Recruiting·Listed Jun 2026

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A Study to Evaluate the Effectiveness of DT-101 as an Adjunctive Treatment in Patients With Depression

for Major Depressive Disorder (MDD)

Sites in Allentown, Media +21 more locations

Sponsor: Draig Therapeutics Ltd

Sex: All·Age: 18 - 75

Code: NCT07610473·Phase 2·Recruiting·Listed May 2026

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First-in-human Study of a New Treatment (4A10) for Patients With Relapsed or Hard-to-treat Acute Lymphoblastic Leukemia or Lymphoblastic Lymphoma, Focused on Safety and How the Drug Behaves in the Body and Early Signs of Effect.

for Lymphoblastic Lymphoma

Sites in Philadelphia +6 more locations

Sponsor: Allterum Therapeutics, Inc

Sex: All·Age: 18+

Code: NCT07586618·Phase 1·Recruiting·Listed May 2026

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Study Evaluating the Efficacy and Safety of RAP-219 in Adult Participants With Focal Seizures FOCUS-1

for Focal Seizure

Sites in Philadelphia +10 more locations

Sponsor: Rapport Therapeutics Inc.

Sex: All·Age: 18 - 75

Code: NCT07563881·Phase 3·Recruiting·Listed May 2026

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Evaluation of the FARAFLEX Mapping and Pulsed Field Ablation System in Subjects With Atrial Fibrillation

for Paroxysmal Atrial Fibrillation (PAF)

Sites in Mechanicsburg +6 more locations

Sponsor: Boston Scientific Corporation

Sex: All·Age: 18+

Code: NCT07575269·Recruiting·Listed May 2026

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NORM-HF Pivotal Study

for Heart Failure

Sites in Philadelphia +8 more locations

Sponsor: Foundry Innovation & Research 1, Limited (FIRE1)

Sex: All·Age: 18+

Code: NCT07574593·Recruiting·Listed May 2026

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A Study Evaluating Disease Characteristics and Outcomes in Participants With Asthma in Routine Clinical Practice

for Asthma

Sites in Pittsburgh +55 more locations

Sponsor: Sanofi

Sex: All·Age: 6+

Code: NCT07556159·Recruiting·Listed Apr 2026

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A Safety and Efficacy Study of hu14 in High-Risk Neuroblastoma Patients

for High-Risk Neuroblastoma

Sites in Philadelphia +4 more locations

Sponsor: Renaissance Pharma Ltd.

Sex: All·Age: 18 Months - 18

Code: NCT07549321·Phase 2, Phase 3·Recruiting·Listed Apr 2026

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A Study to Determine the Effects of ENDS Flavor Availability on Abstinence Within Smokers

for Smoking

Sites in Philadelphia +6 more locations

Sponsor: RAI Services Company

Sex: All·Age: 21 - 65·Accepts healthy volunteers

Code: NCT07598136·Recruiting·Listed May 2026

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EXACT Study: A Blinded Study in Patients With Alport Syndrome to Evaluate Exaluren Efficacy and Safety

for Alport Syndrome, X-Linked

Sites in Philadelphia +7 more locations

Sponsor: Eloxx Pharmaceuticals, Inc.

Sex: All·Age: 12+

Code: NCT07523581·Phase 2·Recruiting·Listed Apr 2026

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A Study to Assess Intravenous (IV) Telisotuzumab Adizutecan in Combination With Fluorouracil, Folinic Acid, and Oxaliplatin (FOLFOX) Compared to Standard of Care in Adult Participants With First-Line Metastatic Pancreatic Ductal Adenocarcinoma

for Metastatic Pancreatic Ductal Adenocarcinoma

Sites in Philadelphia +7 more locations

Sponsor: AbbVie

Sex: All·Age: 18+

Code: NCT07490301·Phase 2, Phase 3·Recruiting·Listed Mar 2026

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Evaluation of the Safety and Efficacy of Abenacianine (VGT-309) to Identify Cancer in Subjects Undergoing Surgery for Cancer in the Lung

for Lung Cancer

Sites in Philadelphia +7 more locations

Sponsor: Vergent Bioscience, Inc.

Sex: All·Age: 18+

Code: NCT07499674·Phase 3·Recruiting·Listed Mar 2026

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Trial of Xaluritamig in Adults With Metastatic Castration-resistant Prostate Cancer

for Metastatic Castration-resistant Prostate Cancer (mCRPC)

Sites in Philadelphia, Pittsburgh +7 more locations

Sponsor: Amgen

Sex: Male·Age: 18+

Code: NCT07493512·Phase 1·Recruiting·Listed Mar 2026

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The Effect of Rinsing on Ocular Inflammation and Symptoms in Patients With Dry Eye Disease

for Dry Eye Syndromes

1 location in Pittsburgh

Sponsor: Rinsada

Sex: All·Age: 18+·Accepts healthy volunteers

Code: NCT07618364·Recruiting·Listed Jun 2026

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A Study to Find Out if Enfortumab Vedotin Given With Pembrolizumab Helps People With Muscle-invasive Bladder Cancer Keep Their Bladder

for Muscle-invasive Bladder Cancer

Sites in Philadelphia, Willow Grove +10 more locations

Sponsor: Astellas Pharma Global Development, Inc.

Sex: All·Age: 18+

Code: NCT07475806·Phase 2·Recruiting·Listed Mar 2026

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Pupillometry in Identifying Risk of Postoperative Opioid-induced Respiratory Depression in Children Undergoing Tonsillectomy

for Opioid-Induced Respiratory Depression

Sites in Pittsburgh +1 more location

Sponsor: NeurOptics Inc

Sex: All·Age: 3 - 17·Accepts healthy volunteers

Code: NCT07573150·Recruiting·Listed May 2026

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Observational Study of Adults and Adolescents With Erythropoietic Protoporphyria (EPP) and X-linked Porphyria (XLP)

for Erythropoietic Protoporphyria (EPP)

Sites in Philadelphia +4 more locations

Sponsor: Portal Therapeutics, Inc.

Sex: All·Age: 12+

Code: NCT07567131·Recruiting·Listed May 2026

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INdependence Through Endovascular Neuroprosthetic Technology (INTENT): an Early Feasibility Study

for Neurological Disorder

Sites in Pittsburgh +4 more locations

Sponsor: Synchron, Inc.

Sex: All·Age: 22+

Code: NCT07543367·Recruiting·Listed Apr 2026

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Post Approval Effectiveness and Durability Evaluation of the Altaviva™ Tibial Device

for Urge Urinary Incontinence

Sites in Philadelphia, Allentown +10 more locations

Sponsor: MedtronicNeuro

Sex: All·Age: 18+

Code: NCT07456865·Recruiting·Listed Mar 2026

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Study to Evaluate the Efficacy and Safety of BMN 333 Versus Vosoritide in Children With Achondroplasia

for Achondroplasia

Drug: Vosoritide

Sites in Philadelphia +8 more locations

Sponsor: BioMarin Pharmaceutical

Sex: All·Age: 2 - 17

Code: NCT07441876·Phase 2, Phase 3·Recruiting·Listed Mar 2026

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A Phase 1 Study of PRT12396 in Participants With Select Myeloproliferative Neoplasms

for Polycythemia Vera (PV)

Sites in Philadelphia +7 more locations

Sponsor: Prelude Therapeutics

Sex: All·Age: 18+

Code: NCT07469891·Phase 1·Recruiting·Listed Mar 2026

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Study of ALK-001 on the Progression of Stargardt Disease

for Stargardt Disease

Sites in Erie +9 more locations

Sponsor: Alkeus Pharmaceuticals, Inc.

Sex: All·Age: 8 - 45

Code: NCT07419334·Phase 3·Recruiting·Listed Feb 2026

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Rezdiffra Pregnancy and Lactation Registry

for MASH - Metabolic Dysfunction-Associated Steatohepatitis

1 location in West Conshohocken

Sponsor: Madrigal Pharmaceuticals, Inc.

Sex: Female·Age: All ages·Accepts healthy volunteers

Code: NCT07541469·Recruiting·Listed Apr 2026

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Extension Study for Participants in Studies That Include Belzutifan (MK-6482-043/LITESPARK-043)

for Von Hippel-Lindau Disease

Sites in Philadelphia +6 more locations

Sponsor: Merck Sharp & Dohme LLC

Sex: All·Age: 18+

Code: NCT07405164·Phase 3·Recruiting·Listed Feb 2026

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A Study of Nuzefatide Pevedotin (BT5528) in Patients With Metastatic Pancreatic Ductal Adenocarcinoma (PDAC)

for Pancreatic Ductal Adenocarcinoma (PDAC)

Sites in Philadelphia +5 more locations

Sponsor: BicycleTx Limited

Sex: All·Age: 18+

Code: NCT07450859·Phase 2·Recruiting·Listed Mar 2026

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A Phase 1 Study of the Safety and Tolerability of CTX-10726

for Gastroesophageal Cancer (GC)

Drug: CTX-10726

Sites in Pittsburgh +4 more locations

Sponsor: Compass Therapeutics

Sex: All·Age: 18+

Code: NCT07419841·Phase 1·Recruiting·Listed Feb 2026

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A Clinical Trial of Ifinatamab Deruxtecan in People With Advanced Esophageal Cancer (MK-3475-06F)

for Oesophageal Squamous Cell Carcinoma

1 location in Pittsburgh

Sponsor: Merck Sharp & Dohme LLC

Sex: All·Age: 18+

Code: NCT07405151·Phase 1, Phase 2·Recruiting·Listed Feb 2026

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A Study of TAK-755 in Adults With Acute Ischemic Stroke

for Acute Ischemic Stroke

Sites in Pittsburgh +8 more locations

Sponsor: Takeda

Sex: All·Age: 18+

Code: NCT07392450·Phase 2·Recruiting·Listed Feb 2026

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Post-Market Study of the Signia Circular Stapler With Tri-Staple Technology in Left-sided Colon, Sigmoid, and Rectal Resections

for Colorectal Anastomosis

Sites in Wynnewood +8 more locations

Sponsor: Medtronic - MITG

Sex: All·Age: 18+

Code: NCT07351071·Recruiting·Listed Jan 2026

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ROCKET-CLL Global Phase 3 Study: Rocbrutinib vs Pirtobrutinib in cBTKi-Pretreated R/R CLL/SLL

for CLL / SLL

Sites in Pittsburgh +5 more locations

Sponsor: Newave Pharmaceutical Inc

Sex: All·Age: 18+

Code: NCT07342478·Phase 3·Recruiting·Listed Jan 2026

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Study of NXP900 With Osimertinib in Subjects With Advanced, EGFR-Mutated Non-Small Cell Lung Cancer

for EGFR Mutation Positive Non-small Cell Lung Cancer

Drug: Osimertinib

Sites in Pittsburgh +5 more locations

Sponsor: Nuvectis Pharma, Inc.

Sex: All·Age: 18+

Code: NCT07315113·Phase 1·Recruiting·Listed Jan 2026

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Study is to Assess the Safety and Tolerability of VTx-002 in Participants With ALS

for Amyotrophic Lateral Sclerosis

Sites in Philadelphia +6 more locations

Sponsor: Vector Y Therapeutics

Sex: All·Age: 18+

Code: NCT07287397·Phase 1, Phase 2·Recruiting·Listed Dec 2025

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A Study to Evaluate Safety, Tolerability, and Efficacy of AB-1009 Gene Therapy (GAA Gene) in Adult Participants With Late-Onset Pompe Disease (PROGRESS-GT LOPD)

for Pompe Disease (Late-onset)

Sites in Philadelphia, Pittsburgh +7 more locations

Sponsor: AskBio Inc

Sex: All·Age: 18 - 65

Code: NCT07282847·Phase 1, Phase 2·Recruiting·Listed Dec 2025

Apply to this trial