Paid Clinical Trials in Pennsylvania

Pennsylvania has 3,479 paid clinical trials enrolling now across cities including Philadelphia, Pittsburgh and Hershey. Search by condition, age, or phase to find compensated research studies accepting participants near you.

Research sites in Pennsylvania include Penn Medicine, Children's Hospital of Philadelphia and UPMC, running studies across oncology, cardiology, neurology, and more. Both patients and healthy volunteers may qualify. Most studies offer compensation for time and travel.

Recruiting trial data synced daily from ClinicalTrials.gov. Last sync: September 4, 2026.

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3,012 clinical trials

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Immune Checkpoint Inhibitor Toxicity Risk Prediction in Solid Tumors

for Malignant Solid Neoplasm

Sites in Allentown, Danville +586 more locations

Sponsor: SWOG Cancer Research Network

Sex: All·Age: 18+

Code: NCT04871542·Recruiting·Listed May 2021

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Observational Study of Pediatric Rheumatic Diseases: The CARRA Registry

for Rheumatic Joint Disease

Sites in Philadelphia, Pittsburgh +64 more locations

Sponsor: Duke University

Sex: All·Age: Up to 21

Code: NCT02418442·Recruiting·Listed Apr 2015

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Study to Evaluate Biological & Clinical Effects of Significantly Corrected CFTR Function in Infants & Young Children

for Cystic Fibrosis

Sites in Philadelphia, Pittsburgh +33 more locations

Sponsor: Sonya Heltshe

Sex: All·Age: Up to 10

Code: NCT04509050·Recruiting·Listed Aug 2020

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Streamlined Treatment of Pulmonary Exacerbations in Pediatrics

for Cystic Fibrosis

Sites in Philadelphia, Pittsburgh +29 more locations

Sponsor: University of Washington, the Collaborative Health Studies Coordinating Center

Sex: All·Age: 3 - 18

Code: NCT06654752·Recruiting·Listed Oct 2024

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Study of Revumenib, Azacitidine, and Venetoclax in Pediatric and Young Adult Patients With Refractory or Relapsed Acute Myeloid Leukemia

for Refractory Acute Myeloid Leukemia

Drug: Venetoclax

Sites in Philadelphia +9 more locations

Sponsor: St. Jude Children's Research Hospital

Sex: All·Age: 1 - 30

Code: NCT06177067·Phase 1·Recruiting·Listed Dec 2023

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Clinical and Basic Investigations Into Congenital Disorders of Glycosylation

for Congenital Disorders of Glycosylation

Sites in Philadelphia, Pittsburgh +10 more locations

Sponsor: Icahn School of Medicine at Mount Sinai

Sex: All·Age: All ages

Code: NCT04199000·Recruiting·Listed Dec 2019

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A Study to Find the Highest Dose of Imetelstat in Combination With Fludarabine and Cytarabine for Patients With AML, MDS or JMML That Has Come Back or Does Not Respond to Therapy

for Recurrent Childhood Acute Myeloid Leukemia

Sites in Philadelphia, Pittsburgh +16 more locations

Sponsor: Children's Oncology Group

Sex: All·Age: 1 - 18

Code: NCT06247787·Phase 1·Recruiting·Listed Feb 2024

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Precision Ventilation vs Standard Care for Acute Respiratory Distress Syndrome

for Acute Respiratory Distress Syndrome

Sites in Philadelphia +32 more locations

Sponsor: Beth Israel Deaconess Medical Center

Sex: All·Age: 18+

Code: NCT06066502·Phase 3·Recruiting·Listed Oct 2023

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Testing the Addition of an Anti-cancer Drug, Sapanisertib, to the Usual Chemotherapy Treatment (Cabozantinib) in Metastatic Liver Cell Cancer With a Change in Genes for the Protein β-Catenin, The SAPHIRE Trial

for Advanced Hepatocellular Carcinoma

Drug: Cabozantinib

Sites in Pittsburgh +3 more locations

Sponsor: National Cancer Institute (NCI)

Sex: All·Age: 18+

Code: NCT06811116·Phase 1, Phase 2·Recruiting·Listed Feb 2025

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Screening Emotions in Adolescents at the Hospital for mTBI

for Brain Injury Traumatic Mild

Sites in Philadelphia +5 more locations

Sponsor: University of California, Davis

Sex: All·Age: 11 - 17

Code: NCT06370520·Recruiting·Listed Apr 2024

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Testing the Addition of an Anti-cancer Drug, Selinexor, to the Usual Chemotherapy Treatment (Temozolomide) for Brain Tumors That Have Returned After Previous Treatment

for Recurrent Glioblastoma, IDH-Wildtype

Drug: Selinexor

Sites in Pittsburgh +27 more locations

Sponsor: National Cancer Institute (NCI)

Sex: All·Age: 18+

Code: NCT05432804·Phase 1, Phase 2·Recruiting·Listed Jun 2022

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Treatment With Endovascular Intervention for STroke Patients With Existing Disability

for Stroke

Sites in Pittsburgh +32 more locations

Sponsor: University of Cincinnati

Sex: All·Age: 18+

Code: NCT05911568·Recruiting·Listed Jun 2023

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Improving Survival for Metastatic Lobular Breast Cancer (PLUMB Registry)

for Metastatic Breast Cancer

Sites in Philadelphia +3 more locations

Sponsor: University of California, San Francisco

Sex: All·Age: 18+

Code: NCT05964504·Recruiting·Listed Jul 2023

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Friedreich Ataxia Global Clinical Consortium UNIFIED Natural History Study

for Friedreich Ataxia

Sites in Philadelphia +8 more locations

Sponsor: Friedreich's Ataxia Research Alliance

Sex: All·Age: All ages·Accepts healthy volunteers

Code: NCT06016946·Recruiting·Listed Aug 2023

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Tipifarnib and Naxitamab for Relapsed/Refractory Neuroblastoma

for Neuroblastoma

Sites in Hershey +11 more locations

Sponsor: Giselle Sholler

Sex: All·Age: 1 - 21

Code: NCT06540963·Phase 2·Recruiting·Listed Aug 2024

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Pancreatic Cancer Detection Consortium (PCDC) Prospective Cohorts

for Pancreatic Carcinoma

Sites in Pittsburgh +8 more locations

Sponsor: Mayo Clinic

Sex: All·Age: 18+

Code: NCT06271291·Recruiting·Listed Feb 2024

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Study of Biomarker-Based Treatment of Acute Myeloid Leukemia

for Previously Untreated Relapsed Refractory Acute Myeloid Leukemia

Sites in Pittsburgh +26 more locations

Sponsor: Beat AML, LLC

Sex: All·Age: 18+

Code: NCT03013998·Phase 2, Phase 3·Recruiting·Listed Jan 2017

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Cabozantinib With Ifosfamide in Relapsed/Refractory Sarcomas

for Ewing Sarcoma

Drug: Cabozantinib

Sites in Philadelphia +3 more locations

Sponsor: Children's Hospital of Philadelphia

Sex: All·Age: 5 - 40

Code: NCT06156410·Phase 1·Recruiting·Listed Dec 2023

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Comparing Analgesic Regimen Effectiveness and Safety for Surgery (CARES) Trial

for Surgery

Sites in Philadelphia +5 more locations

Sponsor: University of Michigan

Sex: All·Age: 18+

Code: NCT05722002·Phase 4·Recruiting·Listed Feb 2023

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Comparison of Breast Cancer Screening With CESM to DBT in Women With Dense Breasts

for Breast Cancer

Sites in Philadelphia +10 more locations

Sponsor: American College of Radiology

Sex: Female·Age: 45 - 74·Accepts healthy volunteers

Code: NCT05625659·Recruiting·Listed Nov 2022

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Responding With Evidence and Access for Childhood Headaches

for Headache

Sites in Philadelphia +14 more locations

Sponsor: Children's Hospital Medical Center, Cincinnati

Sex: All·Age: 10 - 17

Code: NCT05889624·Recruiting·Listed Jun 2023

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Kaempferol Absorption and Pharmacokinetics Evaluation

for No Disease

Sites in Pittsburgh +2 more locations

Sponsor: University of Pittsburgh

Sex: All·Age: 18 - 70·Accepts healthy volunteers

Code: NCT07322406·Recruiting·Listed Jan 2026

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Systemic Hypothermia in Acute Cervical Spinal Cord Injury

for Spinal Cord Injury, Acute

Sites in Philadelphia +4 more locations

Sponsor: University of Miami

Sex: All·Age: 18 - 70

Code: NCT02991690·Recruiting·Listed Dec 2016

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Optimal Pediatric Heart Transplant Immunosuppression With MicroRNAs

for Cardiac Failure

Sites in Pittsburgh +6 more locations

Sponsor: Northwestern University

Sex: All·Age: Up to 18

Code: NCT06532890·Recruiting·Listed Aug 2024

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Testing Whether Cemiplimab (REGN2810) Plus CDX-1140 Given Prior to Surgery Are Better Than Cemiplimab (REGN2810) Alone in Patients With Stage III-IV Head and Neck Cancer

for Head and Neck Squamous Cell Carcinoma

Drug: Cemiplimab

Sites in Pittsburgh +9 more locations

Sponsor: National Cancer Institute (NCI)

Sex: All·Age: 18+

Code: NCT06980038·Phase 2·Recruiting·Listed May 2025

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PEP-CMV Vaccine Targeting CMV Antigen to Treat Newly Diagnosed Pediatric HGG and DIPG and Recurrent Medulloblastoma

for High Grade Glioma

Sites in Philadelphia +12 more locations

Sponsor: Nationwide Children's Hospital

Sex: All·Age: 3 - 39

Code: NCT05096481·Phase 2·Recruiting·Listed Oct 2021

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RA-PRO PRAGMATIC TRIAL

for Rheumatoid Arthritis

Sites in Pittsburgh, Duncansville +46 more locations

Sponsor: University of Alabama at Birmingham

Sex: All·Age: 18+

Code: NCT04692493·Phase 3·Recruiting·Listed Dec 2020

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Neoadjuvant Chemotherapy, Excision And Observation vs Chemoradiotherapy For Rectal Cancer

for Rectal Cancer

Sites in Hershey, Chadds Ford +101 more locations

Sponsor: Canadian Cancer Trials Group

Sex: All·Age: 18+

Code: NCT06205485·Phase 3·Recruiting·Listed Jan 2024

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Testing the Combination of the Anti-Cancer Drugs Temozolomide and M1774 to Evaluate Their Safety and Effectiveness

for Advanced Malignant Solid Neoplasm

Sites in Pittsburgh +14 more locations

Sponsor: National Cancer Institute (NCI)

Sex: All·Age: 18+

Code: NCT05691491·Phase 1, Phase 2·Recruiting·Listed Jan 2023

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INdividualized Screening Trial of Innovative Glioblastoma Therapy (INSIGhT)

for Glioblastoma

Sites in Pittsburgh +3 more locations

Sponsor: David Reardon, MD

Sex: All·Age: 18+

Code: NCT02977780·Phase 2·Recruiting·Listed Nov 2016

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Pimavanserin vs. Quetiapine for Treatment of Parkinson's Psychosis

for Parkinson's Disease Psychosis

Sites in Philadelphia +8 more locations

Sponsor: VA Office of Research and Development

Sex: All·Age: 40+·Accepts healthy volunteers

Code: NCT04373317·Phase 4·Recruiting·Listed May 2020

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Impact of Behavior Modification Interventions and Lung Cancer Screening on Smoking Cessation in People Living With HIV: A Feasibility Study

for HIV Infection

Sites in Philadelphia +10 more locations

Sponsor: AIDS Malignancy Consortium

Sex: All·Age: 45 - 80

Code: NCT04949464·Recruiting·Listed Jul 2021

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Caloric Restriction and Activity to Reduce Chemoresistance in B-ALL

for B-cell Acute Lymphoblastic Leukemia

Sites in Philadelphia +15 more locations

Sponsor: Etan Orgel

Sex: All·Age: 7 - 25

Code: NCT05082519·Phase 2·Recruiting·Listed Oct 2021

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A-LiNK: Improving Outcomes in Autoimmune Liver Disease

for Autoimmune Hepatitis

Sites in Pittsburgh +7 more locations

Sponsor: Children's Hospital Medical Center, Cincinnati

Sex: All·Age: All ages

Code: NCT05750498·Recruiting·Listed Mar 2023

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Neoadjuvant Neratinib in Stage I-III HER2-Mutated Lobular Breast Cancers

for Anatomic Stage I Breast Cancer

Sites in Pittsburgh +4 more locations

Sponsor: Vanderbilt-Ingram Cancer Center

Sex: All·Age: 18+

Code: NCT05919108·Phase 2·Recruiting·Listed Jun 2023

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Standardizing Treatments for Pulmonary Exacerbations - Aminoglycoside Study

for Cystic Fibrosis

Sites in Philadelphia, Pittsburgh +57 more locations

Sponsor: Chris Goss

Sex: All·Age: 6+

Code: NCT05548283·Phase 4·Recruiting·Listed Sep 2022

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Collecting Blood and Stool Samples to Detect Colorectal Cancer or Advanced Neoplasia in Lynch Syndrome Patients

for Colorectal Carcinoma

Sites in Philadelphia +7 more locations

Sponsor: Mayo Clinic

Sex: All·Age: 18+

Code: NCT05410977·Recruiting·Listed Jun 2022

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A Study of a Potential Disease Modifying Treatment in Individuals at Risk for or With a Type of Early Onset AD Caused by a Genetic Mutation

for Alzheimers Disease

Sites in Pittsburgh +12 more locations

Sponsor: Washington University School of Medicine

Sex: All·Age: 18+·Accepts healthy volunteers

Code: NCT06647498·Phase 2, Phase 3·Recruiting·Listed Oct 2024

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A Study of Potential Disease Modifying Treatments in Individuals at Risk for or With a Type of Early Onset AD Caused by a Genetic Mutation

for Alzheimers Disease

Sites in Pittsburgh +12 more locations

Sponsor: Washington University School of Medicine

Sex: All·Age: 18+·Accepts healthy volunteers

Code: NCT05552157·Phase 2, Phase 3·Recruiting·Listed Sep 2022

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Descemet Endothelial Thickness Comparison Trial II

for Fuchs

Sites in Philadelphia +7 more locations

Sponsor: Stanford University

Sex: All·Age: 18+

Code: NCT05275972·Phase 3·Recruiting·Listed Mar 2022

Apply to this trial