Paid Clinical Trials in Pennsylvania

Pennsylvania has 3,659 paid clinical trials enrolling now across cities including Philadelphia, Pittsburgh and Hershey. Search by condition, age, or phase to find compensated research studies accepting participants near you.

Research sites in Pennsylvania include Penn Medicine, Children's Hospital of Philadelphia and UPMC, running studies across oncology, cardiology, neurology, and more. Both patients and healthy volunteers may qualify. Most studies offer compensation for time and travel.

Recruiting trial data synced daily from ClinicalTrials.gov. Last sync: June 4, 2026.

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3,659 clinical trials

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Study to Evaluate Tulisokibart in Adults With Psoriatic Arthritis (MK-7240-015)

for Psoriatic Arthritis

Drug: Tulisokibart

15 locations incl. Sun City

Sponsor: Merck Sharp & Dohme LLC

Sex: All·Age: 18 - 80

Code: NCT07486960·Phase 2·Recruiting

Apply to this trial

In-Shoe Loadsol Force Analysis Study LC1 Fractures

for Geriatric Pelvic Ring Fractures

1 location in Philadelphia

Sponsor: University of Pennsylvania

Sex: All·Age: 65+

Code: NCT07608107·Recruiting

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A Study of Azenosertib (ZN-c3) Versus Investigator's Choice Chemotherapy in Subjects With Platinum-Resistant High-Grade Serous Ovarian, Primary Peritoneal, or Fallopian Tube Cancers Positive for Cyclin E1 Protein Expression

for Ovarian Cancer

11 locations incl. Phoenix

Sponsor: K-Group, Beta, Inc., a wholly owned subsidiary of Zentalis Pharmaceuticals, Inc

Sex: Female·Age: 18+

Code: NCT07546500·Phase 3·Recruiting

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A Clinical Study Evaluating Licaminlimab for Dry Eye Disease

for Dry Eye Disease (DED)

14 locations incl. Aliso Viejo

Sponsor: Oculis

Sex: All·Age: 18+

Code: NCT07548632·Phase 2, Phase 3·Recruiting

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Improving Access to Opioid Use Disorder Treatment Among Marginalized Patients With a Tailored Telehealth Intervention

for Opioid Use Disorder

1 location in Philadelphia

Sponsor: University of Pennsylvania

Sex: All·Age: 18+

Code: NCT06341608·Not Yet Recruiting

Vancomycin and Acute Kidney Injury in Sepsis Treatment - Intervention

for Sepsis

1 location in Philadelphia

Sponsor: Children's Hospital of Philadelphia

Sex: All·Age: 1 Month - 17

Code: NCT07084129·Phase 1·Recruiting

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A Study to Evaluate Safety, Tolerability, and Efficacy of AB-1009 Gene Therapy (GAA Gene) in Adult Participants With Late Onset Pompe Disease (PROGRESS-GT LOPD)

for Pompe Disease (Late-onset)

9 locations incl. Phoenix

Sponsor: AskBio Inc

Sex: All·Age: 18+

Code: NCT07282847·Phase 1, Phase 2·Recruiting

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A Randomized Controlled Trial of Topical 5% Niacinamide for Skin Cancer Prevention in Transplant Recipients

for Skin Cancer

2 locations incl. Pittsburgh

Sponsor: Marissa Lobl

Sex: All·Age: 18+

Code: NCT07286318·EARLY_Phase 1·Not Yet Recruiting

A Clinical Trial of EYE201/MK-8748 in People With Macular Degeneration (MK-8748-003)

for Macular Degeneration

9 locations incl. Mountain View

Sponsor: EyeBiotech Ltd.

Sex: All·Age: 50+

Code: NCT07496567·Phase 2, Phase 3·Recruiting

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AYA-PeerConnect: A Communication Coaching Intervention for Adolescent/Young Adult Cancer Survivors (AYACS)

for Communication

1 location in Hershey

Sponsor: Milton S. Hershey Medical Center

Sex: All·Age: 18 - 35

Code: NCT07454460·Recruiting

Apply to this trial

Improving Hypertension Management Through Preference List Defaults

for Hypertension

1 location in Danville

Sponsor: Geisinger Clinic

Sex: All·Age: 18+

Code: NCT07298694·Enrolling By Invitation

DAREON ® -Lung-1: A Study in People With Advanced Small Cell Lung Cancer to Compare Obrixtamig Plus Atezolizumab, Carboplatin, and Etoposide Treatment With Standard Chemotherapy

for Small Cell Lung Cancer (SCLC)

Drug: Atezolizumab

14 locations incl. Mobile

Sponsor: Boehringer Ingelheim

Sex: All·Age: 18+

Code: NCT07472517·Phase 3·Recruiting

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Consolidative Metastasis and Primary Directed Therapy (MPDT) for Renal Cell Carcinoma (RCC)

for Renal Cell Carcinoma

1 location in Philadelphia

Sponsor: Abramson Cancer Center at Penn Medicine

Sex: All·Age: 18+

Code: NCT06770855·Not Yet Recruiting

Ketamine and Propofol NeuroImaging

for Anesthesia

1 location in Pittsburgh

Sponsor: Keith M Vogt

Sex: All·Age: 18 - 59·Accepts healthy volunteers

Code: NCT07294092·EARLY_Phase 1·Recruiting

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Menopausal HT for Women Living With HIV (HoT)

for HIV Infection

23 locations incl. Birmingham

Sponsor: Advancing Clinical Therapeutics Globally for HIV/AIDS and Other Infections

Sex: Female·Age: 40 - 60

Code: NCT06856174·Phase 4·Recruiting

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A Study to Evaluate Chemotherapy With or Without INCB161734 in Previously Untreated, KRAS G12D-Mutated Metastatic Pancreatic Ductal Adenocarcinoma

for Solid Tumors

Drug: INCB161734

68 locations incl. Birmingham

Sponsor: Incyte Corporation

Sex: All·Age: 18+

Code: NCT07522073·Phase 3·Recruiting

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Testing a Measurement Feedback App to Improve Data Quality, Supervision & Outcomes in Behavioral Health

for Autism

1 location in Philadelphia

Sponsor: University of Pennsylvania

Sex: All·Age: 18+·Accepts healthy volunteers

Code: NCT07042347·Recruiting

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Conquer-AF Protocol for Redo Ablation Procedures in Recurrent Paroxysmal and Persistent Atrial Fibrillation Using the Sphere-9 Catheter and Affera Ablation System (Conquer-AF)

for Atrial Fibrillation (AF)

22 locations incl. Birmingham

Sponsor: Medtronic Cardiac Ablation Solutions

Sex: All·Age: 18+

Code: NCT07298473·Recruiting

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Neoadjuvant CADI-05 in Combination With Pembrolizumab for Surgically Resectable Locally Advanced Head and Neck Squamous Cell Carcinomas

for Squamous Cell Carcinoma of Head and Neck

2 locations incl. Philadelphia

Sponsor: Fox Chase Cancer Center

Sex: All·Age: 18+

Code: NCT07455032·Phase 1·Recruiting

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A Study to Learn About the Safety, Tolerability, and Immunogenicity of a Fifth Dose of 6-Valent OspA-Based Lyme Disease Vaccine

for Lyme Disease

19 locations incl. Bangor

Sponsor: Pfizer

Sex: All·Age: 7+·Accepts healthy volunteers

Code: NCT07500506·Phase 3·Recruiting

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A Study to Evaluate the Long-term Safety and Tolerability of KarXT and KarX-EC for the Treatment of Schizophrenia and Autism-Related Irritability in Adolescents, Respectively

for Schizophrenia

Drug: KarXT

19 locations incl. Anaheim

Sponsor: Karuna Therapeutics, Inc., a Bristol Myers Squibb company

Sex: All·Age: 5 - 17

Code: NCT07424404·Phase 3·Recruiting

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Nutrition Intervention for Pancreatic Cancer

for Pancreatic Ductal Adenocarcinoma (PDAC)

2 locations incl. Philadelphia

Sponsor: Children's Hospital of Philadelphia

Sex: All·Age: 18+

Code: NCT07554560·Recruiting

Apply to this trial

Conversational AI Platform for Early Pregnancy Care City-wide Recruitment: A Feasibility Study

for Early Pregnancy

1 location in Philadelphia

Sponsor: University of Pennsylvania

Sex: Female·Age: 15+

Code: NCT07197892·Recruiting

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Strategy Training for Optimizing Attention for Individuals With Spatial Neglect

for Stroke

1 location in Pittsburgh

Sponsor: University of Pittsburgh

Sex: All·Age: 18+

Code: NCT07331896·Recruiting

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Window of Opportunity in Preserving Laryngeal Function Trial

for Head and Neck Squamous Cell Carcinoma (HNSCC) - Recurrent/Metastatic (R/M)

1 location in Pittsburgh

Sponsor: Matthew Spector

Sex: All·Age: 18+

Code: NCT07423078·Phase 2·Recruiting

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A Study to Evaluate the Efficacy and Safety of ALKS 2680 in Adults With Narcolepsy Type 1

for Narcolepsy Type 1

Drug: ALKS 2680

9 locations incl. Brandon

Sponsor: Alkermes, Inc.

Sex: All·Age: 18 - 70

Code: NCT07455383·Phase 3·Recruiting

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CBG/CBD Oil for Chemotherapy-Induced Peripheral Neuropathy

for Chemotherapy-Induced Peripheral Neuropathy

1 location in Hershey

Sponsor: Milton S. Hershey Medical Center

Sex: All·Age: 21+

Code: NCT07016971·Phase 1·Recruiting

Apply to this trial

Short Course Radiotherapy

for Central Nervous System Cancer

1 location in Philadelphia

Sponsor: Abramson Cancer Center at Penn Medicine

Sex: All·Age: Up to 21

Code: NCT07147179·Recruiting

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Phase 3 Extension Study of ADX-324 in Participants With Hereditary Angioedema (HAE)

for Hereditary Angioedema (HAE)

15 locations incl. Litchfield Park

Sponsor: ADARx Pharmaceuticals, Inc.

Sex: All·Age: 18+

Code: NCT07428499·Phase 3·Recruiting

Apply to this trial

An Evaluation of the Safety and Efficacy of TSND-201 for the Treatment of PTSD (EMPOWER-1)

for Post Traumatic Stress Disorder

26 locations incl. Little Rock

Sponsor: Transcend Therapeutics

Sex: All·Age: 18+

Code: NCT07456696·Phase 3·Recruiting

Apply to this trial

Targeting Ischemia-Induced Autophagy Dependence in Hepatocellular Carcinoma

for Hepatocellular Carcinoma

1 location in Philadelphia

Sponsor: VA Office of Research and Development

Sex: All·Age: 18+

Code: NCT05842174·Phase 1, Phase 2·Recruiting

Apply to this trial

Pilot Study: Establishing Glutamatergic Changes in Rapid Antidepressant Effects of Ketamine

for Major Depressive Disorder (MDD)

1 location in Philadelphia

Sponsor: University of Pennsylvania

Sex: All·Age: 25 - 65

Code: NCT06788249·EARLY_Phase 1·Recruiting

Apply to this trial

INitiation and Titration of Guideline Directed Medical TheRApy in HearT Failure Cardiogenic Shock With ImpElla 5.5 for Cardiac Recovery

for Heart Failure

7 locations incl. Tampa

Sponsor: Abiomed Inc.

Sex: All·Age: 18 - 80

Code: NCT06965504·Not Yet Recruiting

A Multi-Site Hybrid Type I Effectiveness-Implementation Randomized Trial of an Emergency Care Action Plan for Infants With Medical Complexity

for Chronic Disease Management

4 locations incl. Aurora

Sponsor: University of Vermont

Sex: All·Age: 0 Months - 6 Months

Code: NCT06993129·Not Yet Recruiting

Neoadjuvant Intra-tumoral RP2 and FLOT in Gastroesophageal Adenocarcinoma

for Gastric Adenocarcinoma

1 location in Philadelphia

Sponsor: Abramson Cancer Center at Penn Medicine

Sex: All·Age: 18+

Code: NCT07059611·Phase 2·Not Yet Recruiting

Bowel Continence Across the Lifespan in People With Spina Bifida

for Spina Bifida

24 locations incl. Birmingham

Sponsor: David Chu

Sex: All·Age: 5+

Code: NCT07390318·Recruiting

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A Study to Compare Elritercept With Epoetin Alfa to Treat Anemia in Adults With Very Low, Low, or Intermediate Risk Myelodysplastic Syndromes (MDS) Who Need Regular Blood Transfusions

for Myelodysplastic Syndrome

18 locations incl. Orange

Sponsor: Takeda

Sex: All·Age: 18+

Code: NCT07422480·Phase 3·Recruiting

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Engaging M-health for Symptom Monitoring and Health Promotion for Women on Endocrine Therapy for Breast Cancer (EmSHAPE)

for Cancer

1 location in Philadelphia

Sponsor: Abramson Cancer Center at Penn Medicine

Sex: Female·Age: 18+

Code: NCT07454499·Not Yet Recruiting

AERO CAD Study Evaluating the Shockwave C2 Aero IVL System in Coronary Artery Disease

for Coronary Artery Disease (CAD)

8 locations incl. Thousand Oaks

Sponsor: OPCI Core Laboratories LLC

Sex: All·Age: 18+

Code: NCT07512206·Not Yet Recruiting

A Study of Outcomes Following Bio-Reinforced Canaloplasty in Eyes With Open-Angle Glaucoma

for Open-Angle Glaucoma

5 locations incl. Chico

Sponsor: Iantrek, Inc.

Sex: All·Age: All ages

Code: NCT07520175·Enrolling By Invitation