GI oncology Clinical Trials in Philadelphia, PA

As of September 2026, 60 paid clinical trials are recruiting for GI oncology in Philadelphia, Pennsylvania. Compensation typically covers time, travel, and study visits, and many studies also include study-related medical care at no cost.

Recruiting trial data synced daily from ClinicalTrials.gov. Last sync: September 24, 2026.

Filter results

State

City

Facility

Recruitment status

Phase

Study type

Intervention

Condition

Sex

Age

Healthy volunteers only

60 clinical trials for GI oncology

·Clear filters·

Email me when a new gi oncology trial opens in Philadelphia, PA.

Tegavivint for the Treatment of Recurrent or Refractory Solid Tumors, Including Lymphomas and Desmoid Tumors

for Colorectal Carcinoma

Sites in Philadelphia, Pittsburgh +17 more locations

Sponsor: Children's Oncology Group

Sex: All·Age: 12 Months - 30

Code: NCT04851119·Phase 1, Phase 2·Recruiting·Listed Apr 2021

Apply to this trial

A Study of Pembrolizumab With Trastuzumab and Chemotherapy in People With Esophagogastric Cancer

for Esophageal Cancer

Sites in Philadelphia +9 more locations

Sponsor: Memorial Sloan Kettering Cancer Center

Sex: All·Age: 18+

Code: NCT06123338·Phase 2·Recruiting·Listed Nov 2023

Apply to this trial

Maintenance Combinatorial Myeloid Immunotherapy for Unresectable Pancreatic Cancer

for Pancreatic Ductal Adenocarcinoma

1 location in Philadelphia

Sponsor: University of Pennsylvania

Sex: All·Age: 18+

Code: NCT07199764·Phase 2·Recruiting·Listed Sep 2025

Apply to this trial

Y-90 Treatment Response Using Transarterial Radioembolization

for HCC

1 location in Philadelphia

Sponsor: Thomas Jefferson University

Sex: All·Age: 18+

Code: NCT07145801·Phase 2·Recruiting·Listed Aug 2025

Apply to this trial

Study of Suratadenoturev (OBP-301) in Combination With Pembrolizumab in Esophagogastric Adenocarcinoma

for Esophageal Adenocarcinoma

Sites in Philadelphia +1 more location

Sponsor: Weill Medical College of Cornell University

Sex: All·Age: 18+

Code: NCT06340711·Phase 2·Recruiting·Listed Apr 2024

Apply to this trial

Targeting Ischemia-Induced Autophagy Dependence in Hepatocellular Carcinoma

for Hepatocellular Carcinoma

1 location in Philadelphia

Sponsor: VA Office of Research and Development

Sex: All·Age: 18+

Code: NCT05842174·Phase 1, Phase 2·Recruiting·Listed May 2023

Apply to this trial

Collection of Circulating Biomarkers in Pancreatic Cancer

for Pancreas Cancer

1 location in Philadelphia

Sponsor: Abramson Cancer Center at Penn Medicine

Sex: All·Age: 18+

Code: NCT05743049·Recruiting·Listed Feb 2023

Apply to this trial

Combination Therapy in Patients With Localized Pancreatic Ductal Adenocarcinoma

for Pancreatic Ductal Adenocarcinoma

Sites in Philadelphia +4 more locations

Sponsor: Gulam Manji

Sex: All·Age: 18+

Code: NCT06048484·Phase 2·Recruiting·Listed Sep 2023

Apply to this trial

SBRT With Atezo/Bev for HCC

for Hepatocellular Carcinoma

1 location in Philadelphia

Sponsor: Abramson Cancer Center at Penn Medicine

Sex: All·Age: 18 - 99

Code: NCT05488522·Phase 1·Recruiting·Listed Aug 2022

Apply to this trial

Preliminary Evaluation of Screening for Pancreatic Cancer in Patients With Inherited Genetic Risk

for Pancreatic Cancer

1 location in Philadelphia

Sponsor: Abramson Cancer Center at Penn Medicine

Sex: All·Age: 18+

Code: NCT02478892·Recruiting·Listed Jun 2015

Apply to this trial

CTNNA1 Familial Expansion Study

for Cancer Gene Mutation

1 location in Philadelphia

Sponsor: Abramson Cancer Center at Penn Medicine

Sex: All·Age: 18+

Code: NCT05126290·Recruiting·Listed Nov 2021

Apply to this trial

The Cancer of the Pancreas Screening-5 CAPS5)Study

for Pancreas Cancer

Sites in Philadelphia, Pittsburgh +7 more locations

Sponsor: Johns Hopkins University

Sex: All·Age: 18+

Code: NCT02000089·Phase 3·Recruiting·Listed Dec 2013

Apply to this trial

Prehabilitation in High-risk Oncologic Surgery

for Pancreatic Cancer

1 location in Philadelphia

Sponsor: Fox Chase Cancer Center

Sex: All·Age: 18+

Code: NCT07638410·Recruiting·Listed Jun 2026

Apply to this trial

Sonesitatug Vedotin in Combination With Capecitabine With or Without Rilvegostomig in Participants With Advanced or Metastatic Gastric, Gastroesophageal Junction, or Esophageal Adenocarcinoma Expressing Claudin18.2

for Gastric Cancer

Drug: Sonesitatug vedotin

Sites in Philadelphia, Hershey +78 more locations

Sponsor: AstraZeneca

Sex: All·Age: 18+

Code: NCT07431281·Phase 3·Recruiting·Listed Feb 2026

Apply to this trial

A Study of Rilvegostomig or Durvalumab Plus Chemotherapy for First-Line Treatment of Biliary Tract Cancer (ARTEMIDE-Biliary02)

for Biliary Tract Cancer

Drug: Rilvegostomig

Sites in Philadelphia, Lancaster +34 more locations

Sponsor: AstraZeneca

Sex: All·Age: 18+

Code: NCT07221253·Phase 3·Recruiting·Listed Oct 2025

Apply to this trial

A Phase 1 Study of NRM-823 in Participants With Locally Advanced or Metastatic Refractory Solid Tumors

for HNSCC

Sites in Philadelphia +17 more locations

Sponsor: Normunity AccelCo, Inc.

Sex: All·Age: 18+

Code: NCT07182149·Phase 1·Recruiting·Listed Sep 2025

Apply to this trial

DESTINY-PANTUMOUR04

for Adenocarcinoma (NOS)

Sites in Philadelphia +17 more locations

Sponsor: AstraZeneca

Sex: All·Age: 18 - 130

Code: NCT07124000·Recruiting·Listed Aug 2025

Apply to this trial

Phase III Study of Rilvegostomig in Combination With Bevacizumab With or Without Tremelimumab as First-line Treatment of Hepatocellular Carcinoma

for Hepatocellular Carcinoma

Drug: Rilvegostomig

Sites in Philadelphia, Pittsburgh +30 more locations

Sponsor: AstraZeneca

Sex: All·Age: 18+

Code: NCT06921785·Phase 3·Recruiting·Listed Apr 2025

Apply to this trial

Phase 1 Study to Investigate TCRTs KRAS Mutation in Unresectable, Advanced, and/or Metastatic Solid Tumors

for Non-small Cell Lung Cancer

Sites in Philadelphia, Pittsburgh +16 more locations

Sponsor: AstraZeneca

Sex: All·Age: 18+

Code: NCT06218914·Phase 1·Recruiting·Listed Jan 2024

Apply to this trial

Study of Orally Administered MOMA-313 in Participants With Advanced or Metastatic Solid Tumors

for Advanced Solid Tumor

Sites in Philadelphia +7 more locations

Sponsor: MOMA Therapeutics

Sex: All·Age: 18+

Code: NCT06545942·Phase 1·Recruiting·Listed Aug 2024

Apply to this trial

Conditions in GI oncology (Philadelphia, PA)

Colorectal cancer· 27 Pancreatic cancer· 21 Gastric cancer· 15 Esophageal cancer· 10 Liver cancer· 9 Biliary tract cancer· 6 Gastroesophageal junction cancer· 4 Gastrointestinal cancer· 2 Metastatic colorectal cancer· 1