Clinical Trials at Hospital of the University of Pennsylvania

As of August 2026, 79 paid clinical trials are recruiting at Hospital of the University of Pennsylvania, located at 2121 MARKET ST APT 220, PHILADELPHIA, PA 19103-1309, phone (585) 235-7653 in Philadelphia, Pennsylvania. Compensation typically covers time, travel, and study visits — most studies also offer study-related medical care at no cost to participants.

Recruiting trial data synced daily from ClinicalTrials.gov. Last sync: August 13, 2026.

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82 clinical trials at Hospital of the University of Pennsylvania

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CTSN Embolic Protection Trial

for Delirium

Sites in Philadelphia +18 more locations

Sponsor: Icahn School of Medicine at Mount Sinai

Sex: All·Age: 60+

Code: NCT06027788·Recruiting·Listed Sep 2023

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Allergy Delabeling in Antibiotic Stewardship - Intervention

for Beta Lactam Allergy

1 location in Philadelphia

Sponsor: Abramson Cancer Center at Penn Medicine

Sex: All·Age: 18+

Code: NCT07133074·Phase 4·Recruiting·Listed Aug 2025

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Anticoagulation in ICH Survivors for Stroke Prevention and Recovery

for Intracerebral Hemorrhage

Sites in Philadelphia, Hershey +140 more locations

Sponsor: Yale University

Sex: All·Age: 18+

Code: NCT03907046·Phase 3·Recruiting·Listed Apr 2019

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The Diaphragmatic Initiated Ventilatory Assist (DIVA) Trial

for Extubation Failure

Sites in Philadelphia +15 more locations

Sponsor: University of Pennsylvania

Sex: All·Age: 0 Days - 9 Weeks

Code: NCT05446272·Recruiting·Listed Jul 2022

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Lung Injury is One of the Primary Causes of Morbidity and Mortality in Critically Ill Patients. These Patients Will be Monitored for: 1) Immune Cell Activation 2) Blood-based Biomarkers. In Vitro Models Derived From These Samples Will be Treated With Novel Agent PIP-2 to Evaluate Its Efficacy.

for ARDS (Acute Respiratory Distress Syndrome)

1 location in Philadelphia

Sponsor: University of Pennsylvania

Sex: All·Age: 21 - 90

Code: NCT07125079·Recruiting·Listed Aug 2025

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Healing at Home 2.0 - Enhanced Chat Tool for Lowering Postpartum Depression

for Depression, Postpartum

1 location in Philadelphia

Sponsor: University of Pennsylvania

Sex: Female·Age: 18+

Code: NCT06877104·Recruiting·Listed Mar 2025

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An Intervention Mapping Approach to Closing the Gap in Maternal OUD and Infant NAS Care (SUPPORT)

for Opioid Use Disorder

3 locations in Philadelphia

Sponsor: University of Pennsylvania

Sex: All·Age: 18+·Accepts healthy volunteers

Code: NCT06576323·Recruiting·Listed Aug 2024

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Patient Navigation to Improve Surgical Access in Primary Hyperparathyroidism

for Hyperparathyroidism, Primary

1 location in Philadelphia

Sponsor: University of Pennsylvania

Sex: All·Age: 18+

Code: NCT06562881·Recruiting·Listed Aug 2024

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NEPTUNE Match Study

for Nephrotic Syndrome in Children

Sites in Philadelphia +15 more locations

Sponsor: University of Michigan

Sex: All·Age: 1 - 80

Code: NCT04571658·Recruiting·Listed Oct 2020

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Phase I/II Study to Reduce Post-transplantation Cyclophosphamide Dosing for Older or Unfit Patients Undergoing Bone Marrow Transplantation for Hematologic Malignancies

for Hematologic Neoplasms

Sites in Philadelphia +1 more location

Sponsor: National Cancer Institute (NCI)

Sex: All·Age: 12 - 85·Accepts healthy volunteers

Code: NCT04959175·Phase 1, Phase 2·Recruiting·Listed Jul 2021

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Ketamine add-on Therapy for Established Status Epilepticus Treatment Trial (KESETT)

for Status Epilepticus

Sites in Philadelphia, Pittsburgh +50 more locations

Sponsor: University of Virginia

Sex: All·Age: 1+

Code: NCT06907173·Phase 3·Recruiting·Listed Apr 2025

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Azithromycin Prophylaxis for PRElabor CEsarean DElivery Trial

for Obstetrical Complications

Sites in Philadelphia, Pittsburgh +12 more locations

Sponsor: The George Washington University Biostatistics Center

Sex: Female·Age: All ages·Accepts healthy volunteers

Code: NCT06605118·Phase 3·Recruiting·Listed Sep 2024

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Supraglottic Airway for Resuscitation Trial

for Neonatal Resuscitation

Sites in Philadelphia +29 more locations

Sponsor: Children's Hospital of Philadelphia

Sex: All·Age: 0 Days+

Code: NCT07150923·Recruiting·Listed Sep 2025

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Aspirin Dose Escalation for the Prevention of Recurrent Preterm Delivery Trial

for Preterm Delivery

Sites in Philadelphia, Pittsburgh +12 more locations

Sponsor: The George Washington University Biostatistics Center

Sex: Female·Age: 14+·Accepts healthy volunteers

Code: NCT06980025·Phase 3·Recruiting·Listed May 2025

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Uterine Preservation in the Management of Placenta Accreta Spectrum Disorders

for Placenta Accreta Spectrum

1 location in Philadelphia

Sponsor: University of Pennsylvania

Sex: Female·Age: 18+

Code: NCT06512181·Recruiting·Listed Jul 2024

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Randomized Assessment of TcMS for VT Storm

for Ventricular Tachycardia

1 location in Philadelphia

Sponsor: University of Pennsylvania

Sex: All·Age: 18+

Code: NCT05599022·Recruiting·Listed Oct 2022

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Evaluating Novel Healthcare Approaches to Nurturing and Caring for Hospitalized Elders

for Delirium

Sites in Philadelphia, Pittsburgh +5 more locations

Sponsor: University of Michigan

Sex: All·Age: 70+

Code: NCT05929703·Recruiting·Listed Jul 2023

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Prevalence and Clinical Severity of Cutaneous Lupus Erythematosus

for Cutaneous Lupus Erythematosus (CLE)

Sites in Philadelphia +1 more location

Sponsor: University of Pennsylvania

Sex: All·Age: 18+

Code: NCT01510067·Recruiting·Listed Jan 2012

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Autoimmune Blistering Diseases Study

for Pemphigus Vulgaris

3 locations in Philadelphia

Sponsor: University of Pennsylvania

Sex: All·Age: 18+

Code: NCT02753777·Recruiting·Listed Apr 2016

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Clinical Responsiveness of Dermatomyositis Using Cutaneous Dermatomyositis Disease Area and Severity Index (CDASI)

for Dermatomyositis

1 location in Philadelphia

Sponsor: University of Pennsylvania

Sex: All·Age: 18+

Code: NCT02945345·Recruiting·Listed Oct 2016

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Improving Safety and Quality of Tracheal Intubation Practice in Pediatric ICUs

for Failed or Difficult Intubation, Sequela

Sites in Philadelphia, Hershey +49 more locations

Sponsor: Children's Hospital of Philadelphia

Sex: All·Age: All ages

Code: NCT02493478·Recruiting·Listed Jul 2015

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The Erector Spinae Plane Block For Gastrointestinal Malignancy Pain Treatment (EGIPT)

for Gastrointestinal Malignancy

4 locations in Philadelphia

Sponsor: Abramson Cancer Center at Penn Medicine

Sex: All·Age: 18+

Code: NCT07211386·Recruiting·Listed Oct 2025

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iCare4Me Transitions

for Caregiver Stress

3 locations in Philadelphia

Sponsor: University of Pennsylvania

Sex: All·Age: 18+

Code: NCT06167746·Phase 3·Recruiting·Listed Dec 2023

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Gram-Negative Bloodstream Infection Oral Antibiotic Therapy Trial

for Gram-negative Bacteremia

Sites in Philadelphia +10 more locations

Sponsor: Johns Hopkins University

Sex: All·Age: 18+

Code: NCT06080698·Recruiting·Listed Oct 2023

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TUBectomy With Delayed Oophorectomy in High Risk Women to Assess the Safety of Prevention

for BRCA1 Gene Mutation

Sites in Philadelphia +10 more locations

Sponsor: University Medical Center Nijmegen

Sex: Female·Age: 25 - 50

Code: NCT04294927·Recruiting·Listed Mar 2020

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Safe and Explainable AI

for Artifical Inteligence

1 location in Philadelphia

Sponsor: Abramson Cancer Center at Penn Medicine

Sex: All·Age: 18+

Code: NCT06694181·Recruiting·Listed Nov 2024

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External Drainage of Thoracic Duct Lymph to Reduce Inflammatory Cytokines in Septic Shock Patients

for Sepsis

1 location in Philadelphia

Sponsor: University of Pennsylvania

Sex: All·Age: 18 - 80

Code: NCT04855786·Recruiting·Listed Apr 2021

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StrokeNet Thrombectomy Endovascular Platform

for Ischemic Stroke

Sites in Philadelphia, Pittsburgh +39 more locations

Sponsor: Medical University of South Carolina

Sex: All·Age: 18+

Code: NCT06289985·Recruiting·Listed Mar 2024

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Intra-Arterial Tenecteplase to Improve the Microvascular Hemodynamics After Mechanical Thrombectomy

for Acute Ischemic Stroke From Large Vessel Occlusion

1 location in Philadelphia

Sponsor: University of Pennsylvania

Sex: All·Age: 18+

Code: NCT06904911·Phase 2·Recruiting·Listed Apr 2025

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Endovascular Treatment of TAAA and Aortic Arch Aneurysms Using Fenestrated and Branched Stent Grafts

for Aortic Aneurysm, Thoracoabdominal

1 location in Philadelphia

Sponsor: Darren Schneider, M.D.

Sex: All·Age: 18+

Code: NCT02323581·Recruiting·Listed Dec 2014

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Characterization of Cardiac Electrophysiological Effects of Autonomic Neuromodulation

for Ventricular Tachycardia

1 location in Philadelphia

Sponsor: University of Pennsylvania

Sex: All·Age: 18+

Code: NCT05377216·EARLY_Phase 1·Recruiting·Listed May 2022

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Vancomycin Reduction Practices (VRP) in the NICU

for Antibiotic Stewardship

Sites in Philadelphia, West Chester +11 more locations

Sponsor: Children's Hospital of Philadelphia

Sex: All·Age: 18+

Code: NCT06772675·Recruiting·Listed Jan 2025

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Postpartum Care in the NICU (PeliCaN) Transitions

for Stress Disorders, Post-Traumatic

1 location in Philadelphia

Sponsor: University of Pennsylvania

Sex: Female·Age: 16+

Code: NCT06521398·Recruiting·Listed Jul 2024

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T1D Pregnancy & Me

for Diabetes Mellitus, Type 1

Sites in Philadelphia +9 more locations

Sponsor: Jaeb Center for Health Research

Sex: Female·Age: 18+

Code: NCT06959316·Recruiting·Listed May 2025

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Videos to Aid Decision Making for Fibroid Treatment

for Uterine Bleeding

1 location in Philadelphia

Sponsor: University of Pennsylvania

Sex: All·Age: 18 - 55

Code: NCT07072364·Recruiting·Listed Jul 2025

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Multitracer [18F]Fluciclovine and 18F-FDG PET, and Advanced MRI for Metabolic Profiling of Glioblastoma

for Glioblastoma

2 locations in Philadelphia

Sponsor: Abramson Cancer Center at Penn Medicine

Sex: All·Age: 18+

Code: NCT06613841·EARLY_Phase 1·Recruiting·Listed Sep 2024

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Genicular Nerve Block for Knee Pain in the ED

for Knee Pain

4 locations in Philadelphia

Sponsor: University of Pennsylvania

Sex: All·Age: 18+

Code: NCT07158736·Recruiting·Listed Sep 2025

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Foundational Programs to Combat Clinician Stress

for Burnout, Professional

Sites in Philadelphia, Lancaster +4 more locations

Sponsor: Lancaster General Hospital

Sex: All·Age: 25 - 70·Accepts healthy volunteers

Code: NCT07220421·Recruiting·Listed Oct 2025

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Physiologic MR Imaging of Salivary Gland Tumors

for Salivary Gland Tumor

1 location in Philadelphia

Sponsor: Abramson Cancer Center at Penn Medicine

Sex: All·Age: 18+

Code: NCT04452162·Recruiting·Listed Jun 2020

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