Clinical Trials at University of Pennsylvania

As of September 2026, 301 paid clinical trials are recruiting at University of Pennsylvania, located at Perelman School of Medicine at the University of Pennsylvania, 3400 Civic Center Blvd, Philadelphia, PA 19104, phone (215) 898-8001 in Philadelphia, Pennsylvania. Compensation typically covers time, travel, and study visits — most studies also offer study-related medical care at no cost to participants.

Recruiting trial data synced daily from ClinicalTrials.gov. Last sync: September 24, 2026.

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305 clinical trials at University of Pennsylvania

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RE104 Safety and Efficacy Study in Generalized Anxiety Disorder

for Generalized Anxiety Disorder

Sites in Philadelphia, West Chester +26 more locations

Sponsor: Reunion Neuroscience Inc

Sex: All·Age: 18 - 74

Code: NCT07489651·Phase 2·Recruiting·Listed Mar 2026

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A Study to Investigate the Efficacy, Safety and Tolerability of Votoplam in Participants With Huntington's Disease

for Huntington Disease

Sites in Philadelphia, Pittsburgh +38 more locations

Sponsor: Novartis Pharmaceuticals

Sex: All·Age: 21 - 70

Code: NCT07326709·Phase 3·Recruiting·Listed Jan 2026

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Pivotal Study of the SUpira System in Patients Undergoing High-Risk Percutaneous COronaRy InTervention (HRPCI)

for Coronary Artery Disease

Sites in Philadelphia, York +22 more locations

Sponsor: Supira Medical

Sex: All·Age: 18 - 90

Code: NCT07296744·Recruiting·Listed Dec 2025

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A Study of LY4337713 in Participants With FAP-Positive Solid Tumors

for Ovarian Neoplasms

Sites in Philadelphia +18 more locations

Sponsor: Eli Lilly and Company

Sex: All·Age: 18+

Code: NCT07213791·Phase 1·Recruiting·Listed Oct 2025

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Diagnosing Epilepsy To EffeCT Change

for Epilepsy

Sites in Philadelphia +20 more locations

Sponsor: Epiminder America, Inc.

Sex: All·Age: 18 - 75

Code: NCT07110337·Recruiting·Listed Aug 2025

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Long-term Characterization of GORE® TAG® Conformable Thoracic Stent Graft With ACTIVE CONTROL System Performance

for Vascular Disease

Sites in Philadelphia +23 more locations

Sponsor: W.L.Gore & Associates

Sex: All·Age: 18+

Code: NCT06658730·Recruiting·Listed Oct 2024

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A Study of Revumenib in R/R Leukemias Including Those With an MLL/KMT2A Gene Rearrangement or NPM1 Mutation

for Acute Myeloid Leukemia

Drug: Revumenib

Sites in Philadelphia +9 more locations

Sponsor: Syndax Pharmaceuticals

Sex: All·Age: 30 Days+

Code: NCT04065399·Phase 1, Phase 2·Recruiting·Listed Aug 2019

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TVMR With the INNOVALVE System Trial - Early Feasibility Study

for Mitral Valve Regurgitation (Degenerative or Functional)

Sites in Philadelphia +18 more locations

Sponsor: Edwards Lifesciences

Sex: All·Age: 18+

Code: NCT04919980·Recruiting·Listed Jun 2021

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RevCore for In Stent Thrombosis

for In-stent Thrombosis

Sites in Philadelphia, Pittsburgh +13 more locations

Sponsor: Inari Medical

Sex: All·Age: 18+

Code: NCT06394739·Recruiting·Listed May 2024

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A Study of JNJ-88549968 for the Treatment of Calreticulin (CALR)-Mutated Myeloproliferative Neoplasms

for Neoplasms

Sites in Philadelphia +14 more locations

Sponsor: Janssen Research & Development, LLC

Sex: All·Age: 18+

Code: NCT06150157·Phase 1·Recruiting·Listed Nov 2023

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A Study to Test Whether Spesolimab Helps People With a Skin Condition Called Pyoderma Gangrenosum

for Pyoderma Gangrenosum

Sites in Philadelphia +25 more locations

Sponsor: LEO Pharma

Sex: All·Age: 18+

Code: NCT06624670·Phase 3·Recruiting·Listed Oct 2024

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A Study of the Efficacy and Safety of Danicamtiv in Participants With Symptomatic Genetic and Familial Dilated Cardiomyopathy

for Symptomatic Genetic Dilated Cardiomyopathy

Sites in Philadelphia +27 more locations

Sponsor: Kardigan, Inc.

Sex: All·Age: 18+

Code: NCT07210723·Phase 2, Phase 3·Recruiting·Listed Oct 2025

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Diagnosing Epilepsy To EffeCT Change Long-Term Follow-Up

for Epilepsy

Sites in Philadelphia +17 more locations

Sponsor: Epiminder America, Inc.

Sex: All·Age: 18 - 75

Code: NCT07110454·Recruiting·Listed Aug 2025

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A Study of JNJ-90301900 in Combination With Chemoradiation Followed by Consolidation Immunotherapy for Non-Small Cell Lung Cancer (NSCLC)

for Carcinoma, Non-Small-Cell Lung

Sites in Philadelphia +17 more locations

Sponsor: Johnson & Johnson Enterprise Innovation Inc.

Sex: All·Age: 18+

Code: NCT06667908·Phase 2·Recruiting·Listed Oct 2024

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A Study to Test Whether Nerandomilast Can Help Slow Down Changes in the Lung in People With a Family History of Pulmonary Fibrosis

for Familial Pulmonary Fibrosis

Drug: Nerandomilast

Sites in Philadelphia +12 more locations

Sponsor: Boehringer Ingelheim

Sex: All·Age: 40+

Code: NCT07201922·Phase 3·Recruiting·Listed Oct 2025

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A Study of Bispecific Antibody MCLA-158 in Patients With Advanced Solid Tumors

for Advanced/Metastatic Solid Tumors

Sites in Philadelphia +25 more locations

Sponsor: Merus B.V.

Sex: All·Age: 18+

Code: NCT03526835·Phase 1, Phase 2·Recruiting·Listed May 2018

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Phase 1/2 Study of PYX-201 in Combination With Pembrolizumab in Advanced Solid Tumors

for Advanced Solid Tumors

Sites in Philadelphia, Pittsburgh +11 more locations

Sponsor: Pyxis Oncology, Inc

Sex: All·Age: 18+

Code: NCT06795412·Phase 1, Phase 2·Recruiting·Listed Jan 2025

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A Study of the Efficacy and Safety of Lisocabtagene Maraleucel (Liso-cel) as First-Line Therapy in Adults With Transplant-Ineligible Primary Central Nervous System Lymphoma

for Lymphoma

Sites in Philadelphia +13 more locations

Sponsor: Juno Therapeutics, Inc., a Bristol-Myers Squibb Company

Sex: All·Age: 18+

Code: NCT07015242·Phase 2·Recruiting·Listed Jun 2025

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A Study Exploring Changes in a Variety of Biomarkers Following Dosing With MT1988 in Participants at Clinical High Risk for Psychosis

for Clinical High Risk for Psychosis (CHR)

Sites in Philadelphia, Pittsburgh +13 more locations

Sponsor: Monument Therapeutics Limited

Sex: All·Age: 17 - 30

Code: NCT07226895·Phase 1, Phase 2·Recruiting·Listed Nov 2025

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The Use of p48/64 MW HPC Flow Modulation Device in the Treatment of Wide-necked Intracranial Aneurysms

for Hemorrhagic Stroke

Sites in Philadelphia +23 more locations

Sponsor: phenox Inc.

Sex: All·Age: 18+

Code: NCT07143019·Recruiting·Listed Aug 2025

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PANTHER Study of Terumo Aortic Knitted and Woven Grafts, and Cardiovascular Patches

for Aneurysm

Sites in Philadelphia, Allentown +8 more locations

Sponsor: Vascutek Ltd.

Sex: All·Age: 18+

Code: NCT04545502·Recruiting·Listed Sep 2020

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A Study of an MMSET Inhibitor in Patients With Relapsed and Refractory Multiple Myeloma

for Multiple Myeloma

Sites in Philadelphia +16 more locations

Sponsor: K36 Therapeutics, Inc.

Sex: All·Age: 18+

Code: NCT05651932·Phase 1·Recruiting·Listed Dec 2022

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Study of DISC-0974 (RALLY-MF) in Participants With Myelofibrosis or Myelodysplastic Syndrome and Anemia

for Myelofibrosis

Sites in Philadelphia +25 more locations

Sponsor: Disc Medicine, Inc

Sex: All·Age: 18+

Code: NCT05320198·Phase 1, Phase 2·Recruiting·Listed Apr 2022

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A Study to Evaluate the Safety of INCA33890 in Participants With Advanced or Metastatic Solid Tumors

for Solid Tumors

Sites in Philadelphia +10 more locations

Sponsor: Incyte Corporation

Sex: All·Age: 18+

Code: NCT05836324·Phase 1·Recruiting·Listed May 2023

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Real-World Data Collection of the GORE® VIABAHN® VBX Balloon Expandable Endoprosthesis When Used in Covered Endovascular Reconstruction of the Aortic Bifurcation (CERAB) to Treat Aortoiliac Occlusive Disease

for Aortoiliac Occlusive Disease

Sites in Philadelphia, Danville +18 more locations

Sponsor: W.L.Gore & Associates

Sex: All·Age: 18 - 100

Code: NCT06872905·Recruiting·Listed Mar 2025

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MEASuRE: Metreleptin Effectiveness And Safety Registry

for Generalised Lipodystrophy

Sites in Philadelphia +8 more locations

Sponsor: Chiesi Farmaceutici S.p.A.

Sex: All·Age: All ages

Code: NCT02325674·Recruiting·Listed Dec 2014

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Evaluate REC-4881 in Participants With Familial Adenomatous Polyposis (FAP)

for Familial Adenomatous Polyposis

Sites in Philadelphia +6 more locations

Sponsor: Recursion Pharmaceuticals Inc.

Sex: All·Age: 18+

Code: NCT05552755·Phase 1, Phase 2·Recruiting·Listed Sep 2022

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A Phase 1/2, Open-label, Safety and Dosing Study of Autologous CART Cells (Desmoglein 3 Chimeric Autoantibody Receptor T Cells [DSG3-CAART] or CD19-specific Chimeric Antigen Receptor T Cells [CABA-201]) in Subjects With Active, Pemphigus Vulgaris (RESET-PV)

for Pemphigus Vulgaris

Sites in Philadelphia +9 more locations

Sponsor: Cabaletta Bio

Sex: All·Age: 18+

Code: NCT04422912·Phase 1, Phase 2·Recruiting·Listed Jun 2020

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Acellular Dermal Matrix Investigation in Breast Reconstruction

for Breast Reconstruction

Sites in Philadelphia +12 more locations

Sponsor: RTI Surgical

Sex: Female·Age: 22+·Accepts healthy volunteers

Code: NCT06456554·Recruiting·Listed Jun 2024

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A Study Evaluating FMC-376 in Participants With KRAS G12C Mutated Solid Tumors

for Advanced Solid Tumors With KRAS G12C Mutations

Drug: FMC-376

Sites in Philadelphia +11 more locations

Sponsor: Frontier Medicines Corporation

Sex: All·Age: 18+

Code: NCT06244771·Phase 1, Phase 2·Recruiting·Listed Feb 2024

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Study of CP-383 in Patients With Advanced or Metastatic Solid Tumors

for Solid Tumor Malignancies

Sites in Philadelphia +12 more locations

Sponsor: Tasca Therapeutics

Sex: All·Age: 18+

Code: NCT07030257·Phase 1, Phase 2·Recruiting·Listed Jun 2025

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Study of ORIC-114 in Patients With Advanced Solid Tumors Harboring an EGFR or HER2 Alteration

for Solid Tumors

Sites in Philadelphia +16 more locations

Sponsor: ORIC Pharmaceuticals

Sex: All·Age: 18+

Code: NCT05315700·Phase 1, Phase 2·Recruiting·Listed Apr 2022

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A Phase 1/3 Study of T-Cell Receptor Engineered Donor T Cells in Subjects Undergoing Allogeneic Peripheral Blood Stem Cell Transplantation

for AML

Sites in Philadelphia +20 more locations

Sponsor: TScan Therapeutics, Inc.

Sex: All·Age: 18+

Code: NCT05473910·Phase 1·Recruiting·Listed Jul 2022

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Tissue Reinforcement for Breast Reconstruction (TRBR) Pivotal Clinical Study (REDEFINE)

for Breast Reconstruction Surgery

Sites in Philadelphia +19 more locations

Sponsor: W.L.Gore & Associates

Sex: Female·Age: 22+

Code: NCT06556654·Recruiting·Listed Aug 2024

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Terumo Aortic Global Endovascular Registry

for Abdominal Aortic Aneurysm

Sites in Philadelphia, Pittsburgh +15 more locations

Sponsor: Vascutek Ltd.

Sex: All·Age: 18+

Code: NCT04246463·Recruiting·Listed Jan 2020

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Cardiac RADIoablation Versus Repeat Catheter Ablation: a Pivotal Randomized Clinical Trial Evaluating Safety and Efficacy for Patients With High-risk Refractory Ventricular Tachycardia (RADIATE-VT)

for Tachycardia, Ventricular

Sites in Philadelphia, Pittsburgh +9 more locations

Sponsor: Varian, a Siemens Healthineers Company

Sex: All·Age: 18+

Code: NCT05765175·Recruiting·Listed Mar 2023

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Collection of Samples USOPTIVAL Study

for Colorectal Cancer (CRC)

Sites in Philadelphia +3 more locations

Sponsor: Universal Diagnostics

Sex: All·Age: 45 - 84·Accepts healthy volunteers

Code: NCT04792684·Recruiting·Listed Mar 2021

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NORM-HF Pivotal Study

for Heart Failure

Sites in Philadelphia +8 more locations

Sponsor: Foundry Innovation & Research 1, Limited (FIRE1)

Sex: All·Age: 18+

Code: NCT07574593·Recruiting·Listed May 2026

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EXACT Study: A Blinded Study in Patients With Alport Syndrome to Evaluate Exaluren Efficacy and Safety

for Alport Syndrome, X-Linked

Sites in Philadelphia +7 more locations

Sponsor: Eloxx Pharmaceuticals, Inc.

Sex: All·Age: 12+

Code: NCT07523581·Phase 2·Recruiting·Listed Apr 2026

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Study is to Assess the Safety and Tolerability of VTx-002 in Participants With ALS

for Amyotrophic Lateral Sclerosis

Sites in Philadelphia +6 more locations

Sponsor: Vector Y Therapeutics

Sex: All·Age: 18+

Code: NCT07287397·Phase 1, Phase 2·Recruiting·Listed Dec 2025

Apply to this trial