Paid Clinical Trials in South Carolina

South Carolina has 1,217 paid clinical trials enrolling now across cities including Charleston, Greenville and Columbia. Search by condition, age, or phase to find compensated research studies accepting participants near you.

Both patients and healthy volunteers may qualify. Most studies offer compensation for time and travel.

Recruiting trial data synced daily from ClinicalTrials.gov. Last sync: September 14, 2026.

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1,101 clinical trials

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Immune Checkpoint Inhibitor Toxicity Risk Prediction in Solid Tumors

for Malignant Solid Neoplasm

Sites in Charleston, Greenville +586 more locations

Sponsor: SWOG Cancer Research Network

Sex: All·Age: 18+

Code: NCT04871542·Recruiting·Listed May 2021

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OPtimal Adult Heart Transplant Immunosuppression With MicroRNA Levels

for Cardiac Failure

Sites in Charleston +5 more locations

Sponsor: Northwestern University

Sex: All·Age: 18 - 99

Code: NCT06939751·Recruiting·Listed Apr 2025

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Cord Clamping Among Neonates With Congenital Heart Disease

for Congenital Heart Disease (CHD)

Sites in Columbia +17 more locations

Sponsor: Carl Backes, MD

Sex: All·Age: 37 Weeks - 42 Weeks

Code: NCT06153459·Recruiting·Listed Dec 2023

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Standardizing Treatments for Pulmonary Exacerbations - Aminoglycoside Study

for Cystic Fibrosis

Sites in Charleston +58 more locations

Sponsor: Chris Goss

Sex: All·Age: 6+

Code: NCT05548283·Phase 4·Recruiting·Listed Sep 2022

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Anesthetics and Analgesics in Children

for Anesthesia

Sites in Charleston +3 more locations

Sponsor: Chi Dang Hornik

Sex: All·Age: 0 - 17

Code: NCT03427736·Recruiting·Listed Feb 2018

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De-Escalation of Breast Radiation Trial for Hormone Sensitive, HER-2 Negative, Oncotype Recurrence Score Less Than or Equal to 18 Breast Cancer (DEBRA)

for Stage I Breast Cancer

Sites in Charleston, Rock Hill +705 more locations

Sponsor: NRG Oncology

Sex: All·Age: 50 - 70

Code: NCT04852887·Phase 3·Recruiting·Listed Apr 2021

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A Hybrid 1 Effectiveness-Implementation Trial of Partner-Assisted Prolonged Exposure for PTSD

for Post Traumatic Stress Disorder

Sites in Charleston +3 more locations

Sponsor: United States Department of Defense

Sex: All·Age: 18+

Code: NCT06990191·Recruiting·Listed May 2025

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Primary Subtalar Arthrodesis for Calcaneal Fractures

for Calcaneus Fracture

Sites in Greenville +16 more locations

Sponsor: Wake Forest University Health Sciences

Sex: All·Age: 18+

Code: NCT06249126·Recruiting·Listed Feb 2024

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Evaluation of Tirzepatide as an Adjunct to Buprenorphine for the Treatment of Opioid Use Disorder

for Opioid Use Disorder

Drug: Tirzepatide

Sites in Greenville +8 more locations

Sponsor: T. John Winhusen, PhD

Sex: All·Age: 18+

Code: NCT06651177·Phase 2·Recruiting·Listed Oct 2024

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Reducing Dropout and Improving Outcomes From PTSD Therapy: When to Switch Therapies or Stay the Course

for Post Traumatic Stress Disorder

Sites in Charleston +3 more locations

Sponsor: United States Department of Defense

Sex: All·Age: 18+

Code: NCT06957067·Recruiting·Listed May 2025

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Post-stroke Pain tAN-fMRI

for Post Stroke Pain

2 locations in Charleston

Sponsor: Medical University of South Carolina

Sex: All·Age: 18 - 80

Code: NCT07144436·Recruiting·Listed Aug 2025

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Social Functioning in Opioid Use Disorder

for Opioid Use Disorder

1 location in Charleston

Sponsor: Medical University of South Carolina

Sex: All·Age: 18+·Accepts healthy volunteers

Code: NCT07044466·Recruiting·Listed Jul 2025

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Ribociclib And Endocrine Treatment of Physician's Choice for Locoregional Recurrent, Resected Hormone Receptor Positive HER2 Negative Breast Cancer

for Locoregional Recurrence

Drug: Ribociclib

Sites in Charleston +18 more locations

Sponsor: Oana Danciu

Sex: All·Age: 18+

Code: NCT05467891·Phase 2·Recruiting·Listed Jul 2022

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Comparison of Anti-coagulation and Anti-Platelet Therapies for Intracranial Vascular Atherostenosis- Magnetic Resonance Imaging

for Stroke

Sites in Columbia +27 more locations

Sponsor: Yale University

Sex: All·Age: 18+

Code: NCT05907629·Recruiting·Listed Jun 2023

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Correlation of STN-DBS Induced Visuospatial Changes and Freezing of Gait

for Parkinson Disease

1 location in Charleston

Sponsor: Medical University of South Carolina

Sex: All·Age: 18+

Code: NCT06994728·Recruiting·Listed May 2025

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STEPS: Substance Use Trial of E-cigarettes or Pharmacotherapy for Smoking

for Tobacco Use

Sites in Charleston, Greenville +2 more locations

Sponsor: Medical University of South Carolina

Sex: All·Age: 21+·Accepts healthy volunteers

Code: NCT06922617·Recruiting·Listed Apr 2025

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A Study to Determine the Efficacy and Safety of Finerenone on Morbidity and Mortality Among Hospitalized Heart Failure Patients

for Heart Failure

Drug: Finerenone

Sites in Charleston +81 more locations

Sponsor: Colorado Prevention Center

Sex: All·Age: 18+

Code: NCT06008197·Phase 3·Recruiting·Listed Aug 2023

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High-dose Prophylactic Gabapentin (HOPE) vs. Placebo to Prevent Opioid Use for Oral Mucositis Pain During Concurrent Chemoradiation for Head and Neck Cancer

for Head and Neck Squamous Cell Carcinoma

Sites in Spartanburg, Greer +167 more locations

Sponsor: Alliance for Clinical Trials in Oncology

Sex: All·Age: 18+

Code: NCT06992427·Phase 3·Recruiting·Listed May 2025

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Prevention of Ototoxicity in NTM Patients Treated With IV Amikacin

for Ototoxicity, Drug-Induced

Sites in Charleston +7 more locations

Sponsor: Kevin Winthrop

Sex: All·Age: 18 - 80

Code: NCT05730283·Phase 2·Recruiting·Listed Feb 2023

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Development and Evaluation of a Virtual Reality Tool for At-Risk Trauma-Exposed Young People

for Substance Use Disorders

1 location in Charleston

Sponsor: Medical University of South Carolina

Sex: All·Age: 15 - 30·Accepts healthy volunteers

Code: NCT05816083·Recruiting·Listed Apr 2023

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DECIDE: A Comparative Effectiveness Trial of Metformin Versus Insulin for the Treatment of Gestational Diabetes

for Gestational Diabetes Mellitus

Sites in Greenville +20 more locations

Sponsor: Ohio State University

Sex: Female·Age: 18+

Code: NCT06445946·Phase 4·Recruiting·Listed Jun 2024

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Neural Bases of Vocal Sensorimotor Impairment in Aphasia

for Aphasia

Sites in Columbia +2 more locations

Sponsor: The University of Texas at Dallas

Sex: All·Age: 21 - 75·Accepts healthy volunteers

Code: NCT04742894·Recruiting·Listed Feb 2021

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Rett Syndrome Registry

for Rett Syndrome

Sites in Greenwood +18 more locations

Sponsor: International Rett Syndrome Foundation

Sex: All·Age: 0 - 99

Code: NCT05432349·Recruiting·Listed Jun 2022

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Escitalopram and Language Intervention for Subacute Aphasia

for Aphasia

Sites in Charleston, Columbia +1 more location

Sponsor: Johns Hopkins University

Sex: All·Age: 18 - 99

Code: NCT03843463·Phase 2·Recruiting·Listed Feb 2019

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Adding the Immunotherapy Drug Cemiplimab to Usual Treatment for People With Advanced Non-Small Cell Lung Cancer Who Had Previous Treatment With Platinum Chemotherapy and Immunotherapy (An Expanded Lung-MAP Treatment Trial)

for Recurrent Lung Non-Small Cell Carcinoma

Drug: Cemiplimab

Sites in Charleston, Spartanburg +379 more locations

Sponsor: SWOG Cancer Research Network

Sex: All·Age: 18+

Code: NCT06616584·Phase 2, Phase 3·Recruiting·Listed Sep 2024

Apply to this trial

Health Education Approach to Lung Screening

for Lung Cancer

Sites in Charleston +2 more locations

Sponsor: Virginia Commonwealth University

Sex: All·Age: 50 - 80·Accepts healthy volunteers

Code: NCT06070870·Recruiting·Listed Oct 2023

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Improving Needs Among Older Adults

for Critical Illness

Sites in Charleston +3 more locations

Sponsor: Duke University

Sex: All·Age: 18+

Code: NCT06588556·Recruiting·Listed Sep 2024

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Combining rTMS & Aerobic Exercise to Treat Depression and Improve Post-Stroke Walking

for Stroke

Sites in Charleston +1 more location

Sponsor: Medical University of South Carolina

Sex: All·Age: 21+

Code: NCT07050355·Recruiting·Listed Jul 2025

Apply to this trial

The Society for Obstetric Anesthesia and Perinatology Research Network General Anesthesia Registry

for Cesarean Delivery

Sites in Charleston +32 more locations

Sponsor: Yale University

Sex: Female·Age: 15 - 55·Accepts healthy volunteers

Code: NCT06030063·Recruiting·Listed Sep 2023

Apply to this trial

The ECOG-ACRIN SUPPORT Trial: Multilevel Intervention to Improve Diverse Enrollment in Cancer Clinical Trials

for Cancer

Sites in Bluffton, Hilton Head Island +65 more locations

Sponsor: Eastern Cooperative Oncology Group

Sex: All·Age: 18+

Code: NCT06756607·Recruiting·Listed Jan 2025

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Imaging Biomarkers of FOG Response to DBS

for Freezing of Gait Symptoms in Parkinson&#39

1 location in Charleston

Sponsor: Medical University of South Carolina

Sex: All·Age: 40+

Code: NCT06951906·Phase 4·Recruiting·Listed Apr 2025

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Robotic Versus Open Ventral Hernia Repair

for Ventral Hernia

Sites in Greenville +4 more locations

Sponsor: Lucas Beffa

Sex: All·Age: 18+·Accepts healthy volunteers

Code: NCT05472987·Recruiting·Listed Jul 2022

Apply to this trial

CARS: Cannabis and Alcohol Reduction Study

for Cannabis Use

1 location in Charleston

Sponsor: Medical University of South Carolina

Sex: All·Age: 13 - 17

Code: NCT05486234·Recruiting·Listed Aug 2022

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S1703 Serum Tumor Marker Directed Disease Monitoring in Patients With Hormone Receptor Positive Her2 Negative Metastatic Breast Cancer

for Anatomic Stage IV Breast Cancer AJCC v8

Sites in Greenville, Greer +584 more locations

Sponsor: SWOG Cancer Research Network

Sex: All·Age: 18+

Code: NCT03723928·Recruiting·Listed Oct 2018

Apply to this trial

A Clinical Trial of Adaptive Treatment for Early Smoking Cessation Relapse

for Cigarette Smoking

1 location in Charleston

Sponsor: Medical University of South Carolina

Sex: All·Age: 21+·Accepts healthy volunteers

Code: NCT06118502·Recruiting·Listed Nov 2023

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Targeted Treatment for Advanced Non-Small Cell Lung Cancer That Has a MET Exon 14 Skipping Gene Change (An Expanded Lung-MAP Treatment Trial)

for Recurrent Lung Non-Small Cell Carcinoma

Sites in Anderson +240 more locations

Sponsor: SWOG Cancer Research Network

Sex: All·Age: 18 Minutes+

Code: NCT06031688·Phase 2·Recruiting·Listed Sep 2023

Apply to this trial

taVNS or TMS or Both for Depression

for Depression

1 location in Charleston

Sponsor: Medical University of South Carolina

Sex: All·Age: 18 - 75

Code: NCT05725239·Recruiting·Listed Feb 2023

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Intraoperative Molecular Imaging Using ICG for Head and Neck Tumors

for Squamous Cell Carcinoma Head and Neck Cancer (HNSCC)

1 location in Charleston

Sponsor: Medical University of South Carolina

Sex: All·Age: 18+

Code: NCT07149207·Phase 2·Recruiting·Listed Aug 2025

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Phase 3 Study of Teclistamab in Combination With Lenalidomide and Teclistamab Alone Versus Lenalidomide Alone in Participants With Newly Diagnosed Multiple Myeloma as Maintenance Therapy Following Autologous Stem Cell Transplantation

for Multiple Myeloma

Drug: Teclistamab

Sites in Charleston, Spartanburg +39 more locations

Sponsor: European Myeloma Network B.V.

Sex: All·Age: 18+

Code: NCT05243797·Phase 3·Recruiting·Listed Feb 2022

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Intravitreal Faricimab Injections or Fluocinolone Acetonide (0.19 mg) Intravitreal Implants vs Observation for Prevention of VA Loss Due to Radiation Retinopathy

for Radiation Retinopathy

Sites in Greenville +26 more locations

Sponsor: Jaeb Center for Health Research

Sex: All·Age: 18+

Code: NCT05844982·Phase 3·Recruiting·Listed May 2023

Apply to this trial