Paid Clinical Trials in South Carolina

South Carolina has 1,217 paid clinical trials enrolling now across cities including Charleston, Greenville and Columbia. Search by condition, age, or phase to find compensated research studies accepting participants near you.

Both patients and healthy volunteers may qualify. Most studies offer compensation for time and travel.

Recruiting trial data synced daily from ClinicalTrials.gov. Last sync: September 14, 2026.

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1,101 clinical trials

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Optimizing Tobacco Treatment Delivery for People Living With HIV

for Hiv

1 location in Charleston

Sponsor: Medical University of South Carolina

Sex: All·Age: 21+

Code: NCT05019495·Recruiting·Listed Aug 2021

Apply to this trial

A Trial of Varenicline for E-cigarette Cessation

for E-cigarette Use

Sites in Charleston +1 more location

Sponsor: Yale University

Sex: All·Age: 18+

Code: NCT07040566·Phase 2·Recruiting·Listed Jun 2025

Apply to this trial

Physical Capacity Building for Chronic Stroke

for Stroke

1 location in Charleston

Sponsor: Medical University of South Carolina

Sex: All·Age: 18 - 80

Code: NCT07039305·Recruiting·Listed Jun 2025

Apply to this trial

IV Gallium Study for Patients With Cystic Fibrosis Who Have NTM (ABATE Study)

for Nontuberculous Mycobacterium Infection

Sites in Charleston +9 more locations

Sponsor: Chris Goss

Sex: All·Age: 18+

Code: NCT04294043·Phase 1·Recruiting·Listed Mar 2020

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Impact of Nd:YAG Laser Photobiostimulation on Healing of Gingiva

for Wound Healing and Prevention

1 location in Charleston

Sponsor: Medical University of South Carolina

Sex: All·Age: 18+·Accepts healthy volunteers

Code: NCT07095556·Recruiting·Listed Jul 2025

Apply to this trial

High Dose Testosterone for ATM, CDK12 or CHEK2 Altered Prostate Cancers

for Metastatic Prostate Cancer

Sites in Charleston +16 more locations

Sponsor: VA Office of Research and Development

Sex: Male·Age: 18+

Code: NCT05011383·Phase 2·Recruiting·Listed Aug 2021

Apply to this trial

Autophagy Maintenance (AUTOMAIN)

for Ovarian Cancer

1 location in Charleston

Sponsor: Medical University of South Carolina

Sex: All·Age: 18+

Code: NCT06971744·Phase 2·Recruiting·Listed May 2025

Apply to this trial

Multisensory Augmentation for Post-stroke Standing Balance

for Stroke

1 location in Charleston

Sponsor: VA Office of Research and Development

Sex: All·Age: 21+

Code: NCT05760885·EARLY_Phase 1·Recruiting·Listed Mar 2023

Apply to this trial

Melanoma Margins Trial-II: 1cm v 2cm Wide Surgical Excision Margins for AJCC Stage II Primary Cutaneous Melanoma

for Cutaneous Melanoma, Stage II

Sites in Charleston +129 more locations

Sponsor: Melanoma and Skin Cancer Trials Limited

Sex: All·Age: 18+

Code: NCT03860883·Recruiting·Listed Mar 2019

Apply to this trial

sTMS Combined With CIMT and taVNS In Infants With Hemiplegia

for Hemiplegia

1 location in Charleston

Sponsor: Medical University of South Carolina

Sex: All·Age: 8 Months - 24 Months

Code: NCT07063446·Recruiting·Listed Jul 2025

Apply to this trial

Optimal Digital Weight Loss Treatment for Rural Individuals

for Overweight and Obesity

1 location in Columbia

Sponsor: University of South Carolina

Sex: All·Age: 18+·Accepts healthy volunteers

Code: NCT06105957·Recruiting·Listed Oct 2023

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RM1 Project 2 - tAN fMRI

for Auricular Stimulation

1 location in Charleston

Sponsor: Medical University of South Carolina

Sex: All·Age: 18 - 65·Accepts healthy volunteers

Code: NCT05487664·Recruiting·Listed Aug 2022

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RM1 Project 1 - tAN Naloxone

for Analgesia

1 location in Charleston

Sponsor: Medical University of South Carolina

Sex: All·Age: 18 - 65·Accepts healthy volunteers

Code: NCT05490134·EARLY_Phase 1·Recruiting·Listed Aug 2022

Apply to this trial

BabySTrong II taVNS Feeding Trial

for Feeding Delays

1 location in Charleston

Sponsor: Medical University of South Carolina

Sex: All·Age: 39 Weeks - 54 Weeks

Code: NCT07049952·Phase 2, Phase 3·Recruiting·Listed Jul 2025

Apply to this trial

Multi-Site Trial of Navigation vs Treatment as Usual to Improve Initiation of Timely Adjuvant Therapy

for Head and Neck Cancer

Sites in Charleston +3 more locations

Sponsor: Medical University of South Carolina

Sex: All·Age: 18+

Code: NCT05793151·Recruiting·Listed Mar 2023

Apply to this trial

SMYLS Multi-site Trial

for Sickle Cell Disease

1 location in Charleston

Sponsor: Medical University of South Carolina

Sex: All·Age: 14 - 21·Accepts healthy volunteers

Code: NCT06035939·Recruiting·Listed Sep 2023

Apply to this trial

Pistachio Snacking and Metabolic Flexibility

for Overweight (BMI &gt

1 location in Columbia

Sponsor: University of South Carolina

Sex: All·Age: 25 - 45·Accepts healthy volunteers

Code: NCT07340125·Recruiting·Listed Jan 2026

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Advanced Wireless Augmented Reality-Enhanced Exposure Therapy for Posttraumatic Stress Disorder

for PTSD

1 location in Charleston

Sponsor: Wayne State University

Sex: All·Age: 18+

Code: NCT06740487·Recruiting·Listed Dec 2024

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A Study to Evaluate Finerenone on Clinical Efficacy and Safety in Patients With Heart Failure Who Are Intolerant or Not Eligible for Treatment With Steroidal Mineralocorticoid Receptor Antagonists

for Heart Failure

Drug: Finerenone

Sites in Orangeburg +53 more locations

Sponsor: Colorado Prevention Center

Sex: All·Age: 18+

Code: NCT06033950·Phase 3·Recruiting·Listed Sep 2023

Apply to this trial

Fueling Strong Hearts for a Strong South Carolina

for Stroke

1 location in Florence

Sponsor: Clemson University

Sex: All·Age: 45 - 80

Code: NCT07140952·Recruiting·Listed Aug 2025

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Integrated Treatment for Opioid Use Disorder and PTSD

for Opioid Use Disorder

1 location in Charleston

Sponsor: Medical University of South Carolina

Sex: All·Age: 18 - 70

Code: NCT06641115·Recruiting·Listed Oct 2024

Apply to this trial

ACTION: Trial of Adding Buprenorphine, CBT, and TMS to Improve Outcomes of Long-Term Opioid Therapy for Chronic Pain

for Opioid Withdrawal

1 location in Charleston

Sponsor: Medical University of South Carolina

Sex: All·Age: 18+·Accepts healthy volunteers

Code: NCT06442566·Phase 1, Phase 2·Recruiting·Listed Jun 2024

Apply to this trial

Quantitative Cardiac Parametric Mapping

for Cardiomyopathy, Myocarditis, Ischemic Heart Disease

1 location in Charleston

Sponsor: Medical University of South Carolina

Sex: All·Age: 18 - 90·Accepts healthy volunteers

Code: NCT02855554·Recruiting·Listed Aug 2016

Apply to this trial

SCORE Emerging Adult Cannabis Use & Stress

for Cannabis Use Disorder

1 location in Charleston

Sponsor: Medical University of South Carolina

Sex: All·Age: 18 - 25

Code: NCT05885542·Phase 1, Phase 2·Recruiting·Listed Jun 2023

Apply to this trial

AFO Prescription to Optimize Post-Stroke Function

for Ankle Foot Orthosis (AFO)

Sites in Charleston +3 more locations

Sponsor: University of Texas at Austin

Sex: All·Age: 18+

Code: NCT06692686·Recruiting·Listed Nov 2024

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Case Series on the Clinical Performance of VA Clavicle and Clavicle Hook Plate 2.7 Systems

for Clavicle

Sites in Columbia +2 more locations

Sponsor: AO Innovation Translation Center

Sex: All·Age: 18+

Code: NCT04921865·Recruiting·Listed Jun 2021

Apply to this trial

Cognitive Decline Following Deep Brain Stimulation: A DBS-fMRI Study

for Deep Brain Stimulation

1 location in Charleston

Sponsor: Medical University of South Carolina

Sex: All·Age: 18+·Accepts healthy volunteers

Code: NCT06960096·Recruiting·Listed May 2025

Apply to this trial

Enroll -HD: A Prospective Registry Study in a Global Huntington's Disease Cohort

for Huntington's Disease

Sites in Columbia +51 more locations

Sponsor: CHDI Foundation, Inc.

Sex: All·Age: 18+·Accepts healthy volunteers

Code: NCT01574053·Recruiting·Listed Apr 2012

Apply to this trial

Mobile Supportive Teams for Reinforcing Increased Daily Exercise Study

for Physical Activity

1 location in Columbia

Sponsor: University of South Carolina

Sex: All·Age: 18+·Accepts healthy volunteers

Code: NCT06662292·Recruiting·Listed Oct 2024

Apply to this trial

NAC vs Placebo on Opioid Use for Hysterectomy

for Hysterectomy

1 location in Charleston

Sponsor: Medical University of South Carolina

Sex: All·Age: 18+

Code: NCT06039566·Phase 3·Recruiting·Listed Sep 2023

Apply to this trial

Modulating Escape Using Focused Ultrasound

for Anxiety Disorders

1 location in Charleston

Sponsor: Medical University of South Carolina

Sex: All·Age: 18 - 65

Code: NCT06273904·Recruiting·Listed Feb 2024

Apply to this trial

Neuropathic Pain and Operant Conditioning of Cutaneous Reflexes After SCI

for Spinal Cord Injuries

1 location in Charleston

Sponsor: Medical University of South Carolina

Sex: All·Age: 18+

Code: NCT05492188·Recruiting·Listed Aug 2022

Apply to this trial

Effects of Dexrazoxane Hydrochloride on Biomarkers Associated With Cardiomyopathy and Heart Failure After Cancer Treatment

for Hodgkin Lymphoma in Remission

Sites in Charleston, Greenville +54 more locations

Sponsor: Children's Oncology Group

Sex: All·Age: All ages

Code: NCT01790152·Recruiting·Listed Feb 2013

Apply to this trial

Ablation-Index Guided Scar-Mediated Ventricular Tachycardia Ablation in Patients With Ischemic Cardiomyopathy

for Ventricular Tachycardia

Sites in Charleston +4 more locations

Sponsor: Rush University Medical Center

Sex: All·Age: 18+

Code: NCT06138873·Recruiting·Listed Nov 2023

Apply to this trial

Operant Conditioning of Spinal Reflexes Training System--Reflex Operant Down Conditioning

for Spinal Cord Injuries

2 locations in Charleston

Sponsor: Medical University of South Carolina

Sex: All·Age: 18+

Code: NCT05094362·Recruiting·Listed Oct 2021

Apply to this trial

The Pediatric Anesthesia Quality Improvement Project

for Surgery

Sites in Charleston +36 more locations

Sponsor: The Society for Pediatric Anesthesia

Sex: All·Age: Up to 21

Code: NCT00674388·Recruiting·Listed May 2008

Apply to this trial

American Hepato-Pancreato-Biliary Association (AHPBA) Pancreatic Irreversible Electroporation (IRE) Registry

for Pancreatic Cancer

Sites in Spartanburg +10 more locations

Sponsor: University of Louisville

Sex: All·Age: 18+

Code: NCT02674100·Recruiting·Listed Feb 2016

Apply to this trial

A Peer Recovery Coaching Intervention for Hospitalized Alcohol Use Disorder Patients

for Alcohol Use Disorder

Sites in Greenville & Seneca

Sponsor: Clemson University

Sex: All·Age: 18 - 75

Code: NCT06479681·Recruiting·Listed Jun 2024

Apply to this trial

EMG-Controlled Game to Retrain Upper Extremity Muscle Activation Patterns Following Stroke

for Stroke

1 location in Charleston

Sponsor: VA Office of Research and Development

Sex: All·Age: 18+·Accepts healthy volunteers

Code: NCT05628324·Recruiting·Listed Nov 2022

Apply to this trial

Screening Women With Prior HPV for Anal Neoplasia

for HPV-related Lower Genital Tract Neoplasias

Sites in Charleston +2 more locations

Sponsor: Icahn School of Medicine at Mount Sinai

Sex: Female·Age: 35+

Code: NCT05217940·Recruiting·Listed Feb 2022

Apply to this trial