GI oncology Clinical Trials in St Louis, MO

As of September 2026, 69 paid clinical trials are recruiting for GI oncology in St Louis, Missouri. Compensation typically covers time, travel, and study visits, and many studies also include study-related medical care at no cost.

Recruiting trial data synced daily from ClinicalTrials.gov. Last sync: September 1, 2026.

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70 clinical trials for GI oncology

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Tegavivint for the Treatment of Recurrent or Refractory Solid Tumors, Including Lymphomas and Desmoid Tumors

for Colorectal Carcinoma

Sites in St Louis +18 more locations

Sponsor: Children's Oncology Group

Sex: All·Age: 12 Months - 30

Code: NCT04851119·Phase 1, Phase 2·Recruiting·Listed Apr 2021

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Radiotherapy in Combination With TTI-101 in Borderline Resectable and Locally Advanced Pancreatic Ductal Adenocarcinoma

for Pancreatic Cancer

1 location in St Louis

Sponsor: Washington University School of Medicine

Sex: All·Age: 18+

Code: NCT06141031·Phase 1·Recruiting·Listed Nov 2023

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MicroEnvironment Tumor Effects of Radiotherapy - Comprehensive Radiobiology Assessment TRial

for Locally Advanced Cervical Carcinoma

1 location in St Louis

Sponsor: Washington University School of Medicine

Sex: All·Age: 18+

Code: NCT05975593·Recruiting·Listed Aug 2023

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Obeticholic Acid for Prevention in Barrett's Esophagus

for Barrett Esophagus

Sites in St Louis +7 more locations

Sponsor: National Cancer Institute (NCI)

Sex: All·Age: 18+

Code: NCT04939051·Phase 2·Recruiting·Listed Jun 2021

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Itraconazole in Combination With Ablation for the Prevention of Esophageal Cancer in Patients With High-risk Barrett's Esophagus

for Barrett Esophagus

Sites in St Louis +5 more locations

Sponsor: National Cancer Institute (NCI)

Sex: All·Age: 18+

Code: NCT06732388·Phase 2·Recruiting·Listed Dec 2024

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Implementing a Randomized Control Trial to Test the Expanded Web-based Decision Aid

for Cholangiocarcinoma

1 location in St Louis

Sponsor: Washington University School of Medicine

Sex: All·Age: 18+

Code: NCT06910670·Recruiting·Listed Apr 2025

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Washington University Participant Engagement and Cancer Genomic Sequencing Center (WU-PE-CGS)

for Cholangiocarcinoma

1 location in St Louis

Sponsor: Washington University School of Medicine

Sex: All·Age: 18+

Code: NCT06340646·Recruiting·Listed Apr 2024

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Assessing Benefits and Harms of Cannabis/Cannabinoid Use Among Cancer Patients Treated in Community Oncology Clinics

for Breast Carcinoma

Sites in St Louis, Ballwin +462 more locations

Sponsor: Wake Forest University Health Sciences

Sex: All·Age: 18+

Code: NCT06418204·Recruiting·Listed May 2024

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Phase 1/2 Trial of S241656 in Selected RAS/MAPK Mutation- Positive Malignancies

for Non-small Cell Lung Cancer

Sites in St Louis +19 more locations

Sponsor: Institut de Recherches Internationales Servier

Sex: All·Age: 18+

Code: NCT05786924·Phase 1, Phase 2·Recruiting·Listed Mar 2023

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Testing for Safety and Colorectal Cancer Preventive Effects of ONC201

for Colorectal Adenomatous Polyp

Sites in St Louis +4 more locations

Sponsor: National Cancer Institute (NCI)

Sex: All·Age: 18+

Code: NCT05630794·Phase 1·Recruiting·Listed Nov 2022

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Stereotactic Body Radiotherapy Plus FAK and RAF/MEK Inhibition in Advanced Pancreatic Adenocarcinoma

for Pancreatic Adenocarcinoma

1 location in St Louis

Sponsor: Washington University School of Medicine

Sex: All·Age: 18+

Code: NCT07126158·Phase 2·Recruiting·Listed Aug 2025

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Myopenia and Mechanisms of Chemotherapy Toxicity in Older Adults With Colorectal Cancer

for Colorectal Cancer

Sites in St Louis, Sullivan +140 more locations

Sponsor: Wake Forest University Health Sciences

Sex: All·Age: 60+

Code: NCT03998202·Recruiting·Listed Jun 2019

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MK2 Inhibitor in Combination With mFOLFIRINOX for Untreated Metastatic Pancreatic Ductal Adenocarcinoma

for Metastatic Pancreatic Ductal Adenocarcinoma

1 location in St Louis

Sponsor: Washington University School of Medicine

Sex: All·Age: 18+

Code: NCT06648434·Phase 1·Recruiting·Listed Oct 2024

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CA-4948 in Combination With FOLFOX/PD-1 Inhibitor +/- Trastuzumab for Untreated Unresectable Gastric and Esophageal Cancer

for Gastric Cancer

1 location in St Louis

Sponsor: Washington University School of Medicine

Sex: All·Age: 18+

Code: NCT05187182·Phase 1·Recruiting·Listed Jan 2022

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Epacadostat (INCB024360) Added to Preoperative Chemoradiation in Patients With Locally Advanced Rectal Cancer

for Rectal Cancer

Sites in St Louis +1 more location

Sponsor: Washington University School of Medicine

Sex: All·Age: 18+

Code: NCT03516708·Phase 1, Phase 2·Recruiting·Listed May 2018

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Circulating Tumor DNA (ctDNA) for Early Treatment Response Assessment of Solid Tumors

for Healthy Volunteer

1 location in St Louis

Sponsor: Washington University School of Medicine

Sex: All·Age: 18+·Accepts healthy volunteers

Code: NCT04354064·Recruiting·Listed Apr 2020

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Surveillance vs. Endoscopic Therapy for Barrett's Esophagus With Low-grade Dysplasia

for Barretts Esophagus With Dysplasia

Sites in St Louis +22 more locations

Sponsor: University of Colorado, Denver

Sex: All·Age: 18 - 89

Code: NCT05753748·Recruiting·Listed Mar 2023

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Ultrasound and Photoacoustic Imaging for Enhanced Differential Diagnosis of Rectal Cancer

for Rectal Cancer

1 location in St Louis

Sponsor: Washington University School of Medicine

Sex: All·Age: 19+

Code: NCT04339374·Recruiting·Listed Apr 2020

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ColoCare Study - Colorectal Cancer Cohort

for Colorectal Cancer

Sites in St Louis +5 more locations

Sponsor: University of Utah

Sex: All·Age: 18 - 89

Code: NCT02328677·Recruiting·Listed Dec 2014

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TREAT-BE Study (Treatment With Resection and Endoscopic Ablation Techniques for Barrett's Esophagus)

for Barrett's Esophagus

Sites in St Louis +3 more locations

Sponsor: University of Colorado, Denver

Sex: All·Age: 18 - 100·Accepts healthy volunteers

Code: NCT02634645·Recruiting·Listed Dec 2015

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Sonesitatug Vedotin in Combination With Capecitabine With or Without Rilvegostomig in Participants With Advanced or Metastatic Gastric, Gastroesophageal Junction, or Esophageal Adenocarcinoma Expressing Claudin18.2

for Gastric Cancer

Drug: Sonesitatug vedotin

Sites in St Louis, Kansas City +70 more locations

Sponsor: AstraZeneca

Sex: All·Age: 18+

Code: NCT07431281·Phase 3·Recruiting·Listed Feb 2026

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First-in-Human Study of PLX-61639 in Locally Advanced or Metastatic Solid Tumors

for Esophageal Squamous Cell Carcinoma

Sites in St Louis +9 more locations

Sponsor: Plexium, Inc.

Sex: All·Age: 18+

Code: NCT07284186·Phase 1·Recruiting·Listed Dec 2025

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A Phase 1 Study of NRM-823 in Participants With Locally Advanced or Metastatic Refractory Solid Tumors

for HNSCC

Sites in St Louis +17 more locations

Sponsor: Normunity AccelCo, Inc.

Sex: All·Age: 18+

Code: NCT07182149·Phase 1·Recruiting·Listed Sep 2025

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Phase 1 Study to Investigate TCRTs KRAS Mutation in Unresectable, Advanced, and/or Metastatic Solid Tumors

for Non-small Cell Lung Cancer

Sites in St Louis +17 more locations

Sponsor: AstraZeneca

Sex: All·Age: 18+

Code: NCT06218914·Phase 1·Recruiting·Listed Jan 2024

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Phase 3 Study of T-DXd and Rilvegostomig Versus SoC in Advanced HER2-expressing Biliary Tract Cancer

for Biliary Tract Cancer

Drug: Rilvegostomig

Sites in St Louis, Kansas City +29 more locations

Sponsor: AstraZeneca

Sex: All·Age: 18 - 99

Code: NCT06467357·Phase 3·Recruiting·Listed Jun 2024

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First in Human Study to Evaluate AZD9793 in Participants With Advanced or Metastatic Solid Tumours

for Hepatocellular Carcinoma

Sites in St Louis +5 more locations

Sponsor: AstraZeneca

Sex: All·Age: 18+

Code: NCT06795022·Phase 1, Phase 2·Recruiting·Listed Jan 2025

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Study of Orally Administered MOMA-313 in Participants With Advanced or Metastatic Solid Tumors

for Advanced Solid Tumor

Sites in St Louis +7 more locations

Sponsor: MOMA Therapeutics

Sex: All·Age: 18+

Code: NCT06545942·Phase 1·Recruiting·Listed Aug 2024

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Phase III Study of Rilvegostomig in Combination With Bevacizumab With or Without Tremelimumab as First-line Treatment of Hepatocellular Carcinoma

for Hepatocellular Carcinoma

Drug: Rilvegostomig

Sites in St Louis +30 more locations

Sponsor: AstraZeneca

Sex: All·Age: 18+

Code: NCT06921785·Phase 3·Recruiting·Listed Apr 2025

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A Phase Ⅲ Study of Rilvegostomig in Combination With Fluoropyrimidine and Trastuzumab Deruxtecan as the First-line Treatment for HER2-positive Gastric Cancer

for HER2-positive Gastric Cancer

Drug: Rilvegostomig

Sites in St Louis +44 more locations

Sponsor: AstraZeneca

Sex: All·Age: 18+

Code: NCT06764875·Phase 3·Recruiting·Listed Jan 2025

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Conditions in GI oncology (St Louis, MO)

Colorectal cancer· 34 Pancreatic cancer· 19 Esophageal cancer· 15 Gastric cancer· 13 Liver cancer· 9 Rectal cancer· 7 Colon cancer· 6 Biliary tract cancer· 6 Gastroesophageal junction cancer· 5 Metastatic colorectal cancer· 3 Gastrointestinal cancer· 1