Paid Clinical Trials in St Louis, MO
As of August 2026, 1,397 paid clinical trials are recruiting in St Louis, Missouri. Compensation typically covers time, travel, and study visits, with stipends ranging from modest amounts for short outpatient studies to several thousand dollars for long or inpatient protocols.
St Louis offers studies at sites including Washington University School of Medicine for conditions such as Breast Cancer, Prostate Cancer, Colorectal Cancer, Advanced Solid Tumor. Both patients with specific conditions and healthy volunteers can qualify. Most trials offer free study-related medical care alongside compensation.
Recruiting trial data synced daily from ClinicalTrials.gov. Last sync: .
Trials by specialty in St Louis
Trials by drug in St Louis
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Newly added in St Louis
Posted to ClinicalTrials.gov within the last 60 days — these studies are just starting to recruit.
CAMPR-II RWE TRIAL: A Saline-hydrated Allogeneic Dual-layer Amniotic Membrane Product or a Synthetic, Resorbable Polymeric Wound Matrix to a Coarsened Exact Matched Retrospective Control Cohort of Hard to Heal DFUs and VLUs
Cardiac Magnetic Resonance and Echocardiography Study With Acoramidis
Leveraging mHealth to Promote Opioid Use Recovery and Mental Health Among Residents of a Medium-Sized Midwestern City
A Master Protocol to Investigate Efficacy and Safety of Elecoglipron in Participants With Obesity or Overweight With or Without T2DM
A Phase III Study to Investigate the Efficacy and Safety of Elecoglipron Alone or in Combination With Dapagliflozin Compared With Placebo in Adults With Type 2 Diabetes Mellitus
1,269 clinical trials
A Study to Evaluate the Efficacy and Safety of Elismetrep (K-304) in the Acute Treatment of Migraine
A Study to Evaluate Efficacy, Safety, and Immunogenicity With ABP 938 8 mg Versus EYLEA® HD (Aflibercept) in Participants With Neovascular Age-related Macular Degeneration
A Research Study to Look at How Well NNC0487-0111 Works Compared to Placebo in People With Heart Failure and Obesity
A Phase 3 Trial of DT120 for Major Depressive Disorder (Ascend)
A Research Study to Look at How Two Different Doses of CagriSema and One Dose of Semaglutide Help People Living With Obesity With or Without Type 2 Diabetes Lose Weight
An Open Label Extension (OLE) Study (Following Completion of CTQJ230A12301) to Evaluate Long-term Safety and Tolerability of Pelacarsen (TQJ230)
Multicenter Study to Assess the Efficacy and Safety of LB-102 in the Treatment of Adult Patients With BP1MDE.
Symbiotic-GU-06: A Study to Learn About PF-08634404 Alone or In Combination With Enfortumab Vedotin in Urothelial Cancer
A Trial to Investigate Safety, Exposure, and Efficacy of HU6 Compared With Placebo in Adult Participants With Metabolic Dysfunction-associated Steatohepatitis (MASH)
CAPRI: A Phase 3 Randomized, Double-Masked Study Comparing the Efficacy of EYP-1901 Against Aflibercept in DME
Implementation Study of Lenacapavir Pre-exposure Prophylaxis for HIV Prevention
A Study of Brenipatide in Adult Participants With Major Depressive Disorder
LY4268989 in Adults With Moderately to Severely Active Ulcerative Colitis
A Study of Brenipatide in Adult Participants With Schizophrenia
A Study to Evaluate the Effectiveness and Safety of Setidegrasib, Given With Either mFOLFIRINOX or NALIRIFOX Chemotherapies, in People With Pancreatic Cancer
A 26-Wk Study to Assess Safety & Efficacy of Tenapanor for T/t of Chronic Idiopathic Constipation in Adults
A Phase 3 Trial to Compare IV BCV Versus IV CDV for Treatment of Adenovirus Infection After Allo-HCT
A Study to Learn About the Study Medicine Called PF-07275315 in People With Moderate to Severe Chronic Obstructive Pulmonary Disease
A Study of a Thyroid Hormone Receptor Beta Isoform (THRβ) Agonist and an Semicarbazide Sensitive Amine Oxidase (SSAO) Inhibitor, Alone and in Combination, in Adults With Presumed Metabolic Dysfunction-associated Steatohepatitis (MASH)
A Study to Evaluate the Efficacy and Safety of Standard-of-Care Chemotherapy and Bevacizumab With or Without INCA33890 in the First-Line Treatment of Metastatic Microsatellite Stable Colorectal Cancer
A Study of Imlunestrant (LY3484356) in Premenopausal Women With Estrogen Receptor-Positive (ER+) Human Epidermal Growth Factor Receptor 2 Negative (HER2-) Early Breast Cancer
A Study to Learn About a Clostridioides Difficile Vaccine in People 65 Years of Age and Older
A Study of Amivantamab in Addition to Standard of Care Agents (SOC) Compared With SOC Alone in Participants With Recurrent/Metastatic Head and Neck Cancer
Study of DONQ52 in Active Celiac Disease
A Study of Pasritamig With Docetaxel Versus Docetaxel in Participants With Metastatic Castration-Resistant Prostate Cancer
A Study to Evaluate the Efficacy, Safety, and Tolerability of VIM0423 in Individuals With Isolated Dystonia
Symbiotic-GI-13: A Study to Learn About Study Medicine Called PF-08634404 as a Single Treatment and Combination Treatment in Adult Participants With a Liver Cancer Called Hepatocellular Carcinoma, That is Too Advanced to be Removed by Surgery and May Have Spread to Other Parts of the Body.
A Study to Evaluate the Safety and Efficacy of Pumitamig in Combination With Chemotherapy Versus Bevacizumab in Combination With Chemotherapy in Participants With Previously Untreated, Unresectable, or Metastatic Colorectal Cancer
A Study of Vepugratinib (LY3866288) in Participants With Cancer in the Urinary Tract
Study to Assess the Adverse Events of Oral ABBV-932 in Adult Participants With Depressive Episodes Associated With Bipolar I or II Disorder
Screening Study to Determine Individuals With Potential Trial Eligibility for Alzheimer's Disease Studies
OCEAN(a)-PreEvent - Olpasiran Trials of Cardiovascular Events And LipoproteiN(a) Reduction to Prevent First Major Cardiovascular Events
Study to Evaluate INCB123667 Versus Investigator's Choice of Chemotherapy in Participants With Platinum-Resistant Ovarian Cancer With Cyclin E1 Overexpression
EASi-PROTKT™ - A Study to Test Vicadrostat (BI 690517) Taken Together With Empagliflozin in People With Type 2 Diabetes, High Blood Pressure, and Cardiovascular Disease
CLEOPATTRA: A Research Study to Look at the Effects of Treatment With a Medicine Called Coramitug (NNC6019-0001) in People With Heart Failure Due to Transthyretin Amyloid (ATTR) Amyloidosis
BEATRIX: A Study to Learn About a Group B Streptococcus Vaccine in Healthy Pregnant Women and Their Babies
A Study of Trontinemab in Participants With Early Symptomatic Alzheimer's Disease
Study to Assess the Efficacy and Safety of Rina-S Compared to Treatment of Investigator's Choice in Participants With Endometrial Cancer
Evaluating the Impact of Maridebart Cafraglutide on Cardiovascular Outcomes in Participants With Atherosclerotic Cardiovascular Disease and Overweight or Obesity
Pharmacokinetics, Safety, and Efficacy of Povorcitinib in Adolescent Participants With Moderate to Severe Hidradenitis Suppurativa
Top Research Study Locations in St Louis
Researchers run research studies in St Louis, MO at 25 active sites. The clinics below currently host the largest number of recruiting studies — each name is followed by the conditions they focus on most.
| Site | Specializes in | Active trials |
|---|---|---|
| Washington University School of Medicine | Breast Cancer, Colorectal Cancer, Prostate Cancer | 457 |
| Washington University | Advanced Solid Tumor, Amyotrophic Lateral Sclerosis, CRC | 136 |
| Mercy Hospital Saint Louis | Malignant Solid Neoplasm, Anatomic Stage II Breast Cancer AJCC v8, Stage IIIB Lung Cancer AJCC v8 | 90 |
| Washington University in St. Louis | Cardiovascular Diseases, Dementia, Acute Stress Disorder | 85 |
| Mercy Hospital South | Stage IV Lung Cancer AJCC v8, Malignant Solid Neoplasm, Stage IIIB Lung Cancer AJCC v8 | 80 |
| Missouri Baptist Medical Center | Stage IV Lung Cancer AJCC v8, Stage IVB Prostate Cancer AJCC v8, Anatomic Stage II Breast Cancer AJCC v8 | 77 |
| Siteman Cancer Center-South County | Acute Myeloid Leukemia, Stage IVB Prostate Cancer AJCC v8, Anatomic Stage II Breast Cancer AJCC v8 | 70 |
| Siteman Cancer Center at Christian Hospital | Acute Myeloid Leukemia, Stage IVB Prostate Cancer AJCC v8, Anatomic Stage II Breast Cancer AJCC v8 | 64 |
| Mercy Infusion Center - Chippewa | Malignant Solid Neoplasm, RISS Stage I Plasma Cell Myeloma, RISS Stage II Plasma Cell Myeloma | 25 |
| Cardinal Glennon Children's Medical Center | Neuroblastoma, Osteosarcoma, Ewing Sarcoma | 23 |
| Washington University School of Medicine in St. Louis | Ovarian Cancer, Lymphoma, Acute Myeloid Leukemia | 23 |
| St. Louis Children's Hospital | Adolescent Idiopathic Scoliosis, Advanced Solid Tumor, Autoimmune Hepatitis | 19 |
| Saint Louis University | Opioid Use, ACL Surgery, ALS | 18 |
| Barnes Jewish Hospital | Intracerebral Hemorrhage, Ischemic Stroke, Aortic Aneurysm, Abdominal | 14 |
| Siteman Cancer Center | Breast Cancer, Advanced Hepatocellular Carcinoma, Advanced/Metastatic Urothelial Cancer | 12 |
| Arch Clinical Trials | Schizophrenia, Bipolar 1 Disorder, Bipolar Disorder | 11 |
| Barnes-Jewish Hospital | Acute Ischemic Stroke, Advanced Hepatocellular Carcinoma, Advanced/Metastatic Urothelial Cancer | 10 |
| Washington University School of Medicine - Siteman Cancer Center | Advanced Hepatocellular Carcinoma, Advanced Solid Tumors, Adult, Advanced/Metastatic Urothelial Cancer | 9 |
| Washington University, St. Louis | Acute Myeloid Leukemia, Acute Stress Reaction, Alzheimer Disease | 9 |
| The Washington University | Chronic Inflammatory Demyelinating Polyradiculoneuropathy (CIDP), Back Pain, Capsular Contracture Associated With Breast Implant | 8 |
| Washington University in St Louis | AML, Adult, Advanced Solid Tumor, Asymptomatic Bacteriuria | 8 |
| Washington University Medical Center | ALK-Positive Lung Cancer, ALK-positive NSCLC, ALK-positive Non-small Cell Lung Cancer | 7 |
| Washington University St. Louis | Acute Lymphoblastic Leukemia (ALL), Acute Myelogenous Leukemia (AML or ANLL), Advanced Solid Tumors | 7 |
| GSK Investigational Site | Non-alcoholic Fatty Liver Disease, Asthma, Gastrointestinal Neoplasms | 6 |
| Saint Louis Cancer and Breast Institute-South City | Metastatic Malignant Neoplasm in the Brain, Acral Lentiginous Melanoma, Anatomic Stage IV Breast Cancer AJCC v8 | 6 |
Active & Upcoming Studies in St Louis (2026)
Recruiting trials in St Louis grouped by therapeutic area, drawn from ClinicalTrials.gov. Each bucket shows the most recent example studies.
Cancer & tumors (541 active studies)
- TeamTalk: Improving Inter-professional Communication During Cancer Treatment · Washington University School of Medicine
- Total Neoadjuvant Therapy With Short Course Radiation Therapy in Gastric Cancer · Phase 2 · Washington University School of Medicine
Neurology & pain (96 active studies)
- Semaglutide for Low Back Pain · Phase 2 · Washington University School of Medicine
- A Long-Term Safety Study of Elismetrep (K-304) in the Acute Treatment of Migraine · Phase 3 · Kallyope Inc.
Cardiovascular (65 active studies)
- A Prospective, Randomized Multicenter Clinical Trial of the TricValve® Transcatheter Bicaval Valve System in Subjects With Severe Tricuspid Regurgitation. · P+F Products + Features USA Inc.
- A Study of LY3971297 in Participants With Heart Failure · Phase 1 · Eli Lilly and Company
Diabetes & metabolic (42 active studies)
- Semaglutide for Low Back Pain · Phase 2 · Washington University School of Medicine
- A Research Study Investigating How Well the Medicine Zenagamtide Helps People With Excess Body Weight Lose Weight Compared to Semaglutide · Phase 3 · Novo Nordisk A/S
Mental health & behavior (41 active studies)
- Relapse Prevention Trial Evaluating KarXT Treatment in Schizophrenia · Phase 3 · Karuna Therapeutics, Inc., a Bristol Myers Squibb company
- Lumateperone for Late-Life Depression · Phase 3 · Eric Lenze
Pediatric (21 active studies)
- TeamTalk: Improving Inter-professional Communication During Cancer Treatment · Washington University School of Medicine
- Weight Gain in Pediatric Leukemia Survivors · Washington University School of Medicine
HIV / STI (12 active studies)
- A Study of GS-3242 in Combination With Lenacapavir Versus Biktarvy in Virologically Suppressed People With HIV-1 · Phase 2 · Gilead Sciences
- Menopausal HT for Women Living With HIV (HoT) · Phase 4 · Advancing Clinical Therapeutics Globally for HIV/AIDS and Other Infections
Eye & vision (11 active studies)
- A Comparative, Randomized, Investigator-blind, Active-controlled, Parallel-group, Multicenter, Clinical Endpoint Study · Phase 3 · YS Life Science Co., Ltd.
- A Study to Evaluate Efficacy, Safety, and Immunogenicity With ABP 938 8 mg Versus EYLEA® HD (Aflibercept) in Participants With Neovascular Age-related Macular Degeneration · Phase 3 · Amgen
Vaccines (6 active studies)
- A Safety and Immunogenicity Trial of OCU500, ChAd36 Vector Encoding SARS-CoV-2 Spike Vaccine Via Intranasal and Inhalational Routes in Previously Vaccinated Adults · Phase 1 · National Institute of Allergy and Infectious Diseases (NIAID)
- Characterizing the Human Airway Immune Response to FluMist Vaccination · Phase 4 · Washington University School of Medicine
Common conditions studied in St Louis
- Breast Cancer (35 active studies)
- Prostate Cancer (31 active studies)
- Colorectal Cancer (22 active studies)
- Advanced Solid Tumor (21 active studies)
- Acute Myeloid Leukemia (19 active studies)
- Alzheimer Disease (19 active studies)
Leading research sponsors in St Louis
- Washington University School of Medicine
- National Cancer Institute (NCI)
- AstraZeneca
- Children's Oncology Group
- Eli Lilly and Company
Frequently asked questions
How many paid clinical trials are currently recruiting in St Louis?
There are approximately 1,397 recruiting clinical trials in St Louis, Missouri listed on ClinicalTrials.gov. The number changes weekly as new studies open and others close enrollment.
Do clinical trials in St Louis pay participants?
Most recruiting trials in St Louis compensate participants for their time, travel, and study visits. Compensation varies by sponsor, study phase, and visit requirements — the exact amount is disclosed by the study team during the informed consent process.
Who can participate in a clinical trial in St Louis?
Eligibility depends on the specific study. Each trial defines its own inclusion criteria (age, diagnosis, medical history, prior treatments) and exclusion criteria. Both patients with specific conditions and healthy volunteers can qualify, depending on the study design.
What conditions are most commonly studied in St Louis?
The most common conditions under active study in St Louis include Breast Cancer (35), Prostate Cancer (31), Colorectal Cancer (22), Advanced Solid Tumor (21), among many others. Browse the list above to explore every recruiting trial.
Are there clinical trials for healthy volunteers in St Louis?
Yes. Healthy-volunteer studies — often early-phase pharmacology or vaccine trials — recruit in St Louis on an ongoing basis. Use the "Healthy volunteers only" filter above to view trials that accept participants without the study's target condition.
How do I enroll in a clinical trial in St Louis?
Click any study title above to see the full study record, including eligibility criteria, visit schedule, and the study team's contact information. Reach out to the central contact or recruiting site directly — they will guide you through screening and informed consent.
Where can I take part in paid clinical trials in St Louis?
Recruiting research sites in St Louis include Washington University School of Medicine, Washington University, Mercy Hospital Saint Louis, among others. Each site lists its open studies and contact information on the study record above — call or email the site coordinator to ask about screening for a specific protocol.
What kinds of studies are recruiting in St Louis right now?
The largest active categories in St Louis are Cancer & tumors (541), Neurology & pain (96), Cardiovascular (65). Use the filters above to narrow by therapeutic area, phase, age, or healthy-volunteer eligibility.