Paid Clinical Trials in St Louis, MO

As of August 2026, 1,397 paid clinical trials are recruiting in St Louis, Missouri. Compensation typically covers time, travel, and study visits, with stipends ranging from modest amounts for short outpatient studies to several thousand dollars for long or inpatient protocols.

Both patients with specific conditions and healthy volunteers can qualify. Most trials offer free study-related medical care alongside compensation.

Recruiting trial data synced daily from ClinicalTrials.gov. Last sync: August 10, 2026.

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1,269 clinical trials

A Pragmatic Clinical Trial of the WE BEAT Well-Being Education Program in Adolescent Congenital Heart Disease: WE BEAT CHD Study

for Patient-Reported Outcome Measures (PROMs)

Sites in St Louis +13 more locations

Sponsor: Carelon Research

Sex: All·Age: 12 - 17

Code: NCT07525843·Recruiting·Listed Apr 2026

Apply to this trial

A Study of Methylprednisolone in People Having Liver Surgery

for Hepatectomy

Sites in St Louis +18 more locations

Sponsor: Memorial Sloan Kettering Cancer Center

Sex: All·Age: 18+

Code: NCT07507643·Phase 3·Recruiting·Listed Apr 2026

Apply to this trial

Feasibility of HPV Self-Collection Kits for Cervical Cancer Screening

for Cervical Cancer

1 location in St Louis

Sponsor: Washington University School of Medicine

Sex: Female·Age: 25+·Accepts healthy volunteers

Code: NCT07453459·Recruiting·Listed Mar 2026

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Prospective Randomized Trial Comparing Longitudinal vs. Transverse A1 Pulley Release

for Trigger Finger

Sites in St Louis +1 more location

Sponsor: Washington University School of Medicine

Sex: All·Age: 18+

Code: NCT07516652·Recruiting·Listed Apr 2026

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Testing the Addition of Anti-Cancer Drug Sonrotoclax, to the Standard Treatment Zanubrutinib, for Previously Untreated CLL/SLL

for Chronic Lymphocytic Leukemia

Drug: Sonrotoclax

Sites in St Louis, Creve Coeur +179 more locations

Sponsor: Alliance for Clinical Trials in Oncology

Sex: All·Age: 65+

Code: NCT07321652·Phase 3·Recruiting·Listed Jan 2026

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Adding Biotherapy or Placebo to Standard Treatment for Advanced Kidney Cancer

for Advanced Clear Cell Renal Cell Carcinoma

Sites in St Louis, Sullivan +39 more locations

Sponsor: SWOG Cancer Research Network

Sex: All·Age: 18+

Code: NCT07383441·Phase 3·Recruiting·Listed Feb 2026

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Studying the PAGODA Algorithm for Chemotherapy Dose Changes to Prevent Unplanned Treatment Delays

for Ampulla of Vater Carcinoma

Sites in St Louis, Ballwin +347 more locations

Sponsor: Alliance for Clinical Trials in Oncology

Sex: All·Age: 18+·Accepts healthy volunteers

Code: NCT07283939·Recruiting·Listed Dec 2025

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Inflammation in Primary and Secondary Malignancies of the Central Nervous System Using [C-11]-CS1P1

for Central Nervous System Cancer

1 location in St Louis

Sponsor: Washington University School of Medicine

Sex: All·Age: 18+

Code: NCT07462507·Phase 2·Recruiting·Listed Mar 2026

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Remote Ischemic Conditioning for PwSCI

for Spinal Cord Injuries

1 location in St Louis

Sponsor: Washington University School of Medicine

Sex: All·Age: 18+

Code: NCT07488793·Recruiting·Listed Mar 2026

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Safety and Efficacy of CTX-009 With or Without CTX-471 for Recurrent Glioblastoma

for Glioblastoma

1 location in St Louis

Sponsor: Washington University School of Medicine

Sex: All·Age: 18+

Code: NCT07392957·Phase 1, Phase 2·Recruiting·Listed Feb 2026

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PET Imaging of MMP Activation in AAA: Clinical Component

for Abdominal Aortic Aneurysm

1 location in St Louis

Sponsor: Washington University School of Medicine

Sex: All·Age: 18+·Accepts healthy volunteers

Code: NCT07473102·EARLY_Phase 1·Recruiting·Listed Mar 2026

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First-Line Ipilimumab Plus Nivolumab and Nogapendekin Alfa Inbakicept (N-803) in Patients With Stage IV or Recurrent Non-Small Cell Lung Cancer

for Non-small Cell Lung Cancer Stage IV

Drug: Ipilimumab

1 location in St Louis

Sponsor: Washington University School of Medicine

Sex: All·Age: 18+

Code: NCT07355205·Phase 1, Phase 2·Recruiting·Listed Jan 2026

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5-Fluorouracil Response and Optimization STudy (The FROST Trial)

for Squamous Cell Carcinoma of Head and Neck

1 location in St Louis

Sponsor: Washington University School of Medicine

Sex: All·Age: 18+

Code: NCT07419464·Phase 2·Recruiting·Listed Feb 2026

Apply to this trial

PREcision MEDicine In Achalasia (PREMEDIA) - Cohort

for Type III Achalasia

Sites in St Louis +14 more locations

Sponsor: Northwestern University

Sex: All·Age: 18+

Code: NCT07293689·Recruiting·Listed Dec 2025

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Study to Enable New Diagnostics for Pulmonary Microbes in People With CF

for Cystic Fibrosis (CF)

Sites in St Louis +8 more locations

Sponsor: Chris Goss

Sex: All·Age: 16+

Code: NCT07312734·Recruiting·Listed Dec 2025

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PREcision MEDicine In Achalasia (PREMEDIA)

for Type I Achalasia

Sites in St Louis +14 more locations

Sponsor: Northwestern University

Sex: All·Age: 18+

Code: NCT07293650·Phase 3·Recruiting·Listed Dec 2025

Apply to this trial

Therapeutic RSK1 Targeting in Myelofibrosis

for Myelofibrosis

1 location in St Louis

Sponsor: Washington University School of Medicine

Sex: All·Age: 18+

Code: NCT07379125·Phase 1·Recruiting·Listed Jan 2026

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Patient Position Monitoring System for Beam Gated Radiation Therapy of Malignancies of the Chest and Upper Abdomen

for Radiotherapy

1 location in St Louis

Sponsor: Washington University School of Medicine

Sex: All·Age: 18+

Code: NCT07373496·Recruiting·Listed Jan 2026

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Non-invasive Vagus Nerve Stimulation to Reduce Inflammation and Brain Injury Blood Biomarkers Following an Acute Ischemic Stroke

for Large Vessel Occlusion

1 location in St Louis

Sponsor: Washington University School of Medicine

Sex: All·Age: 18 - 99

Code: NCT07404852·Recruiting·Listed Feb 2026

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CARE Tool Study Aim 3

for Gynecologic Cancer

Sites in St Louis, Rolla +1 more location

Sponsor: Washington University School of Medicine

Sex: All·Age: 18+

Code: NCT07296887·Recruiting·Listed Dec 2025

Apply to this trial

Whole Genome Sequencing (ChromoSeq®) for Acute Lymphoblastic Leukemia (ALL) Patients

for Acute Lymphoblastic Leukemia

1 location in St Louis

Sponsor: Washington University School of Medicine

Sex: All·Age: Up to 30

Code: NCT07313592·Recruiting·Listed Jan 2026

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Reduction of Bacterial Seeding in Total Shoulder Arthroplasty

for Joint Arthroplasty

1 location in St Louis

Sponsor: St. Louis University

Sex: Male·Age: 18+

Code: NCT07406893·Recruiting·Listed Feb 2026

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Tofersen in Non-SOD1 ALS

for ALS (Amyotrophic Lateral Sclerosis)

Sites in St Louis +2 more locations

Sponsor: Washington University School of Medicine

Sex: All·Age: 18+

Code: NCT07294144·Phase 2·Recruiting·Listed Dec 2025

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Family Communications After Genetic Testing

for Colon Adenocarcinoma

Sites in St Louis, Ballwin +288 more locations

Sponsor: Alliance for Clinical Trials in Oncology

Sex: All·Age: 18+·Accepts healthy volunteers

Code: NCT07143487·Recruiting·Listed Aug 2025

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Testing Different Dosing Schedules of the Anti-cancer Drug, Lutetium 177Lu PSMA RLT and Its Effect on Patients With Advanced Prostate Cancer, RECIPROCAL Trial

for Metastatic Castration-Resistant Prostate Carcinoma

Sites in St Louis, Saint Joseph +71 more locations

Sponsor: Alliance for Clinical Trials in Oncology

Sex: Male·Age: 18+

Code: NCT07200830·Phase 3·Recruiting·Listed Oct 2025

Apply to this trial

Healthy Behaviors for Insomnia Prevention in People With HIV and Ongoing Pain

for Chronic Pain

1 location in St Louis

Sponsor: Washington University School of Medicine

Sex: All·Age: 25 - 65

Code: NCT07270406·Recruiting·Listed Dec 2025

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Evaluating the Addition of Adjuvant Chemotherapy to Ovarian Function Suppression Plus Endocrine Therapy in Premenopausal Patients With pN0-1, ER-Positive/HER2-Negative Breast Cancer and an Oncotype Recurrence Score Less Than or Equal to 25

for Breast Cancer

Sites in St Louis, Creve Coeur +1098 more locations

Sponsor: NRG Oncology

Sex: Female·Age: 18 - 60

Code: NCT05879926·Phase 3·Recruiting·Listed May 2023

Apply to this trial

Health Information for Persons With Spinal Cord Injury

for Spinal Cord Injuries (SCI)

1 location in St Louis

Sponsor: Washington University School of Medicine

Sex: All·Age: 18+

Code: NCT07386522·Recruiting·Listed Feb 2026

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Testing the Addition of a Type of Drug Called Immunotherapy to the Usual Chemotherapy Treatment for Non-small Cell Lung Cancer, an ALCHEMIST Treatment Trial (Chemo-IO [ACCIO])

for Lung Non-Small Cell Carcinoma

Sites in St Louis, Creve Coeur +631 more locations

Sponsor: National Cancer Institute (NCI)

Sex: All·Age: 18+

Code: NCT04267848·Phase 3·Recruiting·Listed Feb 2020

Apply to this trial

Colon Adjuvant Chemotherapy Based on Evaluation of Residual Disease

for Stage III Colon Cancer

Sites in St Louis, Creve Coeur +913 more locations

Sponsor: NRG Oncology

Sex: All·Age: 18+

Code: NCT05174169·Phase 2, Phase 3·Recruiting·Listed Dec 2021

Apply to this trial

Testing an Enhanced Digital Delivery Model for Inherited Cancer Genetic Testing in Young Adults With Cancer

for Miscellaneous Neoplasm, Nos

Sites in St Louis, Ballwin +276 more locations

Sponsor: Alliance for Clinical Trials in Oncology

Sex: All·Age: 18+·Accepts healthy volunteers

Code: NCT07091617·Recruiting·Listed Jul 2025

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Pembrolizumab vs. Observation in People With Triple-negative Breast Cancer Who Had a Pathologic Complete Response After Chemotherapy Plus Pembrolizumab

for Anatomic Stage II Breast Cancer AJCC v8

Sites in St Louis, Creve Coeur +777 more locations

Sponsor: Alliance for Clinical Trials in Oncology

Sex: All·Age: 18+

Code: NCT05812807·Phase 3·Recruiting·Listed Apr 2023

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Vismodegib, FAK Inhibitor GSK2256098, Capivasertib, and Abemaciclib in Treating Patients With Progressive Meningiomas

for Intracranial Meningioma

Sites in St Louis, Ballwin +444 more locations

Sponsor: Alliance for Clinical Trials in Oncology

Sex: All·Age: 18+

Code: NCT02523014·Phase 2·Recruiting·Listed Aug 2015

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mFOLFIRINOX Versus mFOLFOX With or Without Nivolumab for the Treatment of Advanced, Unresectable, or Metastatic HER2 Negative Esophageal, Gastroesophageal Junction, and Gastric Adenocarcinoma

for Advanced Esophageal Adenocarcinoma

Drug: Nivolumab

Sites in St Louis, Ballwin +630 more locations

Sponsor: Alliance for Clinical Trials in Oncology

Sex: All·Age: 18+

Code: NCT05677490·Phase 3·Recruiting·Listed Jan 2023

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ShortStop-HER2: 12 Months vs. 6 Months of HER2-targeted Medications for People With HER2+ Breast Cancer Who Had a Pathologic Complete Response After Chemotherapy Plus Trastuzumab

for Anatomic Stage I Breast Cancer AJCC v8

Sites in St Louis, Creve Coeur +591 more locations

Sponsor: Alliance for Clinical Trials in Oncology

Sex: All·Age: 18+

Code: NCT06876714·Phase 3·Recruiting·Listed Mar 2025

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Testing the Addition of Chemotherapy or Chemo-Immunotherapy to the Usual Surgery for Advanced Head and Neck Cancer

for Clinical Stage II HPV-Mediated (p16-Positive) Oropharyngeal Carcinoma AJCC v8

Sites in St Louis, Creve Coeur +98 more locations

Sponsor: National Cancer Institute (NCI)

Sex: All·Age: 18+

Code: NCT07195734·Phase 2·Recruiting·Listed Sep 2025

Apply to this trial

Collecting Blood Samples From Patients With and Without Cancer to Evaluate Tests for Early Cancer Detection

for Acute Lymphoblastic Leukemia

Sites in St Louis, Ballwin +616 more locations

Sponsor: Alliance for Clinical Trials in Oncology

Sex: All·Age: 40 - 75·Accepts healthy volunteers

Code: NCT05334069·Recruiting·Listed Apr 2022

Apply to this trial

Spatiotemporal tSCS in Spinal Cord Injury

for Spinal Cord Injuries (SCI)

1 location in St Louis

Sponsor: Washington University School of Medicine

Sex: All·Age: 16 - 65

Code: NCT07397559·Recruiting·Listed Feb 2026

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Testing Early Treatment for Patients With High-Risk Chronic Lymphocytic Leukemia (CLL) or Small Lymphocytic Leukemia (SLL), EVOLVE CLL/SLL Study

for Chronic Lymphocytic Leukemia

Sites in St Louis, Chesterfield +295 more locations

Sponsor: National Cancer Institute (NCI)

Sex: All·Age: 18+

Code: NCT04269902·Phase 3·Recruiting·Listed Feb 2020

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Testing Olaparib for One or Two Years, With or Without Bevacizumab, to Treat Ovarian Cancer

for Fallopian Tube Endometrioid Adenocarcinoma

Drug: Bevacizumab

Sites in St Louis, Ballwin +653 more locations

Sponsor: NRG Oncology

Sex: All·Age: 18+

Code: NCT06580314·Phase 3·Recruiting·Listed Aug 2024

Apply to this trial