Paid Clinical Trials in St Louis, MO

As of August 2026, 1,397 paid clinical trials are recruiting in St Louis, Missouri. Compensation typically covers time, travel, and study visits, with stipends ranging from modest amounts for short outpatient studies to several thousand dollars for long or inpatient protocols.

Both patients with specific conditions and healthy volunteers can qualify. Most trials offer free study-related medical care alongside compensation.

Recruiting trial data synced daily from ClinicalTrials.gov. Last sync: August 10, 2026.

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1,269 clinical trials

Targeted Treatment for Metastatic Prostate Cancer, The PREDICT Trial

for Castration-Resistant Prostate Carcinoma

Sites in St Louis, Creve Coeur +98 more locations

Sponsor: Alliance for Clinical Trials in Oncology

Sex: All·Age: 18+

Code: NCT06632977·Phase 2·Recruiting·Listed Oct 2024

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A Study With Tovorafenib (DAY101) as a Treatment Option for Progressive, Relapsed, or Refractory Langerhans Cell Histiocytosis

for Recurrent Langerhans Cell Histiocytosis

Sites in St Louis +103 more locations

Sponsor: National Cancer Institute (NCI)

Sex: All·Age: 180 Days - 22

Code: NCT05828069·Phase 2·Recruiting·Listed Apr 2023

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A Study of the Drugs Selumetinib vs. Carboplatin and Vincristine in Patients With Low-Grade Glioma

for Low Grade Astrocytoma

Drug: Selumetinib

Sites in St Louis, Kansas City +115 more locations

Sponsor: National Cancer Institute (NCI)

Sex: All·Age: 2 - 21

Code: NCT04166409·Phase 3·Recruiting·Listed Nov 2019

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A Study of the Drug Selinexor With Radiation Therapy in Patients With Newly-Diagnosed Diffuse Intrinsic Pontine (DIPG) Glioma and High-Grade Glioma (HGG)

for Malignant Glioma

Drug: Selinexor

Sites in St Louis, Kansas City +105 more locations

Sponsor: National Cancer Institute (NCI)

Sex: All·Age: 12 Months - 21

Code: NCT05099003·Phase 1, Phase 2·Recruiting·Listed Oct 2021

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Testing the Combination of the Anticancer Drug Durvalumab With Chemotherapy (Gemcitabine and Cisplatin) at Improving Outcomes for High-Risk Resectable Liver Cancer Before Surgery

for Resectable Intrahepatic Cholangiocarcinoma

Drug: Durvalumab

Sites in St Louis, Creve Coeur +51 more locations

Sponsor: National Cancer Institute (NCI)

Sex: All·Age: 18+

Code: NCT06050252·Phase 2·Recruiting·Listed Sep 2023

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Miro3D Randomized Controlled Trial (RCT)

for Wound

1 location in St Louis

Sponsor: Washington University School of Medicine

Sex: All·Age: 18 - 90

Code: NCT07347106·Recruiting·Listed Jan 2026

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Radiotherapy to Block Oligoprogression In Metastatic Non-Small-Cell Lung Cancer

for Non-small Cell Lung Cancer

Sites in St Louis, Creve Coeur +69 more locations

Sponsor: Canadian Cancer Trials Group

Sex: All·Age: 18+

Code: NCT06686771·Phase 3·Recruiting·Listed Nov 2024

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Multicontext Approach for Cognitive Function in Parkinson Disease

for PARKINSON DISEASE (Disorder)

1 location in St Louis

Sponsor: Washington University School of Medicine

Sex: All·Age: 50+

Code: NCT07190404·Recruiting·Listed Sep 2025

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Dinutuximab With Chemotherapy, Surgery and Stem Cell Transplantation for the Treatment of Children With Newly Diagnosed High Risk Neuroblastoma

for Ganglioneuroblastoma, Nodular

Sites in St Louis, Columbia +152 more locations

Sponsor: National Cancer Institute (NCI)

Sex: All·Age: Up to 30

Code: NCT06172296·Phase 3·Recruiting·Listed Dec 2023

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A Multicenter Access and Distribution Protocol for Unlicensed Cryopreserved Cord Blood Units (CBUs)

for Hematologic Malignancies

Sites in St Louis, Kansas City +111 more locations

Sponsor: Center for International Blood and Marrow Transplant Research

Sex: All·Age: All ages

Code: NCT01351545·Recruiting·Listed May 2011

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Anticoagulation for New-Onset Post-Operative Atrial Fibrillation After CABG

for Atrial Fibrillation

Sites in St Louis, Kansas City +33 more locations

Sponsor: Icahn School of Medicine at Mount Sinai

Sex: All·Age: 18+

Code: NCT04045665·Phase 3·Recruiting·Listed Aug 2019

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INCLUDE Program: A Perioperative Wellness Program Tailored for Black Surgical Patients

for Surgery

1 location in St Louis

Sponsor: Washington University School of Medicine

Sex: All·Age: 60+

Code: NCT07283783·Recruiting·Listed Dec 2025

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Immune Checkpoint Inhibitor Toxicity Risk Prediction in Solid Tumors

for Malignant Solid Neoplasm

Sites in St Louis, Ballwin +586 more locations

Sponsor: SWOG Cancer Research Network

Sex: All·Age: 18+

Code: NCT04871542·Recruiting·Listed May 2021

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Testing the Addition of BMS-986016 (Relatlimab) to the Usual Immunotherapy After Initial Treatment for Recurrent or Metastatic Nasopharyngeal Cancer

for Metastatic Nasopharyngeal Carcinoma

Drug: Relatlimab

Sites in St Louis +72 more locations

Sponsor: National Cancer Institute (NCI)

Sex: All·Age: 18+

Code: NCT06029270·Phase 2·Recruiting·Listed Sep 2023

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A Study of Lower Radiotherapy Dose to Treat Children With CNS Germinoma

for Basal Ganglia Germinoma

Sites in St Louis, Kansas City +93 more locations

Sponsor: Children's Oncology Group

Sex: All·Age: 3 - 29

Code: NCT06368817·Phase 2·Recruiting·Listed Apr 2024

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Idiopathic Pulmonary Fibrosis and Interstitial Lung Disease Prospective Outcomes Registry

for Idiopathic Pulmonary Fibrosis, Interstitial Lung Disease

Sites in St Louis +36 more locations

Sponsor: Duke University

Sex: All·Age: 21+

Code: NCT01915511·Recruiting·Listed Aug 2013

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Dabrafenib and Trametinib for BRAF V600 Mutant Low-Grade Gliomas

for BRAF V600 Mutation

Drug: Dabrafenib

Sites in St Louis +8 more locations

Sponsor: University of California, San Francisco

Sex: All·Age: 12 Months - 25

Code: NCT07110246·Phase 2·Recruiting·Listed Aug 2025

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Precision Treatment to Promote Smoking Cessation and Survival in Oncology Patients

for Smoking Cessation

2 locations in St Louis

Sponsor: Washington University School of Medicine

Sex: All·Age: 18 - 89

Code: NCT07166120·Recruiting·Listed Sep 2025

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Clinical and Genetic Evaluation of Individuals With Undiagnosed Disorders Through the Undiagnosed Diseases Network

for Genetic Disease

Sites in St Louis +26 more locations

Sponsor: National Human Genome Research Institute (NHGRI)

Sex: All·Age: 1 Month - 100·Accepts healthy volunteers

Code: NCT02450851·Recruiting·Listed May 2015

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Adjuvant Therapy in POLE-Mutated and p53-Wildtype/NSMP Early Stage Endometrial Cancer RAINBO BLUE & TAPER

for Endometrial Cancer

Sites in St Louis +71 more locations

Sponsor: Canadian Cancer Trials Group

Sex: Female·Age: 18+

Code: NCT05640999·Phase 2·Recruiting·Listed Dec 2022

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Surgical Thromboprophylaxis Practices in Oncology Patients Within the NCORP Network, STOP-VTE Study

for Malignant Digestive System Neoplasm

Sites in St Louis, Springfield +56 more locations

Sponsor: Wake Forest University Health Sciences

Sex: All·Age: 18+·Accepts healthy volunteers

Code: NCT07215624·Recruiting·Listed Oct 2025

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A Study Using Nivolumab, in Combination With Chemotherapy Drugs to Treat Nasopharyngeal Carcinoma (NPC)

for Stage II Nasopharyngeal Carcinoma AJCC v8

Drug: Nivolumab

Sites in St Louis, Kansas City +73 more locations

Sponsor: National Cancer Institute (NCI)

Sex: All·Age: Up to 21

Code: NCT06064097·Phase 2·Recruiting·Listed Oct 2023

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The Pediatric Acute Leukemia (PedAL) Screening Trial - A Study to Test Bone Marrow and Blood in Children With Leukemia That Has Come Back After Treatment or Is Difficult to Treat - A Leukemia & Lymphoma Society and Children's Oncology Group Study

for Acute Lymphoblastic Leukemia

Sites in St Louis, Columbia +154 more locations

Sponsor: PedAL BCU, LLC

Sex: All·Age: Up to 22

Code: NCT04726241·Phase 1, Phase 2·Recruiting·Listed Jan 2021

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PREVENT ALL ALS Study

for Amyotrophic Lateral Sclerosis

Sites in St Louis +30 more locations

Sponsor: St. Joseph's Hospital and Medical Center, Phoenix

Sex: All·Age: 18+·Accepts healthy volunteers

Code: NCT06581861·Recruiting·Listed Sep 2024

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High-dose Prophylactic Gabapentin (HOPE) vs. Placebo to Prevent Opioid Use for Oral Mucositis Pain During Concurrent Chemoradiation for Head and Neck Cancer

for Head and Neck Squamous Cell Carcinoma

Sites in St Louis, Cape Girardeau +167 more locations

Sponsor: Alliance for Clinical Trials in Oncology

Sex: All·Age: 18+

Code: NCT06992427·Phase 3·Recruiting·Listed May 2025

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De-Escalation of Breast Radiation Trial for Hormone Sensitive, HER-2 Negative, Oncotype Recurrence Score Less Than or Equal to 18 Breast Cancer (DEBRA)

for Stage I Breast Cancer

Sites in St Louis, Sullivan +705 more locations

Sponsor: NRG Oncology

Sex: All·Age: 50 - 70

Code: NCT04852887·Phase 3·Recruiting·Listed Apr 2021

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A Study to Compare Blinatumomab Alone to Blinatumomab With Nivolumab in Patients Diagnosed With First Relapse B-Cell Acute Lymphoblastic Leukemia (B-ALL)

for Down Syndrome

Drug: Nivolumab

Sites in St Louis, Kansas City +148 more locations

Sponsor: National Cancer Institute (NCI)

Sex: All·Age: 1 - 30

Code: NCT04546399·Phase 2·Recruiting·Listed Sep 2020

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Comparative Effectiveness of Migraine Preventive Medications: The APT Comparison Study

for Migraine

Sites in St Louis +35 more locations

Sponsor: Mayo Clinic

Sex: All·Age: 18 - 70

Code: NCT06972056·Phase 4·Recruiting·Listed May 2025

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Testing Shorter Duration Radiation Therapy Versus the Usual Radiation Therapy in Patients Receiving the Usual Chemotherapy Treatment for Bladder Cancer, ARCHER Study

for Muscle Invasive Bladder Urothelial Carcinoma

Sites in St Louis, Sullivan +206 more locations

Sponsor: NRG Oncology

Sex: All·Age: 18+

Code: NCT07097142·Phase 3·Recruiting·Listed Jul 2025

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Study to Evaluate Biological & Clinical Effects of Significantly Corrected CFTR Function in Infants & Young Children

for Cystic Fibrosis

Sites in St Louis, Kansas City +33 more locations

Sponsor: Sonya Heltshe

Sex: All·Age: Up to 10

Code: NCT04509050·Recruiting·Listed Aug 2020

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Silmitasertib (CX-4945) in Combination With Chemotherapy for Relapsed Refractory Solid Tumors

for Neuroblastoma

Sites in St Louis, Kansas City +19 more locations

Sponsor: Milton S. Hershey Medical Center

Sex: All·Age: Up to 30

Code: NCT06541262·Phase 1, Phase 2·Recruiting·Listed Aug 2024

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Comparing Sentinel Lymph Node (SLN) Biopsy With Standard Neck Dissection for Patients With Early-Stage Oral Cavity Cancer

for Buccal Mucosa Squamous Cell Carcinoma

Sites in St Louis +86 more locations

Sponsor: NRG Oncology

Sex: All·Age: 18+

Code: NCT04333537·Phase 2, Phase 3·Recruiting·Listed Apr 2020

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Neoadjuvant Chemotherapy, Excision And Observation vs Chemoradiotherapy For Rectal Cancer

for Rectal Cancer

Sites in St Louis +102 more locations

Sponsor: Canadian Cancer Trials Group

Sex: All·Age: 18+

Code: NCT06205485·Phase 3·Recruiting·Listed Jan 2024

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A Study of Treatment for Medulloblastoma Using Sodium Thiosulfate to Reduce Hearing Loss

for Childhood Medulloblastoma

Sites in St Louis, Kansas City +99 more locations

Sponsor: Children's Oncology Group

Sex: All·Age: 4 - 21

Code: NCT05382338·Phase 3·Recruiting·Listed May 2022

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ARTFL LEFFTDS Longitudinal Frontotemporal Lobar Degeneration (ALLFTD)

for Frontotemporal Lobar Degeneration (FTLD)

Sites in St Louis +24 more locations

Sponsor: Mayo Clinic

Sex: All·Age: 18+·Accepts healthy volunteers

Code: NCT04363684·Recruiting·Listed Apr 2020

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Standardizing Treatments for Pulmonary Exacerbations - Aminoglycoside Study

for Cystic Fibrosis

Sites in St Louis +58 more locations

Sponsor: Chris Goss

Sex: All·Age: 6+

Code: NCT05548283·Phase 4·Recruiting·Listed Sep 2022

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Multi-modal Imaging of Myofascial Pain - Phase 2

for Myofascial Pain

1 location in St Louis

Sponsor: Washington University School of Medicine

Sex: All·Age: 18 - 80

Code: NCT07322445·Recruiting·Listed Jan 2026

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Selinexor Maintenance Post CAR-T Cell Therapy for Multiple Myeloma

for Multiple Myeloma

Drug: Selinexor

1 location in St Louis

Sponsor: Washington University School of Medicine

Sex: All·Age: 18+

Code: NCT07200102·Phase 1·Recruiting·Listed Sep 2025

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Chemotherapy Before Surgery and Radiation Therapy or Surgery and Radiation Therapy Alone in Treating Patients With Nasal and Paranasal Sinus Cancer That Can Be Removed by Surgery

for Stage III Nasal Cavity and Paranasal Sinus Squamous Cell Carcinoma AJCC v6 and v7

Sites in St Louis, Creve Coeur +117 more locations

Sponsor: ECOG-ACRIN Cancer Research Group

Sex: All·Age: 18+

Code: NCT03493425·Phase 2·Recruiting·Listed Apr 2018

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Adding the Immunotherapy Drug Cemiplimab to Usual Treatment for People With Advanced Non-Small Cell Lung Cancer Who Had Previous Treatment With Platinum Chemotherapy and Immunotherapy (An Expanded Lung-MAP Treatment Trial)

for Recurrent Lung Non-Small Cell Carcinoma

Drug: Cemiplimab

Sites in St Louis, Creve Coeur +379 more locations

Sponsor: SWOG Cancer Research Network

Sex: All·Age: 18+

Code: NCT06616584·Phase 2, Phase 3·Recruiting·Listed Sep 2024

Apply to this trial