Paid Clinical Trials in St Louis, MO

As of August 2026, 1,397 paid clinical trials are recruiting in St Louis, Missouri. Compensation typically covers time, travel, and study visits, with stipends ranging from modest amounts for short outpatient studies to several thousand dollars for long or inpatient protocols.

Both patients with specific conditions and healthy volunteers can qualify. Most trials offer free study-related medical care alongside compensation.

Recruiting trial data synced daily from ClinicalTrials.gov. Last sync: August 10, 2026.

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1,269 clinical trials

Pediatric Influence of Cooling Duration on Efficacy in Cardiac Arrest Patients (P-ICECAP)

for Cardiac Arrest, Out-Of-Hospital

Sites in St Louis +46 more locations

Sponsor: University of Michigan

Sex: All·Age: 2 Days - 17

Code: NCT05376267·Recruiting·Listed May 2022

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DECIDE: A Comparative Effectiveness Trial of Metformin Versus Insulin for the Treatment of Gestational Diabetes

for Gestational Diabetes Mellitus

Sites in St Louis +20 more locations

Sponsor: Ohio State University

Sex: Female·Age: 18+

Code: NCT06445946·Phase 4·Recruiting·Listed Jun 2024

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Testing Lutetium Lu 177 Dotatate in Patients With Somatostatin Receptor Positive Advanced Bronchial Neuroendocrine Tumors

for Advanced Lung Neuroendocrine Tumor

Sites in St Louis +23 more locations

Sponsor: National Cancer Institute (NCI)

Sex: All·Age: 18+

Code: NCT04665739·Phase 2·Recruiting·Listed Dec 2020

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Streamlined Treatment of Pulmonary Exacerbations in Pediatrics

for Cystic Fibrosis

Sites in St Louis, Kansas City +29 more locations

Sponsor: University of Washington, the Collaborative Health Studies Coordinating Center

Sex: All·Age: 3 - 18

Code: NCT06654752·Recruiting·Listed Oct 2024

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Rett Syndrome Registry

for Rett Syndrome

Sites in St Louis +18 more locations

Sponsor: International Rett Syndrome Foundation

Sex: All·Age: 0 - 99

Code: NCT05432349·Recruiting·Listed Jun 2022

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Trastuzumab Deruxtecan (DS-8201a) for the Treatment of Recurrent or Refractory Osteosarcoma, Wilms Tumor, and Desmoplastic Small Round Cell Tumor

for Desmoplastic Small Round Cell Tumor

Sites in St Louis +8 more locations

Sponsor: National Cancer Institute (NCI)

Sex: All·Age: 12 - 39

Code: NCT04616560·Phase 1, Phase 2·Recruiting·Listed Nov 2020

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A Study About How Blood Cell Growth Patterns Relate to Heart Health After Treatment for Hodgkin Lymphoma

for Cardiovascular Disorder

Sites in St Louis +34 more locations

Sponsor: Children's Oncology Group

Sex: All·Age: 7+

Code: NCT05705531·Recruiting·Listed Jan 2023

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The Vanguard Study: Testing a New Way to Screen for Cancer

for Bladder Carcinoma

Sites in St Louis, Kansas City +37 more locations

Sponsor: National Cancer Institute (NCI)

Sex: All·Age: 45 - 75·Accepts healthy volunteers

Code: NCT06995898·Recruiting·Listed May 2025

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Pragmatic Evaluation of Events And Benefits of Lipid-lowering in Older Adults

for Cognitive Impairment, Mild

Sites in St Louis, Columbia +89 more locations

Sponsor: Duke University

Sex: All·Age: 75+·Accepts healthy volunteers

Code: NCT04262206·Phase 4·Recruiting·Listed Feb 2020

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The Society for Obstetric Anesthesia and Perinatology Research Network General Anesthesia Registry

for Cesarean Delivery

Sites in St Louis +32 more locations

Sponsor: Yale University

Sex: Female·Age: 15 - 55·Accepts healthy volunteers

Code: NCT06030063·Recruiting·Listed Sep 2023

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A Study of a Potential Disease Modifying Treatment in Individuals at Risk for or With a Type of Early Onset AD Caused by a Genetic Mutation

for Alzheimers Disease

Sites in St Louis +12 more locations

Sponsor: Washington University School of Medicine

Sex: All·Age: 18+·Accepts healthy volunteers

Code: NCT06647498·Phase 2, Phase 3·Recruiting·Listed Oct 2024

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A Study of Potential Disease Modifying Treatments in Individuals at Risk for or With a Type of Early Onset AD Caused by a Genetic Mutation

for Alzheimers Disease

Sites in St Louis +12 more locations

Sponsor: Washington University School of Medicine

Sex: All·Age: 18+·Accepts healthy volunteers

Code: NCT05552157·Phase 2, Phase 3·Recruiting·Listed Sep 2022

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Testing the Safety of the Combination of Anti-Cancer Drugs CX-5461 (Pidnarulex) and Trastuzumab Deruxtecan (T-DXd) for Human Epidermal Growth Factor Receptor 2 (HER2)-Positive Solid Tumors and Breast Cancer

for Anatomic Stage III Breast Cancer AJCC v8

Drug: Pidnarulex

Sites in St Louis +1 more location

Sponsor: National Cancer Institute (NCI)

Sex: All·Age: 18+

Code: NCT07137416·Phase 1·Recruiting·Listed Aug 2025

Apply to this trial

Substance Use in Pregnant People - Optimizing Retention in Treatment

for Substance Use Disorder (SUD)

Sites in St Louis +1 more location

Sponsor: Washington University School of Medicine

Sex: Female·Age: 18+

Code: NCT07104123·Recruiting·Listed Aug 2025

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Targeted Treatment for Advanced Non-Small Cell Lung Cancer That Has a MET Exon 14 Skipping Gene Change (An Expanded Lung-MAP Treatment Trial)

for Recurrent Lung Non-Small Cell Carcinoma

Sites in St Louis, Creve Coeur +239 more locations

Sponsor: SWOG Cancer Research Network

Sex: All·Age: 18 Minutes+

Code: NCT06031688·Phase 2·Recruiting·Listed Sep 2023

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Surgery With or Without Neoadjuvant Chemotherapy in High Risk RetroPeritoneal Sarcoma

for Retroperitoneal Sarcoma

Sites in St Louis, Creve Coeur +95 more locations

Sponsor: European Organisation for Research and Treatment of Cancer - EORTC

Sex: All·Age: 18+

Code: NCT04031677·Phase 3·Recruiting·Listed Jul 2019

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Comparing Proton Therapy to Photon Radiation Therapy for Esophageal Cancer

for Clinical Stage I Esophageal Adenocarcinoma AJCC v8

Sites in St Louis, Springfield +63 more locations

Sponsor: NRG Oncology

Sex: All·Age: 18+

Code: NCT03801876·Phase 3·Recruiting·Listed Jan 2019

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Comparison of Anti-coagulation and Anti-Platelet Therapies for Intracranial Vascular Atherostenosis- Magnetic Resonance Imaging

for Stroke

Sites in St Louis +27 more locations

Sponsor: Yale University

Sex: All·Age: 18+

Code: NCT05907629·Recruiting·Listed Jun 2023

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Naxitamab Added to Induction for Newly Diagnosed High-Risk Neuroblastoma

for Neuroblastoma

Sites in St Louis +18 more locations

Sponsor: Giselle Sholler

Sex: All·Age: 12 Months - 21

Code: NCT05489887·Phase 2·Recruiting·Listed Aug 2022

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Testing the Addition of Paclitaxel Administered Into the Abdominal Cavity Combined With Chemotherapy for Patients With Gastric Cancer Spread to the Abdominal Cavity

for Gastric Adenocarcinoma

Sites in St Louis, Creve Coeur +53 more locations

Sponsor: ECOG-ACRIN Cancer Research Group

Sex: All·Age: 18+

Code: NCT07001748·Phase 2, Phase 3·Recruiting·Listed Jun 2025

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S1703 Serum Tumor Marker Directed Disease Monitoring in Patients With Hormone Receptor Positive Her2 Negative Metastatic Breast Cancer

for Anatomic Stage IV Breast Cancer AJCC v8

Sites in St Louis, Ballwin +584 more locations

Sponsor: SWOG Cancer Research Network

Sex: All·Age: 18+

Code: NCT03723928·Recruiting·Listed Oct 2018

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Medical Management With Endovascular Thrombectomy Versus Medical Management Alone in Patients Presenting Beyond 24 Hours of Last Known Well

for Acute Ischemic Stroke

Sites in St Louis +5 more locations

Sponsor: Amrou Sarraj

Sex: All·Age: 18 - 85

Code: NCT07115940·Recruiting·Listed Aug 2025

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Combination Therapy for the Treatment of Diffuse Midline Gliomas

for Diffuse Intrinsic Pontine Glioma

Sites in St Louis +18 more locations

Sponsor: University of California, San Francisco

Sex: All·Age: 2 - 39

Code: NCT05009992·Phase 2·Recruiting·Listed Aug 2021

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Digoxin Medulloblastoma Study

for Medulloblastoma

Sites in St Louis +14 more locations

Sponsor: H. Lee Moffitt Cancer Center and Research Institute

Sex: All·Age: 12 Months - 30

Code: NCT06701812·Phase 2·Recruiting·Listed Nov 2024

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Effect of Ketone Esters on Liver Fat Content and Metabolic Function

for MASLD - Metabolic Dysfunction-Associated Steatotic Liver Disease

1 location in St Louis

Sponsor: Washington University School of Medicine

Sex: All·Age: 18 - 40·Accepts healthy volunteers

Code: NCT07097506·Phase 2·Recruiting·Listed Jul 2025

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Testing Proton Craniospinal Radiation Therapy Versus the Usual Radiation Therapy for Leptomeningeal Metastasis, RADIATE-LM Trial

for Anatomic Stage IV Breast Cancer AJCC v8

Sites in St Louis, Creve Coeur +56 more locations

Sponsor: NRG Oncology

Sex: All·Age: 18+

Code: NCT06500481·Phase 3·Recruiting·Listed Jul 2024

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Adolescent Chatbot

for Body Image Disturbance

1 location in St Louis

Sponsor: Washington University School of Medicine

Sex: All·Age: 13 - 19

Code: NCT07094503·Phase 2·Recruiting·Listed Jul 2025

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Minimizing ICU Neurological Dysfunction With Dexmedetomidine-induced Sleep (MINDDS II)

for Delirium

Sites in St Louis +13 more locations

Sponsor: Massachusetts General Hospital

Sex: All·Age: 60+

Code: NCT06192615·Phase 3·Recruiting·Listed Jan 2024

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Testing Pump Chemotherapy in Addition to Standard of Care Chemotherapy Versus Standard of Care Chemotherapy Alone for Patients With Unresectable Colorectal Liver Metastases: The PUMP Trial

for Metastatic Colorectal Carcinoma

Sites in St Louis, Creve Coeur +58 more locations

Sponsor: ECOG-ACRIN Cancer Research Group

Sex: All·Age: 18+

Code: NCT05863195·Phase 3·Recruiting·Listed May 2023

Apply to this trial

Proton or Photon RT for Retroperitoneal Sarcomas

for Retroperitoneal Sarcoma

Sites in St Louis, Creve Coeur +8 more locations

Sponsor: Massachusetts General Hospital

Sex: All·Age: 18+

Code: NCT01659203·Phase 1, Phase 2·Recruiting·Listed Aug 2012

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Testing the Addition of an Individualized Vaccine to Durvalumab and Tremelimumab and Chemotherapy in Patients With Metastatic Triple Negative Breast Cancer

for Anatomic Stage IV Breast Cancer AJCC v8

Drug: Tremelimumab

Sites in St Louis, Creve Coeur +22 more locations

Sponsor: National Cancer Institute (NCI)

Sex: All·Age: 18+

Code: NCT03606967·Phase 2·Recruiting·Listed Jul 2018

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Kidney Transplantation From Donors With HIV: Impact on Rejection and Long-Term Outcomes (Expanding HOPE Kidney)

for Hiv

Sites in St Louis +17 more locations

Sponsor: Johns Hopkins University

Sex: All·Age: 18+

Code: NCT06263426·Recruiting·Listed Feb 2024

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Interferon-γ (IFN-γ) With Donor Leukocyte Infusion to Treat Relapsed Acute Myeloid Leukemia and Myelodysplastic Syndromes Post Allogeneic Hematopoietic Stem Cell Transplantation

for Acute Myeloid Leukemia

Sites in St Louis +2 more locations

Sponsor: Sawa Ito, MD

Sex: All·Age: 18+

Code: NCT06529731·Phase 2·Recruiting·Listed Jul 2024

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Glucagon-like Peptide 1 (GLP-1) Receptor Agonist Therapy and Exercise Training in People With Obesity

for Obesity

1 location in St Louis

Sponsor: Washington University School of Medicine

Sex: All·Age: 50 - 75

Code: NCT07091500·Recruiting·Listed Jul 2025

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Targeted Treatment for Advanced Non-Small Cell Lung Cancer That Has Increased Copies of the MET Gene (An Expanded Lung-MAP Treatment Trial)

for Lung Non-Small Cell Carcinoma

Sites in St Louis, Sullivan +241 more locations

Sponsor: SWOG Cancer Research Network

Sex: All·Age: 18+

Code: NCT06116682·Phase 2·Recruiting·Listed Nov 2023

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Embryonal Tumor With Multilayered Rosettes

for Embryonal Tumor With Multilayered Rosettes

Sites in St Louis +7 more locations

Sponsor: University of California, San Francisco

Sex: All·Age: All ages

Code: NCT06861244·Phase 2·Recruiting·Listed Mar 2025

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Eflornithine (DFMO) and AMXT 1501 for Neuroblastoma, CNS Tumors, and Sarcomas

for Atypical Teratoid/Rhabdoid Tumor

Sites in St Louis +11 more locations

Sponsor: Milton S. Hershey Medical Center

Sex: All·Age: Up to 26

Code: NCT06465199·Phase 1, Phase 2·Recruiting·Listed Jun 2024

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A Study of Additional Chemotherapy After Surgery for People With Malignant Peritoneal Mesothelioma

for Malignant Peritoneal Mesothelioma

Sites in St Louis +12 more locations

Sponsor: Memorial Sloan Kettering Cancer Center

Sex: All·Age: 18+

Code: NCT06057935·Phase 2·Recruiting·Listed Sep 2023

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Massive Transfusion in Children-2: A Trial Examining Life Threatening Hemorrhage in Children

for Hemorrhagic Shock

Sites in St Louis +19 more locations

Sponsor: Philip Spinella

Sex: All·Age: Up to 17

Code: NCT06070350·Phase 3·Recruiting·Listed Oct 2023

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Durability of Suppl. Rod Constructs-SuppleMentAry Rod Technique for Long-segment Posterior Instrumented Spinal Fusions

for Spinal Fusion

Sites in St Louis +7 more locations

Sponsor: AO Foundation, AO Spine

Sex: All·Age: 45+

Code: NCT06368245·Recruiting·Listed Apr 2024

Apply to this trial