Paid Clinical Trials in St Louis, MO

As of August 2026, 1,397 paid clinical trials are recruiting in St Louis, Missouri. Compensation typically covers time, travel, and study visits, with stipends ranging from modest amounts for short outpatient studies to several thousand dollars for long or inpatient protocols.

Both patients with specific conditions and healthy volunteers can qualify. Most trials offer free study-related medical care alongside compensation.

Recruiting trial data synced daily from ClinicalTrials.gov. Last sync: August 10, 2026.

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1,269 clinical trials

Accelerated Brachytherapy Forward Chemo Radiation Therapy (ABC-RT) for Locally-advanced Cervical Cancer

for Locally Advanced Cervical Carcinoma

1 location in St Louis

Sponsor: Washington University School of Medicine

Sex: Female·Age: 18+

Code: NCT06529809·Phase 1, Phase 2·Recruiting·Listed Jul 2024

Apply to this trial

Endocrine Treatment Alone for Elderly Patients With Estrogen Receptor Positive Operable Breast Cancer and Low Recurrence Score

for Breast Cancer

1 location in St Louis

Sponsor: Washington University School of Medicine

Sex: Female·Age: 70+

Code: NCT02476786·Phase 2·Recruiting·Listed Jun 2015

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Finding the Best Tamoxifen Dose for Breast Cancer Risk Reduction in Premenopausal Women, RENAISSANCE Trial

for Breast Atypical Ductal Hyperplasia

Sites in St Louis +9 more locations

Sponsor: National Cancer Institute (NCI)

Sex: Female·Age: 18 - 55

Code: NCT06184750·Phase 2·Recruiting·Listed Dec 2023

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Assessing Benefits and Harms of Cannabis/Cannabinoid Use Among Cancer Patients Treated in Community Oncology Clinics

for Breast Carcinoma

Sites in St Louis, Ballwin +462 more locations

Sponsor: Wake Forest University Health Sciences

Sex: All·Age: 18+

Code: NCT06418204·Recruiting·Listed May 2024

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Personalized Antibody-Drug Conjugate Therapy Based on RNA and Protein Testing for the Treatment of Advanced or Metastatic Solid Tumors (The ADC MATCH Screening and Treatment Trial)

for Advanced Malignant Solid Neoplasm

Sites in St Louis, Creve Coeur +25 more locations

Sponsor: National Cancer Institute (NCI)

Sex: All·Age: 18+

Code: NCT06311214·Phase 2·Recruiting·Listed Mar 2024

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The Minimalist Trial-2

for HPV-Related Oropharynx Squamous Cell Carcinoma

Sites in St Louis +2 more locations

Sponsor: Washington University School of Medicine

Sex: All·Age: 18+

Code: NCT06702033·Phase 2·Recruiting·Listed Nov 2024

Apply to this trial

High Dose Testosterone for ATM, CDK12 or CHEK2 Altered Prostate Cancers

for Metastatic Prostate Cancer

Sites in St Louis, Kansas City +15 more locations

Sponsor: VA Office of Research and Development

Sex: Male·Age: 18+

Code: NCT05011383·Phase 2·Recruiting·Listed Aug 2021

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Statins in Patients With Clonal Cytopenia of Undetermined Significance (CCUS) and Myelodysplastic Syndromes (MDS)

for Clonal Cytopenia of Undetermined Significance

1 location in St Louis

Sponsor: Washington University School of Medicine

Sex: All·Age: 18+

Code: NCT05483010·Phase 2·Recruiting·Listed Aug 2022

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Preconception Intervention for Incarcerated Women With Substance Use

for Substance Use Disorders

1 location in St Louis

Sponsor: St. Louis University

Sex: Female·Age: 18 - 49

Code: NCT05854836·Recruiting·Listed May 2023

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Belimumab With Rituximab for Primary Membranous Nephropathy

for Membranous Nephropathy

Drug: Rituximab

Sites in St Louis +19 more locations

Sponsor: National Institute of Allergy and Infectious Diseases (NIAID)

Sex: All·Age: 18 - 75

Code: NCT03949855·Phase 2·Recruiting·Listed May 2019

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Memory-Like Natural Killer Cells With Nivolumab and Relatlimab in Advanced or Metastatic Melanoma After Progression on Checkpoint Inhibitors

for Advanced Melanoma

Drug: Relatlimab

1 location in St Louis

Sponsor: Washington University School of Medicine

Sex: All·Age: 18+

Code: NCT05629546·Phase 1·Recruiting·Listed Nov 2022

Apply to this trial

Dominantly Inherited Alzheimer Network (DIAN)

for Alzheimer's Disease

Sites in St Louis +6 more locations

Sponsor: Washington University School of Medicine

Sex: All·Age: 18+·Accepts healthy volunteers

Code: NCT00869817·Recruiting·Listed Mar 2009

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Three Schedules of CUE-101 Administered Before Surgery or Definitive Chemoradiation Therapy in HLA-A*0201 Positive Patients With Locally Advanced, HPV16-Positive Oropharyngeal Squamous-Cell Carcinoma

for Oropharyngeal Squamous Cell Carcinoma

1 location in St Louis

Sponsor: Washington University School of Medicine

Sex: All·Age: 18+

Code: NCT04852328·Phase 2·Recruiting·Listed Apr 2021

Apply to this trial

Outcomes in Pediatric and Young Adult B-Cell Malignancies After Commercially Available Immunotherapy

for Lymphoid Leukemia

Sites in St Louis +21 more locations

Sponsor: Stanford University

Sex: All·Age: Up to 26

Code: NCT05865301·Recruiting·Listed May 2023

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Preventing Liver Cancer Mortality Through Imaging With Ultrasound vs. MRI

for Carcinoma, Hepatocellular

Sites in St Louis +32 more locations

Sponsor: VA Office of Research and Development

Sex: All·Age: 18 - 75

Code: NCT05486572·Recruiting·Listed Aug 2022

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Phase 1/2 Trial of S241656 in Selected RAS/MAPK Mutation- Positive Malignancies

for Non-small Cell Lung Cancer

Sites in St Louis +19 more locations

Sponsor: Institut de Recherches Internationales Servier

Sex: All·Age: 18+

Code: NCT05786924·Phase 1, Phase 2·Recruiting·Listed Mar 2023

Apply to this trial

Stereotactic Radiosurgery Compared With Hippocampal-Avoidant Whole Brain Radiotherapy (HA-WBRT) Plus Memantine for 5 or More Brain Metastases

for Brain Metastases

Sites in St Louis, Creve Coeur +36 more locations

Sponsor: Canadian Cancer Trials Group

Sex: All·Age: 18+

Code: NCT03550391·Phase 3·Recruiting·Listed Jun 2018

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Personalized Cancer Vaccine (PCV) Strategy in Patients With Solid Tumors and Molecular Residual Disease

for Muscle-Invasive Bladder Carcinoma

Sites in St Louis +2 more locations

Sponsor: Washington University School of Medicine

Sex: All·Age: 18+

Code: NCT06529822·Phase 1·Recruiting·Listed Jul 2024

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Evaluation of a Novel Technology to Support Tailored Health Behavior Counseling in Rural Primary Care Clinics

for Cardiovascular Diseases

1 location in St Louis

Sponsor: Washington University School of Medicine

Sex: All·Age: 18 - 64

Code: NCT06397729·Recruiting·Listed May 2024

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Small Extracellular Vesicles and Insulin Action

for Obesity

1 location in St Louis

Sponsor: Washington University School of Medicine

Sex: All·Age: 25 - 55·Accepts healthy volunteers

Code: NCT05933707·Recruiting·Listed Jul 2023

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Radiation Induced Alterations in Resting State Brain Networks in Pediatric Brain Tumor Patients

for Brain Tumor, Primary

1 location in St Louis

Sponsor: Washington University School of Medicine

Sex: All·Age: 8 - 21

Code: NCT06185686·Recruiting·Listed Dec 2023

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Testing the Addition of an Anti-cancer Drug, Lenalidomide, to the Usual Combination Chemotherapy Treatment ("EPOCH") for Adult T-Cell Leukemia-Lymphoma (ATLL)

for Acute Adult T-Cell Leukemia/Lymphoma

Sites in St Louis, Creve Coeur +17 more locations

Sponsor: National Cancer Institute (NCI)

Sex: All·Age: 18+

Code: NCT04301076·Phase 1·Recruiting·Listed Mar 2020

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Adapting and Testing a Novel Digital Health Tool (PREVENT) to Improve Health Behavior Counseling and Cardiovascular Health in Rural Primary Care Clinics

for Obesity

1 location in St Louis

Sponsor: Washington University School of Medicine

Sex: All·Age: 18 - 64

Code: NCT06063564·Recruiting·Listed Oct 2023

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Thoracotomy Versus Thoracoscopic Management of Pulmonary Metastases in Patients With Osteosarcoma

for Metastatic Malignant Neoplasm in the Lung

Sites in St Louis, Columbia +209 more locations

Sponsor: Children's Oncology Group

Sex: All·Age: Up to 50

Code: NCT05235165·Phase 3·Recruiting·Listed Feb 2022

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Intravitreal Faricimab Injections or Fluocinolone Acetonide (0.19 mg) Intravitreal Implants vs Observation for Prevention of VA Loss Due to Radiation Retinopathy

for Radiation Retinopathy

Sites in St Louis +24 more locations

Sponsor: Jaeb Center for Health Research

Sex: All·Age: 18+

Code: NCT05844982·Phase 3·Recruiting·Listed May 2023

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Advancing Transplantation Outcomes in Children

for Kidney Transplant

Sites in St Louis +19 more locations

Sponsor: National Institute of Allergy and Infectious Diseases (NIAID)

Sex: All·Age: 13 - 20

Code: NCT06055608·Phase 2·Recruiting·Listed Sep 2023

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Pacritinib in Vacuoles, E1 Ubiqutin-activating Enzyme, X-linked, Autoinflammatory, Somatic (VEXAS) Syndrome

for E1 Ubiqutin-activating Enzyme, X-linked, Autoinflammatory, Somatic Syndrome

Drug: Pacritinib

1 location in St Louis

Sponsor: Washington University School of Medicine

Sex: All·Age: 18+

Code: NCT06538181·Phase 1·Recruiting·Listed Aug 2024

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Endometriosis and Migraine

for Migraine

1 location in St Louis

Sponsor: Washington University School of Medicine

Sex: Female·Age: 12 - 45·Accepts healthy volunteers

Code: NCT06785129·Recruiting·Listed Jan 2025

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Baseline Atrial Fibrosis Predicts Risk for Post-operative Atrial Fibrillation in Patients Undergoing Cardiac Surgery

for Atrial Fibrillation

Sites in St Louis +2 more locations

Sponsor: Tulane University

Sex: All·Age: 40 - 120

Code: NCT05014802·Recruiting·Listed Aug 2021

Apply to this trial

Washington University Participant Engagement and Cancer Genomic Sequencing Center (WU-PE-CGS)

for Cholangiocarcinoma

1 location in St Louis

Sponsor: Washington University School of Medicine

Sex: All·Age: 18+

Code: NCT06340646·Recruiting·Listed Apr 2024

Apply to this trial

Diffusion Basis Spectrum Imaging of the Prostate

for Prostate Cancer

1 location in St Louis

Sponsor: Washington University School of Medicine

Sex: Male·Age: 18+

Code: NCT04420702·Recruiting·Listed Jun 2020

Apply to this trial

Aging, Geriatric Syndromes and Clonal Hematopoiesis

for Geriatrics

1 location in St Louis

Sponsor: Washington University School of Medicine

Sex: All·Age: 50+·Accepts healthy volunteers

Code: NCT02604563·Recruiting·Listed Nov 2015

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Sleep Trial to Prevent Alzheimer's Disease

for Sleep

1 location in St Louis

Sponsor: University of Minnesota

Sex: All·Age: 65+·Accepts healthy volunteers

Code: NCT04629547·Phase 2·Recruiting·Listed Nov 2020

Apply to this trial

Migraine in Adolescents

for Migraine

1 location in St Louis

Sponsor: Washington University School of Medicine

Sex: All·Age: 10 - 13·Accepts healthy volunteers

Code: NCT05654012·Recruiting·Listed Dec 2022

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Examining Racial and Socioeconomic Differences in Chronic Low Back Pain

for Chronic Pain

1 location in St Louis

Sponsor: Washington University School of Medicine

Sex: All·Age: 18 - 85

Code: NCT05991440·Recruiting·Listed Aug 2023

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Sex Hormones, Postoperative Pain and Opioid Use

for Postoperative Pain

1 location in St Louis

Sponsor: Washington University School of Medicine

Sex: Female·Age: 11 - 16

Code: NCT06023225·Recruiting·Listed Sep 2023

Apply to this trial

Endometriosis Pain

for Pelvic Pain

1 location in St Louis

Sponsor: Washington University School of Medicine

Sex: Female·Age: 12 - 45

Code: NCT06101303·Recruiting·Listed Oct 2023

Apply to this trial

DORA and LP in Alzheimer's Disease Biomarkers

for Alzheimer Disease

1 location in St Louis

Sponsor: University of Minnesota

Sex: All·Age: 65+·Accepts healthy volunteers

Code: NCT06274528·Phase 2·Recruiting·Listed Feb 2024

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A Study Using Risk Factors to Determine Treatment for Children With Favorable Histology Wilms Tumors (FHWT)

for Stage I Mixed Cell Type Kidney Wilms Tumor

Sites in St Louis, Columbia +144 more locations

Sponsor: Children's Oncology Group

Sex: All·Age: Up to 30

Code: NCT06401330·Phase 3·Recruiting·Listed May 2024

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Zanzalintinib in Combination With Ipilimumab and Nivolumab in Patients With Metastatic Soft Tissue Sarcoma

for Metastatic Soft-tissue Sarcoma

Drug: Ipilimumab

1 location in St Louis

Sponsor: Washington University School of Medicine

Sex: All·Age: 18+

Code: NCT06968988·Phase 1·Recruiting·Listed May 2025

Apply to this trial