Paid Clinical Trials in Wilmington, NC

As of July 2026, 107 paid clinical trials are recruiting in Wilmington, North Carolina. Compensation typically covers time, travel, and study visits, with stipends ranging from modest amounts for short outpatient studies to several thousand dollars for long or inpatient protocols.

Both patients with specific conditions and healthy volunteers can qualify. Most trials offer free study-related medical care alongside compensation.

Recruiting trial data synced daily from ClinicalTrials.gov. Last sync: July 28, 2026.

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93 clinical trials

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A Study to Assess the Safety and Efficacy of Different Doses of ELV001 to Treat Active Rheumatoid Arthritis in Patients With an Inadequate Response to Methotrexate and Tumor Necrosis Factor Inhibition (START SYNERGY)

for Active Rheumatoid Arthritis

Sites in Wilmington, Charlotte +20 more locations

Sponsor: Elevara Medicines Limited

Sex: All·Age: 18 - 75

Code: NCT07409103·Phase 2·Recruiting·Listed Feb 2026

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AMAZE 1: A Research Study Investigating How Well the Medicine NNC0487-0111 Helps People With Excess Body Weight Lose Weight

for Obesity

Drug: NNC0487-0111

Sites in Wilmington, Chapel Hill +20 more locations

Sponsor: Novo Nordisk A/S

Sex: All·Age: 18+

Code: NCT07339423·Phase 3·Recruiting·Listed Jan 2026

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A Study to Evaluate the Effectiveness of IDCT (Intradiscal Cell Therapy) in Subjects With One Level, Symptomatic Mild to Moderate Lumbar Degenerative Disc Disease

for Degenerative Disc Disease

Sites in Wilmington, Winston-Salem +16 more locations

Sponsor: DiscGenics, Inc.

Sex: All·Age: 18 - 75

Code: NCT07254806·Phase 3·Recruiting·Listed Nov 2025

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AtraUmatic Laparoscopic HerNia Repair Clinical Investigation to Evaluate the Safety and Performance of The ECLIPSIUM System for Mesh Fixation IDE

for Hernia

Sites in Wilmington, Durham +10 more locations

Sponsor: Tissium

Sex: All·Age: 22+

Code: NCT07277946·Recruiting·Listed Dec 2025

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Study of AGN-151607-DP to Assess Adverse Events and Change in Disease Activity in Adult Participants Undergoing Open Abdominal Ventral Hernia Repair

for Ventral Hernia

Sites in Wilmington +10 more locations

Sponsor: AbbVie

Sex: All·Age: 18 - 80

Code: NCT07226791·Phase 2·Recruiting·Listed Nov 2025

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Evaluation of IV AMBTX-01 (Neridronate) for Treatment of CRPS Type 1 (CRPS-RISE)

for Complex Regional Pain Syndrome Type I

Sites in Wilmington, Charlotte +17 more locations

Sponsor: Ambros Therapeutics, Inc.

Sex: All·Age: 18+

Code: NCT07210515·Phase 3·Recruiting·Listed Oct 2025

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Study of Plozasiran in Adults With Severe Hypertriglyceridemia at Risk of Acute Pancreatitis

for Severe Hypertriglyceridemia

Drug: Plozasiran

Sites in Wilmington, Greensboro +14 more locations

Sponsor: Arrowhead Pharmaceuticals

Sex: All·Age: 18+

Code: NCT06880770·Phase 3·Recruiting·Listed Mar 2025

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A Study to Assess the Safety and Effectiveness of ELAPR002f Injectable Gel in Adult Participants With Atrophic Acne Scars

for Acne Scars

Sites in Wilmington +9 more locations

Sponsor: AbbVie

Sex: All·Age: 22+

Code: NCT07207369·Phase 3·Recruiting·Listed Oct 2025

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Evaluation of Efficacy and Safety of THRV-1268 in Long QT Syndrome Type 2 (LQTS 2)

for Long QT Syndrome (LQTS) 2

Sites in Wilmington +8 more locations

Sponsor: Thryv Therapeutics, Inc.

Sex: All·Age: 15+

Code: NCT07277582·Phase 2, Phase 3·Recruiting·Listed Dec 2025

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A Study to Train a Machine Learning Algorithm for an Evaluation of the Use of Biometric Data Captured at the Wrist for the Identification of Acute Opioid Use Events and the Quantification of Opioid Withdrawal in Opioid Dependent Individuals

for Treatment for Opioid Use Disorder

Sites in Wilmington +3 more locations

Sponsor: OpiAID

Sex: All·Age: 22+·Accepts healthy volunteers

Code: NCT07405398·Recruiting·Listed Feb 2026

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A Study to Describe the Real-world Effectiveness, Safety and Patterns of Use of Dupilumab in Patients With Chronic Spontaneous Urticaria

for Chronic Spontaneous Urticaria

Drug: Dupilumab

1 location in Wilmington

Sponsor: Sanofi

Sex: All·Age: 12+

Code: NCT07316114·Recruiting·Listed Jan 2026

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Real-World Efgartigimod Effectiveness in CIDP: A Prospective Study

for Chronic Inflammatory Demyelinating Polyradiculoneuropathy

1 location in Wilmington

Sponsor: argenx

Sex: All·Age: 18+

Code: NCT07264426·Recruiting·Listed Dec 2025

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Safety and Effectiveness Evaluation of the High-intensity Focused Ultrasound Device for Lifting Lax Submental and Neck Tissue

for Skin Laxity (Submental and Neck)

Sites in Wilmington, Charlotte +3 more locations

Sponsor: CLASSYS Inc.

Sex: All·Age: 30 - 65·Accepts healthy volunteers

Code: NCT07229430·Recruiting·Listed Nov 2025

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A Study Evaluating the Presence and Concentration of BRIUMVI™ (Ublituximab) in Breast Milk

for Relapsing Multiple Sclerosis

Sites in Wilmington +4 more locations

Sponsor: TG Therapeutics, Inc.

Sex: Female·Age: 18+

Code: NCT06143514·Recruiting·Listed Nov 2023

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A Study Evaluating the Effect of BRIUMVI® (Ublituximab) on Pregnancy and Infant Outcomes in Participants With Multiple Sclerosis (MS)

for Multiple Sclerosis

1 location in Wilmington

Sponsor: TG Therapeutics, Inc.

Sex: Female·Age: 15 - 50

Code: NCT06433765·Recruiting·Listed May 2024

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Odevixibat Pregnancy and Lactation Surveillance Program: A Study to Evaluate the Safety of Odevixibat During Pregnancy and/or Lactation

for Pregnancy Related

1 location in Wilmington

Sponsor: Ipsen

Sex: Female·Age: All ages

Code: NCT06258902·Recruiting·Listed Feb 2024

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A Study of Ozanimod in Pregnant Women With Ulcerative Colitis and Their Offspring

for Ulcerative Colitis

1 location in Wilmington

Sponsor: Bristol-Myers Squibb

Sex: Female·Age: All ages

Code: NCT05953402·Recruiting·Listed Jul 2023

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A Study Assessing Safety, Tolerability, and Efficacy of INNA-051 in Preventing Respiratory Illness Due to Viral Infections in Healthy Adults 18 to 45 Years of Age

for Viral Respiratory Infection

Sites in Wilmington, Raleigh +3 more locations

Sponsor: ENA Respiratory Pty Ltd

Sex: All·Age: 18 - 45·Accepts healthy volunteers

Code: NCT07222670·Phase 2·Recruiting·Listed Oct 2025

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Observational Study to Assess Maternal, Fetal and Infant Outcomes Following Exposure to Rimegepant

for Migraine

Drug: Rimegepant

1 location in Wilmington

Sponsor: Pfizer

Sex: Female·Age: 0+

Code: NCT05046613·Recruiting·Listed Sep 2021

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A Global, Multicenter Study to Assess Maternal, Fetal and Infant Outcomes of Exposure to Palynziq® (Pegvaliase) During Pregnancy and Breastfeeding

for Phenylketonuria, Maternal

Drug: Pegvaliase

1 location in Wilmington

Sponsor: BioMarin Pharmaceutical

Sex: Female·Age: All ages

Code: NCT05579548·Recruiting·Listed Oct 2022

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Tenosynovial Giant Cell Tumor (TGCT) Real-World Participant Experience With Vimseltinib

for Tenosynovial Giant Cell Tumor

1 location in Wilmington

Sponsor: Deciphera Pharmaceuticals, LLC

Sex: All·Age: 18+

Code: NCT07075471·Recruiting·Listed Jul 2025

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Mavacamten Pregnancy Surveillance Program

for Breastfeeding

Drug: Mavacamten

1 location in Wilmington

Sponsor: Bristol-Myers Squibb

Sex: Female·Age: 15+

Code: NCT05939700·Recruiting·Listed Jul 2023

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Relugolix Pregnancy Registry: An Observational Study of the Safety of Relugolix-Containing Therapy Exposure in Pregnant Women and Their Offspring

for Pregnancy Related

Drug: Relugolix

1 location in Wilmington

Sponsor: Sumitomo Pharma Switzerland GmbH

Sex: Female·Age: 0+

Code: NCT05739123·Recruiting·Listed Feb 2023

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A Study of the Safety of Vonoprazan Exposure in Pregnant Women and Their Offspring

for Erosive Esophagitis

1 location in Wilmington

Sponsor: Phathom Pharmaceuticals, Inc.

Sex: Female·Age: 15 - 50

Code: NCT06660342·Recruiting·Listed Oct 2024

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SUNOSI® (Solriamfetol) Pregnancy Registry

for Narcolepsy

Drug: Solriamfetol

Sites in Wilmington & Morrisville

Sponsor: Axsome Therapeutics, Inc.

Sex: Female·Age: All ages

Code: NCT06413420·Recruiting·Listed May 2024

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Testing an Enhanced Digital Delivery Model for Inherited Cancer Genetic Testing in Young Adults With Cancer

for Miscellaneous Neoplasm, Nos

Sites in Wilmington, Thomasville +277 more locations

Sponsor: Alliance for Clinical Trials in Oncology

Sex: All·Age: 18+·Accepts healthy volunteers

Code: NCT07091617·Recruiting·Listed Jul 2025

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Induction Pembrolizumab and Chemotherapy Followed by Pembrolizumab Before Chemoradiation and Pembrolizumab Maintenance Compared to Standard Chemoradiation With Pembrolizumab Followed by Pembrolizumab Maintenance in High-Risk Cervical Cancer

for Locally Advanced Cervical Adenocarcinoma

Sites in Wilmington, Raleigh +288 more locations

Sponsor: National Cancer Institute (NCI)

Sex: Female·Age: 18+

Code: NCT07061977·Phase 3·Recruiting·Listed Jul 2025

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ShortStop-HER2: 12 Months vs. 6 Months of HER2-targeted Medications for People With HER2+ Breast Cancer Who Had a Pathologic Complete Response After Chemotherapy Plus Trastuzumab

for Anatomic Stage I Breast Cancer AJCC v8

Sites in Wilmington, Pinehurst +583 more locations

Sponsor: Alliance for Clinical Trials in Oncology

Sex: All·Age: 18+

Code: NCT06876714·Phase 3·Recruiting·Listed Mar 2025

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MYELOMATCH: A Screening Study to Assign People With Myeloid Cancer to a Treatment Study or Standard of Care Treatment Within myeloMATCH (MyeloMATCH Screening Trial)

for Acute Myeloid Leukemia

Sites in Wilmington, Greenville +326 more locations

Sponsor: National Cancer Institute (NCI)

Sex: All·Age: 18+

Code: NCT05564390·Phase 2·Recruiting·Listed Oct 2022

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Testing the Addition of High Dose, Targeted Radiation to the Usual Treatment for Locally-Advanced Inoperable Non-Small Cell Lung Cancer

for Locally Advanced Lung Non-Small Cell Carcinoma

Sites in Wilmington, Raleigh +444 more locations

Sponsor: NRG Oncology

Sex: All·Age: 18+

Code: NCT05624996·Phase 3·Recruiting·Listed Nov 2022

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Anticoagulation in ICH Survivors for Stroke Prevention and Recovery

for Intracerebral Hemorrhage

Sites in Wilmington, Greenville +140 more locations

Sponsor: Yale University

Sex: All·Age: 18+

Code: NCT03907046·Phase 3·Recruiting·Listed Apr 2019

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A Study to Compare Two Surgical Procedures in Individuals With BRCA1 Mutations to Assess Reduced Risk of Ovarian Cancer

for Ovarian Carcinoma

Sites in Wilmington, Raleigh +471 more locations

Sponsor: NRG Oncology

Sex: Female·Age: 35 - 50

Code: NCT04251052·Recruiting·Listed Jan 2020

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Isa-Rd for Frail and/or Much Older Patients With Newly Diagnosed Multiple Myeloma

for Multiple Myeloma

Sites in Wilmington, Durham +3 more locations

Sponsor: UNC Lineberger Comprehensive Cancer Center

Sex: All·Age: 18+

Code: NCT05145400·Phase 2·Recruiting·Listed Dec 2021

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Designing Visual Tools to Enhance Cancer Surgeon Decision-making

for Prostate Cancer

Sites in Wilmington & Chapel Hill

Sponsor: UNC Lineberger Comprehensive Cancer Center

Sex: All·Age: 18+

Code: NCT06965192·Recruiting·Listed May 2025

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IBD Pregnancy Registry

for Inflammatory Bowel Disease (IBD)

1 location in Wilmington

Sponsor: CorEvitas

Sex: Female·Age: 18 - 50

Code: NCT06910553·Recruiting·Listed Apr 2025

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RSV Vaccine Pregnancy Registry

for Respiratory Syncytial Virus (RSV)

1 location in Wilmington

Sponsor: CorEvitas

Sex: Female·Age: 18 - 50·Accepts healthy volunteers

Code: NCT06521944·Recruiting·Listed Jul 2024

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Antiretroviral Pregnancy Registry (APR): Multi-sponsor Registry to Detect Any Major Teratogenic Effect Involving Any of the Registry Drugs When Administered to Pregnant People.

for HIV Infections

1 location in Wilmington

Sponsor: Syneos Health

Sex: Female·Age: 12 - 60

Code: NCT00404989·Recruiting·Listed Nov 2006

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Dose Ranging Study of ORKA-002 in Patients With Moderate-to-Severe Plaque Psoriasis

for Plaque Psoriasis

Sites in Wilmington +23 more locations

Sponsor: Oruka Therapeutics, Inc.

Sex: All·Age: 18 - 79

Code: NCT07474792·Phase 2·Recruiting·Listed Mar 2026

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Sonesitatug Vedotin in Combination With Capecitabine With or Without Rilvegostomig in Participants With Advanced or Metastatic Gastric, Gastroesophageal Junction, or Esophageal Adenocarcinoma Expressing Claudin18.2

for Gastric Cancer

Drug: Sonesitatug vedotin

Sites in Wilmington, Charlotte +70 more locations

Sponsor: AstraZeneca

Sex: All·Age: 18+

Code: NCT07431281·Phase 3·Recruiting·Listed Feb 2026

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A Phase 2b Study Evaluating Oral VH4524184 Regimens in Treatment Naïve Persons With HIV-1 (INNOVATE Study)

for HIV Infections

Sites in Wilmington, Durham +33 more locations

Sponsor: ViiV Healthcare

Sex: All·Age: 18+

Code: NCT07202546·Phase 2·Recruiting·Listed Oct 2025

Apply to this trial