Paid Clinical Trials in Worcester, MA

As of July 2026, 233 paid clinical trials are recruiting in Worcester, Massachusetts. Compensation typically covers time, travel, and study visits, with stipends ranging from modest amounts for short outpatient studies to several thousand dollars for long or inpatient protocols.

Both patients with specific conditions and healthy volunteers can qualify. Most trials offer free study-related medical care alongside compensation.

Recruiting trial data synced daily from ClinicalTrials.gov. Last sync: July 1, 2026.

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205 clinical trials

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Social Needs Screening and Chronic Diseases Study (WE CARE)

for Hyperlipidemias

3 locations incl. Worcester

Sponsor: University of Massachusetts, Worcester

Sex: All·Age: All ages·Accepts healthy volunteers

Code: NCT06903897·Recruiting

Apply to this trial

Evaluation of the Paramedic Evaluation for Acute COPD Exacerbation

for COPD (Chronic Obstructive Pulmonary Disease)

1 location in Worcester

Sponsor: University of Massachusetts, Worcester

Sex: All·Age: 18+

Code: NCT07072039·Recruiting

Apply to this trial

Individualizing Treatment for Asthma in Primary Care (Full Study)

for Asthma

13 locations incl. Aurora

Sponsor: DARTNet Institute

Sex: All·Age: 13 - 75

Code: NCT07052942·Phase 4·Recruiting

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Self-administered ONe-of-a Kind Approach to Epilepsy Therapy Through a Web-based Music Application

for Epilepsy

2 locations incl. Worcester

Sponsor: Dartmouth-Hitchcock Medical Center

Sex: All·Age: 18+

Code: NCT06425029·Recruiting

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Improving Alcohol and Substance Use Care Access, Outcome, Equity During the Reproductive Years

for Alcohol-Related Disorders

4 locations incl. Boston

Sponsor: Emory University

Sex: All·Age: 18+

Code: NCT05910580·Recruiting

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Early Detection of Gestational Diabetes Mellitus in Pregnancy

for Gestational Diabetes Mellitus in Pregnancy

1 location in Worcester

Sponsor: University of Massachusetts, Worcester

Sex: Female·Age: 18+

Code: NCT05388643·Recruiting

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Preventing T2DM After GDM With Immediate Postpartum Screening

for Gestational Diabetes

1 location in Worcester

Sponsor: University of Massachusetts, Worcester

Sex: Female·Age: 18+

Code: NCT06457139·Recruiting

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Moms@Home: A Storytelling-based Mobile Health Intervention to Improve Blood Pressure Management in Pregnancy

for Hypertension in Pregnancy

1 location in Worcester

Sponsor: University of Massachusetts, Worcester

Sex: Female·Age: 18 - 50

Code: NCT06835959·Recruiting

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The Role of Occupational Therapy for Improving Medication Management for Persons With AMD, DR and Glaucoma

for Age-Related Macular Degeneration

1 location in Worcester

Sponsor: MCPHS University

Sex: All·Age: 50 - 100·Accepts healthy volunteers

Code: NCT06593405·EARLY_Phase 1·Recruiting

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Ear-Seizure Detection (EarSD) Study

for Seizures

2 locations incl. Worcester

Sponsor: Felicia Chu

Sex: All·Age: 18+·Accepts healthy volunteers

Code: NCT06598189·Recruiting

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Retropubic Hydrodissection and Trocar-induced Bladder Perforation During Retropubic Midurethral Slings

for Bladder Perforation

1 location in Worcester

Sponsor: University of Massachusetts, Worcester

Sex: Female·Age: 18+·Accepts healthy volunteers

Code: NCT07208682·Recruiting

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Pelvic Vein Quantitative Flow Characterization Using 2D and 4D Flow MRI

for May-Thurner Syndrome

1 location in Worcester

Sponsor: Ningcheng Peter Li

Sex: All·Age: 18 - 89·Accepts healthy volunteers

Code: NCT06888024·Recruiting

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Evaluating Signs of Safety: A Deaf-Accessible Therapy Toolkit for AUD and Trauma

for PTSD

1 location in Worcester

Sponsor: University of Massachusetts, Worcester

Sex: All·Age: 18+

Code: NCT06278922·Recruiting

Apply to this trial

Testimonials and Navigation in Rheumatology

for Rheumatologic Disease

3 locations incl. Birmingham

Sponsor: University of Alabama at Birmingham

Sex: All·Age: 18+

Code: NCT06469788·Recruiting

Apply to this trial

Promoting Early Intervention Timing and Attention to Language

for MONITOR

2 locations incl. Los Angeles

Sponsor: University of California, Los Angeles

Sex: All·Age: 6 Months - 8 Months

Code: NCT05853861·Recruiting

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Effect of Support for Low-Income Mothers of Preterm Infants

for Preterm Birth

4 locations incl. Atlanta

Sponsor: University of Massachusetts, Worcester

Sex: Female·Age: 18+

Code: NCT06362798·Recruiting

Apply to this trial

Head-Cancelled Virtual Reality for Ocular Cranial Nerve Palsies

for Internuclear Ophthalmoplegia

2 locations incl. Jacksonville

Sponsor: Kevin Houston

Sex: All·Age: 18+·Accepts healthy volunteers

Code: NCT06417216·Recruiting

Apply to this trial

Skilled Nursing Facility at Home Trial

for Skilled Nursing Facility

2 locations incl. Springfield

Sponsor: University of Massachusetts, Worcester

Sex: All·Age: 18+

Code: NCT06547645·Recruiting

Apply to this trial

Promoting Improved Functioning Among People Experiencing Stressful Situations

for Acute Stress Reaction

5 locations incl. Belmont

Sponsor: University of North Carolina, Chapel Hill

Sex: All·Age: 18 - 50

Code: NCT06482567·Recruiting

Apply to this trial

Continuous Glucose Monitor Use in Pregnancy

for Type 2 Diabetes Treated With Insulin

1 location in Worcester

Sponsor: University of Massachusetts, Worcester

Sex: Female·Age: 18+

Code: NCT05317585·Recruiting

Apply to this trial

Asthma Link Effectiveness Trial

for Childhood Asthma

1 location in Worcester

Sponsor: University of Massachusetts, Worcester

Sex: All·Age: 5 - 14

Code: NCT06388460·Recruiting

Apply to this trial

Efficacy, Effectiveness, and Implementation of Jaspr Health in Emergency Department- Part A

for Suicidal Ideation

1 location in Worcester

Sponsor: University of Massachusetts, Worcester

Sex: All·Age: 18+

Code: NCT06223867·Recruiting

Apply to this trial

MIRAI-MRI: Comparing Screening MRI for Patients at High Risk for Breast Cancer Identified by Mirai and Tyrer-Cuzick

for Breast Cancer

1 location in Worcester

Sponsor: University of Massachusetts, Worcester

Sex: Female·Age: 40+

Code: NCT05968157·Recruiting

Apply to this trial

Enhanced Coordinated Specialty Care for Early Psychosis

for Psychosis

5 locations incl. Belmont

Sponsor: Mclean Hospital

Sex: All·Age: All ages

Code: NCT06071858·Recruiting

Apply to this trial

ShotBlocker During Intramuscular Injection Randomized Control Trial

for Neonatal Pain

1 location in Worcester

Sponsor: Lauren Fortier

Sex: All·Age: 37 Weeks - 42 Weeks·Accepts healthy volunteers

Code: NCT06624176·Recruiting

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Trauma-informed Approach to Timely Detection and Management of Early Postpartum Hypertension

for Postpartum Hypertension

3 locations incl. New Haven

Sponsor: Yale University

Sex: Female·Age: 18+

Code: NCT05884190·Recruiting

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Real-Time Cholangioscopy Artificial Intelligence Evaluation of Biliary Strictures

for Biliary Stricture

2 locations incl. Worcester

Sponsor: Mayo Clinic

Sex: All·Age: 18+

Code: NCT05779436·Recruiting

Apply to this trial

Botulinum Toxin Therapy in Hidradenitis Suppurativa

for Hidradenitis Suppurativa

1 location in Worcester

Sponsor: University of Massachusetts, Worcester

Sex: All·Age: 18 - 75

Code: NCT05403710·Recruiting

Apply to this trial

Supporting Treatment Access and Recovery in COD

for Opioid Use Disorder

5 locations incl. Holyoke

Sponsor: University of Massachusetts, Worcester

Sex: All·Age: 18+

Code: NCT05138614·Recruiting

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Complex Aortic Aneurysm Repair Using Physician Modified Endografts and Custom Made Devices

for Complex Aortic Aneurysms

1 location in Worcester

Sponsor: Andres Schanzer

Sex: All·Age: 18+

Code: NCT02050113·Recruiting

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Outcomes and Data Collection for Fecal Microbiota Transplantation for the Treatment of Recurrent Clostridium Difficile

for Clostridium Difficile Infection Recurrence

1 location in Worcester

Sponsor: Krunal Patel

Sex: All·Age: 16+

Code: NCT03562741·Recruiting

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ALTO-207 in Adults With Treatment-resistant Depression (TRD)

for Treatment-resistant Depression (TRD)

38 locations incl. Birmingham

Sponsor: Alto Neuroscience

Sex: All·Age: 18 - 75

Code: NCT07553637·Phase 2·Recruiting

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AZD5335 vs. Mirvetuximab Soravtansine in FRα-high and AZD5335 vs. Chemotherapy in FRα-low Platinum-resistant Ovarian Cancer

for Epithelial Ovarian Cancer

17 locations incl. Fort Lauderdale

Sponsor: AstraZeneca

Sex: Female·Age: 18+

Code: NCT07218809·Phase 3·Recruiting

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Evaluating the Effects of Tasimelteon vs. Placebo in Treating Pediatric Insomnia

for Insomnia Disorder

21 locations incl. Dothan

Sponsor: Vanda Pharmaceuticals

Sex: All·Age: 2 - 17

Code: NCT06953869·Phase 3·Recruiting

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DESTINY-Endometrial01: A Phase III Study of Trastuzumab Deruxtecan Plus Rilvegostomig or Pembrolizumab as First-Line Treatment of HER2-Expressing (IHC 3+/2+), Mismatch Repair Proficient (pMMR) Endometrial Cancer

for Endometrial Cancer

Drug: Rilvegostomig

60 locations incl. Tucson

Sponsor: AstraZeneca

Sex: Female·Age: 18+

Code: NCT06989112·Phase 3·Recruiting

Apply to this trial

Imeroprubart in Adult Participants With Chronic Inflammatory Demyelinating Polyneuropathy (CIDP)

for Chronic Inflammatory Demyelinating Polyneuropathy

31 locations incl. Tucson

Sponsor: Immunovant Sciences GmbH

Sex: All·Age: 18+

Code: NCT07032662·Phase 2·Recruiting

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A Phase III Renal Outcomes and Cardiovascular Mortality Study to Investigate the Efficacy and Safety of Baxdrostat in Combination With Dapagliflozin in Participants With Chronic Kidney Disease and High Blood Pressure

for Chronic Kidney Disease and Hypertension

Drug: Dapagliflozin

133 locations incl. Fairhope

Sponsor: AstraZeneca

Sex: All·Age: 18+

Code: NCT06742723·Phase 3·Recruiting

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A Study of Belantamab Mafodotin Administered in Combination With Lenalidomide and Dexamethasone (BRd) Versus Daratumumab, Lenalidomide, and Dexamethasone (DRd) in Participants With Newly Diagnosed Multiple Myeloma (NDMM) Who Are Ineligible for Autologous Stem Cell Transplantation (TI-NDMM)

for Multiple Myeloma

Drug: Belantamab mafodotin

30 locations incl. Mobile

Sponsor: GlaxoSmithKline

Sex: All·Age: 18+

Code: NCT06679101·Phase 3·Recruiting

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Phase 3 Study of T-DXd and Rilvegostomig Versus SoC in Advanced HER2-expressing Biliary Tract Cancer

for Biliary Tract Cancer

Drug: Rilvegostomig

48 locations incl. Scottsdale

Sponsor: AstraZeneca

Sex: All·Age: 18 - 99

Code: NCT06467357·Phase 3·Recruiting

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A Phase 1/2 Study of NKX019 in Subjects With Autoimmune Disease (Ntrust-1)

for Lupus Nephritis

17 locations incl. Little Rock

Sponsor: Nkarta, Inc.

Sex: All·Age: 18 - 75

Code: NCT06557265·Phase 1, Phase 2·Recruiting

Apply to this trial