Combination Chemotherapy in Treating Patients With Unresectable Metastatic Colorectal Cancer

Sponsor
Medical Research Council
Study ID
NCT00008060
Phase
PHASE3
Status
Completed

Conditions

Eligibility Criteria

Sex
ALL
Age
18 Years - N/A
Healthy Volunteers
Not accepted

Interventions

  • FOLFIRI regimen — DRUG
  • FOLFOX regimen — DRUG
  • fluorouracil — DRUG
  • irinotecan hydrochloride — DRUG
  • leucovorin calcium — DRUG
  • oxaliplatin — DRUG

Study Details

RATIONALE: Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. Combining more than one drug may kill more tumor cells. It is not yet known which regimen of combination chemotherapy is more effective for advanced colorectal cancer. PURPOSE: Randomized phase III trial to compare the effectiveness of fluorouracil combined with leucovorin and either irinotecan or oxaliplatin in treating patients who have unresectable metastatic colorectal cancer.

Key Dates

Start date
May 31, 2000
Status verified
Mar 2002
Completion
Dec 31, 2003

Study Design

Allocation
RANDOMIZED
Primary purpose
TREATMENT

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