Efficacy Trial Comparing ZD6474 With Erlotinib in NSCLC After Failure of at Least One Prior Chemotherapy

Part of paid clinical trials in Berkeley, California.

Sponsor
Genzyme, a Sanofi Company
Study ID
NCT00364351
Phase
PHASE3
Status
Completed

Conditions

Eligibility Criteria

Sex
ALL
Age
18 Years - N/A
Healthy Volunteers
Not accepted

Interventions

  • Vandetanib — DRUG
    once daily oral tablet
  • Erlotinib — DRUG
    oral dose

Study Details

To determine if ZD6474 a new investigational drug, is effective in treating Non Small Lung Cancer and if so, how it compares with another type of anti cancer therapy chemotherapy, Erlotinib

Key Dates

First listed
Aug 15, 2006
Start date
Aug 31, 2006
Status verified
Jan 2018
Primary completion
Sep 30, 2008
Completion
Nov 30, 2016

Study Design

Enrollment
1,574 participants (actual)
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT

Arms

  • Active Comparator: 1
    Erlotinib
  • Experimental: 2
    Vandetanib

Primary Outcome Measure

Progression-Free Survival (PFS) [ Time Frame: progressionRECIST tumour assessments carried out every 4 weeks up to week 16 then every 8 weeks thereafter from randomisation until the date of first documented objective disease progression or date of death from any cause, whichever came first, assessed. ]

Locations (29)

FacilityCityStateZIPSite coordinators
Research SiteBerkeleyCalifornia--
Research SiteLos AngelesCalifornia--
Research SiteSanta RosaCalifornia--
Research SiteBoynton BeachFlorida--
Research SiteFort MyersFlorida--
Research SiteJacksonvilleFlorida--
Research SitePort Saint LucieFlorida--
Research SiteWichitaKansas--
Research SiteLexingtonKentucky--
Research SiteLouisvilleKentucky--
Research SiteMetairieLouisiana--
Research SiteBaltimoreMaryland--
Research SiteColumbiaMissouri--
Research SiteSt LouisMissouri--
Research SiteLathamNew York--
Research SiteHickoryNorth Carolina--
Research SiteCantonOhio--
Research SiteCincinnatiOhio--
Research SiteGreenvilleSouth Carolina--
Research SiteChattanoogaTennessee--
Research SiteNashvilleTennessee--
Research SiteAmarilloTexas--
Research SiteGarlandTexas--
Research SiteWebsterTexas--
Research SiteFairfaxVirginia--
Research SiteNorfolkVirginia--
Research SiteRichmondVirginia--
Research SiteBurienWashington--
Research SiteYakimaWashington--

Find similar trials in Berkeley, CA

By condition
Lung cancer
By specialty
OncologyLung oncologyLung disease
By research site
Research Site· Berkeley, CAResearch Site· Los Angeles, CAResearch Site· Santa Rosa, CAResearch Site· Boynton Beach, FLResearch Site· Fort Myers, FLResearch Site· Jacksonville, FL

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